Allergens

Chemical Analysis of Food: Techniques and Applications

Volumn , Issue , 2012, Pages 693-714

  Monaci, Linda ^a   Visconti, Angelo ^a  

^a INSTITUTE OF SCIENCES OF FOOD PRODUCTION   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882778418     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-384862-8.00021-2     Document Type: Chapter

References (109)

1. R.C. Aalberse (2000) Structural biology of allergens. Journal of Allergy and Clinical Immunology 106 228-236.
2. M. Abbott, S. Hayward, W. Ross, S.G. Ben-Rejeb, F. Ulberth, A.J. van Hengel, J. Roberts, H. Akiyama, B. Popping, J.M. Yeung, P. Wehling, S.L. Taylor, R.E. Poms and P. Delahaut (2010) Validation procedures for quantitative food allergen ELISA methods: community guidance and best practices. Journal of AOAC International 93 442-450.
3. M. Akagawa, T. Handoyo, T. Ishii, S. Kumazawa, N. Morita and K. Suyama (2007) Proteomic analysis of wheat flour allergens. Journal of Agricultural and Food Chemistry 55 6863-6870.
4. M. Arlorio, E. Cereti, J.D. Coïsson, F. Travaglia and A. Martelli (2007) Detection of hazelnut (Corylus spp.) in processed foods using real-time PCR. Food Control 18 140-148.
5. G. Barbieri and G. Frigeri (2006) Identification of hidden allergens: detection of pistachio traces in mortadella. Food Additives and Contaminants 23 1260-1264.
6. F. Bettazzi, F. Lucarelli, I. Palchetti, F. Berti, G. Marrazza and M. Mascini (2008) Disposable electrochemical DNA-array for PCR amplified detection of hazelnut allergens in foodstuffs. Analytica Chimica Acta 614 93-102.
7. K. Beyer, E. Morrow, X.-M. Li, L. Bardina, G.A. Bannon, A.W. Burks and H.A. Sampson (2001) Effects of coking methods on peanut allergenicity. Journal of Allergy and Clinical Immunology 107 1077-1081.
8. C. Bignardi, L. Elviri, A. Penna and A. Mangia (2010) Particle-packed column versus silica-based monolithic column for liquid chromatography-electrospray-linear ion trap-tandem mass spectrometry multiallergen trace in foods. Journal of Chromatography A 1217 7579-7585.
9. C. Bindslev-Jensen, B.K. Ballmer-Weber, U. Bengtsson, C. Blanco, et al. (2004) Standardization of food challenges in patients with immediate reactions to foods-position paper form the European Academy of Allergology and Clinical immunology. Allergy 59 690-697.
10. B. Bjorksten (2004) Effects of intestinal microflora and the environment on the development of asthma and allergy. Springer Seminars in Immunopathology 25 257-270.
11. A.M. Branum and S.L. Luckas (2008) Food allergy among U.S. children: trends in prevalence and hospitalizations. NCHS Data Brief 10 1-6.
12. H. Breiteneder and E.N.C. Mills (2005) Molecular properties of food allergens. Journal of Allergy and Clinical Immunology 115 14-22.
13. M.G.E.G. Bremer, N.G.E. Smits and W. Haasnoot (2009) Biosensor immunoassay for traces of hazelnut protein in olive oil. Analytical and Bioanalytical Chemistry 395 119-126.
14. B. Brezná and T. Kuchta (2008) A novel real-time polymerase chain reaction method for the detection of pecan nuts in food. European Food Research and Technology 226 1113-1118.
15. B. Brezná, L. Hudecová and T. Kuchta (2006) A novel real-time polymerase chain reaction method for the detection of walnuts in food. European Food Research and Technology 223 373-377.
16. Z. Bugyi, J. Nagy, K. Török, L. Hajas and S. Tömösközi (2010) Towards development of incurred materials for quality assurance purposes in the analysis of food allergens. Analytica Chimica Acta 672 25-29.
17. W. Burks and B.K. Ballmer-Weber (2006) Food allergy. Molecular Nutrition & Food Research 50 595-603.
18. M. Careri, A. Costa, L. Elviri, J.-B. Lagos, A. Mangia, M. Terenghi, A. Cereti and L.P. Garoffo (2007) Use of specific peptide biomarkers for quantitative confirmation of hidden allergenic peanut proteins Arah2 and Arah3/4 for food control by liquid chromatography tandem mass spectrometry. Bioanalytical Chemistry 389 1901-1907.
