메뉴 건너뛰기




Volumn 32, Issue 14, 2012, Pages 2904-2916

Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated smad1/5-smad3 complexes

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD1 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

EID: 84864020480     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00231-12     Document Type: Article
Times cited : (84)

References (56)
  • 1
    • 79959891289 scopus 로고    scopus 로고
    • Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities
    • Agricola E, Randall RA, Gaarenstroom T, Dupont S, Hill CS. 2011. Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Mol. Cell 43:85-96.
    • (2011) Mol. Cell , vol.43 , pp. 85-96
    • Agricola, E.1    Randall, R.A.2    Gaarenstroom, T.3    Dupont, S.4    Hill, C.S.5
  • 2
    • 70350780570 scopus 로고    scopus 로고
    • Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways
    • Alarcón C, et al. 2009. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways. Cell 139:757-769.
    • (2009) Cell , vol.139 , pp. 757-769
    • Alarcón, C.1
  • 3
    • 58549091280 scopus 로고    scopus 로고
    • BMP7 influences proliferation, migration, and invasion of breast cancer cells
    • Alarmo EL, et al. 2009. BMP7 influences proliferation, migration, and invasion of breast cancer cells. Cancer Lett. 275:35- 43.
    • (2009) Cancer Lett , vol.275 , pp. 35-43
    • Alarmo, E.L.1
  • 4
    • 0033195998 scopus 로고    scopus 로고
    • Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    • Ashcroft GS, et al. 1999. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat. Cell Biol. 1:260 -266.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 260-266
    • Ashcroft, G.S.1
  • 5
    • 77953728005 scopus 로고    scopus 로고
    • Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors
    • BabuRajendran N, et al. 2010. Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors. Nucleic Acids Res. 38:3477-3488.
    • (2010) Nucleic Acids Res , vol.38 , pp. 3477-3488
    • BabuRajendran, N.1
  • 6
    • 40949083607 scopus 로고    scopus 로고
    • Cancer-associated transforming growth factor β type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype
    • Bharathy S, Xie W, Yingling JM, Reiss M. 2008. Cancer-associated transforming growth factor β type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype. Cancer Res. 68:1656 -1666.
    • (2008) Cancer Res , vol.68 , pp. 1656-1666
    • Bharathy, S.1    Xie, W.2    Yingling, J.M.3    Reiss, M.4
  • 7
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor β in human disease
    • Blobe GC, Schiemann WP, Lodish HF. 2000. Role of transforming growth factor β in human disease. N. Engl. J. Med. 342:1350 -1358.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 8
    • 0030663881 scopus 로고    scopus 로고
    • Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads
    • Candia AF, et al. 1997. Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development 124:4467- 4480.
    • (1997) Development , vol.124 , pp. 4467-4480
    • Candia, A.F.1
  • 9
    • 55849145475 scopus 로고    scopus 로고
    • Transforming growth factor β-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth
    • Daly AC, Randall RA, Hill CS. 2008. Transforming growth factor β-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth. Mol. Cell. Biol. 28:6889-6902.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 6889-6902
    • Daly, A.C.1    Randall, R.A.2    Hill, C.S.3
  • 10
    • 77949903708 scopus 로고    scopus 로고
    • Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-beta responses
    • Daly AC, Vizan P, Hill CS. 2010. Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-beta responses. J. Biol. Chem. 285:6489-6497.
    • (2010) J. Biol. Chem. , vol.285 , pp. 6489-6497
    • Daly, A.C.1    Vizan, P.2    Hill, C.S.3
  • 11
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennler S, et al. 1998. Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17:3091-3100.
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1
  • 12
    • 33645907529 scopus 로고    scopus 로고
    • A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos
    • Dorey K, Hill CS. 2006. A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos. Dev. Biol. 292:303-316.
    • (2006) Dev. Biol. , vol.292 , pp. 303-316
    • Dorey, K.1    Hill, C.S.2
  • 13
    • 0035918274 scopus 로고    scopus 로고
    • Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation
    • Ebisawa T, et al. 2001. Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276:12477-12480.
