메뉴 건너뛰기




Volumn 11, Issue 10, 1997, Pages 1226-1241

Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

Author keywords

Brca1; Brca2; embryonic lethality; mouse mutant; p53

Indexed keywords

PROTEIN P53;

EID: 0030924656     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.10.1226     Document Type: Article
Times cited : (474)

References (102)
  • 1
    • 0028848589 scopus 로고
    • Mouse Brca 1: Isolation, sequence analysis and identification of evolutionary conserved domains
    • Abel, K.J., J. Xu, G.-Y. Yin, R.H. Lyons, M.H. Meisler, and B.L. Weber. 1995. Mouse Brca 1: Isolation, sequence analysis and identification of evolutionary conserved domains. Hum. Mol. Genet. 12: 2265-2273.
    • (1995) Hum. Mol. Genet. , vol.12 , pp. 2265-2273
    • Abel, K.J.1    Xu, J.2    Yin, G.-Y.3    Lyons, R.H.4    Meisler, M.H.5    Weber, B.L.6
  • 2
    • 0029347164 scopus 로고
    • High-frequency developmental abnormalities in p53-deficient mice
    • Armstrong, J.F., M.H. Kaufman, D.J. Harrison, and A.R. Clarke. 1995. High-frequency developmental abnormalities in p53-deficient mice. Curr. Biol. 5: 931-936.
    • (1995) Curr. Biol. , vol.5 , pp. 931-936
    • Armstrong, J.F.1    Kaufman, M.H.2    Harrison, D.J.3    Clarke, A.R.4
  • 3
    • 0026666791 scopus 로고
    • Ordering gene function, the interpretation of epistasis in regulatory hierarchies
    • Avery, L. and S. Wasserman. 1992. Ordering gene function, the interpretation of epistasis in regulatory hierarchies. Trends Genet. 8: 312-316.
    • (1992) Trends Genet. , vol.8 , pp. 312-316
    • Avery, L.1    Wasserman, S.2
  • 4
    • 0029670589 scopus 로고    scopus 로고
    • p53 in signaling checkpoint arrest or apoptosis
    • Bates, S. and K.H. Vousden. 1996. p53 in signaling checkpoint arrest or apoptosis. Curr. Opin. Genet. Dev. 6: 12-19.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 12-19
    • Bates, S.1    Vousden, K.H.2
  • 7
    • 0023649609 scopus 로고
    • Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the testis
    • Bishop, C.E. and D. Hatat. 1987. Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the testis. Nucleic Acids Res. 15: 2959-2969.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 2959-2969
    • Bishop, C.E.1    Hatat, D.2
  • 8
    • 0030140414 scopus 로고    scopus 로고
    • Internal repeats in the BRCA2 protein sequence
    • Bork, P., N. Blomberg, and M. Nigles. 1996. Internal repeats in the BRCA2 protein sequence. Nature Genet. 13: 22-23.
    • (1996) Nature Genet. , vol.13 , pp. 22-23
    • Bork, P.1    Blomberg, N.2    Nigles, M.3
  • 9
    • 0031046294 scopus 로고    scopus 로고
    • A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
    • Bork, P., K. Hofmann, P. Bucher, A.F. Neuwald, S.F. Altschul, and E.V. Koonin. 1997. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11: 68-76.
    • (1997) FASEB J. , vol.11 , pp. 68-76
    • Bork, P.1    Hofmann, K.2    Bucher, P.3    Neuwald, A.F.4    Altschul, S.F.5    Koonin, E.V.6
  • 11
    • 0029934489 scopus 로고    scopus 로고
    • The 5′ end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21
    • Brown, M.A., C.-F. Xu, H. Nicolai, B. Griffiths, J.A. Chambers, D. Black, and E. Solomon. 1996. The 5′ end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21. Oncogens 12: 2507-2513.
    • (1996) Oncogens , vol.12 , pp. 2507-2513
    • Brown, M.A.1    Xu, C.-F.2    Nicolai, H.3    Griffiths, B.4    Chambers, J.A.5    Black, D.6    Solomon, E.7
  • 12
    • 0031031787 scopus 로고    scopus 로고
    • From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair
    • Callebaut, I. and J.-P. Mornon. 1997. From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair. FEBS Lett. 400: 25-30.
