EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes

Immunity

Volumn 7, Issue 1, 1997, Pages 25-36

  Sigvardsson, Mikael ^a   O'Riordan, Mary ^a   Grosschedl, Rudolf ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; BINDING SITE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; STEM CELL; TRANSCRIPTION REGULATION;

EID: 0030790713     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80507-5     Document Type: Article

References (71)

1. Alt, F., Blackwell, T., and Yancopoulos, G. (1987). Development of the primary antibody repertoire. Science 238, 1079-1087.
2. Bain, G., Gruenwald, S., and Murre, C. (1993). E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins. Mol. Cell. Biol. 13, 3522-3529.
3. Bain, G., Robanus Maandag, E.C., Izon, D.J., Amsen, D., Kruisbeek, A.M., Weintraub, B.C., Krop, I., Schlissel, M.S., Feeney, A.J., et al. (1994). E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79, 885-892.
4. Barberis, A., Widehorn, K., Vitelli, L., and Busslinger, M. (1990). A novel B cell specific transcription factor present in early but not late stages of differentiation. Genes Dev. 4, 849-858.
5. Benezra, R. (1995). An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures. Cell 79, 1057-1067.
6. Benezra, R., Davis, R.L., Lockshon, D., Turner, D.L., and Weintraub, H. (1990). The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61, 49-59.
7. Borst, J., Jacobs, H., and Brouns, G. (1996). Composition and function of T cell receptor and B cell receptor complexes on precursor lymphocytes. Curr. Opin. Immunol. 8, 181-190.
8. Brennan, T., and Olson, E. (1990). Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element upon heterodimerisation. Genes Dev. 4, 582-595.
9. Brouns, G., De Vries, E., Van Noesel, C., Mason, D., Van Lier, R., and Borst, J. (1993). The structure of the μ pseudo light chain complex on human pre B cells is consistent with a function in signal transduction. Eur. J. Immunol. 23, 1088-1097.
10. Choi, J.K., Shen, C-P., Radomska, H.S., Eckhardt, L.A., and Kadesch, T. (1996). E47 activates the Ig-heavy chain and TdT loci in non-B cells. EMBO J. 15, 5014-5021.
11. Corcoran, L., Karvelas, M., Nossal, G., Ye, Z., Jacks, T., and Baltimore, D. (1993). Oct-2, although not required for early B cell development, is critical for later B cell maturation and for postnatal survival. Genes Dev. 7, 570-582.
12. Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Muller, W., and Rajewsky, K. (1993). Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72, 695-704.
13. Emerson, C. (1993). Skeletal myogenesis: genetics and embryology to the fore. Curr. Opin. Genet. Dev. 3, 265-274.
14. Ephrussi, A., Church, G.M., Tonegawa, S., and Gilbert, W. (1985). B-linage-specific interactions of a immunoglobulin enhancer with cellular factors in vivo. Science 227, 134-140.
15. Fitzsimmons, D., Hodsdon, W., Wheat, W., Maira, S.-M., Wasylyk, B., and Hagman, J. (1996). Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter. Genes Dev. 10, 2198-2211.
16. Gilfillan, S., Dierich, A., Lemeur, M., Benoist, C., and Mathis, D. (1993). Mice lacking TdT: Mature animals with an immature lymphocyte repertoire. Science 261, 1175-1178.
17. Gong, S., and Nussenzweig, M. (1996). Regulation of an early developmental checkpoint in the B cell pathway by Igβ. Science 272, 411-414.
18. Grosschedl, R., and Baltimore, M. (1985). Cell type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell 41, 885-897.
19. Hagman, J., Travis, A., and Grosschedl, R. (1991). A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation. EMBO J. 10, 3409-3417.
20. Hagman, J., Belanger, C., Travis, A., Turck, C.W., and Grosschedl, R. (1993). Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. Genes Dev. 7, 760-773.
21. Hagman, J., Gutch, M.J., Lin, H., and Grosschedl, R. (1995). EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains. EMBO J. 14, 2907-2916.
22. Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D., and Hayakawa, K. (1991). Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225.
