-
2
-
-
48449086316
-
TGF-β: a master of all T cell trades
-
Li MO, Flavell RA. TGF-β: a master of all T cell trades. Cell 2008; 134:392-404.
-
(2008)
Cell
, vol.134
, pp. 392-404
-
-
Li, M.O.1
Flavell, R.A.2
-
4
-
-
0028152937
-
Transforming growth factor β: the good, the bad, and the ugly
-
Wahl SM. Transforming growth factor β: the good, the bad, and the ugly. J Exp Med 1994; 180:1587-90.
-
(1994)
J Exp Med
, vol.180
, pp. 1587-1590
-
-
Wahl, S.M.1
-
5
-
-
0026799402
-
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
-
Shull MM, Ormsby I, Kier AB et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 1992; 359:693-9.
-
(1992)
Nature
, vol.359
, pp. 693-699
-
-
Shull, M.M.1
Ormsby, I.2
Kier, A.B.3
-
6
-
-
0027531528
-
Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death
-
Kulkarni AB, Huh CG, Becker D et al. Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993; 90:770-4.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 770-774
-
-
Kulkarni, A.B.1
Huh, C.G.2
Becker, D.3
-
7
-
-
34248592104
-
T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
-
Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 2007; 26:579-91.
-
(2007)
Immunity
, vol.26
, pp. 579-591
-
-
Li, M.O.1
Wan, Y.Y.2
Flavell, R.A.3
-
8
-
-
33748465396
-
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor
-
Marie JC, Liggitt D, Rudensky AY. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor. Immunity 2006; 25:441-54.
-
(2006)
Immunity
, vol.25
, pp. 441-454
-
-
Marie, J.C.1
Liggitt, D.2
Rudensky, A.Y.3
-
11
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235-8.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
Weiner, H.L.7
Kuchroo, V.K.8
-
12
-
-
0032442852
-
Smads: transcriptional activators of TGF-β responses
-
Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-β responses. Cell 1998; 95:737-40.
-
(1998)
Cell
, vol.95
, pp. 737-740
-
-
Derynck, R.1
Zhang, Y.2
Feng, X.H.3
-
13
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-β family signalling
-
Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003; 425:577-84.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
14
-
-
36448936383
-
TGFβ-SMAD signal transduction: molecular specificity and functional flexibility
-
Schmierer B, Hill CS. TGFβ-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007; 8:970-82.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 970-982
-
-
Schmierer, B.1
Hill, C.S.2
-
15
-
-
0035355473
-
The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway
-
Hocevar BA, Smine A, Xu XX, Howe PH. The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway. EMBO J 2001; 20:2789-801.
-
(2001)
EMBO J
, vol.20
, pp. 2789-2801
-
-
Hocevar, B.A.1
Smine, A.2
Xu, X.X.3
Howe, P.H.4
-
16
-
-
70449709580
-
Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function
-
Jain N, Nguyen H, Friedline RH et al. Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function. J Immunol 2009; 183:4192-6.
-
(2009)
J Immunol
, vol.183
, pp. 4192-4196
-
-
Jain, N.1
Nguyen, H.2
Friedline, R.H.3
-
17
-
-
34247539528
-
A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-β signaling
-
Brown KA, Pietenpol JA, Moses HL. A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-β signaling. J Cell Biochem 2007; 101:9-33.
-
(2007)
J Cell Biochem
, vol.101
, pp. 9-33
-
-
Brown, K.A.1
Pietenpol, J.A.2
Moses, H.L.3
-
18
-
-
23044466047
-
Specificity and versatility in TGF-β signaling through Smads
-
Feng XH, Derynck R. Specificity and versatility in TGF-β signaling through Smads. Annu Rev Cell Dev Biol 2005; 21:659-93.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 659-693
-
-
Feng, X.H.1
Derynck, R.2
-
19
-
-
0032483544
-
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling
-
Shi Y, Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling. Cell 1998; 94:585-94.
-
(1998)
Cell
, vol.94
, pp. 585-594
-
-
Shi, Y.1
Wang, Y.F.2
Jayaraman, L.3
Yang, H.4
Massague, J.5
Pavletich, N.P.6
-
20
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, Kern SE. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998; 1:611-7.
-
(1998)
Mol Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
Kern, S.E.7
-
21
-
-
0033602186
-
A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3
-
Dennler S, Huet S, Gauthier JM. A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncogene 1999; 18:1643-8.
-
(1999)
Oncogene
, vol.18
, pp. 1643-1648
-
-
Dennler, S.1
Huet, S.2
Gauthier, J.M.3
-
22
-
-
11844271440
-
Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile
-
Dunn NR, Koonce CH, Anderson DC, Islam A, Bikoff EK, Robertson EJ. Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. Genes Dev 2005; 19:152-63.
-
(2005)
Genes Dev
, vol.19
, pp. 152-163
-
-
Dunn, N.R.1
Koonce, C.H.2
Anderson, D.C.3
Islam, A.4
Bikoff, E.K.5
Robertson, E.J.6
-
23
-
-
33749344476
-
Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription
-
Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL, Hill CS. Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J 2006; 25:4490-502.
-
(2006)
EMBO J
, vol.25
, pp. 4490-4502
-
-
Ross, S.1
Cheung, E.2
Petrakis, T.G.3
Howell, M.4
Kraus, W.L.5
Hill, C.S.6
-
24
-
-
80051537445
-
Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs
-
Kim SW, Yoon SJ, Chuong E, Oyolu C, Wills AE, Gupta R, Baker J. Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol 2011; 357:492-504.
-
(2011)
Dev Biol
, vol.357
, pp. 492-504
-
-
Kim, S.W.1
Yoon, S.J.2
Chuong, E.3
Oyolu, C.4
Wills, A.E.5
Gupta, R.6
Baker, J.7
-
25
-
-
0038369998
-
A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
-
Kang Y, Chen CR, Massague J. A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 2003; 11:915-26.
