Allergenicity assessment of genetically modified crops - What makes sense?

Nature Biotechnology

Volumn 26, Issue 1, 2008, Pages 73-81

  Goodman, Richard E ^a   Vieths, Stefan ^b   Sampson, Hugh A ^c   Hill, David ^d   Ebisawa, Motohiro ^e   Taylor, Steve L ^a   Van Ree, Ronald ^f  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b PAUL EHRLICH INSTITUT   (Germany)

^c MOUNT SINAI MEDICAL CENTER   (United States)

^d ROYAL CHILDREN'S HOSPITAL   (Australia)

^e SAGAMIHARA NATIONAL HOSPITAL   (Japan)

^f ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGIES; GENETIC ENGINEERING; PESTICIDES; RISK ASSESSMENT;

ALLERGENIC RISKS; ALLERGENICITY ASSESSMENT;

CROPS;

ALLERGENICITY; ALLERGY TEST; CONSUMER; CROP; DNA MODIFICATION; FOOD SAFETY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; TRANSGENIC PLANT;

CONSUMER PRODUCT SAFETY; FOOD ANALYSIS; FOOD HYPERSENSITIVITY; FOOD, GENETICALLY MODIFIED; HUMANS; PLANTS, GENETICALLY MODIFIED; RISK ASSESSMENT; RISK FACTORS;

EID: 38049094662     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1343     Document Type: Review

References (56)

