-
1
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783-801 (2006).
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
3
-
-
21344465240
-
TLR signalling and the function of dendritic cells
-
Hemmi, H. & Akira, S. TLR signalling and the function of dendritic cells. Chem. Immunol. Allergy 86, 120-135 (2005).
-
(2005)
Chem. Immunol. Allergy
, vol.86
, pp. 120-135
-
-
Hemmi, H.1
Akira, S.2
-
4
-
-
20344389060
-
Toll-like receptors: Linking innate and adaptive immunity
-
Pasare, C. & Medzhitov, R. Toll-like receptors: Linking innate and adaptive immunity. Adv. Exp. Med. Biol. 560, 11-18 (2005).
-
(2005)
Adv. Exp. Med. Biol
, vol.560
, pp. 11-18
-
-
Pasare, C.1
Medzhitov, R.2
-
5
-
-
38849199203
-
Shared principles in NF-κB signaling
-
Hayden, M.S. & Ghosh, S. Shared principles in NF-κB signaling. Cell 132, 344-362 (2008).
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
6
-
-
0038393016
-
IKKε and TBK1 are essential components of the IRF3 signaling pathway
-
Fitzgerald, K.A. et al. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491-496 (2003).
-
(2003)
Nat. Immunol
, vol.4
, pp. 491-496
-
-
Fitzgerald, K.A.1
-
7
-
-
0038363463
-
Triggering the interferon antiviral response through an IKK-related pathway
-
Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148-1151 (2003).
-
(2003)
Science
, vol.300
, pp. 1148-1151
-
-
Sharma, S.1
-
8
-
-
0037114185
-
Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling
-
Yamamoto, M. et al. Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J. Immunol. 169 6668-6672 (2002).
-
(2002)
J. Immunol
, vol.169
, pp. 6668-6672
-
-
Yamamoto, M.1
-
9
-
-
0037320451
-
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
-
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. & Seya, T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat. Immunol. 4, 161-167 (2003).
-
(2003)
Nat. Immunol
, vol.4
, pp. 161-167
-
-
Oshiumi, H.1
Matsumoto, M.2
Funami, K.3
Akazawa, T.4
Seya, T.5
-
10
-
-
0043176281
-
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
-
Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640-643 (2003).
-
(2003)
Science
, vol.301
, pp. 640-643
-
-
Yamamoto, M.1
-
11
-
-
0037292275
-
Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members
-
Janssens, S. & Beyaert, R. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol. Cell 11, 293-302 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 293-302
-
-
Janssens, S.1
Beyaert, R.2
-
12
-
-
34547248579
-
Pellino proteins: Novel players in TLR and IL-1R signalling
-
Schauvliege, R., Janssens, S. & Beyaert, R. Pellino proteins: Novel players in TLR and IL-1R signalling. J. Cell. Mol. Med. 11, 453-461 (2007).
-
(2007)
J. Cell. Mol. Med
, vol.11
, pp. 453-461
-
-
Schauvliege, R.1
Janssens, S.2
Beyaert, R.3
-
13
-
-
34248570795
-
Ubiquitin-mediated activation of TAK1 and IKK
-
Adhikari, A., Xu, M. & Chen, Z.J. Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 26, 3214-3226 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 3214-3226
-
-
Adhikari, A.1
Xu, M.2
Chen, Z.J.3
-
14
-
-
0032934595
-
Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal
-
Grosshans, J., Schnorrer, F. & Nüsslein-Volhard, C. Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal. Mech. Dev. 81, 127-138 (1999).
-
(1999)
Mech. Dev
, vol.81
, pp. 127-138
-
-
Grosshans, J.1
Schnorrer, F.2
Nüsslein-Volhard, C.3
-
15
-
-
33746893480
-
Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: A role as novel RING E3-ubiquitin-ligases
-
Schauvliege, R., Janssens, S. & Beyaert, R. Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: A role as novel RING E3-ubiquitin-ligases. FEBS Lett. 580, 4697-4702 (2006).
-
(2006)
FEBS Lett
, vol.580
, pp. 4697-4702
-
-
Schauvliege, R.1
Janssens, S.2
Beyaert, R.3
-
16
-
-
35649022764
-
Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: Direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
-
Butler, M.P., Hanly, J.A. & Moynagh, P.N. Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: Direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. J. Biol. Chem. 282, 29729-29737 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 29729-29737
-
-
Butler, M.P.1
Hanly, J.A.2
Moynagh, P.N.3
-
17
-
-
38149085473
-
The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1
-
Ordureau, A. et al. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. Biochem. J. 409, 43-52 (2008).
-
(2008)
Biochem. J
, vol.409
, pp. 43-52
-
-
Ordureau, A.1
-
18
-
-
27744561393
-
Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-κB activation but does not contribute to interferon regulatory factor 3 activation
-
Cusson-Hermance, N., Khurana, S., Lee, T.H., Fitzgerald, K.A. & Kelliher, M.A. Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-κB activation but does not contribute to interferon regulatory factor 3 activation. J. Biol. Chem. 280, 36560-36566 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 36560-36566
-
-
Cusson-Hermance, N.1
Khurana, S.2
Lee, T.H.3
Fitzgerald, K.A.4
Kelliher, M.A.5
-
19
-
-
2442642691
-
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation
-
Meylan, E. et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation. Nat. Immunol. 5, 503-507 (2004).
-
(2004)
Nat. Immunol
, vol.5
, pp. 503-507
-
-
Meylan, E.1
-
20
-
-
50449088575
-
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors
-
Chen, N.J. et al. Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc. Natl. Acad. Sci. USA 105, 12429-12434 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 12429-12434
-
-
Chen, N.J.1
-
21
-
-
50049125047
-
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses
-
Ermolaeva, M.A. et al. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat. Immunol. 9, 1037-1046 (2008).