    • (1997) FEBS Lett. , vol.400 , pp. 25-30
    • Callebaut, I.1    Mornon, J.-P.2
  • 13
    • 0029865318 scopus 로고    scopus 로고
    • The genetics of familial breast cancer
    • Cannon-Albright, L.A. and M.H. Skolnick. 1996. The genetics of familial breast cancer. Semin. Oncol. 23(Suppl. 2): 1-5.
    • (1996) Semin. Oncol. , vol.23 , Issue.2 SUPPL. , pp. 1-5
    • Cannon-Albright, L.A.1    Skolnick, M.H.2
  • 14
    • 0028797399 scopus 로고
    • The cellular responses to DNA damage
    • Carr, A.M. and M.F. Hoekstra. 1995. The cellular responses to DNA damage. Trends Cell Biol. 5: 32-40.
    • (1995) Trends Cell Biol. , vol.5 , pp. 32-40
    • Carr, A.M.1    Hoekstra, M.F.2
  • 15
    • 0029830051 scopus 로고    scopus 로고
    • Transcriptional activation by BRCA1
    • Chapman, M.S. and I.M. Verma. 1996. Transcriptional activation by BRCA1. Nature 382: 678-679.
    • (1996) Nature , vol.382 , pp. 678-679
    • Chapman, M.S.1    Verma, I.M.2
  • 16
    • 12644270610 scopus 로고    scopus 로고
    • The nuclear localization sequences of the BRCA1 protein interact with the importin-a subunit of the nulcear transport signal receptor
    • Chen, C.-F., S. Li, Y. Chen, P.-L. Chen, Z.D. Sharp, and W.-H. Lee. 1996. The nuclear localization sequences of the BRCA1 protein interact with the importin-a subunit of the nulcear transport signal receptor. J. Biol. Chem. 271: 32863-32868.
    • (1996) J. Biol. Chem. , vol.271 , pp. 32863-32868
    • Chen, C.-F.1    Li, S.2    Chen, Y.3    Chen, P.-L.4    Sharp, Z.D.5    Lee, W.-H.6
  • 17
    • 0029987651 scopus 로고    scopus 로고
    • BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner
    • Chen, Y., A.A. Farmer, C.-F. Chen, D.C. Jones, P.-L. Chen, and W.-H. Lee. 1996. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res. 56: 3168-3172.
    • (1996) Cancer Res. , vol.56 , pp. 3168-3172
    • Chen, Y.1    Farmer, A.A.2    Chen, C.-F.3    Jones, D.C.4    Chen, P.-L.5    Lee, W.-H.6
  • 18
    • 0026092912 scopus 로고
    • Genetic analysis of breast cancer in the cancer and steroid hormone study
    • Claus, E.B., N. Risch, and W.D. Thompson. 1991. Genetic analysis of breast cancer in the cancer and steroid hormone study. Am. J. Hum. Genet. 48: 232-242.
    • (1991) Am. J. Hum. Genet. , vol.48 , pp. 232-242
    • Claus, E.B.1    Risch, N.2    Thompson, W.D.3
  • 21
    • 0028916152 scopus 로고
    • Death before birth: Clues from gene knockouts and mutations
    • Copp, A.J. 1995. Death before birth: Clues from gene knockouts and mutations. Trends Genet. 11: 87-93.
    • (1995) Trends Genet. , vol.11 , pp. 87-93
    • Copp, A.J.1
  • 23
    • 0030012657 scopus 로고    scopus 로고
    • Human/mouse homology relationships
    • DeBry, R.W. and M.F. Seldin. 1996. Human/mouse homology relationships. Genomics 33: 337-351.
    • (1996) Genomics , vol.33 , pp. 337-351
    • DeBry, R.W.1    Seldin, M.F.2
  • 24
    • 0015292802 scopus 로고
    • Embryological effects of a minute deficiency in linkage group II of the mouse
    • Dunn, G.R. 1972. Embryological effects of a minute deficiency in linkage group II of the mouse. J. Embryol. Exp. Morphol. 27: 147-154.
