Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 6038-6045

  Marshall, Aaron J ^a,b   Fleming, Heather E ^a   Wu, Gillian E ^a   Paige, Christopher J ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF WASHINGTON   (United States)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; DNA NUCLEOTIDYLEXOTRANSFERASE; IMMUNOGLOBULIN D; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; LEUKOSIALIN; N MORPHOLINOMETHYL 3 BROMOPHENYLSUCCINIMIDE; RECOMBINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL CULTURE; CELL SORTER; DOSE RESPONSE; GENE EXPRESSION; GENE REARRANGEMENT; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CLONE CELLS; CYTOPLASM; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GENE REARRANGEMENT, B-LYMPHOCYTE; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN MU-CHAINS; INTERLEUKIN-7; KINETICS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, B-CELL; STEM CELLS; TIME FACTORS;

EID: 0032402316     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Osmond, D. 1990. B cell development in the bone marrow. Semin. Immunol. 2:173.
2. Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
3. Ehlich, A., S. Schaal, H. Gu, D. Kitamura, W. Muller, and K. Rajewsky. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72:695.
4. Li, Y., K. Hayakawa, and R. R. Hardy. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951.
5. Young, F., B. Ardman, Y. Shinkai, R. Lansford, T. Blackwell, M. Mendelsohn, A. Rolink, F. Melchers, and F. Alt. 1994. Influence of immunoglobulin heavy-and light-chain expression on B-cell differentiation. Genes Dev. 8:1043.
6. ten Boekel, E., F. Melchers, and A. Rolink. 1995. The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7:1013.
7. Tsubata, T., and M. Reth. 1990. The products of the pre-B cell-specific gene (λ5 and Vpre-B) and the immunoglobulin μ chain form a complex that is transported to the cells surface. J. Exp. Med. 172:973.
8. Karasuyama, H., A. Rolink, and F. Melchers. 1993. A complex of glycoproteins is associated with VpreB/λ5 surrogate light chain on the surface of μ heavy chain-negative early precursor B cell lines. J. Exp. Med. 178:469.
9. Lassoued, K., C. Nunez, L. Billips, H. Kubagawa, R. Monteiro, T. LeBien, and M. Cooper. 1993. Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell 73:73.
10. Decker, D., N. Boyle, J. Koziol, and N. Klinman. 1991. The expression of the immunoglobulin heavy chain repertoire in developing bone marrow B lineage cells. J. Immunol. 146:350.
11. Karasuyama, H., A. Rolink, Y. Shinkai, F. Young, F. Alt, and F. Melchers. 1994. The expression of VpreB/15 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77:133.
12. Kitamura, D., A. Kudo, S. Schaal, W. Muller, F. Melchers, and K. Rajewsky. 1992. A critical role of A5 protein in B cell development. Cell 69:823.
13. Shinkai, Y., G. Rathbum, K.-P. Lam, E. Oltz, V. Stewart, M. Mendelsohn, H. Charron, M. Datta, F. Young, A. Stall, et al. 1992. Rag-2 deficient mice lack mature lymphocytes due to an inability to initiate V(D)J rearrangement. Cell 68:855.
14. Kitamura, D., and K. Rajewsky. 1992. Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356:154.
15. Spanopoulou, E., C. Roman, L. Corcoran, M. Schlissel, D. Silver, D. Nemazee, M. Nussenzweig, S. Shinton, R. Hardy, and D. Baltimore. 1994. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1 deficient mice. Genes Dev. 8:1030.
16. Papavasiliou, F., M. Jankovic, and M. Nussenzweig. 1996. Surrogate or conventional light chains are required for membrane immunoglobulin μ to activate the precursor B cell transition. J. Exp. Med. 184:2025.
17. Papavasiliou, F., M. Jankovic, H. Suh, and M. Nussenzweig. 1995. The cytoplasmic domains of immunoglobulin (Ig) α and Igβ can independently induce the precursor B cell transition and allelic exclusion. J. Exp. Med. 182:1389.
