-
1
-
-
0037100435
-
B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-α and Ig-β
-
Pelanda, R., Braun, U., Hobeika, E., Nussenzweig, M.C. & Reth, M. B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-α and Ig-β. J. Immunol. 169, 865-872 (2002).
-
(2002)
J. Immunol
, vol.169
, pp. 865-872
-
-
Pelanda, R.1
Braun, U.2
Hobeika, E.3
Nussenzweig, M.C.4
Reth, M.5
-
2
-
-
0037097681
-
VpreB1/VpreB2/λ 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus
-
Shimizu, T., Mundt, C., Licence, S., Melchers, F. & Martensson, I. VpreB1/VpreB2/λ 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J. Immunol. 168, 6286-6293 (2002).
-
(2002)
J. Immunol
, vol.168
, pp. 6286-6293
-
-
Shimizu, T.1
Mundt, C.2
Licence, S.3
Melchers, F.4
Martensson, I.5
-
3
-
-
20844448621
-
Both the pre-BCR and the IL-7Rα are essential for expansion at the pre-BII cell stage in vivo
-
Erlandsson, L. et al. Both the pre-BCR and the IL-7Rα are essential for expansion at the pre-BII cell stage in vivo. Eur. J. Immunol. 35, 1969-1976 (2005).
-
(2005)
Eur. J. Immunol
, vol.35
, pp. 1969-1976
-
-
Erlandsson, L.1
-
4
-
-
14544299744
-
The pre-B cell receptor in B cell development: Recent advances, persistent questions and conserved mechanisms
-
Clark, M.R., Cooper, A.B., Wang, L. & Aifantis, I. The pre-B cell receptor in B cell development: Recent advances, persistent questions and conserved mechanisms. Curr. Top. Microbiol. Immunol. 290 87-104 (2005).
-
(2005)
Curr. Top. Microbiol. Immunol
, vol.290
, pp. 87-104
-
-
Clark, M.R.1
Cooper, A.B.2
Wang, L.3
Aifantis, I.4
-
5
-
-
32544436849
-
Pre-BCR signals and the control of Ig gene rearrangements
-
Geier, J.K. & Schlissel, M.S. Pre-BCR signals and the control of Ig gene rearrangements. Semin. Immunol. 18, 31-39 (2006).
-
(2006)
Semin. Immunol
, vol.18
, pp. 31-39
-
-
Geier, J.K.1
Schlissel, M.S.2
-
6
-
-
3242881500
-
The cellular response to general and programmed DNA double strand breaks
-
Bassing, C.H. & Alt, F.W. The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst.) 3, 781-796 (2004).
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 781-796
-
-
Bassing, C.H.1
Alt, F.W.2
-
7
-
-
21844445331
-
The pre-B-cell receptor: Selector of fitting immunoglobulin heavy chains for the B-cell repertoire
-
Melchers, F. The pre-B-cell receptor: Selector of fitting immunoglobulin heavy chains for the B-cell repertoire. Nat. Rev. Immunol. 5 578-584 (2005).
-
(2005)
Nat. Rev. Immunol
, vol.5
, pp. 578-584
-
-
Melchers, F.1
-
8
-
-
34548666994
-
Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling
-
van Loo, P.F., Dingjan, G.M., Maas, A. & Hendriks, R.W. Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling. Immunity 27, 1-13 (2007).
-
(2007)
Immunity
, vol.27
, pp. 1-13
-
-
van Loo, P.F.1
Dingjan, G.M.2
Maas, A.3
Hendriks, R.W.4
-
9
-
-
0034932149
-
The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage
-
Jumaa, H., Mitterer, M., Reth, M. & Nielsen, P.J. The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage. Eur. J. Immunol. 31, 2164-2169 (2001).
-
(2001)
Eur. J. Immunol
, vol.31
, pp. 2164-2169
-
-
Jumaa, H.1
Mitterer, M.2
Reth, M.3
Nielsen, P.J.4
-
11
-
-
34548203816
-
Phospholipase Cγ2 contributes to light-chain gene activation and receptor editing
-
Bai, L. et al. Phospholipase Cγ2 contributes to light-chain gene activation and receptor editing. Mol. Cell. Biol. 27, 5957-5967 (2007).
