Histone H2A variants H2AX and H2AZ

Current Opinion in Genetics and Development

Volumn 12, Issue 2, 2002, Pages 162-169

  Redon, Christophe ^a   Pilch, Duane ^a   Rogakou, Emmy ^b   Sedelnikova, Olga ^a   Newrock, Kenneth ^a   Bonner, William ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA; DOUBLE STRANDED DNA; HISTONE H2A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN P53;

CARBOXY TERMINAL SEQUENCE; DNA STRAND BREAKAGE; ENVIRONMENTAL FACTOR; GENE CONTROL; GENETIC STABILITY; METABOLIC DISORDER; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; TRANSCRIPTION REGULATION; X CHROMATIN;

EID: 0036531895     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00282-4     Document Type: Review

References (45)

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2. Non-allelic variants of histones 2a, 2b and 3 in mammals
3. Stage-specific switches in histone synthesis during embryogenesis of the sea urchin
4. Histone 2A, a heteromorphous family of eight protein species
5. MacroH2A, a core histone containing a large nonhistone region
6. MACROH2A2, a new member of the MARCOH2A core histone family
7. Histone H2A variants and the inactive X chromosome: Identification of a second macroH2A variant
8. A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome
9. H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3′ processing signals
10. Histone H2A.Z has a conserved function that is distinct from that of the major H2A sequence variants
11. Essential and nonessential histone H2A variants in Tetrahymena thermophila
12. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
13. Megabase chromatin domains involved in DNA double-strand breaks in vivo
14. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
15. ATM phosphorylates histone H2AX in response to DNA double-strand breaks
16. Nuclear retention of Atm at sites of DNA double strand breaks
17. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
18. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
19. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
20. A role for Saccharomyces cerevisiae histone H2A in DNA repair
21. Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX
22. Recombinational DNA double-strand breaks in mice precede synapsis
23. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
24. Two complexes that contain histones are required for nucleosome assembly in vitro: Role of nucleoplasmin and N1 in Xenopus egg extracts
25. DNA-dependent phosphorylation of histone H2A.X during nucleosome assembly in Xenopus laevis oocytes: Involvement of protein phosphorylation in nucleosome spacing
26. Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication
27. Minor histone 2A variants and ubiquinated forms in the native H2A:H2B dimer
28. H2A.F: An extremely variant histone H2A sequence expressed in the chicken embryo
29. Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species
30. Either of the major H2A genes but not an evolutionarily conserved H2A.F/Z variant of Tetrahymena thermophila can function as the sole H2A gene in the yeast Saccharomyces cerevisiae
31. Histone H2A.Z regulates transcription and is partially redundant with nucleosome remodeling complexes
32. Analysis of a histone H2A variant from fission yeast: Evidence for a role in chromosome stability
33. Regions of variant histone His2AvD required for Drosophila development
34. A histone variant, H2AvD, is essential in Drosophila melanogaster
35. Histone variant H2A.Z is required for early mammalian development
36. Temporal and spatial association of histone H2A variant hv1 with transcriptionally competent chromatin during nuclear development in Tetrahymena thermophila
37. Histone H2A.Z acetylation modulates an essential charge patch
38. Histone H2A.Z is widely but nonrandomly distributed in chromosomes of Drosophila melanogaster
39. Crystal structure of a nucleosome core particle containing the variant histone H2A.Z
40. Characterization of the stability and folding of H2A.Z chromatin particles. Implications for transcriptional activation
41. A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR
42. H2A.Z is required for global chromatin integrity and for recruitment of RNA polymerase II under specific conditions
43. Site- and time specific gene targeting in the mouse
44. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
45. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization