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Volumn 25, Issue 1, 2013, Pages 19-33

TLR3 immunity to infection in mice and humans

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE EPSILON; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; PHOSPHOTRANSFERASE; PROTEIN TBK1; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

EID: 84875246098     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2012.11.001     Document Type: Review
Times cited : (147)

References (170)
  • 2
    • 39449112512 scopus 로고    scopus 로고
    • Toll-like receptors-taking an evolutionary approach
    • Leulier F., Lemaitre B. Toll-like receptors-taking an evolutionary approach. Nat Rev Genet 2008, 9:165-178.
    • (2008) Nat Rev Genet , vol.9 , pp. 165-178
    • Leulier, F.1    Lemaitre, B.2
  • 3
    • 84861816807 scopus 로고    scopus 로고
    • Molecular evolution of vertebrate Toll-like receptors: evolutionary rate difference between their leucine-rich repeats and their TIR domains
    • Mikami T., Miyashita H., Takatsuka S., Kuroki Y., Matsushima N. Molecular evolution of vertebrate Toll-like receptors: evolutionary rate difference between their leucine-rich repeats and their TIR domains. Gene 2012, 503:235-243.
    • (2012) Gene , vol.503 , pp. 235-243
    • Mikami, T.1    Miyashita, H.2    Takatsuka, S.3    Kuroki, Y.4    Matsushima, N.5
  • 5
    • 33744539798 scopus 로고    scopus 로고
    • Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses
    • Meylan E., Tschopp J. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell 2006, 22:561-569.
    • (2006) Mol Cell , vol.22 , pp. 561-569
    • Meylan, E.1    Tschopp, J.2
  • 7
    • 0030585155 scopus 로고    scopus 로고
    • When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA
    • Jacobs B.L., Langland J.O. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 1996, 219:339-349.
    • (1996) Virology , vol.219 , pp. 339-349
    • Jacobs, B.L.1    Langland, J.O.2
  • 10
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 11
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai T., Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011, 34:637-650.
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 15
    • 79953061608 scopus 로고    scopus 로고
    • Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics
    • Casanova J.L., Abel L., Quintana-Murci L. Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics. Annu Rev Immunol 2011, 29:447-491.
    • (2011) Annu Rev Immunol , vol.29 , pp. 447-491
    • Casanova, J.L.1    Abel, L.2    Quintana-Murci, L.3
  • 20
    • 23044445303 scopus 로고    scopus 로고
    • Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
    • Choe J., Kelker M.S., Wilson I.A. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 2005, 309:581-585.
    • (2005) Science , vol.309 , pp. 581-585
    • Choe, J.1    Kelker, M.S.2    Wilson, I.A.3
  • 23
    • 31344476404 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH
    • de Bouteiller O., Merck E., Hasan U.A., Hubac S., Benguigui B., Trinchieri G., Bates E.E., Caux C. Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J Biol Chem 2005, 280:38133-38145.
    • (2005) J Biol Chem , vol.280 , pp. 38133-38145
    • de Bouteiller, O.1    Merck, E.2    Hasan, U.A.3    Hubac, S.4    Benguigui, B.5    Trinchieri, G.6    Bates, E.E.7    Caux, C.8
  • 25
    • 34249332076 scopus 로고    scopus 로고
    • C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission
    • Takada E., Okahira S., Sasai M., Funami K., Seya T., Matsumoto M. C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission. Mol Immunol 2007, 44:3633-3640.
    • (2007) Mol Immunol , vol.44 , pp. 3633-3640
    • Takada, E.1    Okahira, S.2    Sasai, M.3    Funami, K.4    Seya, T.5    Matsumoto, M.6
  • 28
    • 46449095170 scopus 로고    scopus 로고
    • A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation
    • Pirher N., Ivicak K., Pohar J., Bencina M., Jerala R. A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation. Nat Struct Mol Biol 2008, 15:761-763.
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 761-763
    • Pirher, N.1    Ivicak, K.2    Pohar, J.3    Bencina, M.4    Jerala, R.5
  • 30
    • 78449250992 scopus 로고    scopus 로고
    • Dimerization of Toll-like receptor 3 (TLR3) is required for ligand binding
    • Wang Y., Liu L., Davies D.R., Segal D.M. Dimerization of Toll-like receptor 3 (TLR3) is required for ligand binding. J Biol Chem 2010, 285:36836-36841.
    • (2010) J Biol Chem , vol.285 , pp. 36836-36841
    • Wang, Y.1    Liu, L.2    Davies, D.R.3    Segal, D.M.4
  • 31
    • 26944469056 scopus 로고    scopus 로고
    • Interferon-beta induction through toll-like receptor 3 depends on double-stranded RNA structure
    • Okahira S., Nishikawa F., Nishikawa S., Akazawa T., Seya T., Matsumoto M. Interferon-beta induction through toll-like receptor 3 depends on double-stranded RNA structure. DNA Cell Biol 2005, 24:614-623.