19. M. Careri, L. Elviri, M. Maffini, A. Mangia, C. Mucchino and M. Terenghi (2008) Determination of peanut allergens in cereal-chocolate-based snacks: metal-tag inductively coupled plasma mass spectrometry immunoassay versus liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 22 807-811.
20. H. Chassaigne, M. Brohèe, J.V. Nørgaard and A.J. van Hengel (2007) Investigation on sequential extraction of peanut allergens for subsequent analysis by ELISA and 2D gel electrophoresis. Food Chemistry 105 1671-1681.
21. H. Chassaigne, J.V. Nørgaard and A.J. van Hengel (2007) Proteomics-based approach to detect and identify major allergens in processed peanuts by capillary LC-Q-TOF (MS/MS). Journal of Agricultural and Food Chemistry 55 4461-4473.
22. C.J. Cheftel (2005) Food nutrition labelling in the European Union. Food Chemistry 531-550.
23. M. Chehade and L.J. Mayer (2005) Oral tolerance and its relation to food hypersensitivities. Journal of Allergy and Clinical Immunology 115 3-12.
24. C.-H. Chen (2008) Review of a current role of mass spectrometry for proteome research. Analytica Chimica Acta 624 16-36.
25. S. Cochrane, K. Beyer, M. Clausen, M. Wjst, R. Hiller, C. Nicoletti, Z. Szepfalusi, H. Savelkoul, H. Breteneder, Y. Manios, R. Crittenden and P. Burney (2009) Factors influencing the incidence and prevalence of food allergy. Allergy 64 1246-1255.
26. R.W.R. Crevel, D. Bruggs, S.L. Hefle, A.C. Knulst and S.L. Taylor (2007) Hazard characterization in food allergen risk assessment: the application of statistical approaches and the use of clinical data. Food and Chemical Toxicology 45 691-701.
27. R.W.R. Crevel, B.K. Ballmer-Weber, T. Holzhauser, J.O.B. Hourihane J.O’B., A.C. Knulst, A.R. Mackie, F. Timmermans and S.L. Taylor (2008) Thresholds for food allergens and their value to different stakeholders. Allergy 63 597-609.
28. R.W.R. Crevel (2009) Chapter 5: risk management – the principles. J. Coutts, R. Fielder (Eds) Management of Food Allergens 83-101.
29. R. de Luis, M. Lavilla, L. Sánchez, M. Calvo and M.D. Pérez (2009) Development and evaluation of two commercial ELISA formats for the detection of β-lactoglobulin in model processed and commercial foods. Food Control 20 643-647.
30. A. Demmel, C. Hupfer, E. Hampe, U. Busch and K-H. Engel (2008) Development of a real-time PCR for the detection of lupine DNA (Lupinus species) in foods. Journal of Agricultural and Food Chemistry 56 4328-4332.
31. C. Diaz-Amigo (2010) Towards a comprehensive validation of ELISA kits for food allergens. Food Analytical Methods http://dx.doi.org/10.1007/s12161-009-9095-y Case 2. Milk
32. L. Dovičovičová, L. Olexová, D. Pangallo, P. Siekel and T. Kuchta (2004) Polymerase chain reaction for the detection of celery (Apium graveolens) in food. European Food Research and Technology 218 493-495.
33. D. Dupont and S. Muller-Renaud (2006) Quantification of proteins in dairy products using an optical biosensor. Journal of AOAC International 89 843-844.
34. A. Ehlert, C. Hupfer, A. Demmel, K.H. Engel and U. Busch (2008) Detection of cashew nut in foods by a specific real-time PCR method. Food Analytical Methods 1 136-143.
35. A. Ehlert, A. Demmel, C. Hupfer, U. Busch and K.H. Engel (2009) Simultaneous detection of DNA from 10 food allergens by ligation-dependent probe amplification. Food Additives and Contaminants 26 409-418.
36. European Parliament and Council (2007) Directive 2007/68/EC of 27 November 2007 amending Annex III to Directive 200/13/EC as regards certain food ingredients. Official Journal of the European Union L 310 11-14.
