Functional Characterization of Transforming Growth Factor β Signaling in Smad2- and Smad3-deficient Fibroblasts

Journal of Biological Chemistry

Volumn 276, Issue 23, 2001, Pages 19945-19953

  Piek, Ester ^a   Ju, Wen Jun ^b   Heyer, Jörg ^b   Escalante Alcalde, Diana ^c   Stewart, Colin L ^c   Weinstein, Michael ^d   Deng, Chuxia ^d   Kucherlapati, Raju ^b   Böttinger, Erwin P ^b   Roberts, Anita B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; PROTEINS; SIGNALING; SYNTHESIS (CHEMICAL);

PHOSPHORYLATION; TRANSFORMING GROWTH FACTOR (TGF);

BIOCHEMISTRY;

ACTIVIN; FIBRONECTIN; GELATINASE A; LUCIFERASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN; PROTEIN C FOS; PROTEIN SMAD BINDING ELEMENT; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; THYMIDINE; TRANSFORMING GROWTH FACTOR BETA1; TRITIUM; UNCLASSIFIED DRUG; CDKN1A PROTEIN, MOUSE; CDKN2B PROTEIN, MOUSE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; CYCLINE; DNA BINDING PROTEIN; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; EMBRYO; FIBROBLAST; GENE TARGETING; GENE TRANSLOCATION; HETEROZYGOSITY LOSS; HOMOZYGOSITY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL DIVISION; CYTOLOGY; GENETIC TRANSCRIPTION; GENETICS; IMMEDIATE EARLY GENE; METABOLISM; MOUSE MUTANT; ONCOGENE;

ANIMALIA;

ANIMALS; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA-BINDING PROTEINS; FIBROBLASTS; GENES, FOS; GENES, IMMEDIATE-EARLY; GENES, REPORTER; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 0035827581     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102382200     Document Type: Article

References (45)

