메뉴 건너뛰기




Volumn 23, Issue 1, 2010, Pages 239-245

Involvement of p21Waf1/Cip1 cleavage during roscovitine-induced apoptosis in non-small cell lung cancer cells

Author keywords

Apoptosis; Caspase 3; Non small cell lung cancer; p21Waf1 Cip1 cleavage; Roscovitine

Indexed keywords

CASPASE 3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLINE; GAMMA HISTONE H2AX; HISTONE H2AX; ROSCOVITINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ENZYME INHIBITOR; H2AFX PROTEIN, HUMAN; HISTONE; PURINE DERIVATIVE;

EID: 76049088795     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000629     Document Type: Article
Times cited : (17)

References (23)
  • 1
    • 33645802169 scopus 로고    scopus 로고
    • Cyclin-dependent kinase pathways as targets for cancer treatment
    • Shapiro GI: Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 24: 1770-1783, 2006.
    • (2006) J Clin Oncol , vol.24 , pp. 1770-1783
    • Shapiro, G.I.1
  • 2
    • 0036450831 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol
    • Thomas JP, Tutsch KD, Cleary JF, et al: Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol. Cancer Chemother Pharmacol 50: 465-472, 2002.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 465-472
    • Thomas, J.P.1    Tutsch, K.D.2    Cleary, J.F.3
  • 3
    • 0036789539 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms
    • Tan AR, Headlee D, Messmann R, et al: Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms. J Clin Oncol 20: 4074-4082, 2002.
    • (2002) J Clin Oncol , vol.20 , pp. 4074-4082
    • Tan, A.R.1    Headlee, D.2    Messmann, R.3
  • 4
    • 33846254185 scopus 로고    scopus 로고
    • A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days
    • Benson C, White J, De Bono J, et al: A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days. Br J Cancer 96: 29-37, 2007.
    • (2007) Br J Cancer , vol.96 , pp. 29-37
    • Benson, C.1    White, J.2    De Bono, J.3
  • 5
    • 0031037714 scopus 로고    scopus 로고
    • Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
    • Meijer L, Borgne A, Mulner O, et al: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 243: 527-536, 1997.
    • (1997) Eur J Biochem , vol.243 , pp. 527-536
    • Meijer, L.1    Borgne, A.2    Mulner, O.3
  • 6
    • 27144512221 scopus 로고    scopus 로고
    • Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo
    • Tirado OM, Mateo-Lozano S and Notario V: Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo. Cancer Res 54: 9320-9327, 2005.
    • (2005) Cancer Res , vol.54 , pp. 9320-9327
    • Tirado, O.M.1    Mateo-Lozano, S.2    Notario, V.3
  • 7
    • 24744434754 scopus 로고    scopus 로고
    • Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells
    • Mohapatra S, Chu B, Zhao XH and Pledger WJ: Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells. Cancer Res 65: 7717-7723, 2005.
    • (2005) Cancer Res , vol.65 , pp. 7717-7723
    • Mohapatra, S.1    Chu, B.2    Zhao, X.H.3    Pledger, W.J.4
  • 8
    • 0041622837 scopus 로고    scopus 로고
    • Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine-induced apoptosis of human MCF-7 breast cancer cells
    • Wojciechowski J, Horky M, Gueorguieva M and Wesierska-Gadek J: Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine-induced apoptosis of human MCF-7 breast cancer cells. Int J Cancer 106: 486-495, 2002.
    • (2002) Int J Cancer , vol.106 , pp. 486-495
    • Wojciechowski, J.1    Horky, M.2    Gueorguieva, M.3    Wesierska-Gadek, J.4
  • 9
    • 0347626096 scopus 로고    scopus 로고
    • Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2
    • Mohapatra S, Chu B, Wei S, et al: Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res 63: 8523-8530, 2003.
    • (2003) Cancer Res , vol.63 , pp. 8523-8530
    • Mohapatra, S.1    Chu, B.2    Wei, S.3
  • 11
    • 0036653127 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells
    • Mihara M, Shintani S, Kiyota A, Matsumura T and Wong DT: Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells. Int J Oncol 21: 95-101, 2002.
    • (2002) Int J Oncol , vol.21 , pp. 95-101
    • Mihara, M.1    Shintani, S.2    Kiyota, A.3    Matsumura, T.4    Wong, D.T.5
  • 12
    • 52249092188 scopus 로고    scopus 로고
    • Enhancement of radio-sensitivity by roscovitine pretreatment in human non-small cell lung cancer A549 cells
    • Zhang F, Zhang T, Gu ZP, et al: Enhancement of radio-sensitivity by roscovitine pretreatment in human non-small cell lung cancer A549 cells. J Radiat Res 49: 541-548, 2008.