-
(2003)
Mol Cell
, vol.11
, pp. 915-926
-
-
Kang, Y.1
Chen, C.R.2
Massague, J.3
-
26
-
-
80051520491
-
HEB and E2A function as SMAD/FOXH1 cofactors
-
Yoon SJ, Wills AE, Chuong E, Gupta R, Baker JC. HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev 2011; 25:1654-61.
-
(2011)
Genes Dev
, vol.25
, pp. 1654-1661
-
-
Yoon, S.J.1
Wills, A.E.2
Chuong, E.3
Gupta, R.4
Baker, J.C.5
-
27
-
-
0034682515
-
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and wnt pathways
-
Labbe E, Letamendia A, Attisano L. Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and wnt pathways. Proc Natl Acad Sci USA 2000; 97:8358-63.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8358-8363
-
-
Labbe, E.1
Letamendia, A.2
Attisano, L.3
-
28
-
-
79959891289
-
Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities
-
Agricola E, Randall RA, Gaarenstroom T, Dupont S, Hill CS. Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Mol Cell 2011; 43:85-96.
-
(2011)
Mol Cell
, vol.43
, pp. 85-96
-
-
Agricola, E.1
Randall, R.A.2
Gaarenstroom, T.3
Dupont, S.4
Hill, C.S.5
-
29
-
-
84455167662
-
A poised chromatin platform for TGF-β access to master regulators
-
Xi Q, Wang Z, Zaromytidou AI et al. A poised chromatin platform for TGF-β access to master regulators. Cell 2011; 147:1511-24.
-
(2011)
Cell
, vol.147
, pp. 1511-1524
-
-
Xi, Q.1
Wang, Z.2
Zaromytidou, A.I.3
-
30
-
-
33646876973
-
Hematopoiesis controlled by distinct TIF1γ and Smad4 branches of the TGFβ pathway
-
He W, Dorn DC, Erdjument-Bromage H, Tempst P, Moore MA, Massague J. Hematopoiesis controlled by distinct TIF1γ and Smad4 branches of the TGFβ pathway. Cell 2006; 125:929-41.
-
(2006)
Cell
, vol.125
, pp. 929-941
-
-
He, W.1
Dorn, D.C.2
Erdjument-Bromage, H.3
Tempst, P.4
Moore, M.A.5
Massague, J.6
-
31
-
-
80051925342
-
Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4α in HepG2 cells
-
Mizutani A, Koinuma D, Tsutsumi S et al. Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4α in HepG2 cells. J Biol Chem 2011; 286:29848-60.
-
(2011)
J Biol Chem
, vol.286
, pp. 29848-29860
-
-
Mizutani, A.1
Koinuma, D.2
Tsutsumi, S.3
-
32
-
-
80155137594
-
Master transcription factors determine cell-type-specific responses to TGF-β signaling
-
Mullen AC, Orlando DA, Newman JJ et al. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell 2011; 147:565-76.
-
(2011)
Cell
, vol.147
, pp. 565-576
-
-
Mullen, A.C.1
Orlando, D.A.2
Newman, J.J.3
-
33
-
-
80155123782
-
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
-
Trompouki E, Bowman TV, Lawton LN et al. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell 2011; 147:577-89.
-
(2011)
Cell
, vol.147
, pp. 577-589
-
-
Trompouki, E.1
Bowman, T.V.2
Lawton, L.N.3
-
34
-
-
38349095578
-
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
-
Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, Tone M. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol 2008; 9:194-202.
-
(2008)
Nat Immunol
, vol.9
, pp. 194-202
-
-
Tone, Y.1
Furuuchi, K.2
Kojima, Y.3
Tykocinski, M.L.4
Greene, M.I.5
Tone, M.6
-
35
-
-
71749094333
-
+ regulatory T cells is driven by the c-Rel enhanceosome
-
+ regulatory T cells is driven by the c-Rel enhanceosome. Immunity 2009; 31:932-40.
-
(2009)
Immunity
, vol.31
, pp. 932-940
-
-
Ruan, Q.1
Kameswaran, V.2
Tone, Y.3
Li, L.4
Liou, H.C.5
Greene, M.I.6
Tone, M.7
Chen, Y.H.8
-
36
-
-
0032572723
-
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
-
Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 1998; 394:909-13.
-
(1998)
Nature
, vol.394
, pp. 909-913
-
-
Zhang, Y.1
Feng, X.H.2
Derynck, R.3
-
37
-
-
0035953395
-
Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activation
-
Verrecchia F, Tacheau C, Schorpp-Kistner M, Angel P, Mauviel A. Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activation. Oncogene 2001; 20:2205-11.
-
(2001)
Oncogene
, vol.20
, pp. 2205-2211
-
-
Verrecchia, F.1
Tacheau, C.2
Schorpp-Kistner, M.3
Angel, P.4
Mauviel, A.5
-
38
-
-
0034680863
-
Critical role of Smads and AP-1 complex in transforming growth factor-β-dependent apoptosis
-
Yamamura Y, Hua X, Bergelson S, Lodish HF. Critical role of Smads and AP-1 complex in transforming growth factor-β-dependent apoptosis. J Biol Chem 2000; 275:36295-302.
-
(2000)
J Biol Chem
, vol.275
, pp. 36295-36302
-
-
Yamamura, Y.1
Hua, X.2
Bergelson, S.3
Lodish, H.F.4
-
39
-
-
1642332084
-
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
Seoane J, Le HV, Shen L, Anderson SA, Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004; 117:211-23.