    • (2005) DNA Cell Biol , vol.24 , pp. 614-623
    • Okahira, S.1    Nishikawa, F.2    Nishikawa, S.3    Akazawa, T.4    Seya, T.5    Matsumoto, M.6
  • 32
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 33
  • 36
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA
    • Kariko K., Buckstein M., Ni H., Weissman D. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005, 23:165-175.
    • (2005) Immunity , vol.23 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 37
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • Kadowaki N., Ho S., Antonenko S., Malefyt R.W., Kastelein R.A., Bazan F., Liu Y.J. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001, 194:863-869.
    • (2001) J Exp Med , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6    Liu, Y.J.7
  • 40
    • 3242670505 scopus 로고    scopus 로고
    • Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells
    • Kumar M.V., Nagineni C.N., Chin M.S., Hooks J.J., Detrick B. Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells. J Neuroimmunol 2004, 153:7-15.
    • (2004) J Neuroimmunol , vol.153 , pp. 7-15
    • Kumar, M.V.1    Nagineni, C.N.2    Chin, M.S.3    Hooks, J.J.4    Detrick, B.5
  • 42
    • 36349035570 scopus 로고    scopus 로고
    • Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia
    • Harada K., Sato Y., Itatsu K., Isse K., Ikeda H., Yasoshima M., Zen Y., Matsui A., Nakanuma Y. Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia. Hepatology 2007, 46:1146-1154.
    • (2007) Hepatology , vol.46 , pp. 1146-1154
    • Harada, K.1    Sato, Y.2    Itatsu, K.3    Isse, K.4    Ikeda, H.5    Yasoshima, M.6    Zen, Y.7    Matsui, A.8    Nakanuma, Y.9
  • 43
    • 69749089284 scopus 로고    scopus 로고
    • Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers
    • Nakamura M., Funami K., Komori A., Yokoyama T., Aiba Y., Araki A., Takii Y., Ito M., Matsuyama M., Koyabu M., et al. Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers. Hepatol Int 2008, 2:222-230.
    • (2008) Hepatol Int , vol.2 , pp. 222-230
    • Nakamura, M.1    Funami, K.2    Komori, A.3    Yokoyama, T.4    Aiba, Y.5    Araki, A.6    Takii, Y.7    Ito, M.8    Matsuyama, M.9    Koyabu, M.10
  • 44
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • Cario E., Podolsky D.K. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000, 68:7010-7017.
    • (2000) Infect Immun , vol.68 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 47
    • 0036076593 scopus 로고    scopus 로고
    • Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
    • Matsumoto M., Kikkawa S., Kohase M., Miyake K., Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun 2002, 293:1364-1369.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 1364-1369
    • Matsumoto, M.1    Kikkawa, S.2    Kohase, M.3    Miyake, K.4    Seya, T.5
  • 49
    • 70349278409 scopus 로고    scopus 로고
    • Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells
    • Wang N., Liang Y., Devaraj S., Wang J., Lemon S.M., Li K. Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells. J Virol 2009, 83:9824-9834.
    • (2009) J Virol , vol.83 , pp. 9824-9834
    • Wang, N.1    Liang, Y.2    Devaraj, S.3    Wang, J.4    Lemon, S.M.5    Li, K.6
  • 50
    • 0036841178 scopus 로고    scopus 로고
    • Broad expression of Toll-like receptors in the human central nervous system
    • Bsibsi M., Ravid R., Gveric D., van Noort J.M. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol 2002, 61:1013-1021.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 1013-1021
    • Bsibsi, M.1    Ravid, R.2    Gveric, D.3    van Noort, J.M.4
  • 51
    • 33750138551 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases
    • Jackson A.C., Rossiter J.P., Lafon M. Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases. J Neurovirol 2006, 12:229-234.
    • (2006) J Neurovirol , vol.12 , pp. 229-234
    • Jackson, A.C.1    Rossiter, J.P.2    Lafon, M.3
  • 52
    • 26444552110 scopus 로고    scopus 로고
    • Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon
    • Prehaud C., Megret F., Lafage M., Lafon M. Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon. J Virol 2005, 79:12893-12904.
    • (2005) J Virol , vol.79 , pp. 12893-12904
    • Prehaud, C.1    Megret, F.2    Lafage, M.3    Lafon, M.4
  • 56
    • 77956928890 scopus 로고    scopus 로고
    • TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA
    • Perrot I., Deauvieau F., Massacrier C., Hughes N., Garrone P., Durand I., Demaria O., Viaud N., Gauthier L., Blery M., et al. TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA. J Immunol 2010, 185:2080-2088.
    • (2010) J Immunol , vol.185 , pp. 2080-2088
    • Perrot, I.1    Deauvieau, F.2    Massacrier, C.3    Hughes, N.4    Garrone, P.5    Durand, I.6    Demaria, O.7    Viaud, N.8    Gauthier, L.9    Blery, M.10
  • 57
    • 33644826593 scopus 로고    scopus 로고
    • Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells
    • Kumar A., Zhang J., Yu F.S. Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells. Immunology 2006, 117:11-21.