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 5957-5967
-
-
Bai, L.1
-
12
-
-
0028347698
-
Influnence of immunoglobulin heavy- and light-chain expression on B-cell differentation
-
Young, F. et al. Influnence of immunoglobulin heavy- and light-chain expression on B-cell differentation. Genes Dev. 8 1043-1057 (1994).
-
(1994)
Genes Dev
, vol.8
, pp. 1043-1057
-
-
Young, F.1
-
13
-
-
0030664126
-
Control of B cell development by Ras-mediated activation of Raf
-
Iritani, B.M., Forbush, K.A., Farrar, M.A. & Perlmutter, R.M. Control of B cell development by Ras-mediated activation of Raf. EMBO J. 16, 7019-7031 (1997).
-
(1997)
EMBO J
, vol.16
, pp. 7019-7031
-
-
Iritani, B.M.1
Forbush, K.A.2
Farrar, M.A.3
Perlmutter, R.M.4
-
14
-
-
0033521687
-
Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes
-
Shaw, A.C., Swat, W., Ferrini, R., Davidson, L. & Alt, F.W. Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes. J. Exp. Med. 189, 123-129 (1999).
-
(1999)
J. Exp. Med
, vol.189
, pp. 123-129
-
-
Shaw, A.C.1
Swat, W.2
Ferrini, R.3
Davidson, L.4
Alt, F.W.5
-
15
-
-
0033515093
-
Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras
-
Shaw, A.C., Swat, W., Davidson, L. & Alt, F.W. Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras. Proc. Natl. Acad. Sci. USA 96, 2239-2243 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2239-2243
-
-
Shaw, A.C.1
Swat, W.2
Davidson, L.3
Alt, F.W.4
-
16
-
-
0038506030
-
IRF-4,8 orchestrate the pre-B to B transition in lymphocyte development
-
Lu, R., Kay, L., Lancki, D.W. & Singh, H. IRF-4,8 orchestrate the pre-B to B transition in lymphocyte development. Genes Dev. 17, 1703-1708 (2003).
-
(2003)
Genes Dev
, vol.17
, pp. 1703-1708
-
-
Lu, R.1
Kay, L.2
Lancki, D.W.3
Singh, H.4
-
17
-
-
38949178110
-
Interferon regulatory factors 7 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B cell receptor and promote cell-cycle withdrawal in pre-B cell development
-
Ma, S., Pathak, S., Trinh, L. & Lu, R. Interferon regulatory factors 7 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B cell receptor and promote cell-cycle withdrawal in pre-B cell development. Blood 111, 1396-1403 (2008).
-
(2008)
Blood
, vol.111
, pp. 1396-1403
-
-
Ma, S.1
Pathak, S.2
Trinh, L.3
Lu, R.4
-
18
-
-
40249112989
-
Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
-
Johnson, K. et al. Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity 28, 335-345 (2008).
-
(2008)
Immunity
, vol.28
, pp. 335-345
-
-
Johnson, K.1
-
19
-
-
3242886298
-
Regulation of activation and recombination of the murine Ig. locus
-
Schlissel, M.S. & Baltimore, D. Regulation of activation and recombination of the murine Ig. locus. Immunol. Rev. 200, 215-223 (2004).
-
(2004)
Immunol. Rev
, vol.200
, pp. 215-223
-
-
Schlissel, M.S.1
Baltimore, D.2
-
20
-
-
0033871151
-
E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells
-
Romanow, W.J. et al. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. Mol. Cell 5, 343-353 (2000).
-
(2000)
Mol. Cell
, vol.5
, pp. 343-353
-
-
Romanow, W.J.1
-
21
-
-
8644262467
-
Important roles for E protein binding sites within the immunoglobulin κ chain intronic enhance in activating V-κJ-κ rearrangement
-
Inlay, M.A., Tian, H., Lin, T. & Xu, Y. Important roles for E protein binding sites within the immunoglobulin κ chain intronic enhance in activating V-κJ-κ rearrangement. J. Exp. Med. 200, 1205-1211 (2004).
-
(2004)
J. Exp. Med
, vol.200
, pp. 1205-1211
-
-
Inlay, M.A.1
Tian, H.2
Lin, T.3
Xu, Y.4
-
22
-
-
31344465701
-
-
Lazorchak, A.S., Schlissel, M.S. & Zhuang, Y. E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin κ locus in pre-B cells. Mol. Cell. Biol. 26, 810-821 (2006).