23. Herskowitz, I. (1989). A regulatory hierarchy for cell specialisation in yeast. Nature 342, 749-757.
24. Hombach, J., Lottspeich, F., and Reth, M. (1990a). Identification of the genes encoding the IgM-α and Ig-β components of the IgM antigen receptor complex by aminoterminal sequencing. Eur. J. Immunol. 20, 2795-2799.
25. Hombach, J., Tsubata, T., Leclercq, L., Stappert, H., and Reth, M. (1990b). Molecular components of the B-cell antigen receptor complex of the IgM class. Nature 343, 760-762.
26. Hu, J.-S., Olson, E., and Kingston, R. (1992). HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA binding ability of myogenic regulatory factors. Mol. Cell. Biol. 12, 1031-1042.
27. Jacobs, Y., Xin, X-Q., Dorshkind, K., and Nelson, C. (1994). Pan/ E2A expression precedes immunoglobulin heavy-chain expression during B lymphopoiesis in nontransformed cells, and pan/E2A proteins are not detected in myeloid cells. Mol. Cell. Biol. 14, 4087-4096.
28. Kadesch, T. (1992). Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription. Immunol. Today 13, 31-36.
29. Karasuyama, H., Kudo, A., and Melchers, F. (1990). The proteins encoded by the VpreB and λ5 preB cell specific genes can associate with each other and with m heavy chain. J. Exp. Med. 172, 969-972.
30. Keleher, C.A., Goutte, C., and Johnson, A.D. (1988). The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein. Cell 53, 927-936.
31. Kitamura, D., Kudo, A., Schaal, S., Muller, W., Melchers, F., and Rajewsky, F. (1992). A critical role of λ5 protein in B cell development. Cell 69, 823-831.
32. Komori, T., Okada, A., Steward, W., and Alt, F. (1993). Lack of N regions in antigen receptor variable region genes of TdT deficient lymphocytes. Science 261, 1171-1175.
33. Kudo, A., and Melchers, F. (1987). A second gene, VpreB in the λ5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J. 6, 2267-2272.
34. Kudo, A., Sakaguchi, N., and Melchers, F. (1987). Organization of the murine Ig-related λ5 gene transcribed selectively in pre-B lymphocytes. EMBO J. 6, 103-107.
35. Lassar, A., Davis, R., Wright, W., Kadesch, T., Murre, C., Vovonova, A., Baltimore, D., and Weintraub, H. (1991). Functional activity of myogenic bHLH proteins requires hetero-oligomerisation with E12/ E47-like proteins in vivo. Cell 66, 305-315.
36. Li, Y.-S., Wasserman, R., Hayakawa, K., and Hardy, R. (1996). Identification of the earliest B lineage stage in mouse bone marrow. Immunity 5, 527-535.
37. Lin, H., and Grosschedl, R. (1995). Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376, 263-267.
38. Mårtensson, L., and Melchers, F. (1994). Pre-B cell specific λ5 expression due to supression in non pre-B cells. Int. Immunol. 6, 863-871.
39. Melchers, F., Karasuyama, H., Haasner, D., Bauer, S., Kudo, A., Sakaguchi, N., Jameson, B., and Rolink, A. (1993). The surrogate light chain in B-cell development. Immunol. Today 14, 60-68.
40. Molkentin, J., Black, B., Martin, J., and Olson, E. (1995). Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83, 1125-1136.
41. Mombaerts, P., Iacomini, J., Johnson, R., Herrup, K., Tonegawa, S., and Papaioannou, V. (1992). RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
42. Murre, C., Schonleber Mc-Caw, P., and Baltimore, D. (1989a). A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56, 777-783.
43. Murre, C., Schonleber Mc-Caw, P., Vaessin, H., Caudy, M., Jan, L.Y., Jan, Y.N., Cabrera, C.V., Buskin, J.N., Hauschka, S.D., Lassar, A.B., et al. (1989b). Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58, 537-544.
44. Murre, C., Voronova, A., and Baltimore, D. (1991). B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Mol. Cell. Biol. 11, 1156-1160.
45. Murre, C., Bain, G., van Dijk, M.A., Engel, I., Furnari, B.A., Massari, M.E., Matthews, J.R., Quong, M.W., Rivera, R.R., and Stuiver, M.H. (1994). Structure and function of helix-loop-helix proteins. Biochim. Biophys. Acta 1218, 129-135.
46. Nakamura, T., Kubagawa, H., and Cooper, M. (1992). Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 89, 8522-8526.