    • (1972) J. Embryol. Exp. Morphol. , vol.27 , pp. 147-154
    • Dunn, G.R.1
  • 25
    • 0027818174 scopus 로고
    • Inherited susceptibility to breast cancer
    • Easton, D.F., D. Ford, and J. Peto. 1993. Inherited susceptibility to breast cancer. Cancer Surv. 18: 95-113.
    • (1993) Cancer Surv. , vol.18 , pp. 95-113
    • Easton, D.F.1    Ford, D.2    Peto, J.3
  • 26
    • 0028843102 scopus 로고
    • Breast and ovarian cancer incidence in BRCA1-mutation carriers
    • Easton, D.F., D. Ford, D.T. Bishop, and the Breast Cancer Linkage Consortium. 1995. Breast and ovarian cancer incidence in BRCA1-mutation carriers. Am. J. Hum. Genet. 56: 265-271.
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 265-271
    • Easton, D.F.1    Ford, D.2    Bishop, D.T.3
  • 28
    • 0029922993 scopus 로고    scopus 로고
    • BRCA1, a gene involved in inherited predisposition to breast and ovarian cancer
    • Feunteun, J. and G.M. Lenoir. 1996. BRCA1, a gene involved in inherited predisposition to breast and ovarian cancer. Biochim. Biophys. Acta 1242: 177-180.
    • (1996) Biochim. Biophys. Acta , vol.1242 , pp. 177-180
    • Feunteun, J.1    Lenoir, G.M.2
  • 30
    • 0027239790 scopus 로고
    • The RING finger, a novel protein sequence motif related to the zinc finger
    • Freemont, P.S. 1993. The RING finger, a novel protein sequence motif related to the zinc finger. Ann. N.Y. Acad. Sci. 684: 174-192.
    • (1993) Ann. N.Y. Acad. Sci. , vol.684 , pp. 174-192
    • Freemont, P.S.1
  • 32
    • 0029925957 scopus 로고    scopus 로고
    • Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys
    • Godley, L.A., J.B. Kopp, M. Eckhaus, J.J. Paglino, J. Owens, and H.E. Varmus. 1996. Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys. Genes & Dev. 10: 836-850.
    • (1996) Genes & Dev. , vol.10 , pp. 836-850
    • Godley, L.A.1    Kopp, J.B.2    Eckhaus, M.3    Paglino, J.J.4    Owens, J.5    Varmus, H.E.6
  • 34
    • 0029980043 scopus 로고    scopus 로고
    • p53 in growth control and neoplasia
    • Gottlieb, T.M. and M. Oren. 1996. p53 in growth control and neoplasia. Biochim. Biophys. Acta 1287: 77-102.
    • (1996) Biochim. Biophys. Acta , vol.1287 , pp. 77-102
    • Gottlieb, T.M.1    Oren, M.2
  • 35
    • 0030051903 scopus 로고    scopus 로고
    • Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
    • Gowen, L.C., B.L. Johnson, A.M. Latour, K.K. Sulik, and B.H. Koller. 1996. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet. 12: 191-194.
    • (1996) Nature Genet. , vol.12 , pp. 191-194
    • Gowen, L.C.1    Johnson, B.L.2    Latour, A.M.3    Sulik, K.K.4    Koller, B.H.5
  • 38
    • 0031051042 scopus 로고    scopus 로고
    • p53; from inductive signal to cellular effect
    • Hansen, R. and M. Oren. 1997. p53; from inductive signal to cellular effect. Curr. Opin. Genet. Dev. 7: 46-51.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 46-51
    • Hansen, R.1    Oren, M.2
  • 39
    • 0023944129 scopus 로고
    • Effects of fixation time and enzymatic digestion on immunohistochemical demonstration of bromodeoxyundine in formalin-fixed, paraffin-embedded tissues
    • Hayashi, Y., M. Koike, M. Matsutani, and T. Hoshino. 1988. Effects of fixation time and enzymatic digestion on immunohistochemical demonstration of bromodeoxyundine in formalin-fixed, paraffin-embedded tissues. J. Histochem. Cytochem. 36: 511-514.
