메뉴 건너뛰기




Volumn 31, Issue 9, 2013, Pages 582-599

H2AX a promising biomarker for lung cancer: A review

Author keywords

Carcinogenesis; DNA damage response; H2AX; Lung cancer; PARP inhibitors

Indexed keywords

4B ACRYLAMIDOPODOPHYLLOTOXIN DERIVATIVE; ANTINEOPLASTIC AGENT; CISPLATIN; DNA; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; GEFITINIB; HISTONE H2AX; MITOXANTRONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; ROSCOVITINE; TOPOTECAN; UNCLASSIFIED DRUG; VALPROIC ACID;

EID: 84887222527     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.3109/07357907.2013.849721     Document Type: Article
Times cited : (33)

References (160)
  • 2
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011;61:212-236.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 3
    • 15044352688 scopus 로고    scopus 로고
    • Clinical model to predict survival in chemonaive patients with advanced non-small-cell lung cancer treated with third-generation chemotherapy regimens based on eastern cooperative oncology group data
    • Hoang T, Xu R, Schiller JH, et al. Clinical model to predict survival in chemonaive patients with advanced non-small-cell lung cancer treated with third-generation chemotherapy regimens based on eastern cooperative oncology group data. J Clin Oncol 2005;23:175-183.
    • (2005) J Clin Oncol , vol.23 , pp. 175-183
    • Hoang, T.1    Xu, R.2    Schiller, J.H.3
  • 4
    • 4944221276 scopus 로고    scopus 로고
    • The biology of non-small-cell lung cancer: Identifying new targets for rational therapy
    • Rosell R, Felip E, Garcia-Campelo R, Balana C. The biology of non-small-cell lung cancer: identifying new targets for rational therapy. Lung Cancer 2004;46:135.
    • (2004) Lung Cancer , vol.46 , pp. 135
    • Rosell, R.1    Felip, E.2    Garcia-Campelo, R.3    Balana, C.4
  • 7
    • 12544250589 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage
    • Helt CE, ClibyWA, Keng PC, Bambara RA, O'Reilly MA. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. J Biol Chem 2005;280:1186-1192.
    • (2005) J Biol Chem , vol.280 , pp. 1186-1192
    • Helt, C.E.1    Cliby, W.A.2    Keng, P.C.3    Bambara, R.A.4    O'reilly, M.A.5
  • 8
    • 33745058037 scopus 로고    scopus 로고
    • Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex
    • Dupŕe A, Boyer-Chatenet L, Gautier J. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol 2006;13:451-457.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 451-457
    • Dupre, A.1    Boyer-Chatenet, L.2    Gautier, J.3
  • 9
    • 24944516931 scopus 로고    scopus 로고
    • A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
    • Sun Y, Jiang X, Chen S, Fernandes N, Price BD. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci USA 2005;102:13182-13187.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13182-13187
    • Sun, Y.1    Jiang, X.2    Chen, S.3    Fernandes, N.4    Price, B.D.5
  • 10
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATRdependent manner in response to replicational stress
    • Ward IM, Chen J. Histone H2AX is phosphorylated in an ATRdependent manner in response to replicational stress. J Biol Chem. 2001;276:47759-47762.
    • (2001) J Biol Chem. , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 12
    • 11144305946 scopus 로고    scopus 로고
    • ComplexH2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors
    • Wang H, WangM, Wang H, B̈ockerW, Iliakis G. ComplexH2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors. J Cell Physiol 2005;202:492-502.
    • (2005) J Cell Physiol , vol.202 , pp. 492-502
    • Wang, H.1    Wang, M.2    Wang, H.3    Bocker, W.4    Iliakis, G.5
  • 13
    • 44449136965 scopus 로고    scopus 로고
    • HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
    • Ayoub N, Jeyasekharan AD, Bernal JA, Venkitaraman AR. HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. Nature 2008;453:682-686.
    • (2008) Nature , vol.453 , pp. 682-686
    • Ayoub, N.1    Jeyasekharan, A.D.2    Bernal, J.A.3    Venkitaraman, A.R.4
  • 14
    • 0033197541 scopus 로고    scopus 로고
    • The FHA domain is a modular phosphopeptide recognition motif
    • Durocher D, Henckel J, Fersht AR, Jackson SP. The FHA domain is a modular phosphopeptide recognition motif. Mol Cell 1999;4:387-394.
    • (1999) Mol Cell , vol.4 , pp. 387-394
    • Durocher, D.1    Henckel, J.2    Fersht, A.R.3    Jackson, S.P.4
  • 15
    • 0142240342 scopus 로고    scopus 로고
    • BRCT repeats as phosphopeptide-binding modules involved in protein targeting
    • Manke IA, Lowery DM, Nguyen A, Yaffe MB. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 2003;302:636-639.
    • (2003) Science , vol.302 , pp. 636-639
    • Manke, I.A.1    Lowery, D.M.2    Nguyen, A.3    Yaffe, M.B.4
  • 16
    • 2542490186 scopus 로고    scopus 로고
    • Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
    • Williams RS, Lee MS, Hau DD, Glover JN. Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1. Nat Struct Mol Biol 2004;11:519-525.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 519-525
    • Williams, R.S.1    Lee, M.S.2    Hau, D.D.3    Glover, J.N.4
  • 17
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 2005;123:1213-1226.
    • (2005) Cell , vol.123 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 19
    • 48649100438 scopus 로고    scopus 로고
    • Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
    • Chapman JR, Jackson SP. Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep 2008;9:795-801.
    • (2008) EMBO Rep , vol.9 , pp. 795-801
    • Chapman, J.R.1    Jackson, S.P.2
  • 21
    • 77749334700 scopus 로고    scopus 로고
    • Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX
    • Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Mol Cell Biol 2010;30:1368-1381.
    • (2010) Mol Cell Biol , vol.30 , pp. 1368-1381
    • Douglas, P.1    Zhong, J.2    Ye, R.3    Moorhead, G.B.4    Xu, X.5    Lees-Miller, S.P.6
  • 22
    • 49649089537 scopus 로고    scopus 로고
    • MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
    • Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci USA 2008;105:11200-11205.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11200-11205
    • Wu, L.1    Luo, K.2    Lou, Z.3    Chen, J.4
  • 23
    • 36249031962 scopus 로고    scopus 로고
    • RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
    • HuenMS, Grant R,Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 2007;131:901-914.
    • (2007) Cell , vol.131 , pp. 901-914
    • Huen, M.S.1    Grant, R.2    Manke, I.3    Minn, K.4    Yu, X.5    Yaffe, M.B.6    Chen, J.7
  • 24
    • 33646106590 scopus 로고    scopus 로고
    • GammaH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
    • Stucki M, Jackson SP. gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst) 2006;5:534-543.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 534-543
    • Stucki, M.1    Jackson, S.P.2
  • 25
    • 36849000716 scopus 로고    scopus 로고
    • MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage
    • Wood JL, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem 2007;282:35416-35423.
    • (2007) J Biol Chem , vol.282 , pp. 35416-35423
    • Wood, J.L.1    Singh, N.2    Mer, G.3    Chen, J.4
  • 26
    • 13944269923 scopus 로고    scopus 로고
    • Telomere-binding factors and general DNA repair
    • Wright WE, Shay JW. Telomere-binding factors and general DNA repair. Nat Genet 2005;37:116-118.
