TLR3 deletion limits mortality and disease severity due to phlebovirus infection

Journal of Immunology

Volumn 177, Issue 9, 2006, Pages 6301-6307

  Gowen, Brian B ^a   Hoopes, Justin D ^a   Wong, Min Hui ^a   Jung, Kie Hoon ^a   Isakson, Kevin C ^a   Alexopoulou, Lena ^b   Flavell, Richard A ^c   Sidwell, Robert W ^a  

^a UTAH STATE UNIVERSITY   (United States)

^b CNRS   (France)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; GAMMA INTERFERON; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TOLL LIKE RECEPTOR 3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; HOST RESISTANCE; LIVER DISEASE; MOUSE; NONHUMAN; PHLEBOVIRUS; PRIORITY JOURNAL; PUNTA TORO VIRUS; RECEPTOR INTRINSIC ACTIVITY; RIFT VALLEY FEVER BUNYAVIRUS; SURVIVAL; VIRUS INFECTION; VIRUS LOAD; VIRUS PATHOGENESIS;

EID: 33750338072     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.9.6301     Document Type: Article

References (36)

1. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4: 499-511.
2. Hoebe, K., E. Janssen, and B. Beutler. 2004. The interface between innate and adaptive immunity. Nat. Immunol. 5: 971-974.
3. Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413: 732-738.
4. Edelmann, K. H., S. Richardson-Burns, L. Alexopoulou, K. L. Tyler, R. A. Flavell, and M. B. Oldstone. 2004. Does Toll-like receptor 3 play a biological role in virus infections? Virology 322: 231-238.
5. Guillot, L., R. Le Goffic, S. Bloch, N. Escriou, S. Akira, M. Chignard, and M. Si-Tahar. 2005. Involvement of Toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J. Biol. Chem. 280: 5571-5580.
6. Rudd, B. D., J. J. Smit, R. A. Flavell, L. Alexopoulou, M. A. Schaller, A. Gruber, A. A. Berlin, and N. W. Lukacs. 2006. Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection. J. Immunol. 176: 1937-1942.
7. Tabeta, K., P. Georgel, E. Janssen, X. Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, J. Goode, et al. 2004. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. USA 101: 3516-3521.
8. Wang, T., T. Town, L. Alexopoulou, J. F. Anderson, E. Fikrig, and R. A. Flavell. 2004. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat. Med. 10: 1366-1373.
9. Ferreon, J. C., A. C. Ferreon, K. Li, and S. M. Lemon. 2005. Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease. J. Biol. Chem. 280: 20483-20492.
10. Harte, M. T., I. R. Haga, G. Maloney, P. Gray, P. C. Reading, N. W. Bartlett, G. L. Smith, A. Bowie, and L. A. O'Neill. 2003. The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J. Exp. Med. 197: 343-351.
11. Li, K., E. Foy, J. C. Ferreon, M. Nakamura, A. C. Ferreon, M. Ikeda, S. C. Ray, M. Gale, Jr., and S. M. Lemon. 2005. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc. Natl. Acad. Sci. USA 102: 2992-2997.
12. Stack, J., I. R. Haga, M. Schroder, N. W. Bartlett, G. Maloney, P. C. Reading, K. A. Fitzgerald, G. L. Smith, and A. G. Bowie. 2005. Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J. Exp. Med. 201: 1007-1018.
13. Sidwell, R. W., and D. F. Smee. 2003. Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control. Antiviral Res. 57: 101-111.
14. Peters, C. J., and J. M. Meegan. 1981. Rift Valley fever. In Handbook Series of Zooneses. G. W. Beran, ed. CRC Press, Boca Raton, pp. 403-420.
15. Anderson, G. W., Jr., M. V. Slayter, W. Hall, and C. J. Peters. 1990. Pathogenesis of a phleboviral infection (Punta Toro virus) in golden Syrian hamsters. Arch. Virol. 114: 203-212.
16. Pifat, D. Y., and J. F. Smith. 1987. Punta Toro virus infection of C57BL/6J mice: a model for phlebovirus-induced disease. Microb. Pathog. 3: 409-422.