18. Papavasiliou, F., Z. Misulovin, H. Suh, and M. Nussenzweig. 1995. The role of Igβ in precursor B cell transition and allelic exclusion. Science 268:408.
19. Kierney, P., and K. Dorshkind. 1987. B lymphocyte precursors and myeloid precursors survive in diffusion chamber cultures but B cell differentiation requires close association with stromal cells. Blood 70:1418.
20. Gimble, J., C. Pietrangli, A. Henley, M. Dorheim, J. Silver, A. Namen, M. Takeichi, C. Goridis, and P. Kincade. 1989. Characterization of murine bone marrow and spleen derived stromal cells: analysis of leukocyte marker and growth factor mRNA transcript levels. Blood 74:303.
21. Kincade, P., G. Lee, C. Pietrangeli, S.-I. Hayashi, and J. Gimble. 1989. Cells and molecules that regulate B lymphopoiesis in the bone marrow. Annu. Rev. Immunol. 7:111.
22. Cumano, A., K. Dorshkind, S. Gillis, and C. Paige. 1990. The influence of S17 stromal cells and interleukin 7 on B cell development. Eur. J. Immunol. 20:2183.
23. Rolink, A., A. Kudo, H. Karasuyama, Y. Kikuchi, and F. Melchers. 1991. Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J. 10:327.
24. Namen, A., S. Lupton, D. Mochizuki, A. Schmierer, B. Mosley, C. March, D. Urdal, S. Gillis, D. Cosman, and R. Goodwin. 1988. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 333:571.
25. Lee, G., A. Namen, S. Gillis, L. Ellingsworth, and P. Kincade. 1989. Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming growth factor-β1. J. Immunol. 142:3875.
26. Suda, T., S. Okada, J. Suda, Y. Miura, M. Ito, T. Sudo, S.-I. Hayashi, S. I. Nishikawa, and H. Nakauchi. 1989. A stimulatory effect of recombinant murine interleukin-7 (IL-7) on B cell colony formation and an inhibitory effect of IL-1a. Blood 74:1936.
27. Peschon, J., P. Morrissey, K. Grabstein, F. Ramsdell, E. Maraskovsky, B. Gliniak, L. Park, S. Ziegler, D. William, C. Ware, et al. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180:1955.
28. von Freeden-Jeffry, U., P. Vieira, L. Lucian, T. McNeil, S. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181:1519.
29. Sudo, T., S. Nishikawa, N. Ohno, N. Akiyama, M. Tamakoshi, H. Yoshida, and S.-I. Nishikawa. 1993. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA 90:9125.
30. Era, T., S. Nishikawa, T. Sudo, F. Wang, M. Ogawa, T. Kunisada, S.-I. Hayashi, and S.-I. Nishikawa. 1994. How B-precursor cells are driven to cycle. Immunol. Rev. 137:35.
31. Loffert, D., S. Schaal, A. Ehlich, R. Hardy, Y. Zou, W. Muller, and K. Rajewsky. 1994. Early B cell development in the mouse: insights from mutations introduced by gene targeting. Immunol Rev. 137:135.
32. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350:423.
33. Hayashi, S., T. Kunisada, M. Ogawa, T. Sudo, H. Kodama, T. Suda, S. Nishikawa, and S. Nishikawa. 1990. Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules. J. Exp. Med. 171:1683.
34. Reichman-Fried, M., M. Bosma, and R. Hardy. 1993. B-lineage cells in in-transgenic scid mice proliferate in response to IL-7 but fail to show evidence of immunoglobulin light chain gene rearrangement. Int. Immunol. 5:303.
35. Goody, G., P. Dempsey, and D. Fearon. 1996. Activation of B lymphocytes: integrating signals from CD19, CD22 and FcγRIIb1. Curr. Opin. Immunol. 8:378.