    • (2005) Nat Genet , vol.37 , pp. 116-118
    • Wright, W.E.1    Shay, J.W.2
  • 27
    • 7244251599 scopus 로고    scopus 로고
    • Phosphorylation of H2AX at short telomeres in T cells and fibroblasts
    • Hao LY, Strong MA, Greider CW. Phosphorylation of H2AX at short telomeres in T cells and fibroblasts. J Biol Chem 2004;279:45148-45154.
    • (2004) J Biol Chem , vol.279 , pp. 45148-45154
    • Hao, L.Y.1    Strong, M.A.2    Greider, C.W.3
  • 28
    • 34447532525 scopus 로고    scopus 로고
    • Heterochromatin is refractory to gamma-H2AXmodification in yeast and mammals
    • KimJA, KruhlakM,Dotiwala F,Nussenzweig A,Haber JE. Heterochromatin is refractory to gamma-H2AXmodification in yeast and mammals. J Cell Biol 2007;178:209-218.
    • (2007) J Cell Biol , vol.178 , pp. 209-218
    • Kim, J.A.1    Kruhlak, M.2    Dotiwala, F.3    Nussenzweig, A.4    Haber, J.E.5
  • 30
    • 67449163726 scopus 로고    scopus 로고
    • Telomere length, telomeric proteins andDNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases
    • Raynaud CM, Mercier O, Commo F, Dartevelle P, Gomez-Roca C, de Montpreville V, Sabatier L, Soria JC. Telomere length, telomeric proteins andDNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases. Lung Cancer 2009;65:144-149.
    • (2009) Lung Cancer , vol.65 , pp. 144-149
    • Raynaud, C.M.1    Mercier, O.2    Commo, F.3    Dartevelle, P.4    Gomez-Roca, C.5    De Montpreville, V.6    Sabatier, L.7    Soria, J.C.8
  • 32
    • 30344444484 scopus 로고    scopus 로고
    • Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
    • Murr R, Loizou JI, Yang YG,Cuenin C, Li H,Wang ZQ,Herceg Z. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks Nat Cell Biol 2006;8:91-99.
    • (2006) Nat Cell Biol , vol.8 , pp. 91-99
    • Murr, R.1    Loizou, J.I.2    Yang, Y.G.3    Cuenin, C.4    Li, H.5    Wang, Z.Q.6    Herceg, Z.7
  • 33
    • 35148894396 scopus 로고    scopus 로고
    • DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
    • Ikura T, Tashiro S, Kakino A, et al. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol 2007;20:7028-7040.
    • (2007) Mol Cell Biol , vol.20 , pp. 7028-7040
    • Ikura, T.1    Tashiro, S.2    Kakino, A.3
  • 34
    • 59649124959 scopus 로고    scopus 로고
    • The INO80 chromatin remodeling complex in transcription: Replication and repair
    • Conaway RC, Conaway JW. The INO80 chromatin remodeling complex in transcription: replication and repair. Trends Biochem Sci 2009;34:71-77.
    • (2009) Trends Biochem Sci , vol.34 , pp. 71-77
    • Conaway, R.C.1    Conaway, J.W.2
  • 35
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff T, O'Driscoll M, Rief N, Iwabuchi K, L̈obrich M, Jeggo PA. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res 2004;64:2390-2396.
    • (2004) Cancer Res , vol.64 , pp. 2390-2396
    • Stiff, T.1    O'driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Lobrich, M.5    Jeggo, P.A.6
  • 37
    • 74049095565 scopus 로고    scopus 로고
    • MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX
    • Yuan J, Chen J. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem 2010;285:1097-1104.
    • (2010) J Biol Chem , vol.285 , pp. 1097-1104
    • Yuan, J.1    Chen, J.2
  • 39
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000;14:397-402.
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 40
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the doublestrand break repair Mre11 protein in murine embryonic stem cells
    • Xiao Y, Weaver DT. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the doublestrand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res 1997;25:2985-2991.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2985-2991
    • Xiao, Y.1    Weaver, D.T.2
  • 41
    • 0030924656 scopus 로고    scopus 로고
    • Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
    • Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev 1997;11:1226-1241.
    • (1997) Genes Dev , vol.11 , pp. 1226-1241
    • Ludwig, T.1    Chapman, D.L.2    Papaioannou, V.E.3    Efstratiadis, A.4
  • 42
    • 0030933762 scopus 로고    scopus 로고
    • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
    • Sharan SK, Morimatsu M, Albrecht U, et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 1997;386:804-810.
    • (1997) Nature , vol.386 , pp. 804-810
    • Sharan, S.K.1    Morimatsu, M.2    Albrecht, U.3
  • 43
    • 17644375501 scopus 로고    scopus 로고
    • Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency
    • Chen PL, Liu F, Cai S, et al. Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol 2005;25:3535-3542.
    • (2005) Mol Cell Biol , vol.25 , pp. 3535-3542
    • Chen, P.L.1    Liu, F.2    Cai, S.3
  • 44
    • 0029987450 scopus 로고    scopus 로고
    • Targeted disruption of the Rad51 gene leads to lethality in embryonic mice
    • Tsuzuki T, Fujii Y, Sakumi K, et al. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc Natl Acad Sci USA 1996;93:6236-6240.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6236-6240
    • Tsuzuki, T.1    Fujii, Y.2    Sakumi, K.3
  • 47
    • 70349464806 scopus 로고    scopus 로고
    • Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damage induction in lung cancers
    • Ebi H, Sato T, Sugito N, et al. Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damage induction in lung cancers. Oncogene 2009;28:3371-3379.
    • (2009) Oncogene , vol.28 , pp. 3371-3379
    • Ebi, H.1    Sato, T.2    Sugito, N.3
  • 48
    • 78449307955 scopus 로고    scopus 로고
    • Regulation of DNA polymerase POLD4 influences genomic instability in lung
    • Huang QM, Tomida S,Masuda Y, et al. Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. 2010;70:8407-8416.
    • (2010) Cancer. , vol.70 , pp. 8407-8416
    • Huang, Q.M.1    Tomida, S.2    Masuda, Y.3
  • 49
    • 35848966121 scopus 로고    scopus 로고
    • Replication stress: Defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells
    • Matthew EM, Yen TJ, Dicker DT, Dorsey JF, Yang W, Navaraj A, El-DeiryWS. Replication stress: defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells. Cell Cycle 2007;6:2571-2578.
    • (2007) Cell Cycle , vol.6 , pp. 2571-2578
    • Matthew, E.M.1    Yen, T.J.2    Dicker, D.T.3    Dorsey, J.F.4    Yang, W.5    Navaraj, A.6    El-Deiry, W.S.7
  • 50
    • 0021193203 scopus 로고
    • Microelectrophoretic study of radiationinduced DNA damages in individual mammalian cells
    • OstlingO, JohansonKJ. Microelectrophoretic study of radiationinduced DNA damages in individual mammalian cells. Biochem Biophys Res Commun 1984;123:291-298.
    • (1984) Biochem Biophys Res Commun , vol.123 , pp. 291-298
    • Ostling, O.1    Johanson, K.J.2
  • 53
    • 33744725190 scopus 로고    scopus 로고
    • Detection ofDNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication)
    • Darzynkiewicz Z,Huang X,Okafuji M. Detection ofDNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication). MethodsMol Biol 2006;314:81-93.
    • (2006) MethodsMol Biol , vol.314 , pp. 81-93
    • Darzynkiewicz, Z.1    Huang, X.2    Okafuji, M.3
  • 54
    • 0028199026 scopus 로고
    • Measurement of DNA doublestrand breaks in mammalian cells by pulsed-field gel electrophoresis: A new approach using rarely cutting restriction enzymes
    • L̈obrich M, Ikpeme S, Kiefer J. Measurement of DNA doublestrand breaks in mammalian cells by pulsed-field gel electrophoresis: a new approach using rarely cutting restriction enzymes. Radiat Res 1994;138:186-192.