    • (1988) J. Histochem. Cytochem. , vol.36 , pp. 511-514
    • Hayashi, Y.1    Koike, M.2    Matsutani, M.3    Hoshino, T.4
  • 40
    • 0025950213 scopus 로고
    • Wis mutant embryos
    • Wis mutant embryos. Development 113: 913-917.
    • (1991) Development , vol.113 , pp. 913-917
    • Herrmann, B.G.1
  • 47
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones, S.N., A.E. Roe, L.A. Donehower, and A. Bradley. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 49
    • 0026440993 scopus 로고
    • The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily
    • Kingsley, D.M., A.E. Bland, J.M. Grubber, P.C. Marker, L.B. Russell, N.G. Copeland, and N.A. Jenkins. 1992. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily. Cell 71: 399-410.
    • (1992) Cell , vol.71 , pp. 399-410
    • Kingsley, D.M.1    Bland, A.E.2    Grubber, J.M.3    Marker, P.C.4    Russell, L.B.5    Copeland, N.G.6    Jenkins, N.A.7
  • 50
    • 0030187780 scopus 로고    scopus 로고
    • [BRCA1 protein products], functional motifs
    • Koonin, E.V., S.F. Altschul, and P. Bork. 1996. [BRCA1 protein products], functional motifs. Nature Genet. 13: 266-268.
    • (1996) Nature Genet. , vol.13 , pp. 266-268
    • Koonin, E.V.1    Altschul, S.F.2    Bork, P.3
  • 53
    • 0028828673 scopus 로고
    • Expression of Brca 1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice
    • Lane, T.F., C. Deng, A. Elson, M.S. Lyu, C.A. Kozak, and P. Leder. 1995. Expression of Brca 1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes & Dev. 9: 2712-2722.
    • (1995) Genes & Dev. , vol.9 , pp. 2712-2722
    • Lane, T.F.1    Deng, C.2    Elson, A.3    Lyu, M.S.4    Kozak, C.A.5    Leder, P.6
  • 54
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A.J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 55
    • 0029909565 scopus 로고    scopus 로고
    • A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
    • Lim, D.-S. and P. Hasty. 1996. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53, Mol. Cell. Biol. 16: 7133-7143.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 7133-7143
    • Lim, D.-S.1    Hasty, P.2
  • 56
    • 0029784528 scopus 로고    scopus 로고
    • Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
    • Liu, C.-Y., A. Flesken-Nikitin, S. Li, Y. Zeng, and W.-H. Lee. 1996. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes & Dev. 10: 1835-1843.
    • (1996) Genes & Dev. , vol.10 , pp. 1835-1843
    • Liu, C.-Y.1    Flesken-Nikitin, A.2    Li, S.3    Zeng, Y.4    Lee, W.-H.5
  • 61
    • 6244256053 scopus 로고
    • Bmpr encodes a type 1 bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
    • Mishina, Y., A. Suzuki, N. Ueno, and R.R. Behringer. 1995. Bmpr encodes a type 1 bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes & Dev. 9: 3027-3037.
    • (1995) Genes & Dev. , vol.9 , pp. 3027-3037
    • Mishina, Y.1    Suzuki, A.2    Ueno, N.3    Behringer, R.R.4
  • 62
    • 0030474170 scopus 로고    scopus 로고
    • Evidence for a transcriptional activation function of BRCA1 C-terminal region
    • Monteiro, A.N.A., A. August, and H. Hanafusa. 1996. Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. 93: 13595-13599.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 13595-13599
    • Monteiro, A.N.A.1    August, A.2    Hanafusa, H.3
  • 63
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna, R., D.S. Wagner, and G. Lozano. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203-206.
    • (1995) Nature , vol.378 , pp. 203-206
    • Montes De Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 64
    • 0027960790 scopus 로고
    • Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds
    • Neuhausen, S.L. and C.J. Marshall. 1994. Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds. Cancer Res. 54: 6069-6072.
