메뉴 건너뛰기




Volumn 94, Issue 6, 1998, Pages 703-714

Smad3 mutant mice develop metastatic colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MUTANT PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 0032544448     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81730-4     Document Type: Article
Times cited : (528)

References (63)
  • 1
    • 0032498328 scopus 로고    scopus 로고
    • Genomic structure of human Smad3 gene and its infrequent alterations in colorectal cancers
    • Arai, T., Akiyama, Y., Okabe, S., Ando, M., Endo, M., and Yuasa, Y. (1998). Genomic structure of human Smad3 gene and its infrequent alterations in colorectal cancers. Cancer Lett. 122, 157-163.
    • (1998) Cancer Lett. , vol.122 , pp. 157-163
    • Arai, T.1    Akiyama, Y.2    Okabe, S.3    Ando, M.4    Endo, M.5    Yuasa, Y.6
  • 2
    • 0029829230 scopus 로고    scopus 로고
    • A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway
    • Baker, J.C., and Harland, R.M. (1996). A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev. 10, 1880-1889.
    • (1996) Genes Dev. , vol.10 , pp. 1880-1889
    • Baker, J.C.1    Harland, R.M.2
  • 3
    • 0028349997 scopus 로고
    • Targeted disruption of the neurofibromatosis type-1 gene leads to abnormalities in heart and various neural crest-derived tissues
    • Brannan, C., Perkins, A., Vogel, K., Ratner, N., Nordlund, M., Reid, S., Buchberg, A., Jenkins, N., Parada, L., and Copeland, N. (1994). Targeted disruption of the neurofibromatosis type-1 gene leads to abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8, 1019-1029.
    • (1994) Genes Dev. , vol.8 , pp. 1019-1029
    • Brannan, C.1    Perkins, A.2    Vogel, K.3    Ratner, N.4    Nordlund, M.5    Reid, S.6    Buchberg, A.7    Jenkins, N.8    Parada, L.9    Copeland, N.10
  • 4
    • 0002628002 scopus 로고    scopus 로고
    • Sleisenger and Fordtran's Gastrointestinal and Liver Disease, M. Feldman, B. Scharschmidt, and M. Sleisenger, eds. (Philadelphia: W.B. Saunders and Company)
    • Bresalier, R., and Kim, Y. (1998). Malignant neoplasms of the large intestine. In Sleisenger and Fordtran's Gastrointestinal and Liver Disease, M. Feldman, B. Scharschmidt, and M. Sleisenger, eds. (Philadelphia: W.B. Saunders and Company), pp. 1906-1942.
    • (1998) Malignant Neoplasms of the Large Intestine , pp. 1906-1942
    • Bresalier, R.1    Kim, Y.2
  • 5
  • 6
    • 0030663881 scopus 로고    scopus 로고
    • Cellular interpretation of multiple TGF-β signals: Intracellular antagonism between activin/ BVg1 and BMP-2/4 signaling mediated by Smads
    • Candia, A., Watabe, T., Hawley, S., Onichtchouk, D., Zhang, Y., Derynck, R., Niehrs, C., and Cho, C. (1997). Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/ BVg1 and BMP-2/4 signaling mediated by Smads. Development 124, 4467-4480.
    • (1997) Development , vol.124 , pp. 4467-4480
    • Candia, A.1    Watabe, T.2    Hawley, S.3    Onichtchouk, D.4    Zhang, Y.5    Derynck, R.6    Niehrs, C.7    Cho, C.8
  • 8
    • 0000513018 scopus 로고    scopus 로고
    • Cancer of the colon
    • V. Devita, S. Hellman, and S. Rosenberg, eds. (Philadelphia: Lippincott-Raven)
    • Cohen, A., Minsky, B., and Schilisky, R. (1997). Cancer of the colon. In Cancer: Principles and Practice of Oncology, V. Devita, S. Hellman, and S. Rosenberg, eds. (Philadelphia: Lippincott-Raven), pp. 1144-1197.
    • (1997) Cancer: Principles and Practice of Oncology , pp. 1144-1197
    • Cohen, A.1    Minsky, B.2    Schilisky, R.3
  • 9
    • 0028173316 scopus 로고
    • TGF-β-receptor-mediated signaling
    • Derynck, R. (1994). TGF-β-receptor-mediated signaling. Trends Biol. Sci. 19, 548-553.
    • (1994) Trends Biol. Sci. , vol.19 , pp. 548-553
    • Derynck, R.1
  • 10
    • 0030265714 scopus 로고    scopus 로고
    • Intracellular signaling: The Mad way to do it
    • Derynck, R., and Zhang, Y. (1996). Intracellular signaling: the Mad way to do it. Curr. Biol. 6, 1226-1229.
    • (1996) Curr. Biol. , vol.6 , pp. 1226-1229
    • Derynck, R.Z.Y.1
  • 11
    • 0029074681 scopus 로고
    • Defective haemotopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
    • Dickson, M., Martin, J., Cousins, F., Kulkarni, A., Karlsson, S., and Akhurst, R. (1995). Defective haemotopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice. Development 121, 1845-1854.
