-
1
-
-
44349119351
-
Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study
-
Tsantoulis P.K., Kotsinas A., Sfikakis P.P., Evangelou K., Sideridou M., Levy B., Mo L., Kittas C., Wu X.R., Papavassiliou A.G., and Gorgoulis V.G. Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study. Oncogene 27 (2008) 3256-3264
-
(2008)
Oncogene
, vol.27
, pp. 3256-3264
-
-
Tsantoulis, P.K.1
Kotsinas, A.2
Sfikakis, P.P.3
Evangelou, K.4
Sideridou, M.5
Levy, B.6
Mo, L.7
Kittas, C.8
Wu, X.R.9
Papavassiliou, A.G.10
Gorgoulis, V.G.11
-
2
-
-
27644582835
-
Expression of common chromosomal fragile site genes WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens UV and BPDE but not by IR
-
Thavathiru E., Ludes-Meyers J.H., MacLeod M.C., and Aldaz C.M. Expression of common chromosomal fragile site genes WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens UV and BPDE but not by IR. Mol. Carcinogen. 44 (2005) 174-182
-
(2005)
Mol. Carcinogen.
, vol.44
, pp. 174-182
-
-
Thavathiru, E.1
Ludes-Meyers, J.H.2
MacLeod, M.C.3
Aldaz, C.M.4
-
3
-
-
1842581808
-
The fragile genes, FHIT and WWOX, are inactivated coordinately in invasive breast carcinoma
-
Guler G., Uner A., Guler N., Han S.Y., Iliopoulos D., Hauck W.W., McCue P., and Huebner K. The fragile genes, FHIT and WWOX, are inactivated coordinately in invasive breast carcinoma. Cancer 100 (2004) 1605-1614
-
(2004)
Cancer
, vol.100
, pp. 1605-1614
-
-
Guler, G.1
Uner, A.2
Guler, N.3
Han, S.Y.4
Iliopoulos, D.5
Hauck, W.W.6
McCue, P.7
Huebner, K.8
-
4
-
-
0032533493
-
Loss of FHIT function in lung cancer and preinvasive bronchial lesions
-
Sozzi G., Pastorino U., Moiraghi L., Tagliabue E., Pezzella F., Ghirelli C., Tornielli S., Sard L., Huebner K., Pierotti M.A., Croce C.M., and Pilotti S. Loss of FHIT function in lung cancer and preinvasive bronchial lesions. Cancer Res. 58 (1998) 5032-5037
-
(1998)
Cancer Res.
, vol.58
, pp. 5032-5037
-
-
Sozzi, G.1
Pastorino, U.2
Moiraghi, L.3
Tagliabue, E.4
Pezzella, F.5
Ghirelli, C.6
Tornielli, S.7
Sard, L.8
Huebner, K.9
Pierotti, M.A.10
Croce, C.M.11
Pilotti, S.12
-
5
-
-
0033214597
-
Loss of Fhit is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers
-
Tseng J.E., Kemp B.L., Khuri F.R., Kurie J.M., Lee J.S., Zhou X., Liu D., Hong W.K., and Mao L. Loss of Fhit is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers. Cancer Res. 59 (1999) 4798-4803
-
(1999)
Cancer Res.
, vol.59
, pp. 4798-4803
-
-
Tseng, J.E.1
Kemp, B.L.2
Khuri, F.R.3
Kurie, J.M.4
Lee, J.S.5
Zhou, X.6
Liu, D.7
Hong, W.K.8
Mao, L.9
-
6
-
-
19244370711
-
High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints
-
Wistuba I.I., Behrens C., Virmani A.K., Mele G., Milchgrub S., Girard L., Fondon III J.W., Garner H.R., McKay B., Latif F., Lerman M.I., Lam S., Gazdar A.F., and Minna J.D. High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints. Cancer Res. 60 (2000) 1949-1960
-
(2000)
Cancer Res.
