A prematurely expressed Igκ transgene, but not a VκJκ gene segment targeted into the Igκ locus, can rescue B cell development in λ5-deficient mice

Immunity

Volumn 5, Issue 3, 1996, Pages 229-239

  Pelanda, Roberta ^a   Schaal, Stefan ^a   Torres, Raul M ^a   Rajewsky, Klaus ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL MATURATION; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOGLOBULIN DEFICIENCY; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; TRANSGENE;

EID: 0030249394     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80318-0     Document Type: Article

References (62)

1. Alt, F., Rosenberg, N., Lewis, S., Thomas, E., and Baltimore, D. (1981). Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell 27, 381-390.
2. Arnold, L.W., Pennell, C.A., McCray, S.K., and Clarke, S.H. (1994). Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression. J. Exp. Med. 179, 1585-1595.
3. Blackwell, T.K., Moore, M.W., Yancopoulos, G.D., Suh, H., Lutzker, S., Selsing, E., and Alt, F.W. (1986). Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature 324, 585-589.
4. Brouns, G.S., de Vries, E., van Noesel, C.J., Mason, D.Y., van Lier, R.A., and Borst, J. (1993). The structure of the μ/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction. Eur. J. Immunol. 23, 1088-1097.
5. Coffman, R.L. (1982). Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69, 5-23.
6. Durdik, J., Moore, M.W., and Selsing, E. (1984). Novel κ light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes. Nature 307, 749-752.
7. Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Müller, W., and Rajewsky, K. (1993). Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72, 695-704.
8. Ehlich, A., Martin, V., Müller, W., and Rajewsky, K. (1994). Analysis of the B-cell progenitor compartment at the level of single cells. Curr. Biol. 4, 573-583.
9. Ernst, P., and Smale, S.T. (1995). Combinatorial regulation of transcription II: the immunoglobulin μ heavy chain gene. Immunity 2, 427-438.
10. Ferradini, L., Gu, H., De Smet, A., Rajewsky, K., Reynaud, C.A., and Weill, J.C. (1996). Rearrangement-enhancing element upstream of the mouse immunoglobulin κ chain J cluster. Science 277, 1416-1420.
11. Fiering, S., Epner, E., Robinson, K., Zhuang, Y., Telling, A., Hu, M., Martin, D.I., Enver, T., Ley, T.J., and Groudine, M. (1995). Targeted deletion of 5′HS2 of the murine β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus. Genes Dev. 9, 2203-2213.
12. Förster, I., Vieira, P., and Rajewsky, K. (1989). Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse. Int. Immunol. 1, 321-331.
13. Gay, D., Saunders, T., Camper, S., and Weigert, M. (1993). Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177, 999-1008.
14. Grawunder, U., Leu, T.M., Schatz, D.G., Werner, A., Rolink, A.G., Melchers, F., and Winkler, T.H. (1995). Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity 3, 601-608.
15. Grützmann, R. (1981). Vergleichende idiotypische analyse von rezeptoren mit spezifität für histokompatibilitätsantigene. PhD thesis, University of Cologne, Cologne, Federal Republic of Germany.
16. Gu, H., Zou, Y.R., and Rajewsky, K. (1993). Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-IoxP-mediated gene targeting. Cell 73, 1155-1164.
17. Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D., and Hayakawa, K. (1991). Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225.
18. Hartley, S.B., Cooke, M.P., Fulcher, D.A., Harris, A.W., Cory, S., Basten, A., and Goodnow, C.C. (1993). Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72, 325-335.
19. κ joining. Cell 83, 1113-1123.
20. preB and λ5 pre-B cell-specific genes can associate with each other and with μ heavy chain. J. Exp. Med. 172, 969-972.
21. pre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77, 133-143.
22. Kitamura, D., and Rajewsky, K. (1992). Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356, 154-156.
23. Kitamura, D., Roes, J., Kühn, R., and Rajewsky, K. (1991). A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350, 423-426.
24. Kitamura, D., Kudo, A., Schaal, S., Müller, W., Melchers, F., and Rajewsky, K. (1992). A critical role of λ5 protein in B cell development. Cell 69, 823-831.
25. Kudo, A., and Melchers, F. (1987). A second gene, VpreB in the λ5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J. 6, 2267-2272.
26. Kühn, R., Rajewsky, K., and Müller, W. (1991). Generation and analysis of interleukin-4 deficient mice. Science 254, 707-710.
27. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R., and Berns, A. (1991). Simplified mammalian DNA isolation procedure. Nucl. Acids Res. 19, 4293.
28. Leo, O., Foo, M., Sachs, D.H., Samelson, L.E., and Bluestone, J.A. (1987). Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84, 1374-1378.
29. Lewis, S., Rosenberg, N., Alt, F., and Baltimore, D. (1982). Continuing κ-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. Cell 30, 807-816.
30. Li, Y.S., Hayakawa, K., and Hardy, R.R. (1993). The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178, 951-960.
31. Löffert, D., Schaal, S., Ehlich, A., Hardy, R.R., Zou, Y.R., Müller, W., and Rajewsky, K. (1994). Early B-cell development in the mouse: insights from mutations introduced by gene targeting. Immunol. Rev. 137, 135-153.