37. C.K. Faeste, U. Christians, E. Egaas and K.R. Jonscher (2010) Characterization of potential allergens in fenugreek (Trigonella foenum-graecum). Journal of Proteomics 73 1321-1333.
38. Food Standard Agency (2006) Guidance on Allergen Management and Consumer Information.
39. A. Germini, E. Scaravelli, F. Lesignoli, S. Sforza, R. Corradini and R. Marchelli (2005) Polymerase chain reaction coupled with peptide nucleic acid high-performance liquid chromatography for the sensitive detection of traces of potentially allergenic hazelnut in foodstuffs. European Food Research and Technology 220 619-624.
40. R.E. Goodman, S. Vieths, H.A. Sampson, D. Hill, M. Ebisawa, S.L. Taylor and R. van Ree (2008) Allergenicity assessment of genetically modified crops – what makes sense? Nature Biotechnology 26 73-81.
41. J. Grundy, S. Matthews, B. Bateman, T. Dean and S.H. Arshad (2002) Rising prevalence of allergy to peanut to children: data from 2 sequential cohorts. Journal of Allergy and Clinical Immunology 110 784-789.
42. N. Gryson, K. Messens and K. Dewettinck (2008) PCR detection of soy ingredients in bread. European Food Research and Technology 227 345-351.
43. C. Guarino, S. Arena, L. De Simone, C. D’Ambrosio, S. Santoro, M. Rocco, A. Scaloni and M. Marra (2007) Proteomic analysis of the major soluble components in Annurca apple flesh. Molecular Nutrition and Food Research 51 255-262.
44. R. Gupta, A. Sheikh, D. Strachan and H.R. Anderson (2003) Increasing hospital admissions for systemic allergic disorders in England: analysis of national admissions data. British Medical Journal 327 1142-1143.
45. J. Heick, M. Fisher and B. Popping (2011) First screening method for the simultaneous detection of seven allergens by liquid chromatography mass spectrometry. Journal of Chromatography A 1218 983–943
46. H.M. Hiep, T. Endo, K. Kerman, M. Chikae, D.-K. Kim, S. Yamamura, Y. Takamura and E. Tamiya (2007) A localized surface plasmon resonance based immunosensor for the detection of casein in milk. Science and Technology of Advanced Materials 8 331-338.
47. H. Hird, J. Lloyd, R. Goodier, R. Brown and P. Reece (2003) Detection of peanut using real-time polymerase chain reaction. European Food Research and Technology 217 265-268.
48. V. Hohensinner, I. Maier and F. Pittner (2007) A “gold cluster-linked immunosorbent assay”: optical near-field biosensor chip fort he detection of allergenic β-lactoglobulin in processed milk matrices. Journal of Biotechnology 130 385-388.
49. T. Holzhauser, A. Wangorsch and S. Vieths (2000) Polymerase chain reaction (PCR) for detection of potentially allergenic hazelnut residues in complex food matrixes. European Food Research and Technology 211 360-365.
50. J.O.B. Hourihane J.O’B. and A.C. Knulst (2005) Thresholds of allergenic proteins in foods. Toxicology and Applied Pharmacology 207 S152-S156.
51. Y. Huang, M.C. Bell and I.I. Suni (2008) Impedance biosensor for peanut protein in Ara h1. Analytical Chemistry 80 9157-9161.
52. C. Hupfer, H.V. Waiblinger and U. Busch (2007) Development and validation of a real-time PCR detection method for celery in food. European Food Research and Technology 225 329-335.
53. ISO Guide 33 (2000) Uses of Certified Reference Materials. Geneva: International Organization for Standardization (ISO)
54. O. Ivanciuc, T. Garcia, M. Torres, C.H. Schein and W. Braun (2009) Characteristic motifs for families of allergenic proteins. Molecular Immunology 46 559-568.
55. D. Jarvis, C. Luczynska, S. Chinn, J. Potts, J. Sunyer, C. Janson, et al. (2005) Change in prevalence of IgE sensitization and mean total IgE with age and cohort. Journal of Allergy and Clinical Immunology 116 675-682.