    • (2008) J Radiat Res , vol.49 , pp. 541-548
    • Zhang, F.1    Zhang, T.2    Gu, Z.P.3
  • 13
    • 0034973788 scopus 로고    scopus 로고
    • Activation of p53 by roscovitine-mediated suppression of MDM2 expression
    • Lu W, Chen L, Peng Y and Chen J: Activation of p53 by roscovitine-mediated suppression of MDM2 expression. Oncogene 20: 3206-3216, 2001.
    • (2001) Oncogene , vol.20 , pp. 3206-3216
    • Lu, W.1    Chen, L.2    Peng, Y.3    Chen, J.4
  • 14
    • 2442678063 scopus 로고    scopus 로고
    • Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosisreluctant cells to tumor necrosis factor
    • Demidenko ZN and Blagosklonny MV: Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosisreluctant cells to tumor necrosis factor. Cancer Res 64: 3653-3660, 2004.
    • (2004) Cancer Res , vol.64 , pp. 3653-3660
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 15
    • 0035959745 scopus 로고    scopus 로고
    • Protection against chemotherapy-induced cytotoxicity by cyclin-dependent kinase inhibitors (CKI) in CKI-responsive cells compared with CKI-unresponsive cells
    • Schmidt M and Fan Z: Protection against chemotherapy-induced cytotoxicity by cyclin-dependent kinase inhibitors (CKI) in CKI-responsive cells compared with CKI-unresponsive cells. Oncogene 20: 6164-6171, 2001.
    • (2001) Oncogene , vol.20 , pp. 6164-6171
    • Schmidt, M.1    Fan, Z.2
  • 16
    • 0036594890 scopus 로고    scopus 로고
    • The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
    • Gartel AL and Tyner AL: The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 1: 639-649, 2002.
    • (2002) Mol Cancer Ther , vol.1 , pp. 639-649
    • Gartel, A.L.1    Tyner, A.L.2
  • 17
    • 0033963601 scopus 로고    scopus 로고
    • waf1/cip1 and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate
    • waf1/cip1 and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate. Carcinogenesis 21: 7-14, 2000.
    • (2000) Carcinogenesis , vol.21 , pp. 7-14
    • Chai, F.1    Evdokiou, A.2    Young, G.P.3    Zalewski, P.D.4
  • 18
    • 0032563286 scopus 로고    scopus 로고
    • Cleavage of CDK inhibitor p21Cip1/Waf1 by caspases is an early event during DNA damage-induced apoptosis
    • Gervais JL, Seth P and Zhang H: Cleavage of CDK inhibitor p21Cip1/Waf1 by caspases is an early event during DNA damage-induced apoptosis. J Biol Chem 273: 19207-19212, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 19207-19212
    • Gervais, J.L.1    Seth, P.2    Zhang, H.3
  • 19
    • 33750468718 scopus 로고    scopus 로고
    • waf1/cip1 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: Evidence for a regulatory loop between p53 and caspase 2
    • waf1/cip1 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis 27: 2269-2280, 2006.
    • (2006) Carcinogenesis , vol.27 , pp. 2269-2280
    • Tyagi, A.1    Singh, R.P.2    Agarwal, C.3    Agarwal, R.4
  • 20
    • 68149170764 scopus 로고    scopus 로고
    • Sensitization to γ-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells
    • Zhang F, Zhang T, Teng ZH, Zhang R, Wang JB and Mei QB: Sensitization to γ-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. Cancer Biol Ther 8: 823-831, 2009.
    • (2009) Cancer Biol Ther , vol.8 , pp. 823-831
    • Zhang, F.1    Zhang, T.2    Teng, Z.H.3    Zhang, R.4    Wang, J.B.5    Mei, Q.B.6
  • 21
    • 0034607117 scopus 로고    scopus 로고
    • p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4
    • Xu SQ and El-Deiry WS: p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4. Biochem Biophys Res Commun 269: 179-190, 2000.
    • (2000) Biochem Biophys Res Commun , vol.269 , pp. 179-190
    • Xu, S.Q.1    El-Deiry, W.S.2
  • 22
    • 12844262761 scopus 로고    scopus 로고
    • A novel apoptosis pathway activated by the carboxyl terminus of p21
    • Dong C, Li Q, Lyu SC, Krensky AM and Clayberger C: A novel apoptosis pathway activated by the carboxyl terminus of p21. Blood 105: 1187-1194, 2005.
    • (2005) Blood , vol.105 , pp. 1187-1194
    • Dong, C.1    Li, Q.2    Lyu, S.C.3    Krensky, A.M.4    Clayberger, C.5
  • 23
    • 0029102829 scopus 로고
    • Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21
    • Pan ZQ, Reardon JT, Li L, et al: Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21. J Biol Chem 270: 22008-22016, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 22008-22016
    • Pan, Z.Q.1    Reardon, J.T.2    Li, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.