-
(2004)
Cell
, vol.117
, pp. 211-223
-
-
Seoane, J.1
Le, H.V.2
Shen, L.3
Anderson, S.A.4
Massague, J.5
-
40
-
-
0033605129
-
Convergence of transforming growth factor-β and vitamin D signaling pathways on SMAD transcriptional coactivators
-
Yanagisawa J, Yanagi Y, Masuhiro Y et al. Convergence of transforming growth factor-β and vitamin D signaling pathways on SMAD transcriptional coactivators. Science 1999; 283:1317-21.
-
(1999)
Science
, vol.283
, pp. 1317-1321
-
-
Yanagisawa, J.1
Yanagi, Y.2
Masuhiro, Y.3
-
41
-
-
0035827581
-
Functional characterization of transforming growth factor β signaling in Smad2- and Smad3-deficient fibroblasts
-
Piek E, Ju WJ, Heyer J et al. Functional characterization of transforming growth factor β signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem 2001; 276:19945-53.
-
(2001)
J Biol Chem
, vol.276
, pp. 19945-19953
-
-
Piek, E.1
Ju, W.J.2
Heyer, J.3
-
42
-
-
22144490199
-
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
-
Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005; 122:107-18.
-
(2005)
Cell
, vol.122
, pp. 107-118
-
-
Mazmanian, S.K.1
Liu, C.H.2
Tzianabos, A.O.3
Kasper, D.L.4
-
45
-
-
0348223787
-
+ regulatory T cells by TGF-β induction of transcription factor Foxp3
-
+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003; 198:1875-86.
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
McGrady, G.7
Wahl, S.M.8
-
46
-
-
79952771167
-
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation
-
Gutcher I, Donkor MK, Ma Q, Rudensky AY, Flavell RA, Li MO. Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity 2011; 34:396-408.
-
(2011)
Immunity
, vol.34
, pp. 396-408
-
-
Gutcher, I.1
Donkor, M.K.2
Ma, Q.3
Rudensky, A.Y.4
Flavell, R.A.5
Li, M.O.6
-
47
-
-
59849123627
-
The surprising discovery that TGF β specifically induces the IgA class switch
-
Stavnezer J, Kang J. The surprising discovery that TGF β specifically induces the IgA class switch. J Immunol 2009; 182:5-7.
-
(2009)
J Immunol
, vol.182
, pp. 5-7
-
-
Stavnezer, J.1
Kang, J.2
-
48
-
-
85027947787
-
Induction of colonic regulatory T cells by indigenous Clostridium species
-
Atarashi K, Tanoue T, Shima T et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011; 331:337-41.
-
(2011)
Science
, vol.331
, pp. 337-341
-
-
Atarashi, K.1
Tanoue, T.2
Shima, T.3
-
49
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov II, Atarashi K, Manel N et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139:485-98.
-
(2009)
Cell
, vol.139
, pp. 485-498
-
-
Ivanov, I.I.1
Atarashi, K.2
Manel, N.3
-
50
-
-
70349742524
-
The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
-
Gaboriau-Routhiau V, Rakotobe S, Lecuyer E et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 2009; 31:677-89.
-
(2009)
Immunity
, vol.31
, pp. 677-689
-
-
Gaboriau-Routhiau, V.1
Rakotobe, S.2
Lecuyer, E.3
-
51
-
-
84860216630
-
Microbial exposure during early life has persistent effects on natural killer T cell function
-
Olszak T, An D, Zeissig S et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012; 336:489-93.
-
(2012)
Science
, vol.336
, pp. 489-493
-
-
Olszak, T.1
An, D.2
Zeissig, S.3
-
53
-
-
79960919901
-
Control of TH17 cells occurs in the small intestine
-
Esplugues E, Huber S, Gagliani N et al. Control of TH17 cells occurs in the small intestine. Nature 2011; 475:514-8.
-
(2011)
Nature
, vol.475
, pp. 514-518
-
-
Esplugues, E.1
Huber, S.2
Gagliani, N.3
-
54
-
-
43249097073
-
CD3-specific antibody-induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells
-
Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W. CD3-specific antibody-induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells. Nat Med 2008; 14:528-35.
-
(2008)
Nat Med
, vol.14
, pp. 528-535
-
-
Perruche, S.1
Zhang, P.2
Liu, Y.3
Saas, P.4
Bluestone, J.A.5
Chen, W.6
-
55
-
-
78149310029
-
A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota
-
Chinen T, Volchkov PY, Chervonsky AV, Rudensky AY. A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med 2010; 207:2323-30.
-
(2010)
J Exp Med
, vol.207
, pp. 2323-2330
-
-
Chinen, T.1
Volchkov, P.Y.2
Chervonsky, A.V.3
Rudensky, A.Y.4
-
56
-
-
0033602101
-
Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
-
Ulloa L, Doody J, Massague J. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway. Nature 1999; 397:710-3.
-
(1999)
Nature
, vol.397
, pp. 710-713
-
-
Ulloa, L.1
Doody, J.2
Massague, J.3
-
57
-
-
0034650266
-
A mechanism of suppression of TGF-β/SMAD signaling by NF-kappa B/RelA
-
Bitzer M, von Gersdorff G, Liang D, Dominguez-Rosales A, Beg AA, Rojkind M, Bottinger EP. A mechanism of suppression of TGF-β/SMAD signaling by NF-kappa B/RelA. Genes Dev 2000; 14:187-97.
-
(2000)
Genes Dev
, vol.14
, pp. 187-197
-
-
Bitzer, M.1
von Gersdorff, G.2
Liang, D.3
Dominguez-Rosales, A.4
Beg, A.A.5
Rojkind, M.6
Bottinger, E.P.7
-
58
-
-
0034894059
-
Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease
-
Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT. Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease. J Clin Investig 2001; 108:601-9.
-
(2001)
J Clin Investig
, vol.108
, pp. 601-609
-
-
Monteleone, G.1
Kumberova, A.2
Croft, N.M.3
McKenzie, C.4
Steer, H.W.5
MacDonald, T.T.6
-
59
-
-
77950835033
-
Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis
-
Kleiter I, Song J, Lukas D et al. Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain 2010; 133(Pt 4):1067-81.