    • (2006) Immunology , vol.117 , pp. 11-21
    • Kumar, A.1    Zhang, J.2    Yu, F.S.3
  • 58
    • 33646258023 scopus 로고    scopus 로고
    • Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators
    • Bsibsi M., Persoon-Deen C., Verwer R.W., Meeuwsen S., Ravid R., Van Noort J.M. Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators. Glia 2006, 53:688-695.
    • (2006) Glia , vol.53 , pp. 688-695
    • Bsibsi, M.1    Persoon-Deen, C.2    Verwer, R.W.3    Meeuwsen, S.4    Ravid, R.5    Van Noort, J.M.6
  • 59
  • 60
    • 34247484007 scopus 로고    scopus 로고
    • The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
    • Brinkmann M.M., Spooner E., Hoebe K., Beutler B., Ploegh H.L., Kim Y.M. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol 2007, 177:265-275.
    • (2007) J Cell Biol , vol.177 , pp. 265-275
    • Brinkmann, M.M.1    Spooner, E.2    Hoebe, K.3    Beutler, B.4    Ploegh, H.L.5    Kim, Y.M.6
  • 61
    • 40749098665 scopus 로고    scopus 로고
    • UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
    • Kim Y.M., Brinkmann M.M., Paquet M.E., Ploegh H.L. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 2008, 452:234-238.
    • (2008) Nature , vol.452 , pp. 234-238
    • Kim, Y.M.1    Brinkmann, M.M.2    Paquet, M.E.3    Ploegh, H.L.4
  • 64
    • 84866157114 scopus 로고    scopus 로고
    • TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway
    • Sun H., Zhuang G., Chai L., Wang Z., Johnson D., Ma Y., Chen Y.H. TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway. J Immunol 2012, 189:2768-2773.
    • (2012) J Immunol , vol.189 , pp. 2768-2773
    • Sun, H.1    Zhuang, G.2    Chai, L.3    Wang, Z.4    Johnson, D.5    Ma, Y.6    Chen, Y.H.7
  • 65
    • 7544225495 scopus 로고    scopus 로고
    • Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
    • Sarkar S.N., Peters K.L., Elco C.P., Sakamoto S., Pal S., Sen G.C. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 2004, 11:1060-1067.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 1060-1067
    • Sarkar, S.N.1    Peters, K.L.2    Elco, C.P.3    Sakamoto, S.4    Pal, S.5    Sen, G.C.6
  • 66
    • 0037320451 scopus 로고    scopus 로고
    • TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
    • Oshiumi H., Matsumoto M., Funami K., Akazawa T., Seya T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 2003, 4:161-167.
    • (2003) Nat Immunol , vol.4 , pp. 161-167
    • Oshiumi, H.1    Matsumoto, M.2    Funami, K.3    Akazawa, T.4    Seya, T.5
  • 68
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S., Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004, 4:499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 69
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • O'Neill L.A., Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007, 7:353-364.
    • (2007) Nat Rev Immunol , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 70
    • 2442605662 scopus 로고    scopus 로고
    • Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways
    • Han K.J., Su X., Xu L.G., Bin L.H., Zhang J., Shu H.B. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. J Biol Chem 2004, 279:15652-15661.
    • (2004) J Biol Chem , vol.279 , pp. 15652-15661
    • Han, K.J.1    Su, X.2    Xu, L.G.3    Bin, L.H.4    Zhang, J.5    Shu, H.B.6
  • 71
    • 17144413785 scopus 로고    scopus 로고
    • Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
    • Kaiser W.J., Offermann M.K. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol 2005, 174:4942-4952.
    • (2005) J Immunol , vol.174 , pp. 4942-4952
    • Kaiser, W.J.1    Offermann, M.K.2
  • 72
    • 4344622049 scopus 로고    scopus 로고
    • Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages
    • Ruckdeschel K., Pfaffinger G., Haase R., Sing A., Weighardt H., Hacker G., Holzmann B., Heesemann J. Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages. J Immunol 2004, 173:3320-3328.
    • (2004) J Immunol , vol.173 , pp. 3320-3328
    • Ruckdeschel, K.1    Pfaffinger, G.2    Haase, R.3    Sing, A.4    Weighardt, H.5    Hacker, G.6    Holzmann, B.7    Heesemann, J.8
  • 76
    • 10844219793 scopus 로고    scopus 로고
    • Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation
    • Sasai M., Oshiumi H., Matsumoto M., Inoue N., Fujita F., Nakanishi M., Seya T. Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. J Immunol 2005, 174:27-30.
    • (2005) J Immunol , vol.174 , pp. 27-30
    • Sasai, M.1    Oshiumi, H.2    Matsumoto, M.3    Inoue, N.4    Fujita, F.5    Nakanishi, M.6    Seya, T.7
  • 78
    • 30544447047 scopus 로고    scopus 로고
    • Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
    • Oganesyan G., Saha S.K., Guo B., He J.Q., Shahangian A., Zarnegar B., Perry A., Cheng G. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 2006, 439:208-211.
    • (2006) Nature , vol.439 , pp. 208-211
    • Oganesyan, G.1    Saha, S.K.2    Guo, B.3    He, J.Q.4    Shahangian, A.5    Zarnegar, B.6    Perry, A.7    Cheng, G.8
  • 80
    • 4344613405 scopus 로고    scopus 로고
    • Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling
    • Gohda J., Matsumura T., Inoue J. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J Immunol 2004, 173:2913-2917.