    • (1994) Radiat Res , vol.138 , pp. 186-192
    • Lobrich, M.1    Ikpeme, S.2    Kiefer, J.3
  • 55
    • 34247135323 scopus 로고    scopus 로고
    • An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans
    • Ismail IH, Wadhra TI, Hammarsten O. An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans. Nucleic Acids Res 2007;35(5):e36.
    • (2007) Nucleic Acids Res , vol.35 , Issue.5
    • Ismail, I.H.1    Wadhra, T.I.2    Hammarsten, O.3
  • 56
    • 34548359085 scopus 로고    scopus 로고
    • Gamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: Dependence on the dosedistribution, irradiated site and time from start of treatment
    • Sak A, Grehl S, Erichsen P, et al. gamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: dependence on the dosedistribution, irradiated site and time from start of treatment. Int J Radiat Biol 2007;83:639-652.
    • (2007) J Radiat Biol , vol.83 , pp. 639-652
    • Sak, A.1    Grehl, S.2    Erichsen, P.3
  • 59
    • 76049083071 scopus 로고    scopus 로고
    • Monitoring druginduced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells
    • Wang LH, Pfister TD, Parchment RE, et al. Monitoring druginduced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells. Clin Cancer Res 2010;16:1073-1084.
    • (2010) Clin Cancer Res , vol.16 , pp. 1073-1084
    • Wang, L.H.1    Pfister, T.D.2    Parchment, R.E.3
  • 60
    • 34247530298 scopus 로고    scopus 로고
    • Computerized analysis of cellular features and biomarkers for cytologic diagnosis of early lung cancer
    • Qian W, Zhukov T, Song D, TockmanMS. Computerized analysis of cellular features and biomarkers for cytologic diagnosis of early lung cancer. Anal Quant Cytol Histol 2007;29:103-111.
    • (2007) Anal Quant Cytol Histol , vol.29 , pp. 103-111
    • Qian, W.1    Zhukov, T.2    Song, D.3    Tockman, M.S.4
  • 61
    • 33645511438 scopus 로고    scopus 로고
    • Adduct-specificmonoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei
    • Liedert B, Pluim D, Schellens J,Thomale J. Adduct-specificmonoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei. Nucleic Acids Res 2006;34(6):e47.
    • (2006) Nucleic Acids Res , vol.34 , Issue.6
    • Liedert, B.1    Pluim, D.2    Schellens, J.3    Thomale, J.4
  • 62
    • 34548455064 scopus 로고    scopus 로고
    • Repair capacity for platinum-DNA adducts determines the severity of cisplatininduced peripheral neuropathy
    • Dzagnidze A, Katsarava Z, Makhalova J, et al. Repair capacity for platinum-DNA adducts determines the severity of cisplatininduced peripheral neuropathy. J Neurosci 2007;27:9451-9457.
    • (2007) J Neurosci , vol.27 , pp. 9451-9457
    • Dzagnidze, A.1    Katsarava, Z.2    Makhalova, J.3
  • 63
    • 44249118962 scopus 로고    scopus 로고
    • ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatininduced apoptosis
    • PablaN,Huang S,MiQS, Daniel R, DongZ. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatininduced apoptosis. J Biol Chem 2007;283:6572-6583.
    • (2007) J Biol Chem , vol.283 , pp. 6572-6583
    • Pabla, N.1    Huang, S.2    Mi, Q.S.3    Daniel, R.4    Dong, Z.5
  • 64
    • 77950923924 scopus 로고    scopus 로고
    • Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
    • Oliver TG, Mercer KL, Sayles LC, et al. Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev 2010;24:837-852.
    • (2010) Genes Dev , vol.24 , pp. 837-852
    • Oliver, T.G.1    Mercer, K.L.2    Sayles, L.C.3
  • 65
    • 40949130371 scopus 로고    scopus 로고
    • Platinum resistance: The role of DNA repair pathways
    • Martin LP, Hamilton TC, Schilder RJ. Platinum resistance: the role of DNA repair pathways. Clin Cancer Res 2008;14:1291-1295.
    • (2008) Clin Cancer Res , vol.14 , pp. 1291-1295
    • Martin, L.P.1    Hamilton, T.C.2    Schilder, R.J.3
  • 66
    • 18244379333 scopus 로고    scopus 로고
    • Cellular processing of platinum anticancer drugs
    • Wang D, Lippard SJ. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 2005;4:307-320.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 307-320
    • Wang, D.1    Lippard, S.J.2
  • 67
    • 54349107204 scopus 로고    scopus 로고
    • Enhancement of cisplatin [cis-diamminedichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulumstress
    • Rabik CA, Fishel ML, Holleran JL, et al. Enhancement of cisplatin [cis-diamminedichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulumstress. J Pharmacol Exp Ther 2008;327:442-452.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 442-452
    • Rabik, C.A.1    Fishel, M.L.2    Holleran, J.L.3
  • 69
    • 55949097005 scopus 로고    scopus 로고
    • Insulinlike growth factor-1 attenuates cisplatin-induced gammaH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer
    • Jeon JH, KimSK, Ki HJ, Chang J, Ahn CM, Chang YS. Insulinlike growth factor-1 attenuates cisplatin-induced gammaH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer. Cancer Lett 2008;272:232-241.
    • (2008) Cancer Lett , vol.272 , pp. 232-241
    • Jeon, J.H.1    Kim, S.K.2    Ki, H.J.3    Chang, J.4    Ahn, C.M.5    Chang, Y.S.6
  • 70
    • 77954176768 scopus 로고    scopus 로고
    • Marked anti-tumour activity of the combination of YM155: A novel survivin suppressant and platinum-based drugs
    • Iwasa T, Okamoto I, Takezawa K, et al. Marked anti-tumour activity of the combination of YM155: a novel survivin suppressant and platinum-based drugs. Br J Cancer 2010;103:36-42.
    • (2010) Br J Cancer , vol.103 , pp. 36-42
    • Iwasa, T.1    Okamoto, I.2    Takezawa, K.3
  • 71
    • 80052775738 scopus 로고    scopus 로고
    • Spectrum of cellular responses to pyriplatin: A monofunctional cationic antineoplastic platinum(II) compound in human cancer cells
    • Lovejoy KS, Serova M, Bieche I, et al. Spectrum of cellular responses to pyriplatin: a monofunctional cationic antineoplastic platinum(II) compound in human cancer cells. Mol Cancer Ther 2011;10:1709-1719.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1709-1719
    • Lovejoy, K.S.1    Serova, M.2    Bieche, I.3
  • 72
    • 77957814634 scopus 로고    scopus 로고
    • NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway
    • Jayachandran G, Ueda K, Wang B, Roth JA, Ji L. NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway. PLoS One 2010;5(8):e11994.
    • (2010) PLoS One , vol.5 , Issue.8
    • Jayachandran, G.1    Ueda, K.2    Wang, B.3    Roth, J.A.4    Ji, L.5
  • 73
    • 78449276275 scopus 로고    scopus 로고
    • Obtusilactone A and (?)-sesamin induce apoptosis in human lung cancer cells by inhibiting mitochondrial Lon protease and activating DNA damage checkpoints
    • Wang HM, Cheng KC, Lin CJ, et al. Obtusilactone A and (?)-sesamin induce apoptosis in human lung cancer cells by inhibiting mitochondrial Lon protease and activating DNA damage checkpoints. Cancer Sci 2010;101:2612-2620.
