Quantitative trait loci associated with short-term intake of sucrose, saccharin and quinine solutions in laboratory mice

Chemical Senses

Volumn 24, Issue 4, 1999, Pages 373-385

  Blizard, David A ^a   Kotlus, Brett ^a   Frank, Marion E ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

QUININE; SACCHARIN; SUCROSE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 4; CHROMOSOME 6; CONTROLLED STUDY; DIETARY INTAKE; DNA POLYMORPHISM; FEMALE; GENE LOCUS; GENE MAPPING; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; VARIANCE;

ANALYSIS OF VARIANCE; ANIMALS; DRINKING BEHAVIOR; FEMALE; GENOTYPE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; QUANTITATIVE TRAIT, HERITABLE; QUININE; SACCHARIN; SPECIES SPECIFICITY; SUCROSE; TASTE;

ANIMALIA; CINCHONA PUBESCENS;

EID: 0032766605     PISSN: 0379864X     EISSN: None     Source Type: Journal    
DOI: 10.1093/chemse/24.4.373     Document Type: Article

References (42)

1. Azen, E.A. ( 1991 ) Linkage studies for genes for salivary proline-rich proteins and bitter taste in mouse and humans. In Wysocki, C.J. and Kare, M.R. (eds), Genetics of Perception and Communication. Marcel Decker, New York, pp. 279-290.
2. Azen, E.A., Lush, I.E. and Taylor, B.T. (1986) Close linkage of mouse genes for salivary proline-rich proteins (Prps) and taste. Trends Genet., 2, 199-200.
3. Bachmanov, A.A., Reed, D.R., Ninomiya, Y, Inoue, M., Tordoff, M.G., Price, R.A. and Beauchamp, G.K. (1996) Genetics of sucrose intake in the mouse. Chem. Senses, 21, 575 [abstract].
4. Bachmanov, A.A., Reed, D.R., Ninomiya, Y, Inoue, M., Tordoff, M.G., Price, R.A. and Beauchamp, G.K. (1997) Sucrose consumption in mice: major influence of two genetic loci affecting peripheral sensory responses. Mamm. Genome, 8, 545-548.
5. Bailey, D.W. ( 1971 ) Recombinant-inbred strains: an aid to identify linkage and function of histocompatibility and other genes. Transplantation, 11, 325-327.
6. Beauchamp, G.K. and Fisher, A.S. (1993) Strain differences in consumption of saline solutions by mice. Physiol. Behav., 54, 179-184.
7. Belknap, J.K., Crabbe, J.C., Plomin, R., McClearn, G.E., Sampson, K.E., O'Toole, L.A. and Gora-Maslak, G. (1992) Single locus control of saccharin intake in BxD/Ty recombinant-inbred mice: some methodological implications for Rl strain analysis. Behav. Genet., 22, 81-100.
8. Belknap, J.K., Mitchell, S.R., O'Toole, L.A., Helms, M.L and Crabbe, J.C. (1996) Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant-inbred mouse strains. Behav. Genet., 26, 149-150.
9. Blizard, D.A. and Darvasi, A. (1999) Experimental strategies for quantitative trait loci (QTL) analysis in laboratory animals. In Crusio, W.E. and Gerlai, R.T. (eds), Handbook of Molecular-genetic Techniques for Brain and Behavior Research. Elsevier, Amsterdam, in press.
10. Blizard, D.A., Gudas, E.P. and Frank, M.E. (1996) Gene-mapping of sweet and bitter tastants in Mus musculus. Chem. Senses, 21, 579 [abstract].
11. Capeless, C.G. and Whitney, G. (1996) The genetic basis of preference for sweet substances among inbred strains of mice: preference ratio phenotypes and the alleles of the Sac and dpa loci. Chem. Senses, 20, 291-298.
12. Capeless, C.G., Whitney, G. and Azen, E.A. (1992) Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice. Behav. Genet., 22, 655-663.
13. Davis, J.E. (1973) The effectiveness of some sugars in stimulating licking behavior in the rat. Physiol. Behav., 11, 39-45.
14. Dess, N.K. and Minor, T.R. (1996) Tasfe and emotionality in rats selectively bred for high versus low saccharin intake. Anim. Learn. Behav., 24, 105-115.
15. Frank, M.E. and Blizard, D.A. (1996) Relationship between chorda tympani response and taste preference in inbred strains of mice. Chem. Senses, 21, 602 [abstract].
16. Frank, M.E. and Blizard, D.A. (1999) Chorda tympani responses in two inbred strains of mice with different taste preferences. Physiol. Behav., in press.
17. Fuller, J.L. (1974) Single locus control of saccharin preference in mice. J. Hered, 65, 33-36.
18. Harder, D.B. and Whitney, G. (1998) A common polygenic basis for quinine and PROP avoidance in mice. Chem. Senses, 23, 327-332.