    • (2004) J Immunol , vol.173 , pp. 2913-2917
    • Gohda, J.1    Matsumura, T.2    Inoue, J.3
  • 81
    • 0141923690 scopus 로고    scopus 로고
    • Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling
    • Sato S., Sugiyama M., Yamamoto M., Watanabe Y., Kawai T., Takeda K., Akira S. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol 2003, 171:4304-4310.
    • (2003) J Immunol , vol.171 , pp. 4304-4310
    • Sato, S.1    Sugiyama, M.2    Yamamoto, M.3    Watanabe, Y.4    Kawai, T.5    Takeda, K.6    Akira, S.7
  • 82
    • 0038714270 scopus 로고    scopus 로고
    • Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR
    • Jiang Z., Zamanian-Daryoush M., Nie H., Silva A.M., Williams B.R., Li X. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem 2003, 278:16713-16719.
    • (2003) J Biol Chem , vol.278 , pp. 16713-16719
    • Jiang, Z.1    Zamanian-Daryoush, M.2    Nie, H.3    Silva, A.M.4    Williams, B.R.5    Li, X.6
  • 84
    • 77957252647 scopus 로고    scopus 로고
    • The IKK complex, a central regulator of NF-kappaB activation
    • Israel A. The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb Perspect Biol 2010, 2:a000158.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Israel, A.1
  • 85
    • 73249116346 scopus 로고    scopus 로고
    • Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction
    • Takaki H., Oshiumi H., Sasai M., Kawanishi T., Matsumoto M., Seya T. Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction. Eur J Immunol 2009, 39:3469-3476.
    • (2009) Eur J Immunol , vol.39 , pp. 3469-3476
    • Takaki, H.1    Oshiumi, H.2    Sasai, M.3    Kawanishi, T.4    Matsumoto, M.5    Seya, T.6
  • 86
    • 76949087276 scopus 로고    scopus 로고
    • Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway
    • Sasai M., Tatematsu M., Oshiumi H., Funami K., Matsumoto M., Hatakeyama S., Seya T. Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway. Mol Immunol 2010, 47:1283-1291.
    • (2010) Mol Immunol , vol.47 , pp. 1283-1291
    • Sasai, M.1    Tatematsu, M.2    Oshiumi, H.3    Funami, K.4    Matsumoto, M.5    Hatakeyama, S.6    Seya, T.7
  • 87
    • 79953200483 scopus 로고    scopus 로고
    • TBK1-associated protein in endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and TLR4 signaling pathways
    • Chang C.H., Lai L.C., Cheng H.C., Chen K.R., Syue Y.Z., Lu H.C., Lin W.Y., Chen S.H., Huang H.S., Shiau A.L., et al. TBK1-associated protein in endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and TLR4 signaling pathways. J Biol Chem 2011, 286:7043-7051.
    • (2011) J Biol Chem , vol.286 , pp. 7043-7051
    • Chang, C.H.1    Lai, L.C.2    Cheng, H.C.3    Chen, K.R.4    Syue, Y.Z.5    Lu, H.C.6    Lin, W.Y.7    Chen, S.H.8    Huang, H.S.9    Shiau, A.L.10
  • 88
    • 80055098606 scopus 로고    scopus 로고
    • Toll-like receptor 3 (TLR3) signaling requires TLR4 interactor with leucine-rich repeats (TRIL)
    • Carpenter S., Wochal P., Dunne A., O'Neill L.A. Toll-like receptor 3 (TLR3) signaling requires TLR4 interactor with leucine-rich repeats (TRIL). J Biol Chem 2011, 286:38795-38804.
    • (2011) J Biol Chem , vol.286 , pp. 38795-38804
    • Carpenter, S.1    Wochal, P.2    Dunne, A.3    O'Neill, L.A.4
  • 89
    • 0037020147 scopus 로고    scopus 로고
    • Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases
    • Chariot A., Leonardi A., Muller J., Bonif M., Brown K., Siebenlist U. Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. J Biol Chem 2002, 277:37029-37036.
    • (2002) J Biol Chem , vol.277 , pp. 37029-37036
    • Chariot, A.1    Leonardi, A.2    Muller, J.3    Bonif, M.4    Brown, K.5    Siebenlist, U.6
  • 90
    • 34249058290 scopus 로고    scopus 로고
    • Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
    • Guo B., Cheng G. Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. J Biol Chem 2007, 282:11817-11826.
    • (2007) J Biol Chem , vol.282 , pp. 11817-11826
    • Guo, B.1    Cheng, G.2
  • 91
    • 34447342317 scopus 로고    scopus 로고
    • SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
    • Ryzhakov G., Randow F. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J 2007, 26:3180-3190.
    • (2007) EMBO J , vol.26 , pp. 3180-3190
    • Ryzhakov, G.1    Randow, F.2
  • 93
    • 50149089360 scopus 로고    scopus 로고
    • The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors
    • Pobezinskaya Y.L., Kim Y.S., Choksi S., Morgan M.J., Li T., Liu C., Liu Z. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat Immunol 2008, 9:1047-1054.
