-
1
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
8843194
-
Xu Y Ashley T Brainerd EE Bronson RT Meyn MS Baltimore D Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma Genes Dev 1996 10 19 2411-2422 8843194
-
(1996)
Genes Dev
, vol.10
, Issue.19
, pp. 2411-2422
-
-
Xu, Y.1
Ashley, T.2
Brainerd, E.E.3
Bronson, R.T.4
Meyn, M.S.5
Baltimore, D.6
-
2
-
-
0032524070
-
Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
-
10.1126/science.280.5366.1089 9582124
-
Herzog KH Chong MJ Kapsetaki M Morgan JI McKinnon PJ Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system Science 1998 280 5366 1089-1091 10.1126/ science.280.5366.1089 9582124
-
(1998)
Science
, vol.280
, Issue.5366
, pp. 1089-1091
-
-
Herzog, K.H.1
Chong, M.J.2
Kapsetaki, M.3
Morgan, J.I.4
McKinnon, P.J.5
-
3
-
-
0029848286
-
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
-
24050 8917548 10.1073/pnas.93.23.13084
-
Elson A Wang Y Daugherty CJ Morton CC Zhou F Campos-Torres J Leder P Pleiotropic defects in ataxia-telangiectasia protein-deficient mice Proc Natl Acad Sci U S A 1996 93 23 13084-13089 24050 8917548 10.1073/ pnas.93.23.13084
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.23
, pp. 13084-13089
-
-
Elson, A.1
Wang, Y.2
Daugherty, C.J.3
Morton, C.C.4
Zhou, F.5
Campos-Torres, J.6
Leder, P.7
-
4
-
-
0034798285
-
ATM: Genome stability, neuronal development, and cancer cross paths
-
11665719
-
Shiloh Y Kastan MB ATM: Genome stability, neuronal development, and cancer cross paths Adv Cancer Res 2001 83 209-254 11665719
-
(2001)
Adv Cancer Res
, vol.83
, pp. 209-254
-
-
Shiloh, Y.1
Kastan, M.B.2
-
5
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
10.1101/gad.914401 11544175
-
Abraham RT Cell cycle checkpoint signaling through the ATM and ATR kinases Genes Dev 2001 15 17 2177-2196 10.1101/gad.914401 11544175
-
(2001)
Genes Dev
, vol.15
, Issue.17
, pp. 2177-2196
-
-
Abraham, R.T.1
-
6
-
-
0035313706
-
DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
-
10.1016/S0955-0674(00)00201-5 11248557
-
Durocher D Jackson SP DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol 2001 13 2 225-231 10.1016/ S0955-0674(00)00201-5 11248557
-
(2001)
Curr Opin Cell Biol
, vol.13
, Issue.2
, pp. 225-231
-
-
Durocher, D.1
Jackson, S.P.2
-
7
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
10.1038/nature01368 12556884
-
Bakkenist CJ Kastan MB DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 2003 421 6922 499-506 10.1038/nature01368 12556884
-
(2003)
Nature
, vol.421
, Issue.6922
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
8
-
-
0033198919
-
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
-
1220459 10455009 10.1042/0264-6021:3420249
-
D'Amours D Desnoyers S D'Silva I Poirier GG Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions Biochem J 1999 342 (Pt 2) 249-268 1220459 10455009 10.1042/0264-6021:3420249
-
(1999)
Biochem J
, vol.342
, Issue.PART 2
, pp. 249-268
-
-
D'Amours, D.1
Desnoyers, S.2
D'Silva, I.3
Poirier, G.G.4
-
9
-
-
0040984333
-
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
-
23816 9207086 10.1073/pnas.94.14.7303
-
de Murcia JM Niedergang C Trucco C Ricoul M Dutrillaux B Mark M Oliver FJ Masson M Dierich A LeMeur M Walztinger C Chambon P de Murcia G Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells Proc Natl Acad Sci U S A 1997 94 14 7303-7307 23816 9207086 10.1073/pnas.94.14.7303
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, Issue.14
, pp. 7303-7307
-
-
de Murcia, J.M.1
Niedergang, C.2
Trucco, C.3
Ricoul, M.4
Dutrillaux, B.5
Mark, M.6
Oliver, F.J.7
Masson, M.8
Dierich, A.9
LeMeur, M.10
Walztinger, C.11
Chambon, P.12
de Murcia, G.13
-
10
-
-