    • (2001) J. Biol. Chem. , vol.276 , pp. 12477-12480
    • Ebisawa, T.1
  • 14
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-β signaling through Smads
    • Feng XH, Derynck R. 2005. Specificity and versatility in TGF-β signaling through Smads. Annu. Rev. Cell Dev. Biol. 21:659-693.
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 15
    • 77953802146 scopus 로고    scopus 로고
    • Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells
    • Galvin KE, Travis ED, Yee D, Magnuson T, Vivian JL. 2010. Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J. Biol. Chem. 285:19747-19756.
    • (2010) J. Biol. Chem. , vol.285 , pp. 19747-19756
    • Galvin, K.E.1    Travis, E.D.2    Yee, D.3    Magnuson, T.4    Vivian, J.L.5
  • 16
    • 33748756707 scopus 로고    scopus 로고
    • Decapentaplegic-responsive silencers contain overlapping mad-binding sites
    • Gao S, Laughon A. 2006. Decapentaplegic-responsive silencers contain overlapping mad-binding sites. J. Biol. Chem. 281:25781-25790.
    • (2006) J. Biol. Chem. , vol.281 , pp. 25781-25790
    • Gao, S.1    Laughon, A.2
  • 17
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: open software development for computational biology and bioinformatics
    • Gentleman RC, et al. 2004. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5:R80.
    • (2004) Genome Biol , vol.5
    • Gentleman, R.C.1
  • 18
    • 0034007925 scopus 로고    scopus 로고
    • Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif
    • Germain S, Howell M, Esslemont GM, Hill CS. 2000. Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev. 14:435- 451.
    • (2000) Genes Dev , vol.14 , pp. 435-451
    • Germain, S.1    Howell, M.2    Esslemont, G.M.3    Hill, C.S.4
  • 19
    • 0033625416 scopus 로고    scopus 로고
    • Functional analysis of the TGFβ receptor/ Smad pathway through gene ablation in mice
    • Goumans MJ, Mummery C. 2000. Functional analysis of the TGFβ receptor/ Smad pathway through gene ablation in mice. Int. J. Dev. Biol. 44:253-265.
    • (2000) Int. J. Dev. Biol. , vol.44 , pp. 253-265
    • Goumans, M.J.1    Mummery, C.2
  • 20
    • 0037007226 scopus 로고    scopus 로고
    • Balancing the activation state of the endothelium via two distinct TGF-β type I receptors
    • Goumans MJ, et al. 2002. Balancing the activation state of the endothelium via two distinct TGF-β type I receptors. EMBO J. 21:1743-1753.
    • (2002) EMBO J , vol.21 , pp. 1743-1753
    • Goumans, M.J.1
  • 21
    • 33751160409 scopus 로고    scopus 로고
    • ID proteins as targets in cancer and tools in neurobiology
    • Iavarone A, Lasorella A. 2006. ID proteins as targets in cancer and tools in neurobiology. Trends Mol. Med. 12:588 -594.
    • (2006) Trends Mol. Med. , vol.12 , pp. 588-594
    • Iavarone, A.1    Lasorella, A.2
  • 22
    • 0037185010 scopus 로고    scopus 로고
    • Stoichiometry of active Smad-transcription factor complexes on DNA
    • Inman GJ, Hill CS. 2002. Stoichiometry of active Smad-transcription factor complexes on DNA. J. Biol. Chem. 277:51008 -51016.
    • (2002) J. Biol. Chem. , vol.277 , pp. 51008-51016
    • Inman, G.J.1    Hill, C.S.2
  • 23
    • 0036085920 scopus 로고    scopus 로고
    • SB- 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman GJ, et al. 2002. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62:65-74.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 65-74
    • Inman, G.J.1
  • 24
    • 12344280017 scopus 로고    scopus 로고
    • Summaries of Affymetrix GeneChip probe level data
    • Irizarry RA, et al. 2003. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 31:e15.
    • (2003) Nucleic Acids Res , vol.31
    • Irizarry, R.A.1
  • 26
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • Kang Y, Chen CR, Massagué J. 2003. A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell 11:915-926.
    • (2003) Mol. Cell , vol.11 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massagué, J.3
  • 27
    • 0034517389 scopus 로고    scopus 로고
    • Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation
    • Kavsak P, et al. 2000. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation. Mol. Cell 6:1365- 1375.