    • (2010) Cancer Sci , vol.101 , pp. 2612-2620
    • Wang, H.M.1    Cheng, K.C.2    Lin, C.J.3
  • 74
    • 48749127647 scopus 로고    scopus 로고
    • Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogenactivated protein kinases
    • Park JH, Kim EJ, Jang HY, et al. Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogenactivated protein kinases. Oncol Rep 2008;20:379-384.
    • (2008) Oncol Rep , vol.20 , pp. 379-384
    • Park, J.H.1    Kim, E.J.2    Jang, H.Y.3
  • 75
    • 77956234558 scopus 로고    scopus 로고
    • Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols
    • Yang CS, Lu G, Ju J, Li GX. Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols. Ann N Y Acad Sci 2010;1203:29-34.
    • (2010) Ann N y Acad Sci , vol.1203 , pp. 29-34
    • Yang, C.S.1    Lu, G.2    Ju, J.3    Li, G.X.4
  • 76
    • 77950886851 scopus 로고    scopus 로고
    • A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth
    • Lu G, Xiao H, Li GX, et al. A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth. Carcinogenesis 2010;31:687-694.
    • (2010) Carcinogenesis , vol.31 , pp. 687-694
    • Lu, G.1    Xiao, H.2    Li, G.X.3
  • 77
    • 77952305329 scopus 로고    scopus 로고
    • Pro-oxidative activities and dose-response relationship of (?)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: A comparative study in vivo and in vitro
    • Li GX, Chen YK, Hou Z, et al. Pro-oxidative activities and dose-response relationship of (?)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro. Carcinogenesis 2010;31:902-910.
    • (2010) Carcinogenesis , vol.31 , pp. 902-910
    • Li, G.X.1    Chen, Y.K.2    Hou, Z.3
  • 78
    • 67650677845 scopus 로고    scopus 로고
    • Resveratrol induces senescence-like growth inhibition ofU-2 OS cells associatedwith the instability of telomeric DNA and upregulation of BRCA1
    • Rusin M, Zajkowicz A, Butkiewicz D. Resveratrol induces senescence-like growth inhibition ofU-2 OS cells associatedwith the instability of telomeric DNA and upregulation of BRCA1. Mech Ageing Dev 2009;130:528-537.
    • (2009) Mech Ageing Dev , vol.130 , pp. 528-537
    • Rusin, M.1    Zajkowicz, A.2    Butkiewicz, D.3
  • 79
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis VG, Vassiliou LV, Karakaidos P, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005;434:907-913.
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1    Vassiliou, L.V.2    Karakaidos, P.3
  • 80
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova J, Horejś? Z, Koed K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005;434:864-870.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1    Horejs, Z.2    Koed, K.3
  • 81
    • 33746495515 scopus 로고    scopus 로고
    • Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites
    • Durkin SG, Arlt MF, Howlett NG, Glover TW. Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene 2006;25:4381-4388.
    • (2006) Oncogene , vol.25 , pp. 4381-4388
    • Durkin, S.G.1    Arlt, M.F.2    Howlett, N.G.3    Glover, T.W.4
  • 82
    • 77950021721 scopus 로고    scopus 로고
    • Fhit loss in lung preneoplasia: Relation to DNA damage response checkpoint activation
    • Cirombella R, Montrone G, Stoppacciaro, A et al. Fhit loss in lung preneoplasia: relation to DNA damage response checkpoint activation. Cancer Lett 2010;291:230-236.
    • (2010) Cancer Lett , vol.291 , pp. 230-236
    • Cirombella, R.1    Montrone, G.2    Stoppacciaro, A.3
  • 83
    • 35148812601 scopus 로고    scopus 로고
    • Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression
    • Nuciforo PG, Luise C, Capra M, Pelosi G, d'Adda di Fagagna F. Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression. Carcinogenesis 2007;28:2082-2088.
    • (2007) Carcinogenesis , vol.28 , pp. 2082-2088
    • Nuciforo, P.G.1    Luise, C.2    Capra, M.3    Pelosi, G.4    D'adda Di Fagagna, F.5
  • 84
    • 35448989663 scopus 로고    scopus 로고
    • Molecular analysis of amultistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway
    • BlancoD,Vicent S, FragaMF, et al. Molecular analysis of amultistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway. Neoplasia 2007;9:840-852.
    • (2007) Neoplasia , vol.9 , pp. 840-852
    • Blanco, D.1    Vicent, S.2    Fraga, M.F.3
  • 85
    • 48149087304 scopus 로고    scopus 로고
    • Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells
    • Zhao H, Tanaka T, Mitlitski V, Heeter J, Balazs EA, Darzynkiewicz Z. Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells. Int J Oncol 2008;32:1159-1167.
    • (2008) J Oncol , vol.32 , pp. 1159-1167
    • Zhao, H.1    Tanaka, T.2    Mitlitski, V.3    Heeter, J.4    Balazs, E.A.5    Darzynkiewicz, Z.6
  • 86
  • 87
    • 27144486122 scopus 로고    scopus 로고
    • Novel genotoxicity assays identify norethindrone to activate p53 and phosphorylate H2AX
    • Gallmeier E, Winter JM, Cunningham SC, Kahn SR, Kern SE. Novel genotoxicity assays identify norethindrone to activate p53 and phosphorylate H2AX. Carcinogenesis 2005;26:1811-1820.
    • (2005) Carcinogenesis , vol.26 , pp. 1811-1820
    • Gallmeier, E.1    Winter, J.M.2    Cunningham, S.C.3    Kahn, S.R.4    Kern, S.E.5
  • 88
    • 34547615725 scopus 로고    scopus 로고
    • Water soluble fraction of solar-simulated light-exposed crude oil generates phosphorylation of histoneH2AX in human skin cells under UVA exposure
    • Ibuki Y, Toyooka T, Shirahata J, Ohura T, Goto R. Water soluble fraction of solar-simulated light-exposed crude oil generates phosphorylation of histoneH2AX in human skin cells under UVA exposure. Environ Mol Mutagen 2007;48:430-439.
    • (2007) Environ Mol Mutagen , vol.48 , pp. 430-439
    • Ibuki, Y.1    Toyooka, T.2    Shirahata, J.3    Ohura, T.4    Goto, R.5
  • 89
    • 33750870356 scopus 로고    scopus 로고
    • 50-Hertz electromagnetic fields induce gammaH2AX foci formation in mouse preimplantation embryos in vitro
    • Luo Q, Yang J, Zeng QL, Zhu XM, Qian YL, Huang HF. 50-Hertz electromagnetic fields induce gammaH2AX foci formation in mouse preimplantation embryos in vitro. Biol Reprod 2006;75:673-680.
    • (2006) Biol Reprod , vol.75 , pp. 673-680
    • Luo, Q.1    Yang, J.2    Zeng, Q.L.3    Zhu, X.M.4    Qian, Y.L.5    Huang, H.F.6
  • 90
    • 25444502873 scopus 로고    scopus 로고
    • Immunofluorescence detection of clustered gamma-H2AX foci induced by HZE-particle radiation
    • DesaiN,DavisE,O'Neill P,DuranteM,CucinottaFA,WuH. Immunofluorescence detection of clustered gamma-H2AX foci induced by HZE-particle radiation. Radiat Res 2005;164:518-522.