0000102949
-
Poly(ADP-ribose) polymerase: A molecular nick-sensor
-
10.1016/0968-0004(94)90280-1 8016868
-
de Murcia G Menissier de Murcia J Poly(ADP-ribose) polymerase: A molecular nick-sensor Trends Biochem Sci 1994 19 4 172-176 10.1016/ 0968-0004(94)90280-1 8016868
-
(1994)
Trends Biochem Sci
, vol.19
, Issue.4
, pp. 172-176
-
-
de Murcia, G.1
Menissier de Murcia, J.2
-
11
-
-
0037098407
-
The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells
-
10.1016/S0003-9861(02)00078-4 12051667
-
Marecki JC McCord JM The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells Arch Biochem Biophys 2002 402 2 227-234 10.1016/S0003-9861(02)00078-4 12051667
-
(2002)
Arch Biochem Biophys
, vol.402
, Issue.2
, pp. 227-234
-
-
Marecki, J.C.1
McCord, J.M.2
-
12
-
-
0035131124
-
Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development
-
86747 11238919 10.1128/MCB.21.5.1828-1832.2001
-
Menisser-de Murcia J Mark M Wendling O Wynshaw-Boris A de Murcia G Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development Mol Cell Biol 2001 21 5 1828-1832 86747 11238919 10.1128/MCB.21.5.1828-1832.2001
-
(2001)
Mol Cell Biol
, vol.21
, Issue.5
, pp. 1828-1832
-
-
Menisser-de Murcia, J.1
Mark, M.2
Wendling, O.3
Wynshaw-Boris, A.4
de Murcia, G.5
-
13
-
-
2642513874
-
Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response
-
10.1016/j.bbrc.2004.05.031 15178448
-
Watanabe F Fukazawa H Masutani M Suzuki H Teraoka H Mizutani S Uehara Y Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response Biochem Biophys Res Commun 2004 319 2 596-602 10.1016/ j.bbrc.2004.05.031 15178448
-
(2004)
Biochem Biophys Res Commun
, vol.319
, Issue.2
, pp. 596-602
-
-
Watanabe, F.1
Fukazawa, H.2
Masutani, M.3
Suzuki, H.4
Teraoka, H.5
Mizutani, S.6
Uehara, Y.7
-
14
-
-
85047697499
-
PARP-1 modifies the effectiveness of p53-mediated DNA damage response
-
10.1038/sj.onc.1205169 11850828
-
Valenzuela MT Guerrero R Nunez MI Ruiz De Almodovar JM Sarker M de Murcia G Oliver FJ PARP-1 modifies the effectiveness of p53-mediated DNA damage response Oncogene 2002 21 7 1108-1116 10.1038/sj.onc.1205169 11850828
-
(2002)
Oncogene
, vol.21
, Issue.7
, pp. 1108-1116
-
-
Valenzuela, M.T.1
Guerrero, R.2
Nunez, M.I.3
Ruiz De Almodovar, J.M.4
Sarker, M.5
de Murcia, G.6
Oliver, F.J.7
-
15
-
-
33645532464
-
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
-
1410911 16556909 10.1093/nar/gkl108
-
Bryant HE Helleday T Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair Nucleic Acids Res 2006 34 6 1685-1691 1410911 16556909 10.1093/ nar/gkl108
-
(2006)
Nucleic Acids Res
, vol.34
, Issue.6
, pp. 1685-1691
-
-
Bryant, H.E.1
Helleday, T.2
-
16
-
-
0038449141
-
PARP-1, a determinant of cell survival in response to DNA damage
-
10.1016/S0301-472X(03)00083-3 12829019
-
Bouchard VJ Rouleau M Poirier GG PARP-1, a determinant of cell survival in response to DNA damage Exp Hematol 2003 31 6 446-454 10.1016/ S0301-472X(03)00083-3 12829019
-
(2003)
Exp Hematol
, vol.31
, Issue.6
, pp. 446-454
-
-
Bouchard, V.J.1
Rouleau, M.2
Poirier, G.G.3
-
17
-
-
33645469913
-
Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis
-
10.1158/1535-7163.MCT-05-0418 16546970
-
Noel G Godon C Fernet M Giocanti N Megnin-Chanet F Favaudon V Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis Mol Cancer Ther 2006 5 3 564-574 10.1158/1535-7163.MCT-05-0418 16546970
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.3
, pp. 564-574
-
-
Noel, G.1
Godon, C.2
Fernet, M.3
Giocanti, N.4
Megnin-Chanet, F.5
Favaudon, V.6
-
18
-
-
34247574227
-
ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity
-
In press
-
Horton J. K. SDF Kedar P. S. and Wilson S. H. ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity DNA Repair 2007 In press
