A single-amino-acid change of the gustatory receptor gene, Gr5a, has a major effect on trehalose sensitivity in a natural population of Drosophila melanogaster

Genetics

Volumn 167, Issue 4, 2004, Pages 1749-1758

  Inomata, Nobuyuki ^a   Goto, Hiroki ^a   Itoh, Masanobu ^b   Isono, Kunio ^c  

^a KYUSHU UNIVERSITY   (Japan)

^b KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; THREONINE; TREHALOSE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL BEHAVIOR; ARTICLE; DNA POLYMORPHISM; DROSOPHILA MELANOGASTER; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC RECOMBINATION; GENETIC VARIABILITY; GUSTATORY RECEPTOR 5A GENE; HEREDITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SEGREGATION ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TASTE ACUITY; TASTE BUD;

AMINO ACID SUBSTITUTION; ANALYSIS OF VARIANCE; ANIMALS; BASE SEQUENCE; DNA; DNA PRIMERS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; LINKAGE DISEQUILIBRIUM; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE; TASTE; TREHALOSE;

ANIMALIA; ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; MELANOGASTER;

EID: 4644257225     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.104.027045     Document Type: Article

References (28)

1. AKASHI, H., 1999 Inferring the fitness effects of DNA mutations from polymorphism and divergence data: statistical power to detect directional selection under stationary and free recombination. Genetics 151: 221-238.
2. ANDOLFATTO, P., and J. D. WALL, 2003 Linkage disequilibrium patterns across a recombination gradient in African Drosophila melanogaster. Genetics 165: 1289-1305.
3. BRAVERMAN, J. M., R. R. HUDSON, N. L. KAPLAN, C. H. LANGLEY and W. STEPHAN, 1995 The hitchhiking effect on the site frequency spectrum of DNA polymorphisms. Genetics 140: 783-796.
4. CHYB, S., A. DAHANUKAR, A. WICKENS and J. R. CARLSON, 2003 Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proc. Natl. Acad. Sci. USA 100: 14526-14530.
5. CLYNE, P. J., C. G. WARR and J. R. CARLSON, 2000 Candidate taste receptors in Drosophila. Science 287: 1830-1834.
6. DAHANUKAR, A., K. FOSTER, W. M. VAN DER GOES VAN NATERS and J. R. CARLSON, 2001 A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nat. Neurosci. 4: 1182-1186.
7. DUNIPACE, L., S. MEISTER, C. MCNEALY and H. AMREIN, 2001 Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system. Curr. Biol. 11: 822-835.
8. FU, Y. X., and W. H. LI, 1993 Statistical tests of neutrality of mutations. Genetics 133: 693-709.
9. FAY, J. C., and C.-I WU, 2000 Hitchhiking under positive Darwinian selection. Genetics 155: 1405-1413.
10. GILBERT, D. G., 1996 SeqPup, Biosequence Editor and Analysis Platform (http://iubio.bio.indiana.edu/).
11. HUDSON, R. R., 1987 Estimating the recombination parameter of a finite population model without selection. Genet. Res. 50: 245-250.
12. HUDSON, R. R., 2002 Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics 18: 337-338.
13. HUDSON, R. R., and N. L. KAPLAN, 1985 Statistical properties of the number of recombination events in the history of a sample of DNA sequences. Genetics 111: 147-164.
14. KAPLAN, N. L., R. R. HUDSON and C. H. LANGLEY, 1989 The "hitchhiking effect" revisited. Genetics 123: 887-899.
15. KREITMAN, M., and R. R. HUDSON, 1991 Inferring the evolutionary histories of the Adh and Adh-dup loci in Drosophila melanogaster from patterns of polymorphism and divergence. Genetics 127: 565-582.
16. MAYNARD SMITH, J., and J. HAIGH, 1974 The hitch-hiking effect of a favorable gene. Genet. Res. 23: 23-35.
17. MCDONALD, J. H., and M. KREITMAN, 1991 Adaptive protein evolution at the Adh locus in Drosophila. Nature 351: 652-654.
18. NEI, M., 1987 Molecular Evolutionary Genetics. Columbia University Press, New York.
19. ROBERTSON, H. M., C. G. WARR and J. R. CARLSON, 2003 Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 100: 14537-14542.
20. ROZAS, J., J. C. SACHEZ-DELBARRIO, X. MESSEGYER and R. ROZAS, 2003 DnaSP, DNA polymorphism analyses by the coalescent and other methods. Bioinformatics 19: 2496-2497.
21. SCOTT, K., R. BRADY, JR., A. CRAVCHIK, P. MOROZOV, A. RZHETSKY et al., 2001 A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell 104: 661-673.
22. SIMONSEN, K. L., G. A. CHURCHILL and C. F. AQUADRO, 1995 Properties of statistical tests of neutrality for DNA polymorphism data. Genetics 141: 413-429.
23. TAJIMA, F., 1989 Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 123: 585-595.
24. TANIMURA, T., K. ISONO, T. TAKAMURA and I. SHIMADA, 1982 Genetic dimorphism in the taste sensitivity to trehalose in Drosophila melanogaster. J. Comp. Physiol. 147: 433-437.
25. THOMPSON, J. D., T. J. GIBSON, F. PLEWNIAK, F. JEANMOUGIN and D. G. HIGGINS, 1997 The Clustal X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 25: 4876-4882.
26. UENO, K., M. OHTA, H. MORITA, Y. MIKUNI, S. NAKAJIMA et al., 2001 Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a. Curr. Biol. 11: 1451-1455.
27. WALL, J. D., 1999 Recombination and the power of statistical tests of neutrality. Genet. Res. 74: 65-79.
28. WATTERSON, G. A., 1975 On the number of segregating sites in genetic models without recombination. Theor. Popul. Biol. 7: 256-276.