Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation

Anti-Cancer Drugs

Volumn 18, Issue 7, 2007, Pages 793-800

  Cuneo, Kyle C ^a   Fu, Allie ^b   Osusky, Katherine ^b   Huamani, Jessica ^b   Hallahan, Dennis E ^a,b,c   Geng, Ling ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Histone deacetylase; Histone deacetylase inhibitor; LAQ824; Nonsmall cell lung cancer; Radiosensitizer

Indexed keywords

4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; DNA; HISTONE DEACETYLASE INHIBITOR; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RADIOSENSITIZATION; TREATMENT OUTCOME; TUMOR GROWTH; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; COLONY-FORMING UNITS ASSAY; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; FLOW CYTOMETRY; HISTONE DEACETYLASES; HISTONES; HUMANS; HYDROXAMIC ACIDS; LUNG NEOPLASMS; MICE; MITOSIS; RADIATION, IONIZING; RADIATION-SENSITIZING AGENTS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 34250805910     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e3280b10d57     Document Type: Article

References (40)

1. Richon VM, Emiliani S, Verdin E, Webb Y, Breslow R, Rifkind RA, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A 1998; 95:3003-3007.
2. Kouzarides T. Histone acetylases and deacetylases in cell proliferation. Curr Opinion Genet Dev 1999; 9:40-48.
3. Marks PA, Richon VM, Rifkind RA. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst 2000; 92:1210-1216.
4. Sambucett LC, Fischer DD, Zabludoff S, Kwon PO, Chamberlin H, Trogani N, et al. Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects. J Biol Chem 1999; 274:34940-34947.
5. 2-M transition. Biochem Biophys Res Commun 2003; 17:267-273.
6. Atadja P, Gao L, Kwon P, Trogani N,Walker H, Hsu M, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res 2004; 64:689-695.
7. Jung M. Inhibitors of histone deacetylase as new anticancer agents. Curr Med Chem 2001; 8:1505-1511.
8. Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 2001; 1:194-202.
9. Johnstone RW. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discovery 2002; 1:287-299.
10. Remiszewski SW, Sambucetti L, Bair KW, Bontempo J, Cesarz D, Chandramouli N, et al. N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity. J Med Chem 2003; 46:4609-4624.
11. Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, et al. Involvement of TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 2000; 102:463-473.
12. Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP, et al. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 1998; 391:601-605.
13. Weichselbaum RR, Hallahan DE, Sukhatme V, Dritschilo A, Sherman M, Kufe D. Biological consequences of gene regulation by ionizing radiation. J Natl Cancer Inst 1991; 83:480-484.
14. Palayoor ST, Macklis RM, Bump EA, Coleman CN. Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells. Radiat Res 1995; 141:235-243.
15. Nimmanapalli R, Fuino L, Baili P, Gasparetto M, Glozak M, Tao J, et al. Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. Cancer Res 2003; 63:5126-5135.
16. Camphausen K, Burgan W, Cerra M, Oswald KA, Trepel JB, Lee MJ, et al. Enhanced radiation-induced cell killing and prolongation of γH2AX foci expression by the histone deacetylase inhibitor MS-275. Cancer Res 2004; 64:316-321.
17. Zhang Y, Jung M, Dritschilo A, Jung M. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat Res 2004; 161:667-674.
18. Chinnaiyan P, Vallabhaneni G, Armstrong E, Huang SM, Harari PM. Modulation of radiation response by histone deacetylase inhibition. Int J Radiat Oncol Biol Phys 2005; 62:223-229.
19. Henderson C, Brancolini C. Apoptotic pathways activated by histone deacety lase inhibitors: implications of the drug-resistant phenotype. Drug Resist Uptates 2003; 6:247-256.
20. Jung M, Velena A, Chen B, Petukhov PA, Kozikowski AP, Dritschilo A. Novel HDAC inhibitors with radiosensitizing properties. Radiat Res 2005; 163:488-493.
21. Mountain CF. Revisions in the International System for Staging Lung Cancer. Chest 1997; 111:1710-1717.
22. Choy H, Chakravarthy A, Kim JS. Radiation therapy for non-small cell lung cancer. Cancer Treat Res 2001; 105:121-148.
23. 1-phase cells. Radiat Res 2003; 159:759-767.
24. Geng L, walter S, Melian E, Vaughan AT. Transfection of a vector expressing wild-type p53 into cells of two human glioma cell lines enhances radiation toxicity. Radiat Res 1998; 150:31-37.
25. Hallahan D, Mauceri H, Seung L, Dunphy E, Wayne JD, Hanna NN, et al. Spatial and temporal control of gene therapy by ionizing radiation. Nat Med 1995; 1:786-791.
26. Hanson W, Zhen W, Geng L, Hunter N, Milas L. The prostaglandin E analog, Misoprostal, a normal tissue protector, dose not protect four murine tumors in vivo from radiation injury. Radiat Res 1995; 142:281-287.
27. Bernhard D, Ausserlechner MJ, Tonko M, Loffler M, Hartmann BL, Csordas A, et al. Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts. FASEB J 1999; 13:1991-2001.
28. 2/M checkpoint Rad proteins. J Biol Chem 2000; 275:27909-27916.
29. Cao XX, Mohuiddin L, Ece F, McConkey DJ, Smythe WR. Histone Deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma. Am J Respir cell Mol Biol 2001; 25:562-568.
30. Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG, et al. The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol 2002; 36:233-240.
31. Medina V, Edmonds B, Young GP, James R, Appleton S, Zalewski PD. Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. Cancer Res 1997; 57:3697-3707.
32. Amin HM, Saeed S, Alkan S. Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17). Br J Haematol 2001; 115:287-297.
33. Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, et al. Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. J Biol Chem 2002; 277:2073-2080.
34. Cantoni O, Sestili P, Guidarelli A, Palomba L, Cattabeni F. Cytotoxic impact of DNA single vs. double strands breaks in oxidatively injured cells. Arch Toxicol Suppl 1996; 18:223-235.
35. Lips J, Kaina B. DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts. Carcinogenesis 2001; 22:579-585.
36. Blaise R, Alapetite C, Masdehors P, Merle-Beral H, Roulin C, Delic J, et al. High levels of chromosome aberrations correlate with impaired in vitro radiation-induced apoptosis and DNA repair in human B-chronic lymphocytic leukaemia cells. Int J Radiat Biol 2002; 78:671-679.
37. Munshi A, Tanaka T, Hobbs ML, Tucker SL, Richon VM, Meyn RE. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther 2006; 5:1967-1974.
38. Geng L, Cuneo KC, Fu A, Tu T, Atadja PW, Hallahan DE. Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer. Cancer Res 2006; 66:11298-11304.
39. Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. J Cell Biol 2003; 160:1017-1027.
40. Zhang Y, Adachi M, Zou H, Hareyama M, Imai K, Shinomura Y. Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation. Int J Radiat Biol 2006; 65:859-866.