1. Codex Alimentarius Commission. Alinorm 03/34: Joint FAO/WHO Food Standard Programme, Codex Alimentarius Commission, Twenty-Fifth Session, Rome, 30 June-5 July, 2003. Appendix III, Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants and Appendix IV, Annex on the assessment of possible allergenicity, pp. 47-60 (2003).
2. Sampson, H.A. Food allergy - accurately identifying clinical reactivity. Allergy 60 S79, 19-24 (2005).
3. Taylor, S.L. Review of the development of methodology for evaluating the human allergenic potential of novel proteins. Mol. Nutr. Food Res. 50, 604-609 (2006).
4. Nordlee, J.A., Taylor, S.L., Townsend, J.A., Thomas, J.A. & Bush, R.K. Identification of a Brazil-nut allergen in transgenic soybeans. N. Engl. J. Med. 334, 688-692 (1996).
5. Metcalfe, D.D. et al. Assessment of the allergenic potential of foods derived from genetically modified crop plants. Crit. Rev. Food Sci. Nutr. 36(S), 165-186 (1996).
6. FAO/WHO. Evaluation of allergenicity of genetically modified foods. Report of a joint FAO/WHO expert consultation on allergenicity of foods derived from biotechnology. (Food and Agriculture Organization of the United Nations (FAO), Rome, 2001.
7. Goodman, R.E., Hefle, S.L., Taylor, S.L. & van Ree, R. Assessing genetically modified crops to minimize the risk of increased food allergy: a review. Int. Arch. Allergy Immunol. 137, 153-166 (2005).
8. Aalberse, R.C. Structural biology of allergens. J. Allergy Clin. Immunol. 106, 228-238 (2000).
9. Ladics, G.S., Bannon, G.A., Silvanovich, A. & Cressman, R.F. Comparison of conventional FASTA identity searches with the 80 amino acid sliding window FASTA search for elucidation of potential identities to known allergens. Mol. Nutr. Food Res. 51, 985-998 (2007).
10. Goodman, R.E. & Hefle, S.L. Gaining perspective on the allergenicity assessment of genetically modified crops. Expert Opin. Immunol. 1, 561-578 (2005).
11. Goodman, R.E. & Wise, J. Predicting the allergenicity of novel proteins in genetically modified organisms. in Food Allergy (eds. Maleki S.J. et al.) 219-247 (American Society of Microbiology Press, Washington, DC, 2006).
12. Hileman, R.E. et al. Bioinformatic methods for allergenicity assessment using a comprehensive allergen database. Int. Arch. Allergy Immunol. 128, 280-291 (2002).
13. Stadler, M.B. & Stadler, B.M. Allergenicity prediction by protein sequence. FASEB J. 17, 1141-1143 (2003).
14. Silvanovich, A. et al. The value of short amino acid sequence matches for prediction of protein allergenicity. Toxicol. Sci. 90, 252-258 (2006).
15. Sten, E. et al. A comparative study of the allergenic potency of wild-type and glyphosate-tolerant gene-modified soybean cultivars. APMIS 112, 21-28 (2004).
16. Ladics, G.S., Bardina, L., Cressman, R.F., Mattsson, J.L. & Sampson, H.A. Lack of cross-reactivity between the Bacillus thuringiensis derived protein Cry1F in maize grain and dust mite Der p7 protein with human sera positive for Der p7-IgE. Regul. Toxicol. Pharmacol. 44, 136-143 (2006).
17. van Ree, R. Carbohydrate epitopes and their relevance for the diagnosis and treatment of allergic disease. Int. Arch. Allergy Immunol. 129, 189-197 (2002).
18. Altmann, F. The role of protein glycosylation in allergy. Int. Arch. Allergy Immunol. 142, 99-115 (2007).
19. Asero, R. et al. IgE-mediated food allergy diagnosis: current status and new perspectives. Mol. Nutr. Food Res. 51, 135-147 (2007).
20. Astwood, J.D., Leach, J.N. & Fuchs, R.L. Stability of food allergens to digestion in vitro. Nat. Biotechnol. 14, 1269-1273 (1996).
21. Thomas, K. et al. A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins. Regul. Toxicol. Pharmacol. 39, 87-98 (2004).
22. Asero, R. et al. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int. Arch. Allergy Immunol. 122, 20-32 (2000).
23. Fu, T.J., Abbott, U.R. & Hatzos, C. Digestibility of food allergens and nonallergenic proteins in simulated gastric fluid and simulated intestinal fluid - a comparative study. J. Agric. Food Chem. 50, 7154-7160 (2002).
24. Yagami, T., Haishima, Y., Nakamura, A., Osuna, H. & Ikezawa, Z. Digestibility of allergens extracted from natural rubber latex and vegetable foods. J. Allergy Clin. Immunol. 106, 752-762 (2000).
25. Aalberse, R.C. & Stapel, S.O. Structure of food allergens in relation to allergenicity. Pediatr. Allergy Immunol. 12 Suppl 14, 10-14 (2001).
26. Vassilopoulou, E. et al. Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome. Int. Arch. Allergy Immunol. 143, 92-102 (2007).
27. Pastorello, E.A. et al. Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results. J. Allergy Clin. Immunol. 109, 563-570 (2002).
28. Breiteneder, H. & Radauer, C. A classification of plant food allergens. J. Allergy Clin. Immunol. 114, 127-130 (2004).