-
(2010)
Brain
, vol.133
, Issue.PART 4
, pp. 1067-1081
-
-
Kleiter, I.1
Song, J.2
Lukas, D.3
-
60
-
-
62949223226
-
Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression
-
e1-3.
-
Fantini MC, Rizzo A, Fina D et al. Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 2009; 136:1308-16, e1-3.
-
(2009)
Gastroenterology
, vol.136
, pp. 1308-1316
-
-
Fantini, M.C.1
Rizzo, A.2
Fina, D.3
-
61
-
-
0034679703
-
Blockade of transforming growth factor β/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity
-
Nakao A, Miike S, Hatano M, Okumura K, Tokuhisa T, Ra C, Iwamoto I. Blockade of transforming growth factor β/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity. J Exp Med 2000; 192:151-8.
-
(2000)
J Exp Med
, vol.192
, pp. 151-158
-
-
Nakao, A.1
Miike, S.2
Hatano, M.3
Okumura, K.4
Tokuhisa, T.5
Ra, C.6
Iwamoto, I.7
-
62
-
-
58149251898
-
Late developmental plasticity in the T helper 17 lineage
-
Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT. Late developmental plasticity in the T helper 17 lineage. Immunity 2009; 30:92-107.
-
(2009)
Immunity
, vol.30
, pp. 92-107
-
-
Lee, Y.K.1
Turner, H.2
Maynard, C.L.3
Oliver, J.R.4
Chen, D.5
Elson, C.O.6
Weaver, C.T.7
-
64
-
-
0036207312
-
Localization of intestinal intraepithelial T lymphocytes involves regulation of alphaEβ7 expression by transforming growth factor-β
-
Suzuki R, Nakao A, Kanamaru Y, Okumura K, Ogawa H, Ra C. Localization of intestinal intraepithelial T lymphocytes involves regulation of alphaEβ7 expression by transforming growth factor-β. Int Immunol 2002; 14:339-45.
-
(2002)
Int Immunol
, vol.14
, pp. 339-345
-
-
Suzuki, R.1
Nakao, A.2
Kanamaru, Y.3
Okumura, K.4
Ogawa, H.5
Ra, C.6
-
65
-
-
0024446350
-
Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
-
Coffman RL, Lebman DA, Shrader B. Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J Exp Med 1989; 170:1039-44.
-
(1989)
J Exp Med
, vol.170
, pp. 1039-1044
-
-
Coffman, R.L.1
Lebman, D.A.2
Shrader, B.3
-
66
-
-
0024445451
-
Transforming growth factor β induces IgA production and acts additively with interleukin 5 for IgA production
-
Sonoda E, Matsumoto R, Hitoshi Y et al. Transforming growth factor β induces IgA production and acts additively with interleukin 5 for IgA production. J Exp Med 1989; 170:1415-20.
-
(1989)
J Exp Med
, vol.170
, pp. 1415-1420
-
-
Sonoda, E.1
Matsumoto, R.2
Hitoshi, Y.3
-
68
-
-
0034981658
-
Roles of Ets proteins, NF-κB and nocodazole in regulating induction of transcription of mouse germline Ig α RNA by transforming growth factor-β 1
-
Shi MJ, Park SR, Kim PH, Stavnezer J. Roles of Ets proteins, NF-κB and nocodazole in regulating induction of transcription of mouse germline Ig α RNA by transforming growth factor-β 1. Int Immunol 2001; 13:733-46.
-
(2001)
Int Immunol
, vol.13
, pp. 733-746
-
-
Shi, M.J.1
Park, S.R.2
Kim, P.H.3
Stavnezer, J.4
-
69
-
-
0034595970
-
Transcriptional regulation of the transforming growth factor-β -inducible mouse germ line Ig α constant region gene by functional cooperation of Smad, CREB, and AML family members
-
Zhang Y, Derynck R. Transcriptional regulation of the transforming growth factor-β -inducible mouse germ line Ig α constant region gene by functional cooperation of Smad, CREB, and AML family members. J Biol Chem 2000; 275:16979-85.
-
(2000)
J Biol Chem
, vol.275
, pp. 16979-16985
-
-
Zhang, Y.1
Derynck, R.2
-
70
-
-
0026649466
-
Regulation of transcription of the germ-line Ig α constant region gene by an ATF element and by novel transforming growth factor-β 1-responsive elements
-
Lin YC, Stavnezer J. Regulation of transcription of the germ-line Ig α constant region gene by an ATF element and by novel transforming growth factor-β 1-responsive elements. J Immunol 1992; 149:2914-25.
-
(1992)
J Immunol
, vol.149
, pp. 2914-2925
-
-
Lin, Y.C.1
Stavnezer, J.2
-
71
-
-
32044468317
-
B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-β-directed IgA switching and changes in B cell fate
-
Klein J, Ju W, Heyer J et al. B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-β-directed IgA switching and changes in B cell fate. J Immunol 2006; 176:2389-96.
-
(2006)
J Immunol
, vol.176
, pp. 2389-2396
-
-
Klein, J.1
Ju, W.2
Heyer, J.3
-
72
-
-
0034965164
-
Smad3 and Smad4 mediate transforming growth factor-β1-induced IgA expression in murine B lymphocytes
-
Park SR, Lee JH, Kim PH. Smad3 and Smad4 mediate transforming growth factor-β1-induced IgA expression in murine B lymphocytes. Eur J Immunol 2001; 31:1706-15.
-
(2001)
Eur J Immunol
, vol.31
, pp. 1706-1715
-
-
Park, S.R.1
Lee, J.H.2
Kim, P.H.3
-
73
-
-
0033104503
-
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
-
Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H, Roberts AB, Deng C. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J 1999; 18:1280-91.