56. P. Johnson, S. Baumgartner, T. Aldick, C. Bessant, V. Giosafatto, J. Heick, G. Mamone, G. O’Connor, R. Poms, B. Popping, A. Reute r A., F. Ulberth, A. Watson, L. Monaci and E.N.C. Mills (2011) Journal of AOAC International 94 1026-1033.
57. S. Kerbach, A.J. Alldrick, R.W.R. Crevel, L. Dömötör, A. DunnGalvin, E.N.C. Mills, S. Ptaff, R.E. Poms, B. Popping and S. Tömösközi (2009) Managing food allergens in the food supply chain—viewed from different stakeholder perspectives. Quality Assurance and Safety of Crops and Foods 1 50-60.
58. T.P. King, D. Hoffman, H. Lowenstein, D.G. Marsh and T.A.E. Platts-Mills (1994) Allergen nomenclature. Bulletin of the World Health Organization 72 797–780
59. L.M. Knippels, F. van Wijk and A.H. Penninks (2004) Food allergy: what do we learn from animal models? Current Opinion in Allergy and Clinical Immunology 4 205-209.
60. R. Köppel, V. Dvorak, F. Zimmerli, A. Breitenmoser, A. Eugster and H.-U. Waiblinger (2010) Two tetraplex real-time PCR for the detection and quantification of DNA from eight allergens in food. European Food Research and Technology 230 367-374.
61. C. Madsen (2005) Prevalence of food allergy: an overview. Proceedings of the Nutrition Society 64 413-417.
62. I. Maier, R.A. Morgan, W. Lindner and F. Pittner (2008) Optical resonance-enhanced absorption-based near-field immunochip biosensor for allergen detection. Analytical Chemistry 80 2694-2703.
63. S.J. Maleki and S.K. Sathe (2006) The effects of food processing methods on allergenic food proteins. S.J. Maleki, W.A. Burks, R.M. Helm (Eds) Food Allergy Washington, D.C.: American Society of Microbiology 309-322.
64. S.J. Maleki, S.Y. Chung, E.T. Champagne and J.P. Raufman (2000) The effects of roasting on the allergenic properties of peanut proteins. Journal of Allergy and Clinical Immunology 106 763-768.
65. D.G. Marsh, L. Goodfriend, T.P. King, H. Lowestein and T.A.E. Platt-Mills (1986) Allergen nomenclature. Bulletin of the World Health Organization 64 767-770.
66. N.H. Mermelstein (2008) Testing for allergens. Food Technology 62 70-74.
67. E.N.C. Mills, C. Madsen, P.R. Shewry and H.J. Wichers (2003) Food allergens of plant origin – their molecular and evolutionary relationships. Trends in Food Science and Technology 14 145-156.
68. E.N.C. Mills, A.R. Mackie, P. Burney, K. Beyer, L. Frewer, C. Madsen, E. Botjes, R.W.R. Crevel and R. van Ree (2007) The prevalence, cost and basis of food allergy across Europe. Allergy 62 717-722.
69. I. Mohammed, W.M. Mulett, E.P.C. Lai and J.M. Yeung (2001) Is a biosensor a viable method for food allergen detection? Analytica Chimica Acta 444 97-102.
70. L. Monaci and A. Visconti (2009) Mass-spectrometry-based proteomics methods for analysis of food allergens. TrAC: Trends in Analytical Chemistry 28 581-591.
71. L. Monaci and A. Visconti (2010) Immunochemical and DNA-based methods in food allergen analysis and quality assurance perspectives. Trends in Food Science and Technology 21 272-283.
72. L. Monaci, I. Losito, F. Palmisano and A. Visconti (2010) Identification of allergenic milk proteins markers in fined white wines by capillary liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography A 1217 4300-4305.
73. L. Monaci, V. Tregoat, M. Brohée and A. van Hengel (2011) Influence of baking time and matrix effects on the detection of milk allergens in cookie model food system by ELISA. Food Chemistry 127 669-675.
74. L. Monaci, I. Losito, F. Palmisano and A. Visconti (2011) Reliable identification of milk allergen in food using a high resolution single stage mass spectrometer. Journal of AOAC International 94 1034-1042.