19. Harder, D.B., Capeless, C.G., Maggio, J.C., Boughter, J.D., Jr, Gannon, K.S., Whitney, G. and Azen, E.A. (1992) Intermediate sucrose octa-acetate sensitivity suggests a third allele at mouse bitter taste locus Soa and Soa-Rua identity. Chem. Senses, 17, 391-401.
20. Hoon, M.A., Adler, E., Lindemeier, J., Battey, J.F., Ryba, N.J.P. and Zuker, C.S. (1999) Putative mammalian taste receptors: a class of taste-specific GPCPs with distinct topographic selectivity. Cell, 96, 541-551.
21. Kotlus, B.S. and Blizard, D.A. (1998) Measuring gustatory variation in mice: a short-term fluid-intake test. Physiol. Behav., 64, 37-47.
22. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R. and Berns, A. (1991) Simplified mammalian DNA isolation procedure. Nucleic Acids Res, 19, 4293.
23. Lander, E.S. and Botstein, D. (1989) Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics, 121, 185-199.
24. Lander, E.S. and Kruglyak, L. (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet., 11, 241-247.
25. Lander, E.S., Green, P., Abrahamson, J., Barlow, A., Daly, M.J., Lincoln, S.E. and Newburg, L. (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics, 1, 174-181.
26. Lush, I.E. (1984) The genetics of tasting in mice. III. Quinine. Genet. Res. Camb., 44, 151-160.
27. Lush, I.E. (1986) The genetics of tasting in mice. IV. The acetates of raffinose. galactose and β-lactose. Genet. Res. Camb., 47, 117-123.
28. Lush, I.E. (1991) The genetics of bitterness, sweetness, and saltiness in strains of mice. In Wysocki, C.J. and Kare, M.R. (eds), Genetics of perception and communication. Marcel Decker, New York, pp. 227-241.
29. Lush, I.E. and Holland, I.E. (1988) The genetics of tasting in mice V. Glycine and cycloheximide. Genet. Res. Camb., 52, 207-212.
30. Lush, I.E., Hornigold, N., King, P. and Stoye, J.P. (1995) The genetics of tasting in mice. VII. Glycine revisited, and the chromosomal location of Sac and Soa. Genet. Res. Camb., 66, 167-174.
31. Nachman, M. (1959) The inheritance of saccharin preference. J. Comp. Physiol. Psychol., 52, 451-457.
32. Ninomiya, Y. and Funakoshi, M. (1993) Genetic and neurobehavioral approaches to the taste receptor mechanisms in mammals. In Simon, S.A. and Roper, S.D. (eds), Mechanisms of taste transduction. CRC Press, Boca Raton, FL, pp. 253-272.
33. Ninomiya, Y., Sako, N., Katsukawa, H. and Funakoshi, M. (1991) Taste receptor mechanisms influenced by a gene on chromosome 4 in mice. In Wysocki, C.J. and Kare, M.R.(eds), Genetics of perception and communication. Marcel Decker, New York, pp. 267-278.
34. Phillips, T.J., Crabbe, J.C., Metten, P. and Belknap, J.K. (1994) Localization of genes affecting alcohol drinking in mice. Alc. Clin. Exp. Res., 18, 931-941.
35. Plomin, R., McClearn, G.E., Gora Maslak, G. and Neiderhiser, J.M. (1991) Use of recombinant-inbred strains to detect quantitative trait loci associated with behavior. Behav. Genet., 21, 99-116.
36. Probst, F.J., Fridell, R.A., Raphael, Y., Saunders, T.L., Wang, A., Liang, Y., Morell, R.J., Touchman, J.W., Lyons, R.H., Noben-Trauth, K., Friedman, T.B. and Camper, S. (1998) Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene. Science, 280, 1444-1447.
37. Rodriguez, L.A., Plomin, R., Blizard, D.A., Jones, B.C. and McClearn, G.E. (1994) Alcohol acceptance, preference, and sensitivity in mice, I. Quantitative genetic analysis using BXD recombinant inbred strains. Alc. Clin. Exp. Res., 18, 1416-1422.
38. Spielman, A.I., Huque, T., Nagal, H., Whitney, G. and Brand, J.G. (1994) Generation of inositol phosphates in bitter taste transduction. Physiol. Behav., 56, 1149-1155.
39. Tarantino, L.M., McClearn, G.E., Rodriguez, L.A. and Plomin, R. (1998) Confirmation of quantitative trait loci for alcohol preference in mice. Alc. Clin. Exp. Res., 22, 1099-1105.
40. Taylor, B.A. (1978) Recombinant-inbred strains: use in gene-mapping. In Morse, H. (ed.), Origins of Inbred Mice. Academic Press, New York, pp. 423-438.
41. Wilkinson. L., Hill, M., Welna, J.P. and Birkenbeuel, G.K. (1992) Systat for Windows, Version 5. Systat Inc., Evanston, IL.
42. Wong, G.T., Gannon, K.S. and Margolskee, R.F. (1996) Transduction of bitter and sweet taste by gustducin. Nature, 381, 796-800.