, vol.60
, pp. 1949-1960
-
-
Wistuba, I.I.1
Behrens, C.2
Virmani, A.K.3
Mele, G.4
Milchgrub, S.5
Girard, L.6
Fondon III, J.W.7
Garner, H.R.8
McKay, B.9
Latif, F.10
Lerman, M.I.11
Lam, S.12
Gazdar, A.F.13
Minna, J.D.14
-
7
-
-
18444397159
-
Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis
-
Kitamura A., Yashima K., Okamoto E., Andachi H., Hosoda A., Kishimoto Y., Shiota G., Ito H., Kaibara N., and Kawasaki H. Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis. Oncology 61 (2001) 205-211
-
(2001)
Oncology
, vol.61
, pp. 205-211
-
-
Kitamura, A.1
Yashima, K.2
Okamoto, E.3
Andachi, H.4
Hosoda, A.5
Kishimoto, Y.6
Shiota, G.7
Ito, H.8
Kaibara, N.9
Kawasaki, H.10
-
8
-
-
28044457713
-
Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients
-
Zhao P., Liu W., and Lu Y.L. Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients. World J. Gastroenterol. 11 (2005) 5735-5738
-
(2005)
World J. Gastroenterol.
, vol.11
, pp. 5735-5738
-
-
Zhao, P.1
Liu, W.2
Lu, Y.L.3
-
9
-
-
0036354547
-
Loss of Fhit expression as a potential marker of malignant progression in preinvasive squamous cervical cancer
-
Butler D., Collins C., Mabruk M., Leader M.B., and Kay E.W. Loss of Fhit expression as a potential marker of malignant progression in preinvasive squamous cervical cancer. Gynecol. Oncol. 86 (2002) 144-149
-
(2002)
Gynecol. Oncol.
, vol.86
, pp. 144-149
-
-
Butler, D.1
Collins, C.2
Mabruk, M.3
Leader, M.B.4
Kay, E.W.5
-
10
-
-
0033818623
-
Loss of fhit expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease
-
Connolly D.C., Greenspan D.L., Wu R., Ren X., Dunn R.L., Shah K.V., Jones R.W., Bosch F.X., Muñoz N., and Cho K.R. Loss of fhit expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease. Clin. Cancer Res. 6 (2000) 3505-3510
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3505-3510
-
-
Connolly, D.C.1
Greenspan, D.L.2
Wu, R.3
Ren, X.4
Dunn, R.L.5
Shah, K.V.6
Jones, R.W.7
Bosch, F.X.8
Muñoz, N.9
Cho, K.R.10
-
11
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis V.G., Vassiliou L.V., Karakaidos P., Zacharatos P., Kotsinas A., Liloglou T., Venere M., Ditullio Jr. R.A., Kastrinakis N.G., Levy B., Kletsas D., Yoneta A., Herlyn M., Kittas C., and Halazonetis T.D. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434 (2005) 907-913
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
Venere, M.7
Ditullio Jr., R.A.8
Kastrinakis, N.G.9
Levy, B.10
Kletsas, D.11
Yoneta, A.12
Herlyn, M.13
Kittas, C.14
Halazonetis, T.D.15
-
12
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J., Horejsi Z., Koed K., Krämer A., Tort F., Zieger K., Guldberg P., Sehested M., Nesland J.M., Lukas C., Ørntoft T., Lukas J., and Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434 (2005) 864-870
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
Krämer, A.4
Tort, F.5
Zieger, K.6
Guldberg, P.7
Sehested, M.8
Nesland, J.M.9
Lukas, C.10
Ørntoft, T.11
Lukas, J.12
Bartek, J.13
-
13
-
-
36949005417
-
DNA damage signaling guards against activated oncogenes and tumour progression
-
Bartek J., Bartkova J., and Lukas J. DNA damage signaling guards against activated oncogenes and tumour progression. Oncogene 26 (2007) 7773-7779
-
(2007)
Oncogene
, vol.26
, pp. 7773-7779
-
-
Bartek, J.1
Bartkova, J.2
Lukas, J.3
-
14
-
-
33845796072
-
Fhit modulates the DNA damage checkpoint response
-
Ishii H., Mimori K., Inoue H., Inageta T., Ishikawa K., Semba S., Druck T., Trapasso F., Tani K., Vecchione A., Croce C.M., Mori M., and Huebner K. Fhit modulates the DNA damage checkpoint response. Cancer Res. 66 (2006) 11287-11292
-
(2006)
Cancer Res.