-
(2007)
DNA Repair
-
-
Horton, J.K.S.D.F.1
Kedar, P.S.2
Wilson, S.H.3
-
19
-
-
0024362055
-
Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage
-
10.1007/BF01211256 2508186
-
Little JB Ueno AM Dahlberg WK Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage Radiat Environ Biophys 1989 28 3 193-202 10.1007/BF01211256 2508186
-
(1989)
Radiat Environ Biophys
, vol.28
, Issue.3
, pp. 193-202
-
-
Little, J.B.1
Ueno, A.M.2
Dahlberg, W.K.3
-
20
-
-
0032928476
-
4-Amino-1,8-naphthalimide: A novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer
-
10.1080/095530099140843 9972795
-
Schlicker A Peschke P Burkle A Hahn EW Kim JH 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer Int J Radiat Biol 1999 75 1 91-100 10.1080/095530099140843 9972795
-
(1999)
Int J Radiat Biol
, vol.75
, Issue.1
, pp. 91-100
-
-
Schlicker, A.1
Peschke, P.2
Burkle, A.3
Hahn, E.W.4
Kim, J.H.5
-
21
-
-
12444276597
-
Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies
-
12855651
-
Calabrese CR Batey MA Thomas HD Durkacz BW Wang LZ Kyle S Skalitzky D Li J Zhang C Boritzki T Maegley K Calvert AH Hostomsky Z Newell DR Curtin NJ Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies Clin Cancer Res 2003 9 7 2711-2718 12855651
-
(2003)
Clin Cancer Res
, vol.9
, Issue.7
, pp. 2711-2718
-
-
Calabrese, C.R.1
Batey, M.A.2
Thomas, H.D.3
Durkacz, B.W.4
Wang, L.Z.5
Kyle, S.6
Skalitzky, D.7
Li, J.8
Zhang, C.9
Boritzki, T.10
Maegley, K.11
Calvert, A.H.12
Hostomsky, Z.13
Newell, D.R.14
Curtin, N.J.15
-
22
-
-
25444471892
-
Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
-
16123586
-
Helleday T Bryant HE Schultz N Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy Cell Cycle 2005 4 9 1176-1178 16123586
-
(2005)
Cell Cycle
, vol.4
, Issue.9
, pp. 1176-1178
-
-
Helleday, T.1
Bryant, H.E.2
Schultz, N.3
-
23
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
10.1038/nature03443 15829966
-
Bryant HE Schultz N Thomas HD Parker KM Flower D Lopez E Kyle S Meuth M Curtin NJ Helleday T Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 2005 434 7035 913-917 10.1038/nature03443 15829966
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
Kyle, S.7
Meuth, M.8
Curtin, N.J.9
Helleday, T.10
-
24
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
10.1038/nature03445 15829967
-
Farmer H McCabe N Lord CJ Tutt AN Johnson DA Richardson TB Santarosa M Dillon KJ Hickson I Knights C Martin NM Jackson SP Smith GC Ashworth A Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 2005 434 7035 917-921 10.1038/nature03445 15829967
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.4
Johnson, D.A.5
Richardson, T.B.6
Santarosa, M.7
Dillon, K.J.8
Hickson, I.9
Knights, C.10
Martin, N.M.11
Jackson, S.P.12
Smith, G.C.13
Ashworth, A.14
-
25
-
-
0031985615
-
Radiosensitive melanoma cell line with mutation of the gene for ataxia telangiectasia
-
9459139
-
Ramsay J Birrell G Baumann K Bodero A Parsons P Lavin M Radiosensitive melanoma cell line with mutation of the gene for ataxia telangiectasia Br J Cancer 1998 77 1 11-14 9459139
-
(1998)
Br J Cancer
, vol.77
, Issue.1
, pp. 11-14
-
-
Ramsay, J.1
Birrell, G.2
Baumann, K.3
Bodero, A.4
Parsons, P.5
Lavin, M.6
-
26
-
-
0033199892
-
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
-
10485486
-
Sarkaria JN Busby EC Tibbetts RS Roos P Taya Y Karnitz LM Abraham RT Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine Cancer Res 1999 59 17 4375-4382 10485486
-
(1999)
Cancer Res
, vol.59
, Issue.17
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Busby, E.C.2
Tibbetts, R.S.3
Roos, P.4
Taya, Y.5
Karnitz, L.M.6
Abraham, R.T.7
|