Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 3, 2012, Pages 1023-1030

  Xiong, Hairong ^a,b   Lee, Robert J ^c   Haura, Eric B ^d   Edwards, John G ^e   Dynan, William S ^a   Li, Shuyi ^a,e  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b WUHAN UNIVERSITY   (China)

^c OHIO STATE UNIVERSITY   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^e Apeliotus Technologies Inc   (United States)

Author keywords

DNA repair; DNA dependent protein kinase; Folate mediated delivery; Nonhomologous end joining; Radiosensitization; scFv

Indexed keywords

DNA REPAIR; DNA-DEPENDENT PROTEIN KINASE; FOLATE-MEDIATED DELIVERY; NONHOMOLOGOUS END JOINING; RADIO-SENSITIZATION; SCFV;

ANTIBODIES; CELLS; CYTOLOGY; ENZYMES; IONIZING RADIATION; JOINING; MOLECULAR BIOLOGY; REPAIR; TUMORS;

DNA;

DISULFIDE; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; FOLATE RECEPTOR; FOLIC ACID; RADIOSENSITIZING AGENT; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY 18 2; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL FREE SYSTEM; CELL NUCLEUS; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; DISULFIDE BOND; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; DRUG TARGETING; ENDOCYTOSIS; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG CANCER; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIZATION; TUMOR CELL;

CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; DNA END-JOINING REPAIR; DNA-ACTIVATED PROTEIN KINASE; DRUG COMBINATIONS; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; FOLIC ACID; HUMANS; LINEAR MODELS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; SINGLE-CHAIN ANTIBODIES; TUMOR STEM CELL ASSAY;

EID: 84861626653     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.08.039     Document Type: Article

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