-
(1999)
EMBO J
, vol.18
, pp. 1280-1291
-
-
Yang, X.1
Letterio, J.J.2
Lechleider, R.J.3
Chen, L.4
Hayman, R.5
Gu, H.6
Roberts, A.B.7
Deng, C.8
-
74
-
-
80053909199
-
Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway
-
Wakabayashi Y, Tamiya T, Takada I et al. Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway. J Biol Chem 2011; 286:35456-65.
-
(2011)
J Biol Chem
, vol.286
, pp. 35456-35465
-
-
Wakabayashi, Y.1
Tamiya, T.2
Takada, I.3
-
75
-
-
0035202540
-
Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells
-
Tzachanis D, Freeman GJ, Hirano N, van Puijenbroek AA, Delfs MW, Berezovskaya A, Nadler LM, Boussiotis VA. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol 2001; 2:1174-82.
-
(2001)
Nat Immunol
, vol.2
, pp. 1174-1182
-
-
Tzachanis, D.1
Freeman, G.J.2
Hirano, N.3
van Puijenbroek, A.A.4
Delfs, M.W.5
Berezovskaya, A.6
Nadler, L.M.7
Boussiotis, V.A.8
-
78
-
-
70449711235
-
Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation
-
Das J, Ren G, Zhang L et al. Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009; 206:2407-16.
-
(2009)
J Exp Med
, vol.206
, pp. 2407-2416
-
-
Das, J.1
Ren, G.2
Zhang, L.3
-
80
-
-
0028077321
-
+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-β and IL-4, and is inhibited by IFN-γ
-
+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-β and IL-4, and is inhibited by IFN-γ. J Immunol 1994; 153:3989-96.
-
(1994)
J Immunol
, vol.153
, pp. 3989-3996
-
-
Schmitt, E.1
Germann, T.2
Goedert, S.3
-
83
-
-
84859997488
-
Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells
-
Elyaman W, Bassil R, Bradshaw EM et al. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity 2012; 36:623-34.
-
(2012)
Immunity
, vol.36
, pp. 623-634
-
-
Elyaman, W.1
Bassil, R.2
Bradshaw, E.M.3
-
84
-
-
78149261083
-
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
-
Grainger JR, Smith KA, Hewitson JP et al. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. J Exp Med 2010; 207:2331-41.
-
(2010)
J Exp Med
, vol.207
, pp. 2331-2341
-
-
Grainger, J.R.1
Smith, K.A.2
Hewitson, J.P.3
-
85
-
-
43449135305
-
H17 cell differentiation by antagonizing RORγt function
-
H17 cell differentiation by antagonizing RORγt function. Nature 2008; 453:236-40.
-
(2008)
Nature
, vol.453
, pp. 236-240
-
-
Zhou, L.1
Lopes, J.E.2
Chong, M.M.3
-
86
-
-
72149124496
-
Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation
-
Martinez GJ, Zhang Z, Chung Y, Reynolds JM, Lin X, Jetten AM, Feng XH, Dong C. Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J Biol Chem 2009; 284:35283-6.
-
(2009)
J Biol Chem
, vol.284
, pp. 35283-35286
-
-
Martinez, G.J.1
Zhang, Z.2
Chung, Y.3
Reynolds, J.M.4
Lin, X.5
Jetten, A.M.6
Feng, X.H.7
Dong, C.8
-
87
-
-
77956552342
-
Smad2 positively regulates the generation of Th17 cells
-
Martinez GJ, Zhang Z, Reynolds JM et al. Smad2 positively regulates the generation of Th17 cells. J Biol Chem 2010; 285:29039-43.
-
(2010)
J Biol Chem
, vol.285
, pp. 29039-29043
-
-
Martinez, G.J.1
Zhang, Z.2
Reynolds, J.M.3
-
88
-
-
77957025756
-
Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I
-
Xu L, Kitani A, Stuelten C, McGrady G, Fuss I, Strober W. Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Immunity 2010; 33:313-25.
-
(2010)
Immunity
, vol.33
, pp. 313-325
-
-
Xu, L.1
Kitani, A.2
Stuelten, C.3
McGrady, G.4
Fuss, I.5
Strober, W.6
-
89
-
-
0043194033
-
Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT
-
Long J, Matsuura I, He D, Wang G, Shuai K, Liu F. Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT. Proc Natl Acad Sci USA 2003; 100:9791-6.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9791-9796
-
-
Long, J.1
Matsuura, I.2
He, D.3
Wang, G.4
Shuai, K.5
Liu, F.6
-
90
-
-
68949149159
-
TGF-β promotes Th17 cell development through inhibition of SOCS3
-
Qin H, Wang L, Feng T et al. TGF-β promotes Th17 cell development through inhibition of SOCS3. J Immunol 2009; 183:97-105.
-
(2009)
J Immunol
, vol.183
, pp. 97-105
-
-
Qin, H.1
Wang, L.2
Feng, T.3
-
91
-
-
84864020480
-
Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes
-
Gronroos E, Kingston IJ, Ramachandran A, Randall RA, Vizan P, Hill CS. Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes. Mol Cell Biol 2012; 32:2904-16.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 2904-2916
-
-
Gronroos, E.1
Kingston, I.J.2
Ramachandran, A.3
Randall, R.A.4
Vizan, P.5
Hill, C.S.6
-
92
-
-
77955498891
-
Smad2 and Smad3 are redundantly essential for the TGF-β-mediated regulation of regulatory T plasticity and Th1 development
-
Takimoto T, Wakabayashi Y, Sekiya T et al. Smad2 and Smad3 are redundantly essential for the TGF-β-mediated regulation of regulatory T plasticity and Th1 development. J Immunol 2010; 185:842-55.