    • (2000) Mol. Cell , vol.6 , pp. 1365-1375
    • Kavsak, P.1
  • 28
    • 78650706502 scopus 로고    scopus 로고
    • Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing
    • Kawakatsu M, et al. 2011. Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing. Exp. Mol. Pathol. 90: 107-115.
    • (2011) Exp. Mol. Pathol. , vol.90 , pp. 107-115
    • Kawakatsu, M.1
  • 29
    • 0037085441 scopus 로고    scopus 로고
    • Identification and functional characterization of distinct critically important bone morphogenetic proteinspecific response elements in the Id1 promoter
    • Korchynskyi O, ten Dijke P. 2002. Identification and functional characterization of distinct critically important bone morphogenetic proteinspecific response elements in the Id1 promoter. J. Biol. Chem. 277:4883- 4891.
    • (2002) J. Biol. Chem. , vol.277 , pp. 4883-4891
    • Korchynskyi, O.1    ten Dijke, P.2
  • 30
    • 55849099654 scopus 로고    scopus 로고
    • Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers
    • Leary RJ, et al. 2008. Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc. Natl. Acad. Sci. U. S. A. 105:16224 -16229.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 16224-16229
    • Leary, R.J.1
  • 31
    • 30944444113 scopus 로고    scopus 로고
    • Alterations in components of the TGF-β superfamily signaling pathways in human cancer
    • Levy L, Hill CS. 2006. Alterations in components of the TGF-β superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev. 17:41-58.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 41-58
    • Levy, L.1    Hill, C.S.2
  • 32
    • 34548238145 scopus 로고    scopus 로고
    • Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation
    • Levy L, et al. 2007. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Mol. Cell. Biol. 27: 6068-6083.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 6068-6083
    • Levy, L.1
  • 33
    • 58749089988 scopus 로고    scopus 로고
    • TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch
    • Liu IM, et al. 2009. TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch. EMBO J. 28:88 -98.
    • (2009) EMBO J , vol.28 , pp. 88-98
    • Liu, I.M.1
  • 35
    • 1442313955 scopus 로고    scopus 로고
    • Endogenous TGF-β signaling suppresses maturation of osteoblastic mesenchymal cells
    • Maeda S, Hayashi M, Komiya S, Imamura T, Miyazono K. 2004. Endogenous TGF-β signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J. 23:552-563.
    • (2004) EMBO J , vol.23 , pp. 552-563
    • Maeda, S.1    Hayashi, M.2    Komiya, S.3    Imamura, T.4    Miyazono, K.5
  • 36
    • 47549090432 scopus 로고    scopus 로고
    • TGFβ in cancer
    • Massagué J. 2008. TGFβ in cancer. Cell 134:215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 37
    • 0034644472 scopus 로고    scopus 로고
    • TGFβ signaling in growth control, cancer, and heritable disorders
    • Massagué J, Blain SW, Lo RS. 2000. TGFβ signaling in growth control, cancer, and heritable disorders. Cell 103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massagué, J.1    Blain, S.W.2    Lo, R.S.3
  • 39
    • 0038548187 scopus 로고    scopus 로고
    • Attenuation of the TGF-β-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-β-induced growth arrest
    • Nicolás FJ, Hill CS. 2003. Attenuation of the TGF-β-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-β-induced growth arrest. Oncogene 22:3698 -3711.
    • (2003) Oncogene , vol.22 , pp. 3698-3711
    • Nicolás, F.J.1    Hill, C.S.2
  • 41
    • 70649094222 scopus 로고    scopus 로고
    • BMP2 signaling in bone development and repair
    • Rosen V. 2009. BMP2 signaling in bone development and repair. Cytokine Growth Factor Rev. 20:475- 480.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 475-480
    • Rosen, V.1
  • 42
  • 43
    • 36448936383 scopus 로고    scopus 로고
    • TGFβ-SMAD signal transduction: molecular specificity and functional flexibility
    • Schmierer B, Hill CS. 2007. TGFβ-SMAD signal transduction: molecular specificity and functional flexibility. Nat. Rev. Mol. Cell Biol. 8:970 -982.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 44
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
    • Schreiber E, Matthias P, Muller MM, Schaffner W. 1989. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:6419.
