Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

Journal of Experimental Medicine

Volumn 209, Issue 9, 2012, Pages 1567-1582

  Herman, Melina ^a   Ciancanelli, Michael ^a   Ou, Yi Hung ^b   Lorenzo, Lazaro ^c   Klaudel Dreszler, Maja ^d   Pauwels, Elodie ^a   Sancho Shimizu, Vanessa ^c   Pérez de Diego, Rebeca ^c   Abhyankar, Avinash ^a   Israelsson, Elisabeth ^e   Guo, Yiqi ^a   Cardon, Annabelle ^c   Rozenberg, Flore ^f   Lebon, Pierre ^f   Tardieu, Marc ^g   Heropolitańska Pliszka, Edyta ^d   Chaussabel, Damien ^e   White, Michael A ^b   Abel, Laurent ^a,c   Zhang, Shen Ying ^a,c   Casanova, Jean Laurent ^a,c,h   more..

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^e BENAROYA RESEARCH INSTITUTE   (United States)

^f Cochin Medical School and Paris Descartes University ^*  (France)

^g BICÊTRE HOSPITAL   (France)

^h HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ALPHA INTERFERON; ALPHA2B INTERFERON; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; BETA INTERFERON; DIPHTHERIA PERTUSSIS TETANUS VACCINE; HEPATITIS B VACCINE; IMMUNOGLOBULIN; MANNITOL; MEASLES MUMPS RUBELLA VACCINE; MUMPS VACCINE; PHENOBARBITAL; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN KINASE; STEROID; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; VALPROIC ACID;

ABSENCE OF SIDE EFFECTS; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CASE REPORT; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FIBROBLAST; GENE; GENE MUTATION; HAPLOTYPE; HERPES SIMPLEX ENCEPHALITIS; HERPES SIMPLEX VIRUS 1; HETEROZYGOSITY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TBK1 GENE; VESICULAR STOMATITIS VIRUS; VIRUS ETIOLOGY; VIRUS IMMUNITY; VIRUS REPLICATION;

ANIMALS; CELL DEATH; CELLS, CULTURED; CHILD; ENCEPHALITIS, HERPES SIMPLEX; FEMALE; FIBROBLASTS; GENES, DOMINANT; HERPESVIRUS 1, HUMAN; HUMANS; INTERFERON-BETA; MALE; MICE; MUTATION; POLY I-C; PROTEIN-SERINE-THREONINE KINASES; TOLL-LIKE RECEPTOR 3; VESICULOVIRUS;

EID: 84866393226     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20111316     Document Type: Article

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