75. L. Mondoulet, E. Paty, M.F. Drumare, S. Ah-Leung, P. Scheinmann, R.M. Willemot, J.M. Wal and H. Bernard (2005) Influence of thermal processing on the allergenicity of peanut proteins. Journal of Agricultural and Food Chemistry 53 4547-4553.
76. Monitoring and Quality Assurance in the Food Supply Chain, MoniQA. http://www.moniqa.org/allergens
77. M. Morisset, D.A. Moneret-Vautrin, G. Kanny, L. Guénard, E. Beaudouin, J. Flabbèe and R. Hatahet (2003) Threshold of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind placebo-controlled oral challenge. Clinical and Experimental Allergy 33 1046-1051.
78. S. Muller-Renaud, D. Dupont and P. Dulieu (2004) Quantification of β-casein in milk and cheese using an optical immunosensor. Journal of Agricultural and Food Chemistry 52 659-664.
79. S. Mustorp, C. Engdahl-Axelsson, U. Svenson and A. Holck (2007) Detection of celery (Apium graveolens), mustard (Sinapis alba, Brassica juncea, Brassica nigra) and sesame (Sesamum indicum) in food by real-time PCR. European Food Research and Technology 226 771-778.
80. S. Pafundo, M. Gullí and N. Marmiroli (2009) SYBR® GreenER™ Real-Time PCR to detect almond in traces in processed food. Food Chemistry 116 811-815.
81. S. Pafundo, M. Gullì and N. Marmiroli (2010) Multiplex real-time PCR using SYBR® GreenER™ for the detection of DNA allergens in food. Analytical and Bioanalytical Chemistry 396 1831-1839.
82. D.L. Park, S. Coates, V.A. Brewer, E.A. Garber, M. Abouzied, K. Johnson, B. Ritter and D. McKenzie (2005) Performance tested method multiple laboratory validation study of ELISA-based assays for the detection of peanuts in food. Journal of AOAC International 88 156-160.
83. A. Paschke, H. Kinder, K. Zunker, M. Wigotzki, H. Steinhart, R. Wessbecher and I. Vieluf (2001) Characterisation of cross-reacting allergens in mango fruit and ripening dependence of the allergenic potency. Food and Agricultural Immunology 13 51-61.
84. A. Paschke (2009) Aspects of food processing and its effects on allergen structure. Molecular Nutrition & Food Research 53 959-962.
85. R.E. Poms, M.E. Agazzi, A. Bau, M. Brohèe, C. Capelletti, J.V. Nørgaard and E. Anklam (2005) Inter-laboratory validation study of five commercial ELISA test kits for the determination of peanut proteins in biscuits and dark chocolate. Food Additives and Contaminants 22 104-112.
86. S. Rossi, E. Scaravelli, A. Germini, R. Corradini, C. Fogher and R. Marchelli (2006) A PNA-array platform for the detection of hidden allergens in foodstuffs. European Food Research and Technology 223 1-6.
87. H.A. Sampson (2004) Update on food allergy. Journal of Allergy and Clinical Immunology 113 805-819.
88. S.K. Sathe and G.M. Sharma (2009) Effects of food processing on food allergens. Molecular Nutrition & Food Research 53 970-978.
89. E. Scaravelli, M. Brohèe, R. Marchelli and A.J. van Hengel (2008) Development of three real-time PCR assays to detect peanut residue in processed food products. European Food Research and Technology 227 857-869.
90. E. Scaravelli, M. Brohée, R. Marchelli and A.J. van Hengel (2009) The effect of heat treatment on the detection of peanut allergens as determined by ELISA and real-time PCR. Analytical and Bioanalytical Chemistry 395 127-137.
91. K. Schöringhumer and M. Cichna-Markl (2007) Development of a real-time PCR method to detect potentially allergenic sesame (Sesamum indicum) in food. Journal of Agricultural and Food Chemistry 55 10540-10547.
92. K. Schöringhumer, G. Redl and M. Cichna-Marki (2009) Development and validation of a duplex real-time PCR method to simultaneously detect potentially allergenic sesame and hazelnut in food. Journal of Agricultural and Food Chemistry 57 2126-2134.
93. P. Schubert-Ullrich, J. Rudolf, P. Ansari, B. Galler, M. Führer, A. Molinelli and S. Baumgartner (2009) Commercialized rapid immunoanalytical tests for determination of allergenic food proteins: an overview. Analytical and Bioanalytical Chemistry 395 69-81.