    • (1995) Development , vol.121 , pp. 1845-1854
    • Dickson, M.1    Martin, J.2    Cousins, F.3    Kulkarni, A.4    Karlsson, S.5    Akhurst, R.6
  • 12
    • 0027363063 scopus 로고
    • Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse
    • Dietrich, W., Lander, E., Smith, J., Moser, A., Gould, K., Luongo, C., Borenstein, N., and Dove, W. (1993). Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 75, 631-639.
    • (1993) Cell , vol.75 , pp. 631-639
    • Dietrich, W.1    Lander, E.2    Smith, J.3    Moser, A.4    Gould, K.5    Luongo, C.6    Borenstein, N.7    Dove, W.8
  • 13
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower, L., Harvey, M., Slagle, B., McArthur, M., Montgomery, C., Butel, J., and Bradley, A. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.1    Harvey, M.2    Slagle, B.3    McArthur, M.4    Montgomery, C.5    Butel, J.6    Bradley, A.7
  • 16
    • 0030969573 scopus 로고    scopus 로고
    • Embryonic patterning: To BMP or not to BMP that is the question
    • Graff, J. (1997). Embryonic patterning: to BMP or not to BMP that is the question. Cell 89, 171-174.
    • (1997) Cell , vol.89 , pp. 171-174
    • Graff, J.1
  • 17
    • 0029940972 scopus 로고    scopus 로고
    • Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily
    • Graff, J., Bansal, A., and Melton, D. (1996). Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily. Cell 85, 479-487.
    • (1996) Cell , vol.85 , pp. 479-487
    • Graff, J.1    Bansal, A.2    Melton, D.3
  • 19
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signaling from cell membrane to nucleus through SMAD proteins
    • Heldin, C., Miyazono, K., and ten Dijke, P. (1997). TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.1    Miyazono, K.2    Ten Dijke, P.3
  • 21
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Ionov, Y., Peinado, M., Malkhosyan, S., Shibata, D., and Perucho, M. (1993). Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363, 558-561.
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 24
    • 0028307836 scopus 로고
    • Tumor predisposition in mice heterozygous for a targeted mutation in Nf1
    • Jacks, T., Shih, T., Schmitt, E., Bronson, R., Bernards, A., and Weinberg, R. (1994b). Tumor predisposition in mice heterozygous for a targeted mutation in Nf1. Nat. Genet. 7, 353-361.
    • (1994) Nat. Genet. , vol.7 , pp. 353-361
    • Jacks, T.1    Shih, T.2    Schmitt, E.3    Bronson, R.4    Bernards, A.5    Weinberg, R.6
  • 25
    • 0028328372 scopus 로고
    • Colon cancer and DNA repair: Have mismatches met their match?
    • Jirciny, J. (1994). Colon cancer and DNA repair: have mismatches met their match? Trends Genet. 10, 164-168.
    • (1994) Trends Genet. , vol.10 , pp. 164-168
    • Jirciny, J.1
  • 26
    • 0028806184 scopus 로고
    • Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction
    • Kaartinen, V., Voncken, J., Shuler, C., Warburton, D., Bu, D., Heisterkamp, N., and Groffen, J. (1995). Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat. Genet. 11, 415-421.
    • (1995) Nat. Genet. , vol.11 , pp. 415-421
    • Kaartinen, V.1    Voncken, J.2    Shuler, C.3    Warburton, D.4    Bu, D.5    Heisterkamp, N.6    Groffen, J.7
  • 27
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K., and Vogelstein, B. (1996). Lessons from hereditary colorectal cancer. Cell 87, 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.1    Vogelstein, B.2
  • 28
    • 0024513250 scopus 로고
    • The mRNA encoding elongation factor 1α (EF-1α) is a major transcript at the mid blastula transition in Xenopus
    • Krieg, P.A., Varnum, S., Wormington, M., and Melton, D.A. (1989). The mRNA encoding elongation factor 1α (EF-1α) is a major transcript at the mid blastula transition in Xenopus. Dev. Biol. 133, 93-100.
    • (1989) Dev. Biol. , vol.133 , pp. 93-100
    • Krieg, P.A.1    Varnum, S.2    Wormington, M.3    Melton, D.A.4
  • 32
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoieses
    • Lee, E., Chang, C., Hu, N., Wang, Y., Lai, C., Herrup, K., Lee, W., and Bradley, A. (1992). Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoieses. Nature 359, 288-294.
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.1    Chang, C.2    Hu, N.3    Wang, Y.4    Lai, C.5    Herrup, K.6    Lee, W.7    Bradley, A.8
  • 33
    • 0029931509 scopus 로고    scopus 로고
    • A human Mad protein acting as a BMP-regulated transcriptional activator
    • Liu, F., Hata, A., Baker, J., Doody, J., Caracamo, J., Harland, R., and Massague, J. (1996). A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620-623.
