Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites

Oncogene

Volumn 25, Issue 32, 2006, Pages 4381-4388

  Durkin, S G ^a   Arlt, M F ^a   Howlett, N G ^a   Glover, T W ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Checkpoints; CHK1; CHK2; Fragile sites

Indexed keywords

ATR PROTEIN; BRCA1 PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA; FANCONI ANEMIA GROUP D2 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING SITE; CHROMOSOMAL INSTABILITY; CHROMOSOME FRAGILITY; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; DOSE RESPONSE; ENZYME REGULATION; GENE REARRANGEMENT; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; METAPHASE CHROMOSOME; PRIORITY JOURNAL; PROTEIN DEPLETION;

CELLS, CULTURED; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITES; HCT116 CELLS; HELA CELLS; HUMANS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES;

EID: 33746495515     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209466     Document Type: Article

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