    • (2005) Radiat Res , vol.164 , pp. 518-522
    • Desai, N.1    Davis, E.2    O'neill, P.3    Durante, M.4    Cucinotta, F.A.5    Wu, H.6
  • 91
    • 67349150457 scopus 로고    scopus 로고
    • Cigarette side stream smoke induces phosphorylated histone H2AX
    • Toyooka T, Ibuki Y. Cigarette side stream smoke induces phosphorylated histone H2AX. Mutat Res 2009;676:34-40.
    • (2009) Mutat Res , vol.676 , pp. 34-40
    • Toyooka, T.1    Ibuki, Y.2
  • 92
    • 77953569623 scopus 로고    scopus 로고
    • DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco-and nicotine-free cigarettes
    • Jorgensen ED, Zhao H, Traganos F, Albino AP, Darzynkiewicz Z. DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco-and nicotine-free cigarettes. Cell Cycle 2010;9:2170-2176.
    • (2010) Cell Cycle , vol.9 , pp. 2170-2176
    • Jorgensen, E.D.1    Zhao, H.2    Traganos, F.3    Albino, A.P.4    Darzynkiewicz, Z.5
  • 93
    • 70349495882 scopus 로고    scopus 로고
    • DNA damage response induced by tobacco smoke in normal human bronchial epithelial andA549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry
    • Zhao H, Albino AP, Jorgensen E, Traganos F, Darzynkiewicz Z. DNA damage response induced by tobacco smoke in normal human bronchial epithelial andA549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry. Cytometry A 2009;275:840-847.
    • (2009) Cytometry A , vol.275 , pp. 840-847
    • Zhao, H.1    Albino, A.P.2    Jorgensen, E.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 94
  • 95
    • 33745819903 scopus 로고    scopus 로고
    • Induction of DNA double-strand breaks in A549 and normal human pulmonary epithelial cells by cigarette smoke is mediated by free radicals
    • Albino AP, Huang X, Jorgensen ED, Gietl D, Traganos F, Darzynkiewicz Z. Induction of DNA double-strand breaks in A549 and normal human pulmonary epithelial cells by cigarette smoke is mediated by free radicals. Int J Oncol 2006;28:1491-1505.
    • (2006) J Oncol , vol.28 , pp. 1491-1505
    • Albino, A.P.1    Huang, X.2    Jorgensen, E.D.3    Gietl, D.4    Traganos, F.5    Darzynkiewicz, Z.6
  • 97
    • 77952005470 scopus 로고    scopus 로고
    • Diminished carcinogen detoxification is a novel mechanism for hypoxiainducible factor 1-mediated genetic instability
    • Schults MA, Timmermans L, Godschalk RW, et al. Diminished carcinogen detoxification is a novel mechanism for hypoxiainducible factor 1-mediated genetic instability. J Biol Chem 2010;285:14558-14564.
    • (2010) J Biol Chem , vol.285 , pp. 14558-14564
    • Schults, M.A.1    Timmermans, L.2    Godschalk, R.W.3
  • 98
    • 75349105000 scopus 로고    scopus 로고
    • Expression of glutathione S-transferase M2 in stage I/II non-small cell lung cancer and alleviation of DNA damage exposure to benzo[a]pyrene
    • Tang SC, Sheu GT, Wong RH, et al. Expression of glutathione S-transferase M2 in stage I/II non-small cell lung cancer and alleviation of DNA damage exposure to benzo[a]pyrene. Toxicol Lett 2010;192:316-323.
    • (2010) Toxicol Lett , vol.192 , pp. 316-323
    • Tang, S.C.1    Sheu, G.T.2    Wong, R.H.3
  • 100
    • 36148951013 scopus 로고    scopus 로고
    • H2AX phosphorylation afterUVirradiation is triggered byDNA repair intermediates and ismediated by the ATR kinase
    • Hanasoge S, Ljungman M. H2AX phosphorylation afterUVirradiation is triggered byDNA repair intermediates and ismediated by the ATR kinase. Carcinogenesis 2007;28:2298-2304.
    • (2007) Carcinogenesis , vol.28 , pp. 2298-2304
    • Hanasoge, S.1    Ljungman, M.2
  • 101
    • 34347407201 scopus 로고    scopus 로고
    • Radiation-induced gamma-H2AX inmammalian cells irradiated with a synchrotron X-ray microbeam
    • Usami N, Maeda M, Eguchi-Kasai K, Maezawa H, Kobayashi K. Radiation-induced gamma-H2AX inmammalian cells irradiated with a synchrotron X-ray microbeam. Radiat Prot Dosimetry 2006;122:307-309.
    • (2006) Radiat Prot Dosimetry , vol.122 , pp. 307-309
    • Usami, N.1    Maeda, M.2    Eguchi-Kasai, K.3    Maezawa, H.4    Kobayashi, K.5
  • 102
    • 0038820065 scopus 로고    scopus 로고
    • Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced bymammalian DNA topoisomerase i cleavage complexes
    • Furuta T, Takemura H, Liao ZY, et al. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced bymammalian DNA topoisomerase I cleavage complexes. J Biol Chem 2003;278:20303-20312.
    • (2003) J Biol Chem , vol.278 , pp. 20303-20312
    • Furuta, T.1    Takemura, H.2    Liao, Z.Y.3
  • 103
    • 0345276620 scopus 로고    scopus 로고
    • Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents
    • Liu JS, Kuo SR,Melendy T. Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents. Mutat Res 2003;532:215-226.
    • (2003) Mutat Res , vol.532 , pp. 215-226
    • Liu, J.S.1    Kuo, S.R.2    Melendy, T.3
  • 104
    • 33846913205 scopus 로고    scopus 로고
    • Short-term culture and gammaH2AX flow cytometry determine differences in individual radiosensitivity in human peripheral T lymphocytes
    • Hamasaki K, Imai K, Nakachi K, Takahashi N, Kodama Y, Kusunoki Y. Short-term culture and gammaH2AX flow cytometry determine differences in individual radiosensitivity in human peripheral T lymphocytes. EnvironMolMutagen 2007;48:38-47.
    • (2007) EnvironMolMutagen , vol.48 , pp. 38-47
    • Hamasaki, K.1    Imai, K.2    Nakachi, K.3    Takahashi, N.4    Kodama, Y.5    Kusunoki, Y.6
  • 105
    • 33750092260 scopus 로고    scopus 로고
    • Candidate protein biodosimeters of human exposure to ionizing radiation
    • Marchetti F, Coleman MA, Jones IM, Wyrobek AJ. Candidate protein biodosimeters of human exposure to ionizing radiation. Int J Radiat Biol 2006;82:605-639.
    • (2006) J Radiat Biol , vol.82 , pp. 605-639
    • Marchetti, F.1    Coleman, M.A.2    Jones, I.M.3    Wyrobek, A.J.4
  • 106
    • 66249084554 scopus 로고    scopus 로고
    • Kinetics of H2AX phosphorylation after exposure to cisplatin
    • Olive PL, Bańath JP. Kinetics of H2AX phosphorylation after exposure to cisplatin. Cytometry B Clin Cytom 2009;76:79-90.
    • (2009) Cytometry B Clin Cytom , vol.76 , pp. 79-90
    • Olive, P.L.1    Banath, J.P.2
  • 107
    • 76049088795 scopus 로고    scopus 로고
    • Involvement of p21Waf1/Cip1 cleavage during roscovitineinduced apoptosis in non-small cell lung cancer cells
    • Zhang T, Jiang T, Zhang F, Li C, Zhou YA, Zhu YF, Li XF. Involvement of p21Waf1/Cip1 cleavage during roscovitineinduced apoptosis in non-small cell lung cancer cells. Oncol Rep 2010;23:239-245.
