Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-smad pathway

Journal of Biological Chemistry

Volumn 286, Issue 41, 2011, Pages 35456-35465

  Wakabayashi, Yu ^a,b   Tamiya, Taiga ^a,b   Takada, Ichiro ^a,b   Fukaya, Tomohiro ^a,b   Sugiyama, Yuki ^a,b   Inoue, Naoko ^a,b   Kimura, Akihiro ^a,b   Morita, Rimpei ^a,b   Kashiwagi, Ikko ^a,b   Takimoto, Tomohito ^a,b   Nomura, Masatoshi ^c   Yoshimura, Akihiko ^a,b  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE SILENCING; HISTONE H3; HISTONE METHYLATION; INTERLEUKIN-2; LYSINE-9; METHYLTRANSFERASES; OVER-EXPRESSION; PROMOTER ACTIVITIES; T CELL RECEPTOR; T CELLS; TRANSFORMING GROWTH FACTORS; TRIMETHYLATION; WILD TYPES;

ALKYLATION; AMINO ACIDS; CELL MEMBRANES; GENES; GENETIC ENGINEERING; METHYLATION; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

HISTONE 3 LYSINE 9 METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE; INTERLEUKIN 2; SHORT HAIRPIN RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HISTONE METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TRANSPORT; RECEPTOR UPREGULATION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; WILD TYPE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; GENE SILENCING; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; INTERLEUKIN-2; METHYLATION; METHYLTRANSFERASES; MICE; MICE, KNOCKOUT; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 80053909199     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.236794     Document Type: Article

References (39)

