Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes non-small cell lung cancer cells

Clinical Cancer Research

Volumn 15, Issue 16, 2009, Pages 5117-5125

  Iwasa, Tsutomu ^a   Okamoto, Isamu ^a   Suzuki, Minoru ^b   Hatashita, Erina ^a   Yamada, Yuki ^a   Fukuoka, Masahiro ^a   Ono, Koji ^b   Nakagawa, Kazuhiko ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CP 751871; HISTONE H2AX; RAD51 PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; CELL DEATH; CELL SURVIVAL; CLONOGENESIS; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; DOWN REGULATION; DRUG POTENTIATION; FEMALE; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RADIATION INJURY; RADIOSENSITIVITY; TUMOR GROWTH; TUMOR REGRESSION; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RADIATION-SENSITIZING AGENTS; RECEPTOR, IGF TYPE 1; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 69349103706     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-09-0478     Document Type: Article

References (44)

1. Sell C, Rubini M, Rubin R, Liu JP, Efstratiadis A, Baserga R. Simian virus 40 large tumor antigen is unableto transformmouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci U S A 1993;90:11217-11221 (Pubitemid 23354400)
2. O'Connor R, Kauffmann-Zeh A, Liu Y, et al. Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Mol Cell Biol 1997;17:427-435 (Pubitemid 26425632)
3. Pietrzkowski Z, Mulholland G, Gomella L, Jameson BA, Wernicke D, Baserga R. Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1. Cancer Res 1993;53:1102-1106 (Pubitemid 23087914)
4. D'Ambrosio C, Ferber A, Resnicoff M, Baserga R. A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis. Cancer Res 1996;56: 4013-4020 (Pubitemid 26284753)
5. Muller M, Dietel M, Turzynski A, Wiechen K. Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor I receptor in ovarian cancer cells. Int J Cancer 1998;77:567-571 (Pubitemid 28340905)
6. Scotlandi K, Avnet S, Benini S, et al. Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells. Int J Cancer 2002;101:11-16 (Pubitemid 34832991)
7. Garcia-Echeverria C, Pearson MA, Marti A, et al. In vivo antitumor activity of NVP-AEW541-a novel, potent, and selective inhibitor of the IGFIR kinase. Cancer Cell 2004;5:231-239
8. Maloney EK, McLaughlin JL, Dagdigian NE, et al. An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res 2003;63:5073-5083
9. Burtrum D, Zhu Z, Lu D, et al. A fully human monoclonal antibody to theinsu lin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res 2003;63:8912-8921 (Pubitemid 38064071)
10. Cohen BD, Baker DA, Soderstrom C, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res 2005;11: 2063-2073
11. Wang Y, Hailey J, Williams D, et al. Inhibition of insulin-likeg rowth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody. Mol Cancer Ther 2005;4:1214-1221 (Pubitemid 41149569)
12. Sachdev D, Yee D. Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol Cancer Ther 2007;6:1-12. (Pubitemid 46206663)
13. Garber K. IGF-1: old growth factor shines as new drug target. J Natl Cancer Inst 2005;97: 790-792 (Pubitemid 40909117)
14. Turner BC, Haffty BG, Narayanan L, et al. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res 1997;57:3079-3083 (Pubitemid 27351714)
15. Rocha RL, Hilsenbeck SG, Jackson JG, et al. Insulin-likegro wth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease free survival. Clin Cancer Res 1997;3:103-109
16. Kuhn C, Hurwitz SA, Kumar MG, Cotton J, Spandau DF. Activation of theinsulin -like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation. Int J Cancer 1999;80:431-438 (Pubitemid 29019632)
17. Wen B, Deutsch E, Marangoni E, et al. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. Br J Cancer 2001; 85:2017-2021 (Pubitemid 34775342)
18. Cosaceanu D, Carapancea M, Castro J, et al. Modulationof response to radiationof human lung cancer cells following insulin-like growth factor 1 receptor inactivation. Cancer Lett2005;222:173-181
19. Sak A, Stueben G, Groneberg M, Bocker W, Stuschke M. Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines. Br J Cancer 2005;92:1089-1097 (Pubitemid 40546674)