    • (1994) Cancer Res. , vol.54 , pp. 6069-6072
    • Neuhausen, S.L.1    Marshall, C.J.2
  • 66
    • 0028855714 scopus 로고
    • Proximal 6q, a region showing allele loss in primary breast cancer
    • Orphanos, V., G. McGown, J.M. Boyle, and M. Santibanez-Koref. 1995. Proximal 6q, a region showing allele loss in primary breast cancer. Br. J. Cancer 71: 290-293.
    • (1995) Br. J. Cancer , vol.71 , pp. 290-293
    • Orphanos, V.1    McGown, G.2    Boyle, J.M.3    Santibanez-Koref, M.4
  • 68
    • 0029822055 scopus 로고    scopus 로고
    • Brca2 is coordinately regulated with Brcal during proliferation and differentiation in mammary epithelial cells
    • Rajan, J.V., M. Wang, S.T. Marquis, and L.A. Ghodosh. 1996. Brca2 is coordinately regulated with Brcal during proliferation and differentiation in mammary epithelial cells. Proc. Natl Acad. Sci. 93: 13078-13083.
    • (1996) Proc. Natl Acad. Sci. , vol.93 , pp. 13078-13083
    • Rajan, J.V.1    Wang, M.2    Marquis, S.T.3    Ghodosh, L.A.4
  • 70
    • 0030059385 scopus 로고    scopus 로고
    • Antisense RNA to a putative tumor suppressor gene BRCA1 transforms mouse fibroblasts
    • Rao, V.N., N. Shao, M. Ahmad, and E.S.P. Reddy. 1996. Antisense RNA to a putative tumor suppressor gene BRCA1 transforms mouse fibroblasts. Oncogene 12: 523-528.
    • (1996) Oncogene , vol.12 , pp. 523-528
    • Rao, V.N.1    Shao, N.2    Ahmad, M.3    Reddy, E.S.P.4
  • 71
    • 0014990408 scopus 로고
    • Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations
    • Russell, L.B. 1971. Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat. Res. 11: 107-123.
    • (1971) Mutat. Res. , vol.11 , pp. 107-123
    • Russell, L.B.1
  • 74
    • 0025291459 scopus 로고
    • Oct-4, a germline-specific transcription factor mapping to the mouse t-complex
    • Schöler, H.R., G.R. Dressler, R. Balling, H. Rohdewohld, and P. Gruss. 1990. Oct-4, a germline-specific transcription factor mapping to the mouse t-complex. EMBO J. 9: 2185-2195.
    • (1990) EMBO J. , vol.9 , pp. 2185-2195
    • Schöler, H.R.1    Dressler, G.R.2    Balling, R.3    Rohdewohld, H.4    Gruss, P.5
  • 78
    • 0031105010 scopus 로고    scopus 로고
    • Murine Brca2: Sequence, map position, and expression pattern
    • Sharan, S.K. and A. Bradley. 1997. Murine Brca2: Sequence, map position, and expression pattern. Genomics 40: 234-241.
    • (1997) Genomics , vol.40 , pp. 234-241
    • Sharan, S.K.1    Bradley, A.2
  • 79
    • 0028880054 scopus 로고
    • Murine Brca1, sequence and significance for human missense mutations
    • Sharan, S.K., M. Wims, and A. Bradley. 1995. Murine Brca1, sequence and significance for human missense mutations. Hum. Mol Genet. 12: 2275-2278.
    • (1995) Hum. Mol Genet. , vol.12 , pp. 2275-2278
    • Sharan, S.K.1    Wims, M.2    Bradley, A.3
  • 80
    • 0026935108 scopus 로고
    • Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome
    • Smith, S.A., D.F. Easton, D.G. Evans, and B.A. Ponder. 1992. Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome. Nature Genet. 2: 128-131.