, vol.66
, pp. 11287-11292
-
-
Ishii, H.1
Mimori, K.2
Inoue, H.3
Inageta, T.4
Ishikawa, K.5
Semba, S.6
Druck, T.7
Trapasso, F.8
Tani, K.9
Vecchione, A.10
Croce, C.M.11
Mori, M.12
Huebner, K.13
-
15
-
-
50249162487
-
Molecular parameters of genome instability: roles of fragile genes at common fragile sites
-
Pichiorri F., Ishii H., Okumura H., Trapasso F., Wang Y., and Huebner K. Molecular parameters of genome instability: roles of fragile genes at common fragile sites. J. Cell. Biochem. 104 (2008) 1525-1533
-
(2008)
J. Cell. Biochem.
, vol.104
, pp. 1525-1533
-
-
Pichiorri, F.1
Ishii, H.2
Okumura, H.3
Trapasso, F.4
Wang, Y.5
Huebner, K.6
-
16
-
-
38949212625
-
Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells
-
Yutori H., Semba S., Kumori T., and Yokozaki H. Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells. Cancer Sci. 99 (2008) 524-530
-
(2008)
Cancer Sci.
, vol.99
, pp. 524-530
-
-
Yutori, H.1
Semba, S.2
Kumori, T.3
Yokozaki, H.4
-
17
-
-
0038146962
-
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
-
Hammond E.M., Dorie M.J., and Giaccia A.J. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J. Biol. Chem. 278 (2003) 12207-12213
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12207-12213
-
-
Hammond, E.M.1
Dorie, M.J.2
Giaccia, A.J.3
-
18
-
-
0032472330
-
Overexpression of a kinaseinactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
-
Cliby W.A., Roberts C.J., Cimprich K.A., Stringer C.M., Lamb J.R., Schreiber S.L., and Friend S.H. Overexpression of a kinaseinactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17 (1998) 159-169
-
(1998)
EMBO J.
, vol.17
, pp. 159-169
-
-
Cliby, W.A.1
Roberts, C.J.2
Cimprich, K.A.3
Stringer, C.M.4
Lamb, J.R.5
Schreiber, S.L.6
Friend, S.H.7
-
19
-
-
0034326802
-
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
-
Ahn J.Y., Schwarz J.K., Piwnica-Worms H., and Canman C.E. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res. 60 (2000) 5934-5936
-
(2000)
Cancer Res.
, vol.60
, pp. 5934-5936
-
-
Ahn, J.Y.1
Schwarz, J.K.2
Piwnica-Worms, H.3
Canman, C.E.4
-
20
-
-
0032484084
-
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
-
Matsuoka S., Huang M., and Elledge S.J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282 (1998) 1893-1897
-
(1998)
Science
, vol.282
, pp. 1893-1897
-
-
Matsuoka, S.1
Huang, M.2
Elledge, S.J.3
-
21
-
-
12544250589
-
Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage
-
Helt C.E., Cliby W.A., Keng P.C., Bambara R.A., and O'Reilly M.A. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. J. Biol. Chem. 280 (2005) 1186-1192
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 1186-1192
-
-
Helt, C.E.1
Cliby, W.A.2
Keng, P.C.3
Bambara, R.A.4
O'Reilly, M.A.5
-
22
-
-
33746495515
-
Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites
-
Durkin S.G., Arlt M.F., Howlett N.G., and Glover T.W. Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene 25 (2006) 4381-4388
-
(2006)
Oncogene
, vol.25
, pp. 4381-4388
-
-
Durkin, S.G.1
Arlt, M.F.2
Howlett, N.G.3
Glover, T.W.4
-
23
-
-
33748623634
-
Common fragile sites as targets for chromosome rearrangements
-
(Review)
-
Arlt M.F., Durkin S.G., Ragland R.L., and Glover T.W. Common fragile sites as targets for chromosome rearrangements. DNA Repair (Amst) 5 (2006) 1126-1135 (Review)
-
(2006)
DNA Repair (Amst)
, vol.5
, pp. 1126-1135
-
-
Arlt, M.F.1
Durkin, S.G.2
Ragland, R.L.3
Glover, T.W.4
-
24
-
-
0034058527
-
Molecular and genetic aspects of lung cancer
-
Rom W.N., Hay J.G., Lee T.C., Jiang Y., and Tchou-Wong K.M. Molecular and genetic aspects of lung cancer. Am. J. Respir. Crit. Care Med. 161 (2000) 1355-1367
-
(2000)
Am. J. Respir. Crit. Care Med.