-
(2010)
J Immunol
, vol.185
, pp. 842-855
-
-
Takimoto, T.1
Wakabayashi, Y.2
Sekiya, T.3
-
93
-
-
0034131557
-
Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
-
Gorelik L, Flavell RA. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 2000; 12:171-81.
-
(2000)
Immunity
, vol.12
, pp. 171-181
-
-
Gorelik, L.1
Flavell, R.A.2
-
94
-
-
53349164136
-
The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
-
Sorrentino A, Thakur N, Grimsby S et al. The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol 2008; 10:1199-207.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1199-1207
-
-
Sorrentino, A.1
Thakur, N.2
Grimsby, S.3
-
95
-
-
33746111852
-
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
-
Wan YY, Chi H, Xie M, Schneider MD, Flavell RA. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol 2006; 7:851-8.
-
(2006)
Nat Immunol
, vol.7
, pp. 851-858
-
-
Wan, Y.Y.1
Chi, H.2
Xie, M.3
Schneider, M.D.4
Flavell, R.A.5
-
96
-
-
84863072891
-
Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions
-
Gu AD, Wang Y, Lin L, Zhang SS, Wan YY. Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions. Proc Natl Acad Sci USA 2012; 109:905-10.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 905-910
-
-
Gu, A.D.1
Wang, Y.2
Lin, L.3
Zhang, S.S.4
Wan, Y.Y.5
-
97
-
-
77952777819
-
Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells
-
Lu L, Wang J, Zhang F et al. Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol 2010; 184:4295-306.
-
(2010)
J Immunol
, vol.184
, pp. 4295-4306
-
-
Lu, L.1
Wang, J.2
Zhang, F.3
-
98
-
-
0032544448
-
Smad3 mutant mice develop metastatic colorectal cancer
-
Zhu Y, Richardson JA, Parada LF, Graff JM. Smad3 mutant mice develop metastatic colorectal cancer. Cell 1998; 94:703-14.
-
(1998)
Cell
, vol.94
, pp. 703-714
-
-
Zhu, Y.1
Richardson, J.A.2
Parada, L.F.3
Graff, J.M.4
-
99
-
-
0032934979
-
Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transduction
-
Datto MB, Frederick JP, Pan L, Borton AJ, Zhuang Y, Wang XF. Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transduction. Mol Cell Biol 1999; 19:2495-504.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2495-2504
-
-
Datto, M.B.1
Frederick, J.P.2
Pan, L.3
Borton, A.J.4
Zhuang, Y.5
Wang, X.F.6
-
100
-
-
84862777225
-
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
-
Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, Rudensky AY. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 2012; 482:395-9.
-
(2012)
Nature
, vol.482
, pp. 395-399
-
-
Josefowicz, S.Z.1
Niec, R.E.2
Kim, H.Y.3
Treuting, P.4
Chinen, T.5
Zheng, Y.6
Umetsu, D.T.7
Rudensky, A.Y.8
-
101
-
-
34447503805
-
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
-
Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007; 317:256-60.
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
Park, Y.2
Kim, G.3
Turovskaya, O.4
Scott, I.5
Kronenberg, M.6
Cheroutre, H.7
-
102
-
-
52649179291
-
Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells
-
Samon JB, Champhekar A, Minter LM et al. Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood 2008; 112:1813-21.
-
(2008)
Blood
, vol.112
, pp. 1813-1821
-
-
Samon, J.B.1
Champhekar, A.2
Minter, L.M.3
-
103
-
-
34547757390
-
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
-
Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007; 204:1775-85.
-
(2007)
J Exp Med
, vol.204
, pp. 1775-1785
-
-
Sun, C.M.1
Hall, J.A.2
Blank, R.B.3
Bouladoux, N.4
Oukka, M.5
Mora, J.R.6
Belkaid, Y.7
-
104
-
-
53149137849
-
+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-β-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression
-
+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-β-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol 2008; 181:2277-84.
-
(2008)
J Immunol
, vol.181
, pp. 2277-2284
-
-
Xiao, S.1
Jin, H.2
Korn, T.3
Liu, S.M.4
Oukka, M.5
Lim, B.6
Kuchroo, V.K.7
-
105
-
-
49149104488
-
Notch1 signaling and regulatory T cell function
-
Asano N, Watanabe T, Kitani A, Fuss IJ, Strober W. Notch1 signaling and regulatory T cell function. J Immunol 2008; 180:2796-804.
-
(2008)
J Immunol
, vol.180
, pp. 2796-2804
-
-
Asano, N.1
Watanabe, T.2
Kitani, A.3
Fuss, I.J.4
Strober, W.5
-
106
-
-
39049152572
-
IL-27 inhibits the development of regulatory T cells via STAT3
-
Huber M, Steinwald V, Guralnik A, Brustle A, Kleemann P, Rosenplanter C, Decker T, Lohoff M. IL-27 inhibits the development of regulatory T cells via STAT3. Int Immunol 2008; 20:223-34.
-
(2008)
Int Immunol
, vol.20
, pp. 223-234
-
-
Huber, M.1
Steinwald, V.2
Guralnik, A.3
Brustle, A.4
Kleemann, P.5
Rosenplanter, C.6
Decker, T.7
Lohoff, M.8
-
107
-
-
84355162720
-
Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment
-
Hu W, Troutman TD, Edukulla R, Pasare C. Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment. Immunity 2011; 35:1010-22.
-
(2011)
Immunity
, vol.35
, pp. 1010-1022
-
-
Hu, W.1
Troutman, T.D.2
Edukulla, R.3
Pasare, C.4
-
108
-
-
46749138596
-
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
-
Yang XO, Nurieva R, Martinez GJ et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008; 29:44-56.
