Replication-dependent γ-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells

Oncology Reports

Volumn 24, Issue 5, 2010, Pages 1297-1305

  Zhang, Feng ^a   Zhang, Tao ^b   Qu, Yang ^a   Jiang, Tao ^b   Cao, Yun Xin ^a   Li, Chen ^a   Fan, Lei ^a   Mei, Qi Bing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

H2AX; Apoptosis; Docetaxel; Non small cell lung cancer; Replication

Indexed keywords

ALPHA TUBULIN; APHIDICOLIN; CASPASE 3; DOCETAXEL; GAMMA H2AX PROTEIN; HISTONE H2AX; KU ANTIGEN; LIPOCORTIN 5; MATRIX METALLOPROTEINASE; PROTEIN P21; RAD50 PROTEIN; UNCLASSIFIED DRUG; WORTMANNIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE M PHASE; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DOSE RESPONSE; DRUG ACETYLATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CELL DIVISION; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA REPLICATION; HISTONES; HUMANS; LUNG NEOPLASMS; TAXOIDS;

EID: 78149333462     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000986     Document Type: Article

References (32)

1. Hadfield JA, Ducki S, Hirst N and McGown AT: Tubulin and microtubules as targets for anticancer drugs. Prog Cell Cycle Res 5: 309-325, 2003.
2. Jordan MA and Wilson L: Microtubules as a target for anticancer drugs. Nat Rev Cancer 4: 253-265, 2004.
3. Halder J, Landen CN Jr, Lutgendorf SK, et al: Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells. Clin Cancer Res 11: 8829-8836, 2005. (Pubitemid 43005935)
4. Honma K, Iwao-Koizumi K, Takeshita F, et al: RPN2 gene confers docetaxel resistance in breast cancer. Nat Med 14: 939-948, 2008.
5. Mhaidat NM, Zhang XD, Jiang CC and Hersey P: Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway. Clin Cancer Res 13: 1308-1314, 2007. (Pubitemid 46424072)
6. Cullen M and Thatcher N: Gefitinib or docetaxel in advanced non-small-cell lung cancer. Lancet 372: 1785-1786, 2008.
7. Cunha KS, Reguly ML, Graf U and de Andrade HH: Taxanes: the genetic toxicity of paclitaxel and docetaxel in somatic cells of Drosophila melanogaster. Mutagenesis 16: 79-84, 2001.
8. Kolfschoten GM, Hulscher TM, Duyndam MC, Pinedo HM and Boven E: Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel. Biochem Pharmacol 63: 733-743, 2002.
9. Furuta T, Takemura H, Liao ZY, et al: Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem 278: 20303-20312, 2003.
10. Léonce S, Kraus-Berthier L, Golsteyn RM, et al: Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1. Cancer Res 66: 7203-7210, 2006. (Pubitemid 44197699)
11. Bosco EE, Mayhew CN, Hennigan RF, Sage J, Jacks T and Knudsen ES: RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult. Nucleic Acids Res 32: 25-34, 2004. (Pubitemid 38228601)
12. Ochs K and Kaina B: Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent. Cancer Res 60: 5815-5824, 2000.
13. Kaina B: DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling. Biochem Pharmacol 66: 1547-1554, 2003.
14. Lips J and Kaina B: DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts. Carcinogenesis 22: 579-585, 2001. (Pubitemid 32288658)
15. Zhang F, Zhang T, Teng ZH, Zhang R, Wang JB and Mei QB: Sensitization to γ-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. Cancer Biol Ther 8: 823-831, 2009.
16. Westermann S and Weber K: Post-translational modifications regulate microtubule function. Nat Rev Mol Cell Biol 4: 938-947, 2003. (Pubitemid 37493642)
17. Taniguchi T, Takahashi M, Shinohara F, Sato T, Echigo S and Rikiishi H: Involvement of NF-kappaB and mitochondrial pathways in docetaxel-induced apoptosis of human oral squamous cell carcinoma. Int J Mol Med 15: 667-673, 2005.
18. Collis SJ, DeWeese TL, Jeggo PA and Parker AR: The life and death of DNA-PK. Oncogene 24: 949-961, 2005.
19. Maser RS, Monsen KJ, Nelms BE and Petrini JH: hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol 17: 6087-6096, 1997.
20. Abuzeid WM, Jiang X, Shi G et al: Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy. J Clin Invest 119: 1974-1985, 2009.
21. Radhakrishnan A, Bitran JD, Milton DT, Tolzien K, Hallmeyer S and Nabhan C: Docetaxel and oxaliplatin as first-line therapy for advanced non-small cell lung cancer: a phase II trial. J Chemother 21: 439-444, 2009.
22. Belani CP: Optimizing chemotherapy for advanced non-small cell lung cancer: focus on docetaxel. Lung Cancer 50 (Suppl 2): S3-S8, 2005.
23. Hammond EM, Green SL and Giaccia AJ: Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutat Res 532: 205-213, 2003.
24. Sargent JM, Elgie AW, Williamson CJ and Taylor CG: Aphidicolin markedly increases the platinum sensitivity of cells from primary ovarian tumours. Br J Cancer 74: 1730-1733, 1996.
25. Sargent JM, Elgie AW, Williamson CJ, Lewandowicz GM and Taylor CG: Circumvention of ara-C resistance by aphidicolin in blast cells from patients with AML. Br J Cancer 84: 680-685, 2001.
26. Zhang F, Zhang T, Jiang T, et al: Wortmannin potentiates roscovitine-induced growth inhibition in human solid tumor cells by repressing PI3K/Akt pathway. Cancer Lett 286: 232-239, 2009.
27. Furuta T, Hayward RL, Meng LH, et al: p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. Oncogene 25: 2839-2849, 2006.
28. Zhang T, Jiang T, Zhang F, et al: Involvement of p21Waf1/Cip1 cleavage during roscovitine-induced apoptosis in non-small cell lung cancer cells. Oncol Rep 23: 239-245, 2010.
29. Mirzayans R, Pollock S, Scott A, Enns L, Andrais B and Murray D: Relationship between the radiosensitizing effect of wortmannin, DNA double-strand break rejoining, and p21WAF1 induction in human normal and tumor-derived cells. Mol Carcinog 39: 164-172, 2004.
30. Ortiz T, Burguillos MA, López-Lluch G, et al: Enhanced induction of apoptosis in a radio-resistant bladder tumor cell line by combined treatments with X-rays and wortmannin. Radiat Environ Biophys 47: 445-452, 2008.
31. Yoshida M, Shiojima I, Ikeda H and Komuro I: Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity. J Mol Cell Cardiol 47: 664-675, 2009.
32. Lu CR, Zhu F, Cho YY, et al: Cell apoptosis: requirement of H2AX in DNA ladder formation but not for the activation of caspase-3. Mol Cell 23: 121-132, 2006. (Pubitemid 43963445)