    • (2010) Oncol Rep , vol.23 , pp. 239-245
    • Zhang, T.1    Jiang, T.2    Zhang, F.3    Li, C.4    Zhou, Y.A.5    Zhu, Y.F.6    Li, X.F.7
  • 108
    • 44949101465 scopus 로고    scopus 로고
    • Kinetics of histoneH2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase
    • Zhao H, Traganos F,Darzynkiewicz Z. Kinetics of histoneH2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase. Cytometry A 2008;73:480-489.
    • (2008) Cytometry A , vol.73 , pp. 480-489
    • Zhao, H.1    Traganos, F.2    Darzynkiewicz, Z.3
  • 109
    • 80054827515 scopus 로고    scopus 로고
    • Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells
    • Knobel PA, Kotov IN, Felley-Bosco E, Stahel RA, Marti TM. Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells. Neoplasia 2011;13:961-970.
    • (2011) Neoplasia , vol.13 , pp. 961-970
    • Knobel, P.A.1    Kotov, I.N.2    Felley-Bosco, E.3    Stahel, R.A.4    Marti, T.M.5
  • 111
    • 78149333462 scopus 로고    scopus 로고
    • Replication-dependent ?-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells
    • Zhang F, Zhang T, Qu Y, et al. Replication-dependent ?-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells. Oncology Reports 2010;24:1297-1305.
    • (2010) Oncology Reports , vol.24 , pp. 1297-1305
    • Zhang, F.1    Zhang, T.2    Qu, Y.3
  • 112
    • 78649432051 scopus 로고    scopus 로고
    • Inhibition of PI3 kinases enhances the sensitivity of non-small cell lung cancer cells to ionizing radiation
    • Zhang T, Cui GB, Zhang J, et al. Inhibition of PI3 kinases enhances the sensitivity of non-small cell lung cancer cells to ionizing radiation. Oncol Rep 2010;24:1683-1689.
    • (2010) Oncol Rep , vol.24 , pp. 1683-1689
    • Zhang, T.1    Cui, G.B.2    Zhang, J.3
  • 113
    • 81755163137 scopus 로고    scopus 로고
    • Effection and mechanism of radiosensitivity of non-small cell lung cancer cell line H358 following gefitinib treatment
    • Deng J, Zhuang L, Chen Y. Effection and mechanism of radiosensitivity of non-small cell lung cancer cell line H358 following gefitinib treatment. Zhongguo Fei Ai Za Zhi 2011;14:841-847.
    • (2011) Zhongguo Fei Ai Za Zhi , vol.14 , pp. 841-847
    • Deng, J.1    Zhuang, L.2    Chen, Y.3
  • 114
    • 39749129748 scopus 로고    scopus 로고
    • Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity
    • Tanaka T, Munshi A, Brooks C, Liu J, Hobbs ML, Meyn RE. Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity. Clin Cancer Res 2008;14:1266-1273.
    • (2008) Clin Cancer Res , vol.14 , pp. 1266-1273
    • Tanaka, T.1    Munshi, A.2    Brooks, C.3    Liu, J.4    Hobbs, M.L.5    Meyn, R.E.6
  • 115
    • 77952582492 scopus 로고    scopus 로고
    • Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy
    • Hubaux R, Vandermeers F, Crisanti MC, et al. Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy. Eur J Cancer 2010;46:1724-1734.
    • (2010) Eur J Cancer , vol.46 , pp. 1724-1734
    • Hubaux, R.1    Vandermeers, F.2    Crisanti, M.C.3
  • 116
    • 77957276131 scopus 로고    scopus 로고
    • Opposite expression of securin and ?-H2AX regulates baicalein-induced cancer cell death
    • Jiang RH, SuWC, Liu HF, Huang HS, Chao JI. Opposite expression of securin and ?-H2AX regulates baicalein-induced cancer cell death. J Cell Biochem 2010;111:274-283.
    • (2010) J Cell Biochem , vol.111 , pp. 274-283
    • Jiang, R.H.1    Su, W.C.2    Liu, H.F.3    Huang, H.S.4    Chao, J.I.5
  • 117
    • 10844286478 scopus 로고    scopus 로고
    • Evidence for the involvement of double-strand breaks in heat-induced cell killing
    • Takahashi A,Matsumoto H, Nagayama K, et al. Evidence for the involvement of double-strand breaks in heat-induced cell killing. Cancer Res 2004;64:8839-8845.
    • (2004) Cancer Res , vol.64 , pp. 8839-8845
    • Takahashi, A.1    Matsumoto, H.2    Nagayama, K.3
  • 118
    • 66449132564 scopus 로고    scopus 로고
    • Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage
    • Krynetskaia NF, Phadke MS, Jadhav SH, Krynetskiy EY. Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther 2009;8:864-872.
    • (2009) Mol Cancer Ther , vol.8 , pp. 864-872
    • Krynetskaia, N.F.1    Phadke, M.S.2    Jadhav, S.H.3    Krynetskiy, E.Y.4
  • 119
    • 79960561101 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 4?-acrylamidopodophyllotoxin congeners as DNA damaging agents
    • Kamal A, Suresh P, Janaki Ramaiah M, et al. Synthesis and biological evaluation of 4?-acrylamidopodophyllotoxin congeners as DNA damaging agents. Bioorg Med Chem 2011;19:4589-4600.
    • (2011) Bioorg Med Chem , vol.19 , pp. 4589-4600
    • Kamal, A.1    Suresh, P.2    Janaki Ramaiah, M.3
  • 121
    • 77950203807 scopus 로고    scopus 로고
    • MiR-181a and miR-630 regulate cisplatin-induced cancer cell death
    • Galluzzi L, Morselli E, Vitale I. miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res 2010;70:1793-1803.
    • (2010) Cancer Res , vol.70 , pp. 1793-1803
    • Galluzzi, L.1    Morselli, E.2    Vitale, I.3
  • 122
    • 79959690267 scopus 로고    scopus 로고
    • Activation of DNA damage response signaling in lung adenocarcinoma A549 cells following oxygen beam irradiation
    • Ghosh S, Narang H, Sarma A, Kaur H, Krishna M. Activation of DNA damage response signaling in lung adenocarcinoma A549 cells following oxygen beam irradiation. Mutat Res 2011;723:190-198.
    • (2011) Mutat Res , vol.723 , pp. 190-198
    • Ghosh, S.1    Narang, H.2    Sarma, A.3    Kaur, H.4    Krishna, M.5
  • 123
    • 80053576211 scopus 로고    scopus 로고
    • DNA damage response signaling in lung adenocarcinoma A549 cells following gamma and carbon beam irradiation
    • Ghosh S,NarangH, Sarma A, KrishnaM. DNA damage response signaling in lung adenocarcinoma A549 cells following gamma and carbon beam irradiation. Mutat Res 2011;716:10-9.
    • (2011) Mutat Res , vol.716 , pp. 10-19
    • Ghosh, S.1    Narang, H.2    Sarma, A.3    Krishna, M.4
  • 124
    • 77749265017 scopus 로고    scopus 로고
    • DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle
    • Roig AI,Hight SK,Minna JD, Shay JW, Rusek A, StoryMD. DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle. Int J Radiat Biol 2010;86:194-204.