-
(2008)
Immunity
, vol.29
, pp. 44-56
-
-
Yang, X.O.1
Nurieva, R.2
Martinez, G.J.3
-
109
-
-
77956546075
-
SMAD2 is essential for TGF β-mediated Th17 cell generation
-
Malhotra N, Robertson E, Kang J. SMAD2 is essential for TGF β-mediated Th17 cell generation. J Biol Chem 2010; 285:29044-8.
-
(2010)
J Biol Chem
, vol.285
, pp. 29044-29048
-
-
Malhotra, N.1
Robertson, E.2
Kang, J.3
-
110
-
-
76749133610
-
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
-
Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010; 463:808-12.
-
(2010)
Nature
, vol.463
, pp. 808-812
-
-
Zheng, Y.1
Josefowicz, S.2
Chaudhry, A.3
Peng, X.P.4
Forbush, K.5
Rudensky, A.Y.6
-
111
-
-
84862621461
-
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
-
Zhang N, Bevan MJ. TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat Immunol 2012; 13:667-73.
-
(2012)
Nat Immunol
, vol.13
, pp. 667-673
-
-
Zhang, N.1
Bevan, M.J.2
-
112
-
-
80053430421
-
Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice
-
Hahn JN, Falck VG, Jirik FR. Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice. J Clin Investig 2011; 121:4030-42.
-
(2011)
J Clin Investig
, vol.121
, pp. 4030-4042
-
-
Hahn, J.N.1
Falck, V.G.2
Jirik, F.R.3
-
113
-
-
33745578957
-
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
-
Kim BG, Li C, Qiao W et al. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature 2006; 441:1015-9.
-
(2006)
Nature
, vol.441
, pp. 1015-1019
-
-
Kim, B.G.1
Li, C.2
Qiao, W.3
-
114
-
-
24344483878
-
Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses
-
Levy L, Hill CS. Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol 2005; 25:8108-25.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 8108-8125
-
-
Levy, L.1
Hill, C.S.2
-
115
-
-
4444249320
-
Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo
-
Chu GC, Dunn NR, Anderson DC, Oxburgh L, Robertson EJ. Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo. Development 2004; 131:3501-12.
-
(2004)
Development
, vol.131
, pp. 3501-3512
-
-
Chu, G.C.1
Dunn, N.R.2
Anderson, D.C.3
Oxburgh, L.4
Robertson, E.J.5
-
116
-
-
67449152496
-
iNKT cell development is orchestrated by different branches of TGF-β signaling
-
Doisne JM, Bartholin L, Yan KP et al. iNKT cell development is orchestrated by different branches of TGF-β signaling. J Exp Med 2009; 206:1365-78.
-
(2009)
J Exp Med
, vol.206
, pp. 1365-1378
-
-
Doisne, J.M.1
Bartholin, L.2
Yan, K.P.3
-
117
-
-
84861980130
-
Interactions between the microbiota and the immune system
-
Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science 2012; 336:1268-73.
-
(2012)
Science
, vol.336
, pp. 1268-1273
-
-
Hooper, L.V.1
Littman, D.R.2
Macpherson, A.J.3
-
118
-
-
84864659874
-
HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria
-
Shui JW, Larange A, Kim G, Vela JL, Zahner S, Cheroutre H, Kronenberg M. HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria. Nature 2012; 488:222-5.
-
(2012)
Nature
, vol.488
, pp. 222-225
-
-
Shui, J.W.1
Larange, A.2
Kim, G.3
Vela, J.L.4
Zahner, S.5
Cheroutre, H.6
Kronenberg, M.7
-
120
-
-
38149047616
-
+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease
-
+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Investig 2008; 118:281-93.
-
(2008)
J Clin Investig
, vol.118
, pp. 281-293
-
-
Bhagat, G.1
Naiyer, A.J.2
Shah, J.G.3
Harper, J.4
Jabri, B.5
Wang, T.C.6
Green, P.H.7
Manavalan, J.S.8
-
121
-
-
80155164160
-
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
-
Li Y, Innocentin S, Withers DR, Roberts NA, Gallagher AR, Grigorieva EF, Wilhelm C, Veldhoen M. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 2011; 147:629-40.
-
(2011)
Cell
, vol.147
, pp. 629-640
-
-
Li, Y.1
Innocentin, S.2
Withers, D.R.3
Roberts, N.A.4
Gallagher, A.R.5
Grigorieva, E.F.6
Wilhelm, C.7
Veldhoen, M.8
-
123
-
-
84859890898
-
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
-
Narayan K, Sylvia KE, Malhotra N et al. Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes. Nat Immunol 2012; 13:511-8.
-
(2012)
Nat Immunol
, vol.13
, pp. 511-518
-
-
Narayan, K.1
Sylvia, K.E.2
Malhotra, N.3
-
124
-
-
29244468256
-
The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs
-
Lambolez F, Arcangeli ML, Joret AM, Pasqualetto V, Cordier C, Di Santo JP, Rocha B, Ezine S. The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs. Nat Immunol 2006; 7:76-82.
-
(2006)
Nat Immunol
, vol.7
, pp. 76-82
-
-
Lambolez, F.1
Arcangeli, M.L.2
Joret, A.M.3
Pasqualetto, V.4
Cordier, C.5
Di Santo, J.P.6
Rocha, B.7
Ezine, S.8
-
125
-
-
0037020246
-
A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes
-
Mysorekar IU, Lorenz RG, Gordon JI. A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes. J Biol Chem 2002; 277:37811-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 37811-37819
-
-
Mysorekar, I.U.1
Lorenz, R.G.2
Gordon, J.I.3
-
127
-
-
0035854790
-
Bcl-xL blocks transforming growth factor-β1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells
-
Chipuk JE, Bhat M, Hsing AY, Ma J, Danielpour D. Bcl-xL blocks transforming growth factor-β1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells. J Biol Chem 2001; 276:26614-21.