, vol.161
, pp. 1355-1367
-
-
Rom, W.N.1
Hay, J.G.2
Lee, T.C.3
Jiang, Y.4
Tchou-Wong, K.M.5
-
25
-
-
34848840601
-
Introduction: diagnosis and management of lung cancer: ACCP evidence-based clinical practice guidelines
-
Alberts W.M. Introduction: diagnosis and management of lung cancer: ACCP evidence-based clinical practice guidelines. Chest 132 (2007) 20S-22S
-
(2007)
Chest
, vol.132
-
-
Alberts, W.M.1
-
28
-
-
38349186895
-
Replication stress induces tumor-like microdeletions in FHIT/FRA3B
-
Durkin S.G., Ragland R.L., Arlt M.F., Mulle J.G., Warren S.T., and Glover T.W. Replication stress induces tumor-like microdeletions in FHIT/FRA3B. Proc. Natl. Acad. Sci. USA 105 (2008) 246-251
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 246-251
-
-
Durkin, S.G.1
Ragland, R.L.2
Arlt, M.F.3
Mulle, J.G.4
Warren, S.T.5
Glover, T.W.6
-
29
-
-
0342711220
-
Early stage human colorectal cancer: prognostic value of nm23-H1 protein overexpression
-
Indinnimeo M., Giarnieri E., Stazi A., Cicchini C., Brozzetti S., Valli C., Carreca I., and Vecchione A. Early stage human colorectal cancer: prognostic value of nm23-H1 protein overexpression. Cancer Lett. 111 (1997) 1-5
-
(1997)
Cancer Lett.
, vol.111
, pp. 1-5
-
-
Indinnimeo, M.1
Giarnieri, E.2
Stazi, A.3
Cicchini, C.4
Brozzetti, S.5
Valli, C.6
Carreca, I.7
Vecchione, A.8
-
30
-
-
0002294347
-
A simple sequentially rejective multiple test procedure
-
Holm S. A simple sequentially rejective multiple test procedure. Scand. J. Stat. 6 (1979) 65-70
-
(1979)
Scand. J. Stat.
, vol.6
, pp. 65-70
-
-
Holm, S.1
-
31
-
-
33646106590
-
GammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes
-
Stucki M., and Jackson S.P. GammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst) 5 (2006) 534-543
-
(2006)
DNA Repair (Amst)
, vol.5
, pp. 534-543
-
-
Stucki, M.1
Jackson, S.P.2
-
32
-
-
63349103961
-
Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project
-
Verri C., Roz L., Conte D., Liloglou T., Livio A., Vesin A., Fabbri A., Andriani F., Brambilla C., Tavecchio L., Calarco G., Calabrò E., Mancini A., Tosi D., Bossi P., Field J.K., Brambilla E., Sozzi G., and Consortium E.U.E.L.C. Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project. Am. J. Respir. Crit. Care Med. 179 (2009) 396-401
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.179
, pp. 396-401
-
-
Verri, C.1
Roz, L.2
Conte, D.3
Liloglou, T.4
Livio, A.5
Vesin, A.6
Fabbri, A.7
Andriani, F.8
Brambilla, C.9
Tavecchio, L.10
Calarco, G.11
Calabrò, E.12
Mancini, A.13
Tosi, D.14
Bossi, P.15
Field, J.K.16
Brambilla, E.17
Sozzi, G.18
Consortium, E.U.E.L.C.19
-
33
-
-
51449113045
-
Targeted therapy for cancer using PARP inhibitors
-
(Review)
-
Lord C.J., and Ashworth A. Targeted therapy for cancer using PARP inhibitors. Curr. Opin. Pharmacol. 8 (2008) 363-369 (Review)
-
(2008)
Curr. Opin. Pharmacol.
, vol.8
, pp. 363-369
-
-
Lord, C.J.1
Ashworth, A.2
|