    • (2008) Nat Immunol , vol.9 , pp. 1047-1054
    • Pobezinskaya, Y.L.1    Kim, Y.S.2    Choksi, S.3    Morgan, M.J.4    Li, T.5    Liu, C.6    Liu, Z.7
  • 95
    • 58149401211 scopus 로고    scopus 로고
    • CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages
    • Liu X., Yao M., Li N., Wang C., Zheng Y., Cao X. CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages. Blood 2008, 112:4961-4970.
    • (2008) Blood , vol.112 , pp. 4961-4970
    • Liu, X.1    Yao, M.2    Li, N.3    Wang, C.4    Zheng, Y.5    Cao, X.6
  • 97
    • 77953397065 scopus 로고    scopus 로고
    • Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages
    • Zheng Y., An H., Yao M., Hou J., Yu Y., Feng G., Cao X. Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages. J Immunol 2010, 184:6447-6456.
    • (2010) J Immunol , vol.184 , pp. 6447-6456
    • Zheng, Y.1    An, H.2    Yao, M.3    Hou, J.4    Yu, Y.5    Feng, G.6    Cao, X.7
  • 99
    • 65449153592 scopus 로고    scopus 로고
    • TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response
    • Yang K., Shi H.X., Liu X.Y., Shan Y.F., Wei B., Chen S., Wang C. TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response. J Immunol 2009, 182:3782-3792.
    • (2009) J Immunol , vol.182 , pp. 3782-3792
    • Yang, K.1    Shi, H.X.2    Liu, X.Y.3    Shan, Y.F.4    Wei, B.5    Chen, S.6    Wang, C.7
  • 101
    • 84867801015 scopus 로고    scopus 로고
    • TRIM56 is an essential component of the TLR3 antiviral signaling pathway
    • Shen Y., Li N.L., Wang J., Liu B., Lester S., Li K. TRIM56 is an essential component of the TLR3 antiviral signaling pathway. J Biol Chem 2012, 287:36404-36413.
    • (2012) J Biol Chem , vol.287 , pp. 36404-36413
    • Shen, Y.1    Li, N.L.2    Wang, J.3    Liu, B.4    Lester, S.5    Li, K.6
  • 102
    • 72949091663 scopus 로고    scopus 로고
    • Scavenger receptor A1 is required for sensing HCMV by endosomal TLR-3/-9 in monocytic THP-1 cells
    • Yew K.H., Carsten B., Harrison C. Scavenger receptor A1 is required for sensing HCMV by endosomal TLR-3/-9 in monocytic THP-1 cells. Mol Immunol 2009, 47:883-893.
    • (2009) Mol Immunol , vol.47 , pp. 883-893
    • Yew, K.H.1    Carsten, B.2    Harrison, C.3
  • 103
    • 77951214649 scopus 로고    scopus 로고
    • Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling
    • Han K.J., Yang Y., Xu L.G., Shu H.B. Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling. J Biol Chem 2010, 285:12543-12550.
    • (2010) J Biol Chem , vol.285 , pp. 12543-12550
    • Han, K.J.1    Yang, Y.2    Xu, L.G.3    Shu, H.B.4
  • 104
    • 49649125136 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3
    • Higgs R., Ni Gabhann J., Ben Larbi N., Breen E.P., Fitzgerald K.A., Jefferies C.A. The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. J Immunol 2008, 181:1780-1786.
    • (2008) J Immunol , vol.181 , pp. 1780-1786
    • Higgs, R.1    Ni Gabhann, J.2    Ben Larbi, N.3    Breen, E.P.4    Fitzgerald, K.A.5    Jefferies, C.A.6
  • 105
    • 70349472923 scopus 로고    scopus 로고
    • Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
    • Chang M., Jin W., Sun S.C. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 2009, 10:1089-1095.
    • (2009) Nat Immunol , vol.10 , pp. 1089-1095
    • Chang, M.1    Jin, W.2    Sun, S.C.3
  • 106
    • 33845438110 scopus 로고    scopus 로고
    • SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production
    • An H., Zhao W., Hou J., Zhang Y., Xie Y., Zheng Y., Xu H., Qian C., Zhou J., Yu Y., et al. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity 2006, 25:919-928.
    • (2006) Immunity , vol.25 , pp. 919-928
    • An, H.1    Zhao, W.2    Hou, J.3    Zhang, Y.4    Xie, Y.5    Zheng, Y.6    Xu, H.7    Qian, C.8    Zhou, J.9    Yu, Y.10
  • 107
    • 30944431519 scopus 로고    scopus 로고
    • TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling
    • Su X., Li S., Meng M., Qian W., Xie W., Chen D., Zhai Z., Shu H.B. TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling. Eur J Immunol 2006, 36:199-206.