20. Albert JM, Cao C, Kim KW, et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res 2007;13:3033-3042 (Pubitemid 46849580)
21. United Kingdom Co-ordinating Committee on Cancer Research. Guidelines for the welfare of animals in experimental neoplasia (2nd ed.). Br J Cancer 1998;77:1-10.
22. Chou TC, Talalay P. Quantitative analysi s of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
23. Tezuka M, Watanabe H, Nakamura S, et al. Antiapoptotic activity is dispensable for insulin-like growth factor I receptor-mediated clonogenic radioresistance after γ-irradiation. Clin Cancer Res 2001;7:3206-3214 (Pubitemid 32963845)
24. Gao Y, Ferguson DO, Xie W, et al. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature2000;404:897- 900.
25. Yang S, Chintapalli J, Sodagum L, et al. Activated IGF-1R inhibits hyperglycemia-induced DNA damage and promotes DNA repair by homologous recombination. Am J Physiol Renal Physiol 2005;289:F1144-52. (Pubitemid 41447071)
26. Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 2001;276:42462-42467 (Pubitemid 37371158)
27. Chen G, Yuan SS, Liu W, et al. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Chem 1999;274:12748-12752 (Pubitemid 129518046)
28. Gooch JL, Van Den Berg CL, Yee D. Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death-proliferative and anti-apoptotic effects. Breast Cancer Res Treat 1999;56:1-10. (Pubitemid 29435810)
29. Cosaceanu D, Budiu RA, Carapancea M, Castro J, Lewensohn R, Dricu A. Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism. Oncogene 2007;26:2423-2434 (Pubitemid 46597267)
30. Bowers G, Reardon D, Hewitt T, et al. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. Oncogene 2001;20:1388-1397 (Pubitemid 32269943)
31. Griffin RJ, Williams BW, Wild R, Cherrington JM, Park H, Song CW. Simultaneous inhibition of there ceptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response. Cancer Res 2002;62:1702-1706 (Pubitemid 34408492)
32. Schmidt-Ullrich RK, Dent P, Grant S, Mikkelsen RB, Valerie K. Signal transduction and cellular radiation responses. Radiat Res 2000;153: 245-257 (Pubitemid 30224838)
33. Leach JK, Van Tuyle G, Lin PS, Schmidt-Ullrich R, Mikkelsen RB. Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Res 2001;61: 3894-3901 (Pubitemid 32720947)
34. Leach JK, Black SM, Schmidt-Ullrich RK, Mikkelsen RB. Activation of constitutive nitricoxide synthase activity is an early signaling event induced by ionizing radiation. J Biol Chem 2002;277:15400-15406
35. Shvartsman SY, Hagan MP, Yacoub A, Dent P, Wiley HS, Lauffenburger DA. Autocrine loops with positive feedback enable context-dependent cell signaling.Am J Physiol Cell Physiol 2002;282: C545-59.
36. Dent P, Han SI, Mitchell C, et al. Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes. Biochem Pharmacol 2005;70:1685-1696 (Pubitemid 41540361)
37. Dent P, Yacoub A, Contessa J, et al. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiat Res 2003;159: 283-300. (Pubitemid 36314943)
38. Benini S, Manara MC, Baldini N, et al. Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells. Clin Cancer Res 2001;7:1790-1797 (Pubitemid 32708650)
39. Akagi Y, Ito K, Sawada S. Radiationinduced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification. Int J Radiat Biol 1993;64: 47-56. (Pubitemid 23248328)
40. Lawrence TS, Davis MA, Hough A, Rehemtulla A. The role of apoptosis in 2′,2′-difluoro-2′-deoxycytidine (gemcitabine)-mediated radiosensitization. Clin Cancer Res 2001;7:314-319 (Pubitemid 32183035)
41. Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 2004;59:928-942 (Pubitemid 38834285)
42. Heron-Milhavet L, LeRoith D. Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage. J Biol Chem 2002;277: 15600-15606 (Pubitemid 34967830)
43. Trojanek J, Ho T, Del Valle L, et al. Role of the insulin-like growth factor I/insulin receptor substrate1 axis in Rad51 trafficking and DNA repair by homologous recombination. Mol Cell Biol 2003;23:7510-7524 (Pubitemid 37271452)
44. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998;273:5858-5868