1. Yoshimura, A., Wakabayashi, Y., and Mori, T. (2010) J. Biochem. 147, 781-792
2. Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A. K., and Flavell, R. A. (2006) Annu. Rev. Immunol. 24, 99-146
3. Wan, Y. Y., and Flavell, R. A. (2007) Immunol. Rev. 220, 199-213
4. Moore, K. W., de Waal Malefyt, R., Coffman, R. L., and O'Garra, A. (2001) Annu. Rev. Immunol. 19, 683-765
5. Li M. O., and Flavell, R. A. (2008) Immunity 28, 468-476
6. Rudner, L. A., Lin, J. T., Park, I. K., Cates, J. M., Dyer, D. A., Franz, D. M., French, M. A., Duncan, E. M., White, H. D., and Gorham, J. D. (2003) J. Immunol. 170, 4785-4792
7. Letterio, J. J., Geiser, A. G., Kulkarni, A. B., Dang, H., Kong, L., Nakabayashi, T., Mackall, C. L., Gress, R. E., and Roberts, A. B. (1996) J. Clin. Invest. 98, 2109-2119
8. Brabletz, T., Pfeuffer, I., Schorr, E., Siebelt, F., Wirth, T., and Serfling, E. (1993) Mol. Cell. Biol. 13, 1155-1162
9. Massagué, J. (1998) Annu. Rev. Biochem. 67, 753-791
10. Derynck, R., and Zhang, Y. E. (2003) Nature 425, 577-584
11. Yang, X. O., Nurieva, R., Martinez, G. J., Kang, H. S., Chung, Y., Pappu, B. P., Shah, B., Chang, S. H., Schluns, K. S., Watowich, S. S., Feng, X. H., Jetten, A. M., and Dong, C. (2008) Immunity 29, 44-56
12. Nomura, M., and Li, E. (1998) Nature 393, 737-730
13. Yang, X., Letterio, J. J., Lechleider, R. J., Chen, L., Hayman, R., Gu, H., Roberts, A. B., and Deng, C. (1999) EMBO J. 18, 1280-1291
14. Takimoto, T., Wakabayashi, Y., Sekiya, T., Inoue, N., Morita, R., Ichiyama, K., Takahashi, R., Asakawa, M., Muto, G., Mori, T., Hasegawa, E., Saika, S., Hara, T., Nomura, M., Yoshimura, A. (2010) J. Immunol. 185, 842-855
15. Wei, G., Wei, L., Zhu, J., Zang, C., Hu-Li, J., Yao, Z., Cui, K., Kanno, Y., Roh, T. Y., Watford, W. T., Schones, D. E., Peng, W., Sun, H. W., Paul, W. E., O'Shea, J. J., and Zhao, K. (2009) Immunity 30, 155-167
16. Tzachanis, D., Freeman, G. J., Hirano, N., van Puijenbroek, A. A., Delfs, M. W., Berezovskaya, A., Nadler, L. M., and Boussiotis, V. A. (2001) Nat. Immunol. 2, 1174-1182
17. Miyazono, K., Maeda, S., and Imamura, T. (2004) Oncogene 23, 4232-4237
18. Takaki, H., Ichiyama, K., Koga, K., Chinen, T., Takaesu, G., Sugiyama, Y., Kato, S., Yoshimura, A., and Kobayashi, T. (2008) J. Biol. Chem. 283, 14955-14962
19. Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M. L., Greene, M. I., and Tone, M. (2008) Nat Immunol. 9, 194-202
20. Wilson, C. B., Rowell, E., and Sekimata, M. (2009) Nat Rev Immunol. 9, 91-105
21. Ruthenburg, A. J., Li, H., Patel, D. J., and Allis, C. D. (2007) Nat. Rev. Mol. Cell Biol. 8, 983-994
22. Ichiyama, K., Yoshida, H., Wakabayashi, Y., Chinen, T., Saeki, K., Nakaya, M., Takaesu, G., Hori, S., Yoshimura, A., and Kobayashi, T. (2008) J. Biol. Chem. 283, 17003-17008
23. Koga, K., Takaesu, G., Yoshida, R., Nakaya, M., Kobayashi, T., Kinjyo, I., and Yoshimura, A. (2009) Immunity 30, 372-383
24. Chinen, T., Komai, K., Muto, G., Morita, R., Inoue, N., Yoshida, H., Sekiya, T., Yoshida, R., Nakamura, K., Takayanagi, R., and Yoshimura, A. (2011) Nat. Commun. 2, 190
25. Tanaka, K., Ichiyama, K., Hashimoto, M., Yoshida, H., Takimoto, T., Takaesu, G., Torisu, T., Hanada, T., Yasukawa, H., Fukuyama, S., Inoue, H., Nakanishi, Y., Kobayashi. T., and Yoshimura, A. (2008) J. Immunol. 180, 3746-3756
26. Yoshida, R., Takaesu, G., Yoshida, H., Okamoto, F., Yoshioka, T., Choi, Y., Akira, S., Kawai, T., Yoshimura, A., and Kobayashi, T. (2008) J. Biol. Chem. 283, 36211-36220
27. Ichiyama, K., Sekiya, T., Inoue, N., Tamiya, T., Kashiwagi, I., Kimura, A., Morita, R., Muto, G., Shichita, T., Takahashi, R., and Yoshimura, A. (2011) Immunity 34, 741-754
28. Nonami, A., Taketomi, T., Kimura, A., Saeki, K., Takaki, H., Sanada, T., Taniguchi, K., Harada, M., Kato, R., and Yoshimura, A. (2005) Genes Cells 10, 887-895
29. Sekiya, T., Kashiwagi, I., Inoue, N., Morita, R., Hori, S., Waldmann, H., Rudensky, A. Y., Ichinose, H., Metzger, D., Chambon, P., and Yoshimura, A. (2011) Nat. Commun. 2, 269
30. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) EMBO J. 17, 3091-3100
31. Shi, Y., Wang, Y. F., Jayaraman, L., Yang, H., Massagué, J., and Pavletich, N. P. (1998) Cell 94, 585-594
32. Berger, S. L. (2007) Nature 447, 407-412
33. Datto, M. B., Frederick, J. P., Pan, L., Borton, A. J., Zhuang, Y., and Wang, X. F. (1999) Mol. Cell. Biol. 19, 2495-2504
34. McKarns, S. C., Schwartz, R. H., and Kaminski, N. E. (2004) J. Immunol. 172, 4275-4284
35. Shen, X., Hu, P. P., Liberati, N. T., Datto, M. B., Frederick, J. P., and Wang, X. F. (1998) Mol. Biol. Cell 9, 3309-3319
36. Ward, S. B., Hernandez-Hoyos, G., Chen, F., Waterman, M., Reeves, R., Rothenberg, E. V. (1998) Nucleic Acids Res. 26, 2923-2934
37. Yamamura, Y., Hua, X., Bergelson, S., and Lodish, H. F. (2000) J. Biol. Chem. 275, 36295-36302
38. López-Rovira, T., Chalaux, E., Rosa, J. L., Bartrons, R., and Ventura, F. (2000) J. Biol. Chem. 275, 28937-28946
39. Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X. P., Forbush, K., and Rudensky, A. Y. (2010) Nature. 463, 808-812