TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

Nature Immunology

Volumn 13, Issue 7, 2012, Pages 667-673

  Zhang, Nu ^a   Bevan, Michael J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD45; AUTOIMMUNITY; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; LYMPHOCYTE ACTIVATION; LYMPHOPENIA; LYMPHOPROLIFERATIVE DISORDERS; MALE; MICE; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84862621461     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2319     Document Type: Article

References (37)

1. Li, M.O., Wan, Y.Y., Sanjabi, S., Robertson, A.K. & Flavell, R.A. Transforming growth factor-β regulation of immune responses. Annu. Rev. Immunol. 24, 99-146 (2006).
2. Massagué, J. TGFβ in cancer. Cell 134, 215-230 (2008).
3. Blobe, G.C., Schiemann, W.P. & Lodish, H.F. Role of transforming growth factor β in human disease. N. Engl. J. Med. 342, 1350-1358 (2000).
4. Hill, C.S. Nucleocytoplasmic shuttling of Smad proteins. Cell Res. 19, 36-46 (2009).
5. Zhang, Y.E. Non-Smad pathways in TGF-β signaling. Cell Res. 19, 128-139 (2009).
6. Ikushima, H. & Miyazono, K. TGFβ signalling: a complex web in cancer progression. Nat. Rev. Cancer 10, 415-424 (2010).
7. Yang, L., Pang, Y. & Moses, H.L. TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol. 31, 220-227 (2010).
8. Kulkarni, A.B. et al. Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA 90, 770-774 (1993).
9. Shull, M.M. et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359, 693-699 (1992).
10. Diebold, R.J. et al. Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated. Proc. Natl. Acad. Sci. USA 92, 12215-12219 (1995).
11. + T cells but not B cells eliminates inflammation and prolongs the survival of TGFβ1-deficient mice. Cell. Immunol. 232, 96-104 (2004).
12. + T cells. J. Immunol. 170, 4785-4792 (2003).
13. Letterio, J.J. et al. Autoimmunity associated with TGF-β1-deficiency in mice is dependent on MHC class II antigen expression. J. Clin. Invest. 98, 2109-2119 (1996).
14. Gorelik, L. & Flavell, R.A. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12, 171-181 (2000).
15. Lucas, P.J., Kim, S.J., Melby, S.J. & Gress, R.E. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor βII receptor. J. Exp. Med. 191, 1187-1196 (2000).
16. Li, M.O., Sanjabi, S. & Flavell, R.A. Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25, 455-471 (2006).
17. Marie, J.C., Liggitt, D. & Rudensky, A.Y. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor. Immunity 25, 441-454 (2006).
18. + regulatory T cells. Nat. Immunol. 4, 330-336 (2003).
19. Li, M.O., Wan, Y.Y. & Flavell, R.A. T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26, 579-591 (2007).
20. + regulatory T cells. Nat. Immunol. 9, 632-640 (2008).
21. + regulatory T cells. J. Exp. Med. 201, 1061-1067 (2005).
22. Starr, T.K., Jameson, S.C. & Hogquist, K.A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21, 139-176 (2003).
23. Sprent, J. & Surh, C.D. Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat. Immunol. 12, 478-484 (2011).
24. Kieper, W.C. et al. Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J. Immunol. 174, 3158-3163 (2005).
25. Min, B., Yamane, H., Hu-Li, J. & Paul, W.E. Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. J. Immunol. 174, 6039-6044 (2005).
26. King, C., Ilic, A., Koelsch, K. & Sarvetnick, N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117, 265-277 (2004).
27. Krupica, T. Jr., Fry, T.J. & Mackall, C.L. Autoimmunity during lymphopenia: a two-hit model. Clin. Immunol. 120, 121-128 (2006).
28. Le Campion, A. et al. Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development. Blood 114, 1784-1793 (2009).
29. Hale, J.S., Ames, K.T., Boursalian, T.E. & Fink, P.J. Cutting edge: Rag deletion in peripheral T cells blocks TCR revision. J. Immunol. 184, 5964-5968 (2010).
30. Zhang, D.J. et al. Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene. J. Immunol. 174, 6725-6731 (2005).
31. + T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease. J. Exp. Med. 201, 1647-1657 (2005).
32. Feng, T., Wang, L., Schoeb, T.R., Elson, C.O. & Cong, Y. Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J. Exp. Med. 207, 1321-1332 (2010).
33. Zehn, D., Lee, S.Y. & Bevan, M.J. Complete but curtailed T-cell response to very low-affinity antigen. Nature 458, 211-214 (2009).
34. Doisne, J.M. et al. iNKT cell development is orchestrated by different branches of TGF-β signaling. J. Exp. Med. 206, 1365-1378 (2009).
35. Ouyang, W., Beckett, O., Ma, Q. & Li, M.O. Transforming growth factor-β signaling curbs thymic negative selection promoting regulatory T cell development. Immunity 32, 642-653 (2010).
36. Daniels, M.A. et al. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444, 724-729 (2006).
37. + proliferation in vivo. Blood 106, 4234-4240 (2005).