    • (1992) Nature Genet. , vol.2 , pp. 128-131
    • Smith, S.A.1    Easton, D.F.2    Evans, D.G.3    Ponder, B.A.4
  • 82
    • 0017739051 scopus 로고
    • Gastrulation in the mouse: Growth and regionalization of the epiblast
    • Snow, M.H.L. 1977. Gastrulation in the mouse: Growth and regionalization of the epiblast. J. Embryol. Exp. Morphol. 42: 293-303.
    • (1977) J. Embryol. Exp. Morphol. , vol.42 , pp. 293-303
    • Snow, M.H.L.1
  • 83
    • 0029997175 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to es trogen
    • Spillman, M.A. and A.M. Bowcock. 1996. BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to es trogen. Oncogene 13: 1639-1645.
    • (1996) Oncogene , vol.13 , pp. 1639-1645
    • Spillman, M.A.1    Bowcock, A.M.2
  • 84
    • 0030026142 scopus 로고    scopus 로고
    • Hereditary predisposition to breast cancer
    • Stratton, M.R. and R. Wooster. 1996. Hereditary predisposition to breast cancer. Curr. Opin. Genet. Dev. 6: 93-97.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 93-97
    • Stratton, M.R.1    Wooster, R.2
  • 85
    • 0029969418 scopus 로고    scopus 로고
    • p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction
    • Stürzbecher, H.-W., B. Donzelmann, W. Henning, U. Knippschild, and S. Buchhop. 1996. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J. 15: 1992-2002.
    • (1996) EMBO J. , vol.15 , pp. 1992-2002
    • Stürzbecher, H.-W.1    Donzelmann, B.2    Henning, W.3    Knippschild, U.4    Buchhop, S.5
  • 86
    • 0029125296 scopus 로고
    • Inherited breast and ovarian cancer
    • Szabo, C.I. and M.-C. King. 1995. Inherited breast and ovarian cancer. Hum. Mol. Genet. 4: 1811-1817.
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 1811-1817
    • Szabo, C.I.1    King, M.-C.2
  • 90
    • 0028950999 scopus 로고
    • Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
    • Thompson, M.E., R.A. Jensen, P.S. Obermiller, D.L. Page, and J.T. Holt. 1995. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nature Genet. 9: 444-450.
    • (1995) Nature Genet. , vol.9 , pp. 444-450
    • Thompson, M.E.1    Jensen, R.A.2    Obermiller, P.S.3    Page, D.L.4    Holt, J.T.5
  • 94
    • 0001244671 scopus 로고
    • Whole-mount in situ hybridization of vertebrate embryos
    • (ed. D.G. Wilkinson), IRL Press, Oxford, UK
    • Wilkinson, D.G. 1992. Whole-mount in situ hybridization of vertebrate embryos. In In situ hybridization: A practical approach (ed. D.G. Wilkinson), pp. 75-83. IRL Press, Oxford, UK.
    • (1992) In Situ Hybridization: A Practical Approach , pp. 75-83
    • Wilkinson, D.G.1
  • 95
    • 0025054992 scopus 로고
    • Expression pattern of the mouse T gene and its role in mesoderm formation
    • Wilkinson, D.G., S. Bhatt, and B.G. Herrmann. 1990. Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343: 657-659.
    • (1990) Nature , vol.343 , pp. 657-659
    • Wilkinson, D.G.1    Bhatt, S.2    Herrmann, B.G.3
  • 100
    • 0030007144 scopus 로고    scopus 로고
    • Mutations of the BRCA1 gene in human cancer
    • Xu, C.-f. and E. Solomon. 1996. Mutations of the BRCA1 gene in human cancer. Cancer Biol. 7: 33-40.
    • (1996) Cancer Biol. , vol.7 , pp. 33-40
    • Xu, C.-F.1    Solomon, E.2
  • 102
    • 84993912315 scopus 로고
    • Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homolog
    • Zeitlin, S., J.-P. Liu, D.L. Chapman, V.E. Papaioannou, and A. Efstratiadis. 1995. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homolog. Nature Genet. 11: 155-163.
    • (1995) Nature Genet. , vol.11 , pp. 155-163
    • Zeitlin, S.1    Liu, J.-P.2    Chapman, D.L.3    Papaioannou, V.E.4    Efstratiadis, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.