    • (2006) Eur J Immunol , vol.36 , pp. 199-206
    • Su, X.1    Li, S.2    Meng, M.3    Qian, W.4    Xie, W.5    Chen, D.6    Zhai, Z.7    Shu, H.B.8
  • 111
    • 33748871187 scopus 로고    scopus 로고
    • The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
    • Carty M., Goodbody R., Schroder M., Stack J., Moynagh P.N., Bowie A.G. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol 2006, 7:1074-1081.
    • (2006) Nat Immunol , vol.7 , pp. 1074-1081
    • Carty, M.1    Goodbody, R.2    Schroder, M.3    Stack, J.4    Moynagh, P.N.5    Bowie, A.G.6
  • 112
    • 3142636527 scopus 로고    scopus 로고
    • PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis
    • Zhang J., Xu L.G., Han K.J., Wei X., Shu H.B. PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis. FEBS Lett 2004, 570:97-101.
    • (2004) FEBS Lett , vol.570 , pp. 97-101
    • Zhang, J.1    Xu, L.G.2    Han, K.J.3    Wei, X.4    Shu, H.B.5
  • 113
    • 28644433321 scopus 로고    scopus 로고
    • SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
    • Huang J., Liu T., Xu L.G., Chen D., Zhai Z., Shu H.B. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J 2005, 24:4018-4028.
    • (2005) EMBO J , vol.24 , pp. 4018-4028
    • Huang, J.1    Liu, T.2    Xu, L.G.3    Chen, D.4    Zhai, Z.5    Shu, H.B.6
  • 114
    • 84868554937 scopus 로고    scopus 로고
    • TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1
    • Zhang M., Wang L., Zhao X., Zhao K., Meng H., Zhao W., Gao C. TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J Exp Med 2012, 209:1703-1711.
    • (2012) J Exp Med , vol.209 , pp. 1703-1711
    • Zhang, M.1    Wang, L.2    Zhao, X.3    Zhao, K.4    Meng, H.5    Zhao, W.6    Gao, C.7
  • 116
    • 34249058119 scopus 로고    scopus 로고
    • The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways
    • Zhao T., Yang L., Sun Q., Arguello M., Ballard D.W., Hiscott J., Lin R. The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways. Nat Immunol 2007, 8:592-600.
    • (2007) Nat Immunol , vol.8 , pp. 592-600
    • Zhao, T.1    Yang, L.2    Sun, Q.3    Arguello, M.4    Ballard, D.W.5    Hiscott, J.6    Lin, R.7
  • 118
    • 80755126865 scopus 로고    scopus 로고
    • Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
    • Li S., Wang L., Berman M., Kong Y.Y., Dorf M.E. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity 2011, 35:426-440.
    • (2011) Immunity , vol.35 , pp. 426-440
    • Li, S.1    Wang, L.2    Berman, M.3    Kong, Y.Y.4    Dorf, M.E.5
  • 119
    • 79959344720 scopus 로고    scopus 로고
    • DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells
    • Zhang Z., Kim T., Bao M., Facchinetti V., Jung S.Y., Ghaffari A.A., Qin J., Cheng G., Liu Y.J. DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity 2011, 34:866-878.
    • (2011) Immunity , vol.34 , pp. 866-878
    • Zhang, Z.1    Kim, T.2    Bao, M.3    Facchinetti, V.4    Jung, S.Y.5    Ghaffari, A.A.6    Qin, J.7    Cheng, G.8    Liu, Y.J.9
  • 124
    • 58149458888 scopus 로고    scopus 로고
    • Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection
    • Richer M.J., Lavallee D.J., Shanina I., Horwitz M.S. Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection. PLoS ONE 2009, 4:e4127.
    • (2009) PLoS ONE , vol.4
    • Richer, M.J.1    Lavallee, D.J.2    Shanina, I.3    Horwitz, M.S.4
  • 125
    • 84855954760 scopus 로고    scopus 로고
    • The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice
    • Abe Y., Fujii K., Nagata N., Takeuchi O., Akira S., Oshiumi H., Matsumoto M., Seya T., Koike S. The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice. J Virol 2012, 86:185-194.
    • (2012) J Virol , vol.86 , pp. 185-194
    • Abe, Y.1    Fujii, K.2    Nagata, N.3    Takeuchi, O.4    Akira, S.5    Oshiumi, H.6    Matsumoto, M.7    Seya, T.8    Koike, S.9
  • 126
    • 81455141907 scopus 로고    scopus 로고
    • The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection
    • Oshiumi H., Okamoto M., Fujii K., Kawanishi T., Matsumoto M., Koike S., Seya T. The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection. J Immunol 2011, 187:5320-5327.
    • (2011) J Immunol , vol.187 , pp. 5320-5327
    • Oshiumi, H.1    Okamoto, M.2    Fujii, K.3    Kawanishi, T.4    Matsumoto, M.5    Koike, S.6    Seya, T.7
  • 127
    • 77951935483 scopus 로고    scopus 로고
    • Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo
    • Davey G.M., Wojtasiak M., Proietto A.I., Carbone F.R., Heath W.R., Bedoui S. Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo. J Immunol 2010, 184:2243-2246.
