Induction of DNA double-strand breaks in A549 and normal human pulmonary epithelial cells by cigarette smoke is mediated by free radicals

International Journal of Oncology

Volumn 28, Issue 6, 2006, Pages 1491-1505

  Albino, Anthony P ^a   Xuan, Huang ^b   Jorgensen, Ellen D ^a   Diana, Gietl ^a   Frank, Traganos ^b   Zbigniew, Darzynkiewicz ^b  

^a Vector Research Ltd   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Cigarette smoke; Double strand breaks; H2AX; Oxidative stress

Indexed keywords

1,3-DIMETHYLTHIOUREA; DIMETHYLTHIOUREA; DRUG DERIVATIVE; FREE RADICAL; H2AFX PROTEIN, HUMAN; HISTONE; PHOSPHOPROTEIN; SCAVENGER; THIOUREA;

ARTICLE; DNA DAMAGE; DRUG EFFECT; HUMAN; LUNG; LUNG TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; SMOKE; SMOKING; TUMOR CELL LINE;

CELL LINE, TUMOR; DNA DAMAGE; FREE RADICAL SCAVENGERS; FREE RADICALS; HISTONES; HUMANS; LUNG; LUNG NEOPLASMS; PHOSPHOPROTEINS; RESPIRATORY MUCOSA; SMOKE; SMOKING; THIOUREA;

EID: 33745819903     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.28.6.1491     Document Type: Article

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