    • (2010) J Radiat Biol , vol.86 , pp. 194-204
    • Roig, A.I.1    Hight, S.K.2    Minna, J.D.3    Shay, J.W.4    Rusek, A.5    Story, M.D.6
  • 125
    • 39049118839 scopus 로고    scopus 로고
    • Sustained metaphase arrest in response to ionizing radiation in a non-small cell lung cancer cell line
    • Kodym E, Kodym R, Choy H, Saha D. Sustained metaphase arrest in response to ionizing radiation in a non-small cell lung cancer cell line. Radiat Res 2008;169:46-58.
    • (2008) Radiat Res , vol.169 , pp. 46-58
    • Kodym, E.1    Kodym, R.2    Choy, H.3    Saha, D.4
  • 126
    • 17444402057 scopus 로고    scopus 로고
    • Targeting of Rad51-dependent homologous recombination: Implications for the radiation sensitivity of human lung cancer cell lines
    • Sak A, Stueben G, Groneberg M, B̈ocker W, Stuschke M. Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines. Br J Cancer 2005;92:1089-1097.
    • (2005) Br J Cancer , vol.92 , pp. 1089-1097
    • Sak, A.1    Stueben, G.2    Groneberg, M.3    Bocker, W.4    Stuschke, M.5
  • 127
    • 34249027011 scopus 로고    scopus 로고
    • Adenoviral-mediated PTEN expression radiosensitizes nonsmall cell lung cancer cells by suppressing DNA repair capacity
    • Pappas G, Zumstein LA, Munshi A, Hobbs M, Meyn RE. Adenoviral-mediated PTEN expression radiosensitizes nonsmall cell lung cancer cells by suppressing DNA repair capacity. Cancer Gene Therapy 2007;14:543-549.
    • (2007) Cancer Gene Therapy , vol.14 , pp. 543-549
    • Pappas, G.1    Zumstein, L.A.2    Munshi, A.3    Hobbs, M.4    Meyn, R.E.5
  • 128
    • 79958050066 scopus 로고    scopus 로고
    • Comparison of RBE values of high-LET ?-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death
    • Franken NA, ten Cate R, Krawczyk PM, Stap J, Haveman J, Aten J, Barendsen GW. Comparison of RBE values of high-LET ?-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death. Radiat Oncol 2011;8;6:64.
    • (2011) Radiat Oncol , vol.8 , Issue.6 , pp. 64
    • Franken, N.A.1    Cate, R.2    Krawczyk, P.M.3    Stap, J.4    Haveman, J.5    Aten, J.6    Barendsen, G.W.7
  • 129
    • 78149320175 scopus 로고    scopus 로고
    • Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo
    • Fukushima M, Sakamoto K, Sakata M, Nakagawa F, Saito H, Sakata Y. Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo. Oncol Rep 2010;24:1307-1313.
    • (2010) Oncol Rep , vol.24 , pp. 1307-1313
    • Fukushima, M.1    Sakamoto, K.2    Sakata, M.3    Nakagawa, F.4    Saito, H.5    Sakata, Y.6
  • 130
    • 77951058314 scopus 로고    scopus 로고
    • Enhancement of radiation-induced DNAdamage and inhibition of its repair by a novel camptothecin analog
    • Huang G,Wang H, Yang LX. Enhancement of radiation-induced DNAdamage and inhibition of its repair by a novel camptothecin analog. Anticancer Res 2010;30:937-944.
    • (2010) Anticancer Res , vol.30 , pp. 937-944
    • Huang, G.1    Wang, H.2    Yang, L.X.3
  • 131
    • 81155127527 scopus 로고    scopus 로고
    • Albendazole sensitizes cancer cells to ionizing radiation
    • Patel K, Doudican NA, Schiff PB, Orlow SJ. Albendazole sensitizes cancer cells to ionizing radiation. Radiat Oncol 2011;17;6:160.
    • (2011) Radiat Oncol , vol.17 , Issue.6 , pp. 160
    • Patel, K.1    Doudican, N.A.2    Schiff, P.B.3    Orlow, S.J.4
  • 132
    • 84861626653 scopus 로고    scopus 로고
    • Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit
    • Xiong H, Lee RJ, Haura EB, Edwards JG, Dynan WS, Li S. Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit. Int J Radiat Oncol Biol Phys 2012;83:1023-1030.
    • (2012) J Radiat Oncol Biol Phys , vol.83 , pp. 1023-1030
    • Xiong, H.1    Lee, R.J.2    Haura, E.B.3    Edwards, J.G.4    Dynan, W.S.5    Li, S.6
  • 133
    • 33845741562 scopus 로고    scopus 로고
    • Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer
    • Geng L, Cuneo KC, Fu A, Tu T, Atadja PW, Hallahan DE. Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer. Cancer Res 2006;66:11298-11304.
    • (2006) Cancer Res , vol.66 , pp. 11298-11304
    • Geng, L.1    Cuneo, K.C.2    Fu, A.3    Tu, T.4    Atadja, P.W.5    Hallahan, D.E.6
  • 134
    • 34250805910 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation
    • Cuneo KC, Fu A, Osusky K, Huamani J, Hallahan DE, Geng L. Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation. Anticancer Drugs 2007;18:793-800.
    • (2007) Anticancer Drugs , vol.18 , pp. 793-800
    • Cuneo, K.C.1    Fu, A.2    Osusky, K.3    Huamani, J.4    Hallahan, D.E.5    Geng, L.6
  • 135
    • 33646944722 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation
    • Zhang Y, AdachiM, Zou H, Hareyama M, Imai K, Shinomura Y. Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation. Int J Radiat Oncol Biol Phys 2006;65:859-866.
    • (2006) J Radiat Oncol Biol Phys , vol.65 , pp. 859-866
    • Zhang, Y.1    Adachi, M.2    Zou, H.3    Hareyama, M.4    Imai, K.5    Shinomura, Y.6
  • 136
    • 34548713013 scopus 로고    scopus 로고
    • Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library
    • Lally BE, Geiger GA, Kridel S, et al. Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Cancer Res 2007;67:8791-8799.
    • (2007) Cancer Res , vol.67 , pp. 8791-8799
    • Lally, B.E.1    Geiger, G.A.2    Kridel, S.3
  • 137
    • 69349103706 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes nonsmall cell lung cancer cells
    • Iwasa T, Okamoto I, Suzuki M, et al. Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes nonsmall cell lung cancer cells. Clin Cancer Res 2009;15:5117-5125.
    • (2009) Clin Cancer Res , vol.15 , pp. 5117-5125
    • Iwasa, T.1    Okamoto, I.2    Suzuki, M.3
  • 138
    • 79953025164 scopus 로고    scopus 로고
    • Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer
    • Singh-Gupta V, Joiner MC, et al. Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer. JThorac Oncol 2011;6:688-698.
    • (2011) JThorac Oncol , vol.6 , pp. 688-698
    • Singh-Gupta, V.1    Joiner, M.C.2
  • 139
    • 81055124289 scopus 로고    scopus 로고
    • Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals
    • Hudson D, Kovalchuk I, Koturbash I, Kolb B, Martin OA, Kovalchuk O. Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals. Aging (Albany NY) 2011;3: 609-620.
    • (2011) Aging (Albany NY) , vol.3 , pp. 609-620
    • Hudson, D.1    Kovalchuk, I.2    Koturbash, I.3    Kolb, B.4    Martin, O.A.5    Kovalchuk, O.6
  • 140
    • 84862489824 scopus 로고    scopus 로고
    • Downregulation of peroxiredoxin i by a novel fully human phage display recombinant antibody induces apoptosis and enhances radiation sensitization in A549 lung carcinoma cells
    • Guo Q, Huang X, Zhang J, Luo Y, Peng Z, Li S. Downregulation of peroxiredoxin I by a novel fully human phage display recombinant antibody induces apoptosis and enhances radiation sensitization in A549 lung carcinoma cells. Cancer Biother Radiopharm 2012;27:307-316.