-
Lazorchak, A.S., Schlissel, M.S. & Zhuang, Y. E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin κ locus in pre-B cells. Mol. Cell. Biol. 26, 810-821 (2006).
-
-
-
-
23
-
-
0033946934
-
-
Kee, B.L., Quong, M.W. & Murre, C. E2A proteins: Essential regulators at multiple stages of B-cell development. Immunol. Rev. 175, 138-149 (2000).
-
Kee, B.L., Quong, M.W. & Murre, C. E2A proteins: Essential regulators at multiple stages of B-cell development. Immunol. Rev. 175, 138-149 (2000).
-
-
-
-
24
-
-
33645964321
-
A unique function for cyclin D3 in early B cell development
-
Cooper, A.B. et al. A unique function for cyclin D3 in early B cell development. Nat. Immunol. 7, 489-497 (2006).
-
(2006)
Nat. Immunol
, vol.7
, pp. 489-497
-
-
Cooper, A.B.1
-
25
-
-
44049101651
-
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway
-
Herzog, S. et al. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat. Immunol. 9, 623-631 (2008).
-
(2008)
Nat. Immunol
, vol.9
, pp. 623-631
-
-
Herzog, S.1
-
26
-
-
0034748389
-
Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway
-
Fleming, H.E. & Paige, C.J. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. Immunity 15, 521-531 (2001).
-
(2001)
Immunity
, vol.15
, pp. 521-531
-
-
Fleming, H.E.1
Paige, C.J.2
-
27
-
-
34249670327
-
Btk and phospholipase C.2 can function independently during B cell development
-
Halcomb, K.E. et al. Btk and phospholipase C.2 can function independently during B cell development. Eur. J. Immunol. 37 1033-1042 (2007).
-
(2007)
Eur. J. Immunol
, vol.37
, pp. 1033-1042
-
-
Halcomb, K.E.1
-
28
-
-
0030972497
-
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
-
Morgan, B. et al. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16, 2004-2013 (1997).
-
(1997)
EMBO J
, vol.16
, pp. 2004-2013
-
-
Morgan, B.1
-
29
-
-
33947153094
-
Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits
-
Thompson, E.C. et al. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity 26, 335-344 (2007).
-
(2007)
Immunity
, vol.26
, pp. 335-344
-
-
Thompson, E.C.1
-
30
-
-
0032191170
-
Aiolos regulates B cell activation and maturation to effector state
-
Wang, J.H. et al. Aiolos regulates B cell activation and maturation to effector state. Immunity 9, 543-553 (1998).
-
(1998)
Immunity
, vol.9
, pp. 543-553
-
-
Wang, J.H.1
-
31
-
-
0030993348
-
Transcription factors required for lymphoid lineage commitment
-
Georgopoulos, K. Transcription factors required for lymphoid lineage commitment. Curr. Opin. Immunol. 9, 222-227 (1997).
-
(1997)
Curr. Opin. Immunol
, vol.9
, pp. 222-227
-
-
Georgopoulos, K.1
-
32
-
-
0028978116
-
Repression of the immunoglobulin heavy chain 3′ enhancer by helix-loop-helix protein Id3 via a functionally important E47/E12 binding site: Implications for developmental control of enhancer function
-
Meyer, K.B., Skogberg, M., Margenfeld, C., Ireland, J. & Petterson, S. Repression of the immunoglobulin heavy chain 3′ enhancer by helix-loop-helix protein Id3 via a functionally important E47/E12 binding site: Implications for developmental control of enhancer function. Eur. J. Immunol. 25, 1770-1777 (1995).
-
(1995)
Eur. J. Immunol
, vol.25
, pp. 1770-1777
-
-
Meyer, K.B.1
Skogberg, M.2
Margenfeld, C.3
Ireland, J.4
Petterson, S.5
-
33
-
-
0025931233
-
Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: Implications for B-lymphoid-cell development
-
Wilson, R.B. et al. Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: Implications for B-lymphoid-cell development. Mol. Cell. Biol. 11, 6185-6191 (1991).