    • (2010) J Immunol , vol.184 , pp. 2243-2246
    • Davey, G.M.1    Wojtasiak, M.2    Proietto, A.I.3    Carbone, F.R.4    Heath, W.R.5    Bedoui, S.6
  • 128
    • 31144451555 scopus 로고    scopus 로고
    • Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection
    • Rudd B.D., Smit J.J., Flavell R.A., Alexopoulou L., Schaller M.A., Gruber A., Berlin A.A., Lukacs N.W. Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection. J Immunol 2006, 176:1937-1942.
    • (2006) J Immunol , vol.176 , pp. 1937-1942
    • Rudd, B.D.1    Smit, J.J.2    Flavell, R.A.3    Alexopoulou, L.4    Schaller, M.A.5    Gruber, A.6    Berlin, A.A.7    Lukacs, N.W.8
  • 130
    • 83755187877 scopus 로고    scopus 로고
    • TLR3 signaling is either protective or pathogenic for the development of Theiler's virus-induced demyelinating disease depending on the time of viral infection
    • Jin Y.H., Kaneyama T., Kang M.H., Kang H.S., Koh C.S., Kim B.S. TLR3 signaling is either protective or pathogenic for the development of Theiler's virus-induced demyelinating disease depending on the time of viral infection. J Neuroinflamm 2011, 8:178.
    • (2011) J Neuroinflamm , vol.8 , pp. 178
    • Jin, Y.H.1    Kaneyama, T.2    Kang, M.H.3    Kang, H.S.4    Koh, C.S.5    Kim, B.S.6
  • 134
    • 11144273976 scopus 로고    scopus 로고
    • Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
    • Wang T., Town T., Alexopoulou L., Anderson J.F., Fikrig E., Flavell R.A. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 2004, 10:1366-1373.
    • (2004) Nat Med , vol.10 , pp. 1366-1373
    • Wang, T.1    Town, T.2    Alexopoulou, L.3    Anderson, J.F.4    Fikrig, E.5    Flavell, R.A.6
  • 135
    • 15744387169 scopus 로고    scopus 로고
    • Herpes simplex encephalitis: children and adolescents
    • Whitley R.J., Kimberlin D.W. Herpes simplex encephalitis: children and adolescents. Semin Pediatr Infect Dis 2005, 16:17-23.
    • (2005) Semin Pediatr Infect Dis , vol.16 , pp. 17-23
    • Whitley, R.J.1    Kimberlin, D.W.2
  • 136
    • 33747172270 scopus 로고    scopus 로고
    • Herpes simplex encephalitis: adolescents and adults
    • Whitley R.J. Herpes simplex encephalitis: adolescents and adults. Antiviral Res 2006, 71:141-148.
    • (2006) Antiviral Res , vol.71 , pp. 141-148
    • Whitley, R.J.1
  • 137
    • 0016795964 scopus 로고
    • RNA synthesis in cells infected with herpes simplex virus. X. Properties of viral symmetric transcripts and of double-stranded RNA prepared from them
    • Jacquemont B., Roizman B. RNA synthesis in cells infected with herpes simplex virus. X. Properties of viral symmetric transcripts and of double-stranded RNA prepared from them. J Virol 1975, 15:707-713.
    • (1975) J Virol , vol.15 , pp. 707-713
    • Jacquemont, B.1    Roizman, B.2
  • 138
    • 33646453915 scopus 로고    scopus 로고
    • Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
    • Weber F., Wagner V., Rasmussen S.B., Hartmann R., Paludan S.R. Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J Virol 2006, 80:5059-5064.
    • (2006) J Virol , vol.80 , pp. 5059-5064
    • Weber, F.1    Wagner, V.2    Rasmussen, S.B.3    Hartmann, R.4    Paludan, S.R.5
  • 143
    • 27744534928 scopus 로고    scopus 로고
    • Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses
    • Yang K., Puel A., Zhang S., Eidenschenk C., Ku C.L., Casrouge A., Picard C., von Bernuth H., Senechal B., Plancoulaine S., et al. Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity 2005, 23:465-478.
    • (2005) Immunity , vol.23 , pp. 465-478
    • Yang, K.1    Puel, A.2    Zhang, S.3    Eidenschenk, C.4    Ku, C.L.5    Casrouge, A.6    Picard, C.7    von Bernuth, H.8    Senechal, B.9    Plancoulaine, S.10
  • 144
    • 34948904198 scopus 로고    scopus 로고
    • Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity
    • Ku C.L., von Bernuth H., Picard C., Zhang S.Y., Chang H.H., Yang K., Chrabieh M., Issekutz A.C., Cunningham C.K., Gallin J., et al. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med 2007, 204:2407-2422.
    • (2007) J Exp Med , vol.204 , pp. 2407-2422
    • Ku, C.L.1    von Bernuth, H.2    Picard, C.3    Zhang, S.Y.4    Chang, H.H.5    Yang, K.6    Chrabieh, M.7    Issekutz, A.C.8    Cunningham, C.K.9    Gallin, J.10
  • 145
    • 35548956882 scopus 로고    scopus 로고
    • Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases
    • Quintana-Murci L., Alcais A., Abel L., Casanova J.L. Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases. Nat Immunol 2007, 8:1165-1171.