17. Sidwell, R. W., J. H. Huffman, D. L. Barnard, D. F. Smee, R. P. Warren, M. A. Chirigos, M. Kende, and J. Huggins. 1994. Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections. Antiviral Res. 25: 105-122.
18. Sidwell, R. W., J. H. Huffman, D. L. Barnard, and D. Y. Pifat. 1988. Effects of ribamidine, a 3-carboxamidine derivative of ribavirin, on experimentally induced Phlebovirus infections. Antiviral Res. 10: 193-207.
19. Sidwell, R. W., J. H. Huffman, B. B. Barnett, and D. Y. Pifat. 1988. In vitro and in vivo Phlebovirus inhibition by ribavirin. Antimicrob. Agents Chemother. 32: 331-336.
20. Mead, J. R., R. A. Burger, L. J. Yonk, J. Coombs, R. P. Warren, M. Kende, J. Huggins, and R. W. Sidwell. 1991. Effect of human, recombinant interleukin 2 on Punta Toro virus infections in C57BL/6 mice. Antiviral Res. 15: 331-340.
21. Smee, D. F., J. H. Huffman, A. C. Gessaman, J. W. Huggins, and R. W. Sidwell. 1991. Prophylactic and therapeutic activities of 7-thia-8-oxoguanosine against Punta Toro virus infections in mice. Antiviral Res, 15: 229-239.
22. Sidwell, R. W., J. H. Huffman, D. F. Smee, J. Gilbert, A. Gessaman, A. Pease, R. P. Warren, J. Huggins, and M. Kende. 1992. Potential role of immunomodulators for treatment of phlebovirus infections of animals. Ann. NY Acad. Sci. 653: 344-355.
23. Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 27: 493-497.
24. Geisbert, T. W., and P. B. Jahrling. 2004. Exotic emerging viral diseases: progress and challenges. Nat. Med. 10: S110-S121.
25. Le Goffic, R., V. Balloy, M. Lagranderie, L. Alexopoulou, N. Escriou, R. A. Flavell, M. Chignard, and M. Si-Tahar. 2006. Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog. 2: e53.
26. Bray, M. 2005. Pathogenesis of viral hemorrhagic fever. Curr. Opin. Immunol. 17: 399-403.
27. Leroy, E. M., S. Baize, V. E. Volchkov, S. P. Fisher-Hoch, M. C. Georges-Courbot, J. Lansoud-Soukate, M. Capron, P. Debre, J. B. McCormick, and A. J. Georges. 2000. Human asymptomatic Ebola infection and strong inflammatory response. Lancet 355: 2210-2215.
28. Romani, L., P. Puccetti, and F. Bistoni. 1997. Interleukin-12 in infectious diseases. Clin. Microbiol. Rev. 10: 611-636.
29. Hegde, S., J. Pahne, and S. Smola-Hess. 2004. Novel immunosuppressive properties of interleukin-6 in dendritic cells: inhibition of NF-κB binding activity and CCR7 expression. FASEB J. 18: 1439-1441.
30. Calandra, T., J. Gerain, D. Heumann, J. D. Baumgartner, and M. P. Glauser. 1991. High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines: the Swiss-Dutch J5 Immunoglobulin Study Group. Am. J. Med. 91: 23-29.
31. Damas, P., D. Ledoux, M. Nys, Y. Vrindts, D. De Groote, P. Franchimont, and M. Lamy. 1992. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann. Surg. 215: 356-362.
32. Lei, H. Y., T. M. Yeh, H. S. Liu, Y. S. Lin, S. H. Chen, and C. C. Liu. 2001. Immunopathogenesis of dengue virus infection. J. Biomed. Sci. 8: 377-388.
33. Kurt-Jones, E. A., J. Belko, C. Yu, P. E. Newburger, J. Wang, M. Chan, D. M. Knipe, and R. W. Finberg. 2005. The role of Toll-like receptors in herpes simplex infection in neonates. J. Infect. Dis. 191: 746-748.
34. Kopf, M., H. Baumann, G. Freer, M. Freudenberg, M. Lamers, T. Kishimoto, R. Zinkernagel, H. Bluethmann, and G. Kohler. 1994. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368: 339-342.
35. Khan, M. A., C. Ma, L. A. Knodler, Y. Valdez, C. M. Rosenberger, W. Deng, B. B. Finlay, and B. A. Vallance. 2006. Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect. Immun. 74: 2522-2536.
36. Kurt-Jones, E. A., M. Chan, S. Zhou, J. Wang, G. Reed, R. Bronson, M. M. Arnold, D. M. Knipe, and R. W. Finberg. 2004. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc. Natl. Acad. Sci. USA 101: 1315-1320.