1. Roberts, A. B., and Sporn, M. B. (1990) in Handbook of Experimental Pharmacology, Peptide Growth Factors and Their Receptors (Sporn, M. B., and Roberts, A. B., eds), pp. 419-472. Springer-Verlag, Berlin
2. Heldin, C. H., Miyazono, K., and ten Dijke, P. (1997) Nature 390, 465-471
3. Piek, E., Heldin, C. H., and ten Dijke, P. (1999) FASEB J. 13, 2105-2124
4. Nomura, M., and Li, E. (1998) Nature 393, 786-790
5. Weinstein, M., Yang, X., Li, C., Xu, X., Gotay, J., and Deng, C. X. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9378-9383
6. Waldrip, W. R., Bikoff, E. K., Hoodless, P. A., Wrana, J. L., and Robertson, E. J. (1998) Cell 92, 797-808
7. Heyer, J., Escalante-Alcalde, D., Lia, M., Boettinger, E., Edelmann, W., Stewart, C. L., and Kucherlapati, R. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 12595-12600
8. Datto, M. B., Frederick, J. P., Pan, L., Borton, A. J., Zhuang, Y., and Wang, X. F. (1999) Mol. Cell. Biol. 19, 2495-2504
9. Yang, X., Letterio, J. J., Lechleider, R. J., Chen, L., Hayman, R., Gu, H., Roberts, A. B., and Deng, C. (1999) EMBO J. 18, 1280-1291
10. Ashcroft, G. S., Yang, X., Glick, A. B., Weinstein, M., Letterio, J. L., Mizel, D. E., Anzano, M., Greenwell-Wild, T., Wahl, S. M., Deng, C., and Roberts, A. B. (1999) Nat. Cell Biol. 1, 260-266
11. Zhu, Y., Richardson, J. A., Parada, L. F., and Graff, J. M. (1998) Cell 94, 703-714
12. Glick, A. B., Lee, M. M., Darwiche, N., Kulkarni, A. B., Karlsson, S., and Yuspa, S. H. (1994) Genes Dev. 8, 2429-2440
13. Fujii, M., Takeda, K., Imamura, T., Aoki, H., Sampath, T. K., Enomoto, S., Kawabata, M., Kato, M., Ichijo, H., and Miyazono, K. (1999) Mol. Biol. Cell 10, 3801-3813
14. Brown, P. D., Levy, A. T., Margulies, I. M., Liotta, L. A., and Stetler-Stevenson, W. G. (1990) Cancer Res. 50, 6184-6191
15. Danielpour, D., Dart, L. L., Flanders, K. C., Roberts, A. B., and Sporn, M. B. (1989) J. Cell. Physiol. 138, 79-86
16. Church, G. M., and Gilbert, W. (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 1991-1995
17. Wrana, J. L., Attisano, L., Carcamo, J., Zentella, A., Doody, J., Laiho, M., Wang, X. F., and Massague, J. (1992) Cell 71, 1003-1014
18. Kleiner, D. E., and Stetler-Stevenson, W. G. (1994) Anal. Biochem. 218, 325-329
19. von Gersdorff, G., Susztak, K., Rezvani, F., Bitzer, M., Liang, D., and Bottinger, E. P. (2000) J. Biol. Chem. 275, 11320-11326
20. Chen, X., Rubock, M. J., and Whitman, M. (1996) Nature 383, 691-696
21. Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G., and Whitman, M. (1997) Nature 389, 85-89
22. Labbe, E., Silvestri, C., Hoodless, P. A., Wrana, J. L., and Attisano, L. (1998) Mol. Cell 2, 109-120
23. Nagarajan, R. P., Liu, J., and Chen, Y. (1999) J. Biol. Chem. 274, 31229-31235
24. Sirard, C., Kim, S., Mirtsos, C., Tadich, P., Hoodless, P. A., Iti, Maxson, R., Wrana, J. L., and Mak, T. W. (2000) J. Biol. Chem. 275, 2063-2070
25. Hu, P. P., Datto, M. B., and Wang, X. F. (1998) Endocr. Rev. 19, 349-363
26. Kim, S. J., Angel, P., Lafyatis, R., Hattori, K., Kim, K. Y., Sporn, M. B., Karin, M., and Roberts, A. B. (1990) Mol. Cell. Biol. 10, 1492-1497
27. Yue, J., and Mulder, K. M. (2000) J. Biol. Chem. 275, 30765-30773
28. Hocevar, B. A., Brown, T. L., and Howe, P. H. (1999) EMBO J. 18, 1345-1356
29. Overall, C. M., Wrana, J. L., and Sodek, J. (1991) J. Biol. Chem. 266, 14064-14071
30. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) EMBO J. 17, 3091-3100
31. Dennler, S., Huet, S., and Gauthier, J. M. (1999) Oncogene 18, 1643-1648
32. Yagi, K., Goto, D., Hamamoto, T., Takenoshita, S., Kato, M., and Miyazono, K. (1999) J. Biol. Chem. 274, 703-709
33. Zawel, L., Dai, J. L., Buckhaults, P., Zhou, S., Kinzler, K. W., Vogelstein, B., and Kern, S. E. (1998) Mol. Cell 1, 611-617
34. Jonk, L. J., Itoh, S., Heldin, C. H., ten Dijke, P., and Kruijer, W. (1998) J. Biol. Chem. 273, 21145-21152
35. Shen, X., Li, J., Hu, P. P-c., Waddell, D., Zhang, J., and Wang, X.-F. (2001) J. Biol. Chem. 276, 15362-15368
36. Blain, S. W., and Massague, J. (2000) J. Biol. Chem. 275, 32066-32070
37. Hata, A., Shi, Y., and Massague, J. (1998) Mol. Med. Today 4, 257-262
38. Massague, J. (1998) Annu. Rev. Biochem. 67, 753-791
39. Arai, T., Akiyama, Y., Okabe, S., Ando, M., Endo, M., and Yuasa, Y. (1998) Cancer Lett. 122, 157-163
40. Riggins, G. J., Kinzler, K. W., Vogelstein, B., and Thiagalingam, S. (1997) Cancer Res. 57, 2578-2580
41. Piek, E., and Roberts, A. B. (2001) Adv. Cancer Res., in press
42. de Caestecker, M. P., Piek, E., and Roberts, A. B. (2000) J. Natl. Cancer Inst. 92, 1388-1402
43. Nagarajan, R. P., Zhang, J., Li, W., and Chen, Y. (1999) J. Biol. Chem. 274, 33412-33418
44. Takenoshita, S., Mogi, A., Nagashima, M., Yang, K., Yagi, K., Hanyu, A., Nagamachi, Y., Miyazono, K., and Hagiwara, K. (1998) Genomics 48, 1-11
45. Rich, J. N., Zhang, M., Datto, M. B., Bigner, D. D., and Wang, X. F. (1999) J. Biol. Chem. 274, 35053-35058