    • (2012) Cancer Biother Radiopharm , vol.27 , pp. 307-316
    • Guo, Q.1    Huang, X.2    Zhang, J.3    Luo, Y.4    Peng, Z.5    Li, S.6
  • 141
    • 58149197153 scopus 로고    scopus 로고
    • Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in nonsmall cell lung cancer cell lines
    • Iwasa T, Okamoto I, Suzuki M. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in nonsmall cell lung cancer cell lines. Clin Cancer Res 2008;14:6496-6504.
    • (2008) Clin Cancer Res , vol.14 , pp. 6496-6504
    • Iwasa, T.1    Okamoto, I.2    Suzuki, M.3
  • 142
    • 35148834590 scopus 로고    scopus 로고
    • Gamma-H2AX in bystander cells: Not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication
    • Sokolov MV, Dickey JS, Bonner WM, Sedelnikova OA. gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication. Cell Cycle 2007;6:2210-2212.
    • (2007) Cell Cycle , vol.6 , pp. 2210-2212
    • Sokolov, M.V.1    Dickey, J.S.2    Bonner, W.M.3    Sedelnikova, O.A.4
  • 143
    • 78449313327 scopus 로고    scopus 로고
    • Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells
    • Klammer H, Kadhim M, Iliakis G. Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells. Cancer Res 2010;70:8498-8506.
    • (2010) Cancer Res , vol.70 , pp. 8498-8506
    • Klammer, H.1    Kadhim, M.2    Iliakis, G.3
  • 144
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-921.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 145
    • 33746100822 scopus 로고    scopus 로고
    • Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer
    • Tutt AN, Lord CJ, McCabe N, et al. Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer. Cold Spring Harb Symp Quant Biol 2005;70:139-148.
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 139-148
    • Tutt, A.N.1    Lord, C.J.2    McCabe, N.3
  • 146
    • 34248586036 scopus 로고    scopus 로고
    • Interaction betweenATMand PARP-1 in response toDNAdamage and sensitization of ATM deficient cells through PARP inhibition
    • Aguilar-Quesada R,Munoz-Ǵamez JA,Mart́?n-Oliva D, et al. Interaction betweenATMand PARP-1 in response toDNAdamage and sensitization of ATM deficient cells through PARP inhibition. BMC Mol Biol 2007;25;8:29.
    • (2007) BMC Mol Biol , vol.25 , Issue.8 , pp. 29
    • Aguilar-Quesada, R.1    Munoz-Gamez, J.A.2    Martn-Oliva, D.3
  • 147
    • 34249784216 scopus 로고    scopus 로고
    • Inhibition of poly (ADPribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models
    • Albert JM, Cao C, Kim KW, et al. Inhibition of poly (ADPribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res 2007;13:3033-3042.
    • (2007) Clin Cancer Res , vol.13 , pp. 3033-3042
    • Albert, J.M.1    Cao, C.2    Kim, K.W.3
  • 148
    • 77950974130 scopus 로고    scopus 로고
    • Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors
    • Mukhopadhyay A, Elattar A, Cerbinskaite A, et al. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clin Cancer Res 2010;16:2344-2351.
    • (2010) Clin Cancer Res , vol.16 , pp. 2344-2351
    • Mukhopadhyay, A.1    Elattar, A.2    Cerbinskaite, A.3
  • 149
    • 77956686608 scopus 로고    scopus 로고
    • Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers
    • Redon CE, Nakamura AJ, Zhang YW, et al. Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. Clin Cancer Res 2010;16:4532-4542.
    • (2010) Clin Cancer Res , vol.16 , pp. 4532-4542
    • Redon, C.E.1    Nakamura, A.J.2    Zhang, Y.W.3
  • 150
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361:123-134.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 151
    • 58149263490 scopus 로고    scopus 로고
    • Preclinical modeling of a phase 0 clinical trial: Qualification of a pharmacodynamic assay of poly (ADP-ribose) polymerase in tumor biopsies of mouse xenografts
    • Kinders RJ, Hollingshead M, Khin S, et al. Preclinical modeling of a phase 0 clinical trial: qualification of a pharmacodynamic assay of poly (ADP-ribose) polymerase in tumor biopsies of mouse xenografts. Clin Cancer Res 2008;14:6877-6885.
    • (2008) Clin Cancer Res , vol.14 , pp. 6877-6885
    • Kinders, R.J.1    Hollingshead, M.2    Khin, S.3
  • 152
    • 59449085305 scopus 로고    scopus 로고
    • Phase i study of the poly (ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors
    • Plummer R, Jones C,MiddletonM, et al. Phase I study of the poly (ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res 2008;14:7917-7923.
    • (2008) Clin Cancer Res , vol.14 , pp. 7917-7923
    • Plummer, R.1    Jones, C.2    Middleton, M.3
  • 153
    • 9744271049 scopus 로고    scopus 로고
    • Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
    • Hickson I, Zhao Y, Richardson CJ, et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 2004;64: 9152-9159.
    • (2004) Cancer Res , vol.64 , pp. 9152-9159
    • Hickson, I.1    Zhao, Y.2    Richardson, C.J.3
  • 154
    • 0141619287 scopus 로고    scopus 로고
    • Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly (ADPribose) polymerase-1
    • Veuger SJ, Curtin NJ, Richardson CJ. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly (ADPribose) polymerase-1. Cancer Res 2003;63:6008-6015.
    • (2003) Cancer Res , vol.63 , pp. 6008-6015
    • Veuger, S.J.1    Curtin, N.J.2    Richardson, C.J.3
  • 157
    • 33746721468 scopus 로고    scopus 로고
    • Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability
    • Yu T,MacPhail SH, Bańath JP, Klokov D, Olive PL. Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability. DNA Repair (Amst) 2006;5:935-946.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 935-946
    • Yu, T.1    MacPhail, S.H.2    Banath, J.P.3    Klokov, D.4    Olive, P.L.5
  • 158
    • 84873916028 scopus 로고    scopus 로고
    • H2AX expression detected by immunohistochemistry correlates with prognosis in early operable non-small cell lung cancer
    • Matthaios D, Foukas P, Kefala M, et al. ?-H2AX expression detected by immunohistochemistry correlates with prognosis in early operable non-small cell lung cancer. Onco Targets Ther 2012;5:309-314.
    • (2012) Onco Targets Ther , vol.5 , pp. 309-314
    • Matthaios, D.1    Foukas, P.2    Kefala, M.3
  • 159
    • 84872493359 scopus 로고    scopus 로고
    • H2AX and lung cancer: Is it the Ariadne's thread
    • Matthaios D, Bouros D, Kakolyris S. H2AX and lung cancer: Is it the Ariadne's thread? DNA Repair (Amst) 2013;12(2):90-91.
    • (2013) DNA Repair , vol.12 , Issue.2 , pp. 90-91
    • Matthaios, D.1    Bouros, D.2    Kakolyris, S.3
  • 160
    • 84887261716 scopus 로고    scopus 로고
    • Euripides, Aeolus, fragment 38. Greek tragic dramatist (484 BC-406 BC)
    • Euripides, Aeolus, fragment 38. Greek tragic dramatist (484 BC-406 BC)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.