94. K.E. Sharpless, J.B. Thomas, S.J. Christopher, R.R. Greenberg, L.C. Sander, M.M. Schantz, M.J. Welch and S.A. Wise (2007) Standard reference materials for foods and dietary supplements. Analytical and Bioanalytical Chemistry 389 171-178.
95. K.J. Shefcheck and S.M.J. Musser (2004) Confirmation of the allergenic peanut protein Arah1, in a model food matrix using liquid chromatography/tandem mass spectrometry. Journal of Agricultural and Food Chemistry 52 2785-2790.
96. K.J. Shefcheck, J.H. Callahan and S. Musser (2006) Confirmation of peanut protein using peptide markers in dark chocolate using liquid chromatography-tandem mass spectrometry. Journal of Agricultural and Food Chemistry 54 7953-7959.
97. P. Šotkovský, M. Hubálek, L. Hernychová, P. Novák, M. Havranová, I. Šetinová, A. Kitanovicová, M. Fuchs, J. Stulík and L. Tucková (2008) Proteomic analysis of wheat proteins recognized by IgE antibodies of allergic patients. Proteomics 8 1677-1691.
98. O. Stephan and S. Vieths (2004) Development of real-time PCR and a sandwich ELISA for detection of potentially allergenic trace amounts of peanut (Arachis hypogea) in processed foods. Journal of Agricultural and Food Chemistry 52 3754-3760.
99. N. Sudo, Y. Aiba, N. Oyama, X.N. Yu, M. Matsunga, Y. Koga, et al. (2004) Dietary nucleic acid and intestinal microbiota synergistically promote a shift in the Th1/Th2 balance toward Th1-skewed immunity. International Archives of Allergy and Immunology 135 132-135.
100. S.L. Taylor and J.O.B. Hourihane J.O’B. (2008) Food allergen thresholds reactivity. D.D. Metcalfe, H.A. Sampson, R.A. Simon (Eds) Food Allergy – Adverse Reactions to Foods and Food Additives fourth ed. Malden MA: Blackwell Publishing 82-89.
101. S.L. Taylor, J.A. Nordlee, L.M. Niemann and D.M. Lambrecht (2009) Allergen immunoassays – consideration for use of naturally incurred standards. Analytical and Bioanalytical Chemistry 395 83-92.
102. K. Thomas, C. Herouet-Guicheney, G. Ladics, G. Bannon, A. Cockburn, R. Crevel, J. Fitzpatrick, C. Mills, L. Privalle and S. Vieths (2007) Evaluating the effect of food processing on the potential human allergenicity of novel proteins: international workshop report. Food and Chemical Toxicology 45 1116-1122.
103. M. Thompson and R. Wood (2002) Harmonized guidelines for single-laboratory validation of methods of analysis. Pure and Applied Chemistry 74 835-855.
104. F. Ulberth and H. Emons (2005) Reference materials: are they fit-for-purpose for food analysis? Analytical and Bioanalytical Chemistry 381 99-101.
105. E.C.H. Van Beresteijn, R.A. Peeters, J. Kaper, R.J.G. Meijer, et al. (1994) Molecular mass distribution, immunological properties and nutritive value of whey protein hydrolysates. Journal of Food Science 57 619-625.
106. A.J. van Hengel (2007) Food allergen detection methods and the challenge to protect food-allergic consumers. Analytical and Bioanalytical Chemistry 389 111-118.
107. S. Vieths, B. Schöning and A. Jankiewicz (1993) Occurrence of IgE binding allergens during ripening of apple fruits. Food and Agricultural Immunology 5 93-105.
108. D. Weber, P. Raymond, S. Ben-Rejeb and B. Lau (2006) Development of a liquid chromatography-tandem mass spectrometry method using capillary liquid chromatography and nano-electrospray ionization-quadrupole time-of-flight hybrid mass spectrometer for the detection of milk allergens. Journal of Agricultural and Food Chemistry 54 1604-1610.
109. I. Yman, A. Eriksson, M.A. Johansson and K-E. Hellenäs (2006) Food allergen detection with biosensor immunoassays. Journal of AOAC International 89 856-861.