    • (1996) Nature , vol.381 , pp. 620-623
    • Liu, F.1    Hata, A.2    Baker, J.3    Doody, J.4    Caracamo, J.5    Harland, R.6    Massague, J.7
  • 34
    • 0030886204 scopus 로고    scopus 로고
    • Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
    • Liu, X., Sun, Y., Constantinescu, S., Karam, E., Weinberg, R., and Lodish, H. (1997). Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl. Acad. Sci. USA 94, 10669-10674.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10669-10674
    • Liu, X.1    Sun, Y.2    Constantinescu, S.3    Karam, E.4    Weinberg, R.5    Lodish, H.6
  • 37
    • 0030604542 scopus 로고    scopus 로고
    • TGFβ signaling: Receptors, transducers, and Mad proteins
    • Massague, J. (1996). TGFβ signaling: receptors, transducers, and Mad proteins. Cell 85, 947-950.
    • (1996) Cell , vol.85 , pp. 947-950
    • Massague, J.1
  • 41
    • 0030579203 scopus 로고    scopus 로고
    • TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
    • Oshima, M., Oshima, H., and Taketo, M. (1996). TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev. Biol. 179, 297-302.
    • (1996) Dev. Biol. , vol.179 , pp. 297-302
    • Oshima, M.1    Oshima, H.2    Taketo, M.3
  • 45
    • 0029868841 scopus 로고    scopus 로고
    • Negative regulation of cell growth by TGFβ
    • Polyak, K. (1996). Negative regulation of cell growth by TGFβ. Biochim. Biophys. Acta 1242, 185-199.
    • (1996) Biochim. Biophys. Acta , vol.1242 , pp. 185-199
    • Polyak, K.1
  • 51
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su, L., Kinzler, K., Vogelstein, B., Preisinger, A., Mosher, A., Luongo, C., Gould, K., and Dove, W. (1992). Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256, 658-670.
    • (1992) Science , vol.256 , pp. 658-670
    • Su, L.1    Kinzler, K.2    Vogelstein, B.3    Preisinger, A.4    Mosher, A.5    Luongo, C.6    Gould, K.7    Dove, W.8
  • 53
    • 0032489508 scopus 로고    scopus 로고
    • Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    • Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M., and Taketo, M. (1998). Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92, 645-656.
    • (1998) Cell , vol.92 , pp. 645-656
    • Takaku, K.1    Oshima, M.2    Miyoshi, H.3    Matsui, M.4    Seldin, M.5    Taketo, M.6
  • 56
    • 0032549806 scopus 로고    scopus 로고
    • Smad2 signaling in extraembryonic tissues determines the anterior-posterior polarity of the early mouse embryo
    • Waldrip, W., Bikoff, E., Hoodless, P., Wrana, J., and Robertson, E. (1998). Smad2 signaling in extraembryonic tissues determines the anterior-posterior polarity of the early mouse embryo. Cell 92, 797-808.
    • (1998) Cell , vol.92 , pp. 797-808
    • Waldrip, W.1    Bikoff, E.2    Hoodless, P.3    Wrana, J.4    Robertson, E.5
  • 57
    • 0030890656 scopus 로고    scopus 로고
    • Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth
    • Wang, H., and Anderson, D. (1997). Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron 18, 383-396.
    • (1997) Neuron , vol.18 , pp. 383-396
    • Wang, H.1    Anderson, D.2
  • 58
    • 0029131403 scopus 로고
    • Demonstration that mutation of the type II transforming growth factor β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells
    • Wang, J., Sun, L., Myeroff, L., Wang, X., Gentry, L., Yang, J., Liang, J., Zbrowska, E., Markowitz, S., Wilson, J., and Brattain, M. (1995). Demonstration that mutation of the type II transforming growth factor β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J. Biol. Chem. 270, 22044-22049.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22044-22049
    • Wang, J.1    Sun, L.2    Myeroff, L.3    Wang, X.4    Gentry, L.5    Yang, J.6    Liang, J.7    Zbrowska, E.8    Markowitz, S.9    Wilson, J.10    Brattain, M.11
  • 59
    • 0032489549 scopus 로고    scopus 로고
    • Tumor suppressing pathways
    • White, R. (1998). Tumor suppressing pathways. Cell 92, 591-592.
    • (1998) Cell , vol.92 , pp. 591-592
    • White, R.1
  • 61
    • 0029842713 scopus 로고    scopus 로고
    • MAD-related proteins in TGFβ signaling
    • Wrana, J., and Attisano, L. (1996). MAD-related proteins in TGFβ signaling. Trends Genet. 12, 493-496.
    • (1996) Trends Genet. , vol.12 , pp. 493-496
    • Wrana, J.1    Attisano, L.2
  • 62
    • 0032584068 scopus 로고    scopus 로고
    • The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
    • Yang, X., Li, C., Xu, X., and Deng, C. (1998). The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc. Natl. Acad. Sci. USA 95, 3667-3672.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3667-3672
    • Yang, X.1    Li, C.2    Xu, X.3    Deng, C.4
  • 63
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGFβ response
    • Zhang, Y., Feng, X., Wu, R., and Derynck, R. (1996). Receptor-associated Mad homologues synergize as effectors of the TGFβ response. Nature 383, 168-172.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.2    Wu, R.3    Derynck, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.