29. Untersmayr, E. et al. The effects of gastric digestion on codfish allergenicity. J. Allergy Clin. Immunol. 115, 377-382 (2005).
30. Bannon, G.A. et al. Digestive stability in the context of assessing the potential allergenicity of food proteins. Comments Toxicol. 8, 271-285 (2002).
31. Burks, A.W. & Fuchs, R.L. Assessment of the endogenous allergenicity in glyphosate-tolerant and commercial soybean varieties. J. Allergy Clin. Immunol. 96, 1008-1010 (1995).
32. Lehrer, S.B. & Reese, G. Recombinant proteins in newly developed foods: identification of allergenic activity. Int. Arch. Allergy Immunol. 113, 122-124 (1997).
33. Gao, Z.S. et al. Genomic cloning and linkage mapping of Mal d 1 (PR-10) gene family in apple (Malus domestica). Theor. Appl. Genet. 111, 171-183 (2005).
34. Carnes, J., Ferrer, A. & Fernandez-Caldas, E. Allergenicity of 10 different apple varieties. Ann. Allergy Asthma Immunol. 96, 564-570 (2006).
35. Zuidmeer, L. Allergenicity assessment of apple cultivars: hurdles in quantifying labile fruit allergens. Int. Arch. Allergy Immunol. 141, 230-240 (2006).
36. Codina, R., Ardusso, L., Lockey, R.F., Crisci, C. & Medina, I. Allergenicity of varieties of soybean. Allergy 58, 1293-1298 (2003).
37. Sancho, A.I. et al. Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein. J. Agric. Food Chem. 54, 5098-5104 (2006a).
38. Sancho, A.I. et al. Effect of postharvest storage on the expression of the apple allergen Mal d 1. J. Agric. Food Chem. 54, 5917-5923 (2006b).
39. Marzban, G. et al. Localization and distribution of the major allergens in apple fruits. Plant Sci. 169, 387-394 (2005).
40. Jenkins, J.A., Griffiths-Jones, S., Shewry, P.R., Breiteneder, H. & Mills, E.N.C. Structural relatedness of plant food allergens with specific reference to cross-reactive allergens: an in silico analysis. J. Allergy Clin. Immunol. 115, 163-170 (2005).
41. Ibanez, M.D., Marinez, M., Sanchez, J.J. & Fernandez-Caldas, E. Legume cross-reactivity (in Spanish). Allergol. Immunopathol. (Madr.) 31, 151-161 (2003).
42. Bindslev-Jensen, C., et al. Assessment of the potential allergenicity of ice structuring protein type III HPLC 12 using the FAO/WHO 2001 decision tree for novel foods. Food Chem. Toxicol. 41, 81-87 (2003).
43. Ferriera, F., Hawranek, T., Gruber, P., Wopfner, N. & Mari, A. Allergic cross-reactivity: from gene to the clinic. Allergy 59, 243-267 (2004).
44. Dearman, R.J. & Kimber, I. A mouse model for food allergy using intraperitoneal sensitization. Methods 41, 91-98 (2007).
45. McClain, S. & Bannon, G.A. Animal models of food allergy: opportunities and barriers. Curr. Allergy Asthma Rep. 6, 141-144 (2006).
46. Matsuda, T., Matsubara, T. & Hino, S. Immunogenic and allergenic potentials of natural and recombinant innocuous proteins. J. Biosci. Bioeng. 101, 203-211 (2006).
47. Perzanowski, M.S., Ronmark, E., Nold, B., Lundback, B. & Platts-Mills, T.A. Relevance of allergens from cats and dogs to asthma in the northernmost province of Sweden: schools as a major site of exposure. J. Allergy Clin. Immunol. 103, 1018-1024 (1999).
48. Fernandez-Rivas, M. et al. Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J. Allergy Clin. Immunol. 118, 481-488 (2006).
49. Reuter, A. et al. A critical assessment of allergen component-based in vitro diagnosis in cherry allergy across Europe. Clin. Exp. Allergy 36, 815-823 (2006).
50. Herouet, C. et al. Safety evaluation of the phosphinothricin acetyltransferase proteins encoded by the pat and bar sequences that confer tolerance to glufosinate-ammonium herbicide in transgenic plants. Regul. Toxicol. Pharmacol. 41, 134-149 (2005).
51. Jones, S.M., Magnolfi, C.F., Cooke, S.K. & Sampson, H.A. Immunologic cross-reactivity among cereal grains and grasses in children with food hypersensitivity. J. Allergy Clin. Immunol. 96, 341-351 (1995).
52. Ikematsu, K., Tachimoto, H., Sugiasaki, C., Syukuya, A. & Ebisawa, M. Feature of food allergy developed during infancy (1) - relationship between infantile atopic dermatitis and food allergy (in Japanese). Arerugi 55, 140-150 (2006).
53. Morton, R.L. et al. Bean alpha-amylase inhibitor 1 in transgenic peas (Pisum sativum) provides complete protection from pea weevil (Bruchus pisorum) under field conditions. Proc. Natl. Acad. Sci. USA 97, 3820-3825 (2000).
54. Prescott, V.E. et al. Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity. J. Agric. Food Chem. 53, 9023-9030 (2005).
55. Editorial. Genetically modified mush. Nat. Biotechnol. 24, 2 (2006).
56. Sinagawa-Garcia, S.R. et al. Safety assessment by in vitro digestibility and allergenicity of genetically modified maize with Amaranth 11S globulin. J. Agric. Food Chem. 52, 2709-2714 (2004).