    • (1989) Nucleic Acids Res , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 45
    • 1642539976 scopus 로고    scopus 로고
    • GADD34-PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor
    • Shi W, et al. 2004. GADD34-PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor. J. Cell Biol. 164:291-300.
    • (2004) J. Cell Biol. , vol.164 , pp. 291-300
    • Shi, W.1
  • 46
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi Y, Massagué J. 2003. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113:685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 47
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling
    • Shi Y, et al. 1998. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling. Cell 94:585-594.
    • (1998) Cell , vol.94 , pp. 585-594
    • Shi, Y.1
  • 48
    • 33644872577 scopus 로고    scopus 로고
    • Limma: linear models for microarray data
    • Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W (ed), Springer, New York, NY
    • Smyth GK. 2005. Limma: linear models for microarray data, p 397-420. In Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W (ed), Bioinformatics and computational biology solutions using R and Bioconductor. Springer, New York, NY.
    • (2005) Bioinformatics and computational biology solutions using R and Bioconductor , pp. 397-420
    • Smyth, G.K.1
  • 49
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical Bayes methods for assessing differential expression in microarray experiments
    • Article3
    • Smyth GK. 2004. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3:Article3.
    • (2004) Stat. Appl. Genet. Mol. Biol , pp. 3
    • Smyth, G.K.1
  • 50
    • 0032979988 scopus 로고    scopus 로고
    • Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β Mol
    • Wong C, et al. 1999. Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β Mol. Cell. Biol. 19:1821-1830.
    • (1999) Cell. Biol. , vol.19 , pp. 1821-1830
    • Wong, C.1
  • 51
    • 65649105437 scopus 로고    scopus 로고
    • Transforming growth factor β can stimulate Smad1 phosphorylation independently of bone morphogenic protein receptors
    • Wrighton KH, Lin X, Yu PB, Feng XH. 2009. Transforming growth factor β can stimulate Smad1 phosphorylation independently of bone morphogenic protein receptors. J. Biol. Chem. 284:9755-9763.
    • (2009) J. Biol. Chem. , vol.284 , pp. 9755-9763
    • Wrighton, K.H.1    Lin, X.2    Yu, P.B.3    Feng, X.H.4
  • 52
    • 61749097816 scopus 로고    scopus 로고
    • TGF- β superfamily signaling in embryonic development and homeostasis
    • Wu MY, Hill CS. 2009. TGF-β superfamily signaling in embryonic development and homeostasis. Dev. Cell 16:329 -343.
    • (2009) Dev. Cell , vol.16 , pp. 329-343
    • Wu, M.Y.1    Hill, C.S.2
  • 53
    • 79952268523 scopus 로고    scopus 로고
    • SNW1 is a critical regulator of spatial BMP activity, neural plate border formation and neural crest specification in vertebrate embryos
    • Wu MY, Ramel M-C, Howell M, Hill CS. 2011. SNW1 is a critical regulator of spatial BMP activity, neural plate border formation and neural crest specification in vertebrate embryos. PLoS Biol. 9:e1000593.
    • (2011) PLoS Biol , vol.9
    • Wu, M.Y.1    Ramel, M.-C.2    Howell, M.3    Hill, C.S.4
  • 54
    • 33747614295 scopus 로고    scopus 로고
    • Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells
    • Xiao L, Yuan X, Sharkis SJ. 2006. Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells 24:1476 -1486.
    • (2006) Stem Cells , vol.24 , pp. 1476-1486
    • Xiao, L.1    Yuan, X.2    Sharkis, S.J.3
  • 55
    • 0035947301 scopus 로고    scopus 로고
    • Nodal signals to Smads through Criptodependent and Cripto-independent mechanisms
    • Yeo C, Whitman M. 2001. Nodal signals to Smads through Criptodependent and Cripto-independent mechanisms. Mol. Cell 7:949 -957.
    • (2001) Mol. Cell , vol.7 , pp. 949-957
    • Yeo, C.1    Whitman, M.2
  • 56
    • 0032014216 scopus 로고    scopus 로고
    • Human Smad3 and Smad4 are sequence-specific transcription activators
    • Zawel L, et al. 1998. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1:611- 617.
    • (1998) Mol. Cell , vol.1 , pp. 611-617
    • Zawel, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.