-
(2001)
J Biol Chem
, vol.276
, pp. 26614-26621
-
-
Chipuk, J.E.1
Bhat, M.2
Hsing, A.Y.3
Ma, J.4
Danielpour, D.5
-
128
-
-
67749127709
-
Runx1 is a co-activator with FOXO3 to mediate transforming growth factor β (TGFβ)-induced Bim transcription in hepatic cells
-
Wildey GM, Howe PH. Runx1 is a co-activator with FOXO3 to mediate transforming growth factor β (TGFβ)-induced Bim transcription in hepatic cells. J Biol Chem 2009; 284:20227-39.
-
(2009)
J Biol Chem
, vol.284
, pp. 20227-20239
-
-
Wildey, G.M.1
Howe, P.H.2
-
129
-
-
77953267301
-
Transforming growth factor-β signaling curbs thymic negative selection promoting regulatory T cell development
-
Ouyang W, Beckett O, Ma Q, Li MO. Transforming growth factor-β signaling curbs thymic negative selection promoting regulatory T cell development. Immunity 2010; 32:642-53.
-
(2010)
Immunity
, vol.32
, pp. 642-653
-
-
Ouyang, W.1
Beckett, O.2
Ma, Q.3
Li, M.O.4
-
131
-
-
0034644472
-
TGFβ signaling in growth control, cancer, and heritable disorders
-
Massague J, Blain SW, Lo RS. TGFβ signaling in growth control, cancer, and heritable disorders. Cell 2000; 103:295-309.
-
(2000)
Cell
, vol.103
, pp. 295-309
-
-
Massague, J.1
Blain, S.W.2
Lo, R.S.3
-
132
-
-
0029970132
-
Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor α and β
-
Dignass AU, Stow JL, Babyatsky MW. Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor α and β. Gut 1996; 38:687-93.
-
(1996)
Gut
, vol.38
, pp. 687-693
-
-
Dignass, A.U.1
Stow, J.L.2
Babyatsky, M.W.3
-
133
-
-
0037331535
-
Transforming growth factor-β mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells
-
Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK. Transforming growth factor-β mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 2003; 162:597-608.
-
(2003)
Am J Pathol
, vol.162
, pp. 597-608
-
-
Beck, P.L.1
Rosenberg, I.M.2
Xavier, R.J.3
Koh, T.4
Wong, J.F.5
Podolsky, D.K.6
-
134
-
-
14044250862
-
IL-10 gene-deficient mice lack TGF-β/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis
-
Ruiz PA, Shkoda A, Kim SC, Sartor RB, Haller D. IL-10 gene-deficient mice lack TGF-β/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis. J Immunol 2005; 174:2990-9.
-
(2005)
J Immunol
, vol.174
, pp. 2990-2999
-
-
Ruiz, P.A.1
Shkoda, A.2
Kim, S.C.3
Sartor, R.B.4
Haller, D.5
-
135
-
-
33846234333
-
Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation
-
Shkoda A, Ruiz PA, Daniel H, Kim SC, Rogler G, Sartor RB, Haller D. Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation. Gastroenterology 2007; 132:190-207.
-
(2007)
Gastroenterology
, vol.132
, pp. 190-207
-
-
Shkoda, A.1
Ruiz, P.A.2
Daniel, H.3
Kim, S.C.4
Rogler, G.5
Sartor, R.B.6
Haller, D.7
-
136
-
-
14044251499
-
Transforming growth factor-β differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling
-
Naiki Y, Michelsen KS, Zhang W, Chen S, Doherty TM, Arditi M. Transforming growth factor-β differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling. J Biol Chem 2005; 280:5491-5.
-
(2005)
J Biol Chem
, vol.280
, pp. 5491-5495
-
-
Naiki, Y.1
Michelsen, K.S.2
Zhang, W.3
Chen, S.4
Doherty, T.M.5
Arditi, M.6
-
137
-
-
0031941570
-
Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-α plays a critical role in maintaining secondary immunity in the absence of IFN-γ
-
Zhou P, Miller G, Seder RA. Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-α plays a critical role in maintaining secondary immunity in the absence of IFN-γ. J Immunol 1998; 160:1359-68.
-
(1998)
J Immunol
, vol.160
, pp. 1359-1368
-
-
Zhou, P.1
Miller, G.2
Seder, R.A.3
-
138
-
-
0142219250
-
Transforming growth factor (TGF)- β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis
-
Kitani A, Fuss I, Nakamura K, Kumaki F, Usui T, Strober W. Transforming growth factor (TGF)- β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis. J Exp Med 2003; 198:1179-88.
-
(2003)
J Exp Med
, vol.198
, pp. 1179-1188
-
-
Kitani, A.1
Fuss, I.2
Nakamura, K.3
Kumaki, F.4
Usui, T.5
Strober, W.6
-
139
-
-
79955935457
-
Intestinal microbiota in inflammatory bowel disease: friend or foe?
-
Fava F, Danese S. Intestinal microbiota in inflammatory bowel disease: friend or foe? World J Gastroenterol 2011; 17:557-66.
-
(2011)
World J Gastroenterol
, vol.17
, pp. 557-566
-
-
Fava, F.1
Danese, S.2
-
140
-
-
34547789841
-
TGF-β signaling alterations and susceptibility to colorectal cancer
-
R14-R20
-
Xu Y, Pasche B. TGF-β signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet 2007; 16(Spec No 1):R14-20.
-
(2007)
Hum Mol Genet
, vol.16
, Issue.SPEC NO 1
-
-
Xu, Y.1
Pasche, B.2
-
141
-
-
78650310810
-
The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
-
Spits H, Di Santo JP. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol 2011; 12:21-7.
-
(2011)
Nat Immunol
, vol.12
, pp. 21-27
-
-
Spits, H.1
Di Santo, J.P.2
|