32. Löffert, D., Ehlich, A., Müller, W., and Rajewsky, K. (1996). Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity 4, 133-144.
33. Mansour, S.L., Thomas, K.R., and Capecchi, M.R. (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336, 348-352.
34. Matsuo, T., Nomura, J., Kuwahara, K., Igarashi, H., Inui, S., Hamaguchi, M., Kimoto, M., and Sakaguchi, N. (1993). Cross-linking of B cell receptor-related MB-1 molecule induces protein tyrosine phosphorylation in early B lineage cells. J. Immunol. 150, 3766-3775.
35. Miltenyi, S., Müller, W., Weichel, W., and Radbruch, A. (1990). High gradient magnetic cell separation with MACS. Cytometry 11, 231-238.
36. Misener, V., Downey, G.P., and Jongstra, J. (1991). The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule. Int. Immunol. 3, 1129-1136.
37. Nemazee, D.A., and Bürki, K. (1989). Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337, 562-566.
38. Osmond, D.G. (1991). Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs. Curr. Opin. Immunol. 3, 179-185.
39. Ozato, K., Mayer, N., and Sachs, D.H. (1980). Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J. Immunol. 124, 533-540.
40. Prak, E.L., and Weigert, M. (1995). Light chain replacement: a new model for antibody gene rearrangement. J. Exp. Med. 182, 541-548.
41. Reichman-Fried, M., Hardy, R.R., and Bosma, M.J. (1990). Development of B-lineage cells in the bone marrow of seid/seid mice following the introduction of functionally rearranged immunoglobulin transgenes. Proc. Natl. Acad. Sci. USA 87, 2730-2734.
42. Roes, J., Müller, W., and Rajewsky, K. (1995). Mouse anti-mouse IgD monoclonal antibodies generated in IgD-deficient mice. J. Immunol. Meth. 183, 231-237.
43. Rolink, A., Karasuyama, H., Grawunder, U., Haasner, D., Kudo, A., and Melchers, F. (1993). B cell development in mice with a defective λ5 gene. Eur. J. Immunol. 23, 1284-1288.
44. Rolink, A., ten Boekel, E., Melchers, F., Fearon, D.T., Krop, I., and Andersson, J. (1996). A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J. Exp. Med. 183, 187-194.
45. Sakaguchi, N., and Melchers, F. (1986). λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes. Nature 324, 579-582.
46. Spanopoulou, E., Roman, C.A., Corcoran, L.M., Schlissel, M.S., Silver, D.P., Nemazee, D., Nussenzweig, M.C., Shinton, S.A., Hardy, R.R., and Baltimore, D. (1994). Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8, 1030-1042.
47. Springer, T., Galfre, G., Secher, D.S., and Milstein, C. (1979). Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur. J. Immunol. 9, 301-306.
48. Staudt, L.M., and Lenardo, M.J. (1991). Immunoglobulin gene transcription. Annu. Rev. Immunol. 9, 373-398.
49. Sternberg, N., and Hamilton, D. (1981). Bacteriophage P1 site-specific recombination. I. Recombination between IoxP sites. J. Mol. Biol. 150, 467-486.
50. Storb, U., Denis, K.A., Brinster, R.L., and Witte, O.N. (1985). Pre-B cells in κ-transgenic mice. Nature 316, 356-358.
51. Takemori, T., Mizuguchi, J., Miyazoe, I., Nakanishi, M., Shigemoto, K., Kimoto, H., Shirasawa, T., Maruyama, N., and Taniguchi, M. (1990). Two types of μ chain complexes are expressed during differentiation from pre-B to mature B cells. EMBO J. 9, 2493-2500.
52. ten Boekel, E., Melchers, F., and Rolink, A. (1995). The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7, 1013-1019.
53. Tiegs, S.L., Russell, D.M., and Nemazee, D. (1993). Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020.
54. Torres, R.M., Flaswinkel, H., Reth, M., and Rajewsky, K. (1996). Aberrant B cell development and immune response in mice with a compromised BCR complex. Science 272, 1804-1808.
55. preB) and the immunoglobulin μ chain form a complex that is transported onto the cell surface. J. Exp. Med. 172, 973-976.
56. Tsubata, T., Tsubata, R., and Reth, M. (1992). Crosslinking of the cell surface immunoglobulin (μ-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin κ locus. Int. Immunol. 4, 637-641.
57. Van Ness, B.G., Weigert, M., Coleclough, C., Mather, E.L., Kelley, D.E., and Perry, R.P. (1981). Transcription of the unrearranged mouse Cκ locus: sequence of the initiation region and comparison of activity with a rearranged Vκ-Cκ gene. Cell 27, 593-602.
58. Xu, Y., Davidson, L., Alt, F.W., and Baltimore, D. (1996). Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish VκJκ rearrangement. Immunity 4, 377-385.
59. Yancopoulos, G.D., and Alt, F.W. (1986). Regulation of the assembly and expression of variable-region genes. Annu. Rev. Immunol. 4, 339-368.
60. Young, F., Ardman, B., Shinkai, Y., Lansford, R., Blackwell, T.K., Mendelsohn, M., Rolink, A., Melchers, F., and Alt, F.W. (1994). Influence of immunoglobulin heavy-and light-chain expression on B-cell differentiation. Genes Dev. 8, 1043-1057.
61. Zou, Y.R., Takeda, S., and Rajewsky, K. (1993). Gene targeting in the Igκ locus: efficient generation of λ chain-expressing B cells, independent of gene rearrangements in Igκ. EMBO J. 12, 811-820.
62. Zou, Y.R., Müller, W., Gu, H., and Rajewsky, K. (1994). Cre-IoxP-mediated gene replacement: a mouse strain producing humanized antibodies. Curr. Biol. 4, 1099-1103.