Regulation of lymphocyte fate by Ras/ERK signals

Cell Cycle

Volumn 7, Issue 23, 2008, Pages 3634-3640

  Yasuda, Tomoharu ^a   Kurosaki, Tomohiro ^a,b  

^a RIKEN Center for Integrative Medical Sciences   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

BCR; Differentiation; ERK; IEG; Proliferation; Ras; RasGRP; Sos; TCR; Transcription factor

Indexed keywords

B LYMPHOCYTE RECEPTOR; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN; ENZYME ACTIVATION; GENETIC TRANSFECTION; LYMPHOCYTE; NONHUMAN; REVIEW;

EID: 57349087078     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.23.7103     Document Type: Review

References (58)

1. Thomson S, Mahadevan LC, Clayton AL. MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction. Semin Cell Dev Biol 1999; 10:205-14.
2. Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004; 68:320-44.
3. Murphy LO, Blenis J. MAPK signal specificity: the right place at the right time. Trends Biochem Sci 2006; 31:268-75.
4. Werlen G, Hausmann B, Palmer E. A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity. Nature 2000; 406:422-6.
5. Rincon M. MAP-kinase signaling pathways in T cells. Curr Opin Immunol 2001; 13:339-45.
6. Alberola-Ila J, Hernandez-Hoyos G. The Ras/MAPK cascade and the control of positive selection. Immunol Rev 2003; 191:79-96.
7. Marshall CJ. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Dev 1994; 4:82-9.
8. Genot E, Cantrell DA. Ras regulation and function in lymphocytes. Curr Opin Immunol 2000; 12:289-94.
9. Katz ME, McCormick F. Signal transduction from multiple Ras effectors. Curr Opin Genet Dev 1997; 7:75-9.
10. Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ. Increasing complexity of Ras signaling. Oncogene 1998; 17:1395-413.
11. Mitin N, Rossman KL, Der CJ. Signaling interplay in Ras superfamily function. Curr Biol 2005; 15:563-74.
12. 2+. J Cell Biol 2005; 170:183-90.
13. Traverse S, Seedorf K, Paterson H, Marshall CJ, Cohen P, Ullrich A. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol 1994; 4:694-701.
14. Dikic I, Schlessinger J, Lax I. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation. Curr Biol 1994; 4:702-8.
15. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995; 80:179-85.
16. York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, et al. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 1998; 392:622-6.
17. Kao S, Jaiswal RK, Kolch W, Landreth GE. Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells. J Biol Chem 2001; 276:18169-77.
18. Wu C, Lai CF, Mobley WC. Nerve growth factor activates persistent Rap1 signaling in endosomes. J Neurosci 2001; 21:5406-16.
19. Dower NA, Stang SL, Bottorff DA, Ebinu JO, Dickie P, Ostergaard HL, et al. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol 2000; 1:317-21.
20. Oh-hora M, Johmura S, Hashimoto A, Hikida M, Kurosaki T. Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J Exp Med 2003; 198:1841-51.
21. Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol 2005; 25:4426-41.
22. Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol 2007; 27:2732-45.
23. Rogge RD, Karlovich CA, Banerjee U. Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Cell 1991; 64:39-48.
24. Buday L, Downward J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 1993; 73:611-20.
25. Hashimoto A, Okada H, Jiang A, Kurosaki M, Greenberg S, Clark EA, et al. Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor. J Exp Med 1998; 188:1287-95.
26. Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE. Association of Grb2, Gads and phospholipase C-gamma1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. J Biol Chem 2000; 275:23355-61.
27. Lin J, Weiss A. Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem 2001; 276:29588-95.
28. Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, et al. Structural evidence for feedback activation by Ras. GTP of the Ras-specific nucleotide exchange factor SOS. Cell 2003; 112:685-95.
29. Boykevisch S, Zhao C, Sondermann H, Philippidou P, Halegoua S, Kuriyan J, et al. Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol 2006; 16:2173-9.
30. Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H, et al. Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol 2002; 4:343-50.
31. Bivona TG, Perez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, et al. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature 2003; 424:694-8.
32. Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 1988; 336:73-6.
33. Teh HS, Kisielow P, Scott B, Kishi H, Uematsu Y, Bluthmann H, et al. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 1988; 335:229-33.
34. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 1989; 341:746-9.
35. Starr TK, Jameson SC, Hogquist KA. Positive and negative selection of T cells. Annu Rev Immunol 2003; 21:139-76.
36. Daniels MA, Teixeiro E, Gill J, Hausmann B, Roubaty D, Holmberg K, et al. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 2006; 444:724-9.
37. Mor A, Philips MR. Compartmentalized Ras/MAPK signaling. Annu Rev Immunol 2006; 24:771-800.
38. Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E. Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell 2004; 7:33-44.
39. Treisman R. Ternary complex factors: growth factor regulated transcriptional activators. Curr Opin Genet Dev 1994; 4:96-101.
40. Buchwalter G, Gross C, Wasylyk B. Ets ternary complex transcription factors. Gene 2004; 324:1-14.
41. Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J. Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol 2002; 4:556-64.
42. Hardy RR, Hayakawa K. B cell development pathways. Annu Rev Immunol 2001; 19:595-621.
43. Meffre E, Casellas R, Nussenzweig MC. Antibody regulation of B cell development. Nat Immunol 2000; 1:379-85.
44. Hendriks RW, Middendorp S. The pre-BCR checkpoint as a cell-autonomous proliferation switch. Trends Immunol 2004; 25:249-56.
45. Melchers F. The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire. Nat Rev Immunol 2005; 5:578-84.
46. Geier JK, Schlissel MS. Pre-BCR signals and the control of Ig gene rearrangements. Semin Immunol 2006; 18:31-9.
47. Yasuda T, Sanjo H, Pages G, Kawano Y, Karasuyama H, Pouyssegur J, et al. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 2008; 28:499-508.
48. Chen HC, Byrd JC, Muthusamy N. Differential role for cyclic AMP response element binding protein-1 in multiple stages of B cell development, differentiation and survival. J Immunol 2006; 176:2208-18.
49. Cesari F, Brecht S, Vintersten K, Vuong LG, Hofmann M, Klingel K, et al. Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation. Mol Cell Biol 2004; 24:294-305.
50. Costello PS, Nicolas RH, Watanabe Y, Rosewell I, Treisman R. Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection. Nat Immunol 2004; 5:289-98.
51. von Boehmer H, Fehling HJ. Structure and function of the pre-T cell receptor. Annu Rev Immunol 1997; 15:433-52.
52. Crompton T, Gilmour KC, Owen MJ. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 1996; 86:243-51.
53. Iritani BM, Alberola-Ila J, Forbush KA, Perimutter RM. Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors. Immunity 1999; 10:713-22.
54. Fischer AM, Katayama CD, Pages G, Pouyssegur J, Hedrick SM. The role of erk1 and erk2 in multiple stages of T cell development. Immunity 2005; 23:431-43.
55. Torres RM, Flaswinkel H, Reth M, Rajewsky K. Aberrant B cell development and immune response in mice with a compromised BCR complex. Science 1996; 272:1804-8.
56. Turner M, Gulbranson-Judge A, Quinn ME, Walters AE, MacLennan IC, Tybulewicz VL. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool. J Exp Med 1997; 186:2013-21.
57. Martin F, Kearney JF. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19 and btk. Immunity 2000; 12:39-49.
58. Chambard JC, Lefloch R, Pouyssegur J, Lenormand P. ERK implication in cell cycle regulation. Biochim Biophys Acta 2007; 1773:1299-310.