47. Neuhold, L.A., and Wold, B. (1993). HLH forced dimers: Tethering MyoD to E47 generates a dominant positive myogenic factor insulated from negative regulation by Id. Cell 74, 1033-1042.
48. Nutt, S., Urbanek, P., Rolink, A., and Busslinger, M. (1997). Essential functions of Pax-5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoesis and reduced V-to DJ recombination in the IgH locus. Genes Dev. 11, 476-491.
49. Okabe, T., Bauer, S.R., and Kudo, A. (1992a). Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene. Eur. J. Immunol. 22, 31-36.
50. Okabe, T., Watanabe, T., and Kudo, A. (1992b). A pre-B-and B cell-specific DNA-binding protein, EBB-1, which binds to the promoter of the VpreB1 gene. Eur. J. Immunol. 22, 37-43.
51. Olson, E.N. (1990). MyoD family: a paradigm for development? Genes Dev. 4, 1454-1461.
52. Palacios, R., and Steinmetz, M. (1985). IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell 41, 727-734.
53. Papavasiliou, F., Misulovin, Z., Suh, H., and Nussenzweig, M. (1995). The role of Igβ in precursor B cell transition and alleleic exclusion. Science 268, 408-411.
54. Peverali, F.A., Ramqvist, T., Saffrich, R., Pepperkok, R., Barone, M.V., and Philipson, L. (1994). Regulation of G1 progression by E2A and Id helix-loop-helix proteins. EMBO J. 13, 4291-4301.
55. Quong, M., Massari, M., Zwart, R., and Murre, C. (1993). A new transcriptional activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol. Cell. Biol. 13, 792-800.
56. Schlissel, M., Voronova, A., and Baltimore, D. (1991). Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev. 5, 1367-1376.
57. Schreiber, E., Matthias, P., Muller, M., and Schaffner, W. (1989). Rapid detection of octamer binding proteins with "mini-extracts" prepared from a small number of cells. Nucleic Acids Res. 17, 6419.
58. Shen, C. -P., and Kadesch, T. (1995). B cell specific DNA binding by an E47 homodimer. Mol. Cell. Biol. 15, 4518-4524.
59. Shinkai, Y., Rathbun, G., Lam, K.-P., Oltz, E., Stewart, V., Mendelson, M., Charron, J., Datta, M., Young, F., Stall, A., et al. (1992). RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867.
60. Sigvardsson, M., Åkerblad, P., and Leanderson, T. (1996). Early B cell Factor interacts with a subset of k promoters. J. Immunol. 156, 3788-3796.
61. Sloan, S., Shen, C.-P., McGarrick-Walmsley, R., and Kadesch, T. (1996). Phosphorylation of E47 as a potential determinant of B cell specific activity. Mol. Cell. Biol. 16, 6900-6908.
62. Sun, X.-H. (1994). Constitutive expression of the Id1 gene impairs mouse B cell development. Cell 79, 893-900.
63. Tontonoz, P., Hu, E., and Spiegelman, M. (1994). Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147-1156.
64. Travis, A., Hagman, J., and Grosschedl, R. (1991). Heterogeneously initiated transcription from the preB and B cell specific mb-1 promoter: Analysis of the requirements for upstream factor binding sites and initiation site sequences. Mol. Cell. Biol. 11, 5756-5766.
65. Travis, A., Hagman, J., Hwang, L., and Grosschedl, R. (1993). Purification of early-B-cell factor and characterization of its DNA-binding specificity. Mol. Cell. Biol. 13, 3392-3400.
66. Tsubata, T., and Reth, M. (1990). The products of the pre B cell specific genes λ5 and VpreB and the immunoglobulin m chain form a complex that is transported onto the cell surface. J. Exp. Med. 172, 973-976.
67. Urbanek, P., Wang, Z.-Q., Fetka, I., Wagner, E., and Busslinger, M. (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901-912.
68. Wang, M.W., and Reed, R.R. (1993). Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast. Nature 364, 121-126.
69. Weintraub, H., Davis, R., Tapscott, S., Thayer, M., Krause, M., Benezra, R., Blackwell, T.K., Turner, D., Rupp, R., Hollenberg, S., et al. (1991). The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251, 761-766.
70. Yang, J., Glozak, M.A., and Blomberg, B.B. (1995). Identification and localization of a developmental stage-specific promoter activity from the murine λ5 gene. J. Immunol. 155, 2498-2514.
71. Zhuang, Y., Soriano, P., and Weintraub, H. (1994). The helix-loop-helix gene E2A is required for B cell formation. Cell 79, 875-884.