36. Cyster, J., and C. Goodnow. 1997. Tuning antigen receptor signaling by CD22: integrating signals from antigens and the microenvironment. Immunity 6:509.
37. Noguchi, M., S. Nakamura, S. Russel, S. Ziegler, M. Tsang, X. Cao, and W. Leonard. 1993. Interleukin 2-receptor γ chain: a functional component of the interleukin-7 receptor. Science 262:1877.
38. Sudo, T., M. Ito, Y. Ogawa, M. Iizuka, H. Kodama, T. Kunisada, S.-I. Hayashi, M. Ogawa, K. Sakai, S. Nishikawa, et al. 1989. Interleukin 7 production and function in stromal cell-dependent B cell development. J. Exp. Med. 170:333.
39. Marshall, A. 1997. Molecular and cellular selection of the immunoglobalin heavy chain repertoire during B cell development. Ph.D. Thesis. University of Toronto. Toronto, Canada.
40. Clarke, D., O. Katoh, R. Gibbs, S. Griffiths, and M. Gordon. 1995. Interaction of interleukin 7 (IL-7) with glycosaminoglycans and its biological relevance. Cytokine 7:325.
41. Ariel, A., R. Hershkoviz, L. Cahalon, D. Williams, S. Akiyama, K. Yamada, C. Chen, R. Alon, T. Lapidot, and O. Lider. 1997. Induction of T cell adhesion to extracellular matrix or endothelial cell ligands by soluble or matrix-bound interleukin-7. Eur. J. Immunol. 27:2562.
42. Stephan, R., C. Reilly, and P. Witte. 1998. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood 91:75.
43. Mertsching, E., U. Grawunder, V. Meyer, A. Rolink, and R. Ceredig. 1996. Phenotypic and functional analysis of B lymphopoiesis in interleukin-7-transgenic mice: expansion of pro/pre-B cell number and persistence of B lymphocyte development in lymph nodes and spleen. Eur. J. Immunol. 26:28.
44. Valenzona, H., R. Pointer, R. Ceredig, and D. Osmond. 1996. Prelymphomatous B cell hyperplasia in the bone marrow of interleukin-7 transgenic mice: precursor B cell dynamics, microenvironmental organization and osteolysis. Exp. Hematol. 24:1521.
45. Morrissey, P., P. Conlon, K. Charrier, S. Braddy, A. Alpert, D. Williams, A. Namen, and D. Mochizuki. 1991. Administration of IL-7 to normal mice stimulates B-lymphopoiesis and peripheral lymphadenopathy. J. Immunol. 147:561.
46. Huetz, F., L. Carlsson, U. Tornberg, and D. Holmberg. 1993. V-region directed selection in differentiating B lymphocytes. EMBO J. 12:1819.
47. H gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 7:357.
48. Faust, E., D. Saffran, D. Toksoz, A. Williams, and O. Witte. 1993. Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells. J. Exp. Med. 177:915.
49. Corcoran, A., F. Smart, R. Cowling, T. Crompton, M. Owen, and A. Venkitaraman. 1996. The interleukin 7 receptor α chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO J. 15:1924.
50. Misener, V., G. Downey, and J. Jongstra. 1991. The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transduction molecule. Int. Immunol. 3:1129.
51. Matsuo, T., J. Nomura, K. Kuwahara, H. Igarashi, S. Inui, M. Hamaguchi, M. Kimoto, and N. Sakaguchi. 1993. Cross-linking of B cell receptor-related molecule MB-1 molecule induces protein tyrosine phosphorylation in early B lineage cells. J. Immunol. 150:3766.
52. Dittel, B., and T. LeBien. 1995. The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34. J. Immunol. 154:58.
53. Henderson, A., R. Narayanan, L. Collins, and K. Dorshkind. 1992. Status of κL chain gene rearrangements and c-kit and IL-7 receptor expression in stromal cell-dependent pre-B cells. J. Immunol. 149:1973.