-
(1991)
Mol. Cell. Biol
, vol.11
, pp. 6185-6191
-
-
Wilson, R.B.1
-
34
-
-
23944495647
-
Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5
-
Bertolino, E. et al. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat. Immunol. 6, 836-843 (2005).
-
(2005)
Nat. Immunol
, vol.6
, pp. 836-843
-
-
Bertolino, E.1
-
35
-
-
44949223609
-
Interleukin-7 receptor signaling network: An integrated systems perspective
-
Palmer, M.J. et al. Interleukin-7 receptor signaling network: An integrated systems perspective. Cell. Mol. Immunol. 5, 79-89 (2008).
-
(2008)
Cell. Mol. Immunol
, vol.5
, pp. 79-89
-
-
Palmer, M.J.1
-
36
-
-
0031836964
-
Identification and charactgerization of a constitutively active STAT5 mutant that promotes cell proliferation
-
Onishi, T. et al. Identification and charactgerization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol. Cell. Biol. 18, 3871-3879 (1998).
-
(1998)
Mol. Cell. Biol
, vol.18
, pp. 3871-3879
-
-
Onishi, T.1
-
37
-
-
0037080219
-
-
Kelly, E., Won, A., Refaeli, Y. & Parijs, L.V. IL-2 and related cytokines can promote T cell survival by activating AKT. J. Immunol. 168, 597-603 (2002).
-
Kelly, E., Won, A., Refaeli, Y. & Parijs, L.V. IL-2 and related cytokines can promote T cell survival by activating AKT. J. Immunol. 168, 597-603 (2002).
-
-
-
-
38
-
-
1842477169
-
STAT5 activation underlies IL7 receptor-dependent B cell development
-
Goetz, C.A., Harmon, I.R., O'Neil, J.J., Burchill, M.A. & Farrar, M.A. STAT5 activation underlies IL7 receptor-dependent B cell development. J. Immunol. 172, 4770-4778 (2004).
-
(2004)
J. Immunol
, vol.172
, pp. 4770-4778
-
-
Goetz, C.A.1
Harmon, I.R.2
O'Neil, J.J.3
Burchill, M.A.4
Farrar, M.A.5
-
39
-
-
0033793874
-
Ras proteins in the control of the cell cycle and cell differentiation
-
Crespo, P. & Leon, J. Ras proteins in the control of the cell cycle and cell differentiation. Cell. Mol. Life Sci. 57, 1613-1636 (2000).
-
(2000)
Cell. Mol. Life Sci
, vol.57
, pp. 1613-1636
-
-
Crespo, P.1
Leon, J.2
-
40
-
-
0035260791
-
Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade
-
Bain, G. et al. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat. Immunol. 2, 165-171 (2001).
-
(2001)
Nat. Immunol
, vol.2
, pp. 165-171
-
-
Bain, G.1
-
41
-
-
0038783576
-
A conserved transcriptional enhancer regulates RAG gene expression in developing B cells
-
Hsu, L.Y. et al. A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity 19, 105-117 (2003).
-
(2003)
Immunity
, vol.19
, pp. 105-117
-
-
Hsu, L.Y.1
-
42
-
-
41549103208
-
Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion
-
Yasuda, T. et al. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28, 499-508 (2008).
-
(2008)
Immunity
, vol.28
, pp. 499-508
-
-
Yasuda, T.1
-
43
-
-
33846187999
-
STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas
-
Walker, S.B., Nelson, E.A. & Frank, D.A. STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas. Oncogene 26, 224-233 (2006).
-
(2006)
Oncogene
, vol.26
, pp. 224-233
-
-
Walker, S.B.1
Nelson, E.A.2
Frank, D.A.3
-
44
-
-
41149149301
-
Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
-
Hennighausen, L. & Robinson, G.W. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev. 22, 711-721 (2008).
-
(2008)
Genes Dev
, vol.22
, pp. 711-721
-
-
Hennighausen, L.1
Robinson, G.W.2
-
45
-
-
44049091757
-
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
-
Amin, R.H. & Schlissel, M.S. Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat. Immunol. 9, 613-622 (2008).
-
(2008)
Nat. Immunol
, vol.9
, pp. 613-622
-
-
Amin, R.H.1
Schlissel, M.S.2
|