    • (2007) Nat Immunol , vol.8 , pp. 1165-1171
    • Quintana-Murci, L.1    Alcais, A.2    Abel, L.3    Casanova, J.L.4
  • 146
    • 34547732069 scopus 로고    scopus 로고
    • Primary immunodeficiencies: a field in its infancy
    • Casanova J.L., Abel L. Primary immunodeficiencies: a field in its infancy. Science 2007, 317:617-619.
    • (2007) Science , vol.317 , pp. 617-619
    • Casanova, J.L.1    Abel, L.2
  • 149
    • 33646746802 scopus 로고    scopus 로고
    • TRAF3: a new component of the TLR-signaling apparatus
    • Hoebe K., Beutler B. TRAF3: a new component of the TLR-signaling apparatus. Trends Mol Med 2006, 12:187-189.
    • (2006) Trends Mol Med , vol.12 , pp. 187-189
    • Hoebe, K.1    Beutler, B.2
  • 151
    • 35348895992 scopus 로고    scopus 로고
    • Multiple roles of TRAF3 signaling in lymphocyte function
    • Bishop G.A., Xie P. Multiple roles of TRAF3 signaling in lymphocyte function. Immunol Res 2007, 39:22-32.
    • (2007) Immunol Res , vol.39 , pp. 22-32
    • Bishop, G.A.1    Xie, P.2
  • 158
    • 4644232615 scopus 로고    scopus 로고
    • Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
    • Olson J.K., Miller S.D. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol 2004, 173:3916-3924.
    • (2004) J Immunol , vol.173 , pp. 3916-3924
    • Olson, J.K.1    Miller, S.D.2
  • 159
    • 33749129426 scopus 로고    scopus 로고
    • TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5
    • Rivieccio M.A., Suh H.S., Zhao Y., Zhao M.L., Chin K.C., Lee S.C., Brosnan C.F. TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J Immunol 2006, 177:4735-4741.
    • (2006) J Immunol , vol.177 , pp. 4735-4741
    • Rivieccio, M.A.1    Suh, H.S.2    Zhao, Y.3    Zhao, M.L.4    Chin, K.C.5    Lee, S.C.6    Brosnan, C.F.7
  • 161
    • 20744437144 scopus 로고    scopus 로고
    • High susceptibility of a human oligodendroglial cell line to herpes simplex type 1 infection
    • Bello-Morales R., Fedetz M., Alcina A., Tabares E., Lopez-Guerrero J.A. High susceptibility of a human oligodendroglial cell line to herpes simplex type 1 infection. J Neurovirol 2005, 11:190-198.
    • (2005) J Neurovirol , vol.11 , pp. 190-198
    • Bello-Morales, R.1    Fedetz, M.2    Alcina, A.3    Tabares, E.4    Lopez-Guerrero, J.A.5
  • 162
    • 33745598506 scopus 로고    scopus 로고
    • Microglial cells initiate vigorous yet non-protective immune responses during HSV-1 brain infection
    • Marques C.P., Hu S., Sheng W., Lokensgard J.R. Microglial cells initiate vigorous yet non-protective immune responses during HSV-1 brain infection. Virus Res 2006, 121:1-10.
    • (2006) Virus Res , vol.121 , pp. 1-10
    • Marques, C.P.1    Hu, S.2    Sheng, W.3    Lokensgard, J.R.4
  • 164
    • 84867763154 scopus 로고    scopus 로고
    • Protein kinase PKR amplification of interferon beta induction occurs through initiation factor eIF-2alpha-mediated translational control
    • McAllister C.S., Taghavi N., Samuel C.E. Protein kinase PKR amplification of interferon beta induction occurs through initiation factor eIF-2alpha-mediated translational control. J Biol Chem 2012, 287:36384-36392.
    • (2012) J Biol Chem , vol.287 , pp. 36384-36392
    • McAllister, C.S.1    Taghavi, N.2    Samuel, C.E.3
  • 166
    • 79956314622 scopus 로고    scopus 로고
    • Immune signaling by RIG-I-like receptors
    • Loo Y.M., Gale M. Immune signaling by RIG-I-like receptors. Immunity 2011, 34:680-692.
    • (2011) Immunity , vol.34 , pp. 680-692
    • Loo, Y.M.1    Gale, M.2
  • 167
    • 80053590435 scopus 로고    scopus 로고
    • Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter
    • Belgnaoui S.M., Paz S., Hiscott J. Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter. Curr Opin Immunol 2011, 23:564-572.
    • (2011) Curr Opin Immunol , vol.23 , pp. 564-572
    • Belgnaoui, S.M.1    Paz, S.2    Hiscott, J.3
  • 169
    • 27944453599 scopus 로고    scopus 로고
    • Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
    • Okabe Y., Kawane K., Akira S., Taniguchi T., Nagata S. Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp Med 2005, 202:1333-1339.
    • (2005) J Exp Med , vol.202 , pp. 1333-1339
    • Okabe, Y.1    Kawane, K.2    Akira, S.3    Taniguchi, T.4    Nagata, S.5
  • 170
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson D.B., Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006, 24:93-103.
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.