-
(2008)
Nat. Immunol
, vol.9
, pp. 1037-1046
-
-
Ermolaeva, M.A.1
-
22
-
-
50149089360
-
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors
-
Pobezinskaya, Y.L. et al. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat. Immunol. 9, 1047-1054 (2008).
-
(2008)
Nat. Immunol
, vol.9
, pp. 1047-1054
-
-
Pobezinskaya, Y.L.1
-
23
-
-
4344613405
-
Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/ IL-1 receptor domain-containing adaptor-inducing IFN-β (TRIF -dependent pathway in TLR signaling
-
Gohda, J., Matsumura, T. & Inoue, J. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/ IL-1 receptor domain-containing adaptor-inducing IFN-β (TRIF -dependent pathway in TLR signaling. J. Immunol. 173, 2913-2917 (2004).
-
(2004)
J. Immunol
, vol.173
, pp. 2913-2917
-
-
Gohda, J.1
Matsumura, T.2
Inoue, J.3
-
24
-
-
0000352873
-
Galactosamine-induced sensitization to the lethal effects of endotoxin
-
Galanos, C.F.M., Reutter, W. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc. Natl. Acad. Sci. USA 76, 5939-5943 (1979).
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 5939-5943
-
-
Galanos, C.F.M.1
Reutter, W.2
-
25
-
-
0027297663
-
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
-
Pfeffer, K. et al. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73, 457-467 (1993).
-
(1993)
Cell
, vol.73
, pp. 457-467
-
-
Pfeffer, K.1
-
26
-
-
0029989339
-
Immune and inflammatory responses in TNFα-deficient mice: A critical requirement for TNFα in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
-
Pasparakis, M., Alexopoulou, L., Episkopou, V. & Kollias, G. Immune and inflammatory responses in TNFα-deficient mice: A critical requirement for TNFα in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184, 1397-1411 (1996).
-
(1996)
J. Exp. Med
, vol.184
, pp. 1397-1411
-
-
Pasparakis, M.1
Alexopoulou, L.2
Episkopou, V.3
Kollias, G.4
-
27
-
-
41149083879
-
Tumor necrosis factor β mediates the lethal hepatotoxic effects of poly(I:C) in D-galactosamine-sensitized mice
-
Dejager, L. & Libert, C. Tumor necrosis factor β mediates the lethal hepatotoxic effects of poly(I:C) in D-galactosamine-sensitized mice. Cytokine 42, 55-61 (2008).
-
(2008)
Cytokine
, vol.42
, pp. 55-61
-
-
Dejager, L.1
Libert, C.2
-
28
-
-
0025148355
-
Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine
-
Vanguri, P. & Farber, J.M. Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine. J. Biol. Chem. 265, 15049-15057 (1990).
-
(1990)
J. Biol. Chem
, vol.265
, pp. 15049-15057
-
-
Vanguri, P.1
Farber, J.M.2
-
29
-
-
27844541797
-
Control of B cell responses by Toll-like receptors
-
Pasare, C. & Medzhitov, R. Control of B cell responses by Toll-like receptors. Nature 438, 364-368 (2005).
-
(2005)
Nature
, vol.438
, pp. 364-368
-
-
Pasare, C.1
Medzhitov, R.2
-
30
-
-
33645956556
-
TLR stimulation as a third signal required for activation of human naive B cells
-
Ruprecht, C.R. & Lanzavecchia, A. TLR stimulation as a third signal required for activation of human naive B cells. Eur. J. Immunol. 36, 810-816 (2006).
-
(2006)
Eur. J. Immunol
, vol.36
, pp. 810-816
-
-
Ruprecht, C.R.1
Lanzavecchia, A.2
-
31
-
-
34548411427
-
Regulating B cell activation and survival in response to TLR signals
-
Gerondakis, S., Grumont, R.J. & Banerjee, A. Regulating B cell activation and survival in response to TLR signals. Immunol. Cell Biol. 85, 471-475 (2007).
-
(2007)
Immunol. Cell Biol
, vol.85
, pp. 471-475
-
-
Gerondakis, S.1
Grumont, R.J.2
Banerjee, A.3
-
32
-
-
0032526607
-
CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry
-
Yi, A.K., Chang, M., Peckham, D.W., Krieg, A.M. & Ashman, R.F. CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry. J. Immunol. 160, 5898-5906 (1998).
-
(1998)
J. Immunol
, vol.160
, pp. 5898-5906
-
-
Yi, A.K.1
Chang, M.2
Peckham, D.W.3
Krieg, A.M.4
Ashman, R.F.5
-
33
-
-
3543097542
-
RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation
-
Vivarelli, M.S. et al. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J. Exp. Med. 200 399-404 (2004).
-
(2004)
J. Exp. Med
, vol.200
, pp. 399-404
-
-
Vivarelli, M.S.1
-
34
-
-
0037799886
-
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex
-
Jiang, Z. et al. Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. J. Biol. Chem. 278, 10952-10956 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 10952-10956
-
-
Jiang, Z.1
-
35
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
O'Neill, L.A. & Bowie, A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7 353-364 (2007).
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.1
Bowie, A.G.2
-
36
-
-
0141923690
-
Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the Toll-like receptor signaling
-
Sato, S. et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171, 4304-4310 (2003).
-
(2003)
J. Immunol
, vol.171
, pp. 4304-4310
-
-
Sato, S.1
-
37
-
-
36448943427
-
DUBA: A deubiquitinase that regulates type I interferon production
-
Kayagaki, N. et al. DUBA: A deubiquitinase that regulates type I interferon production. Science 318, 1628-1632 (2007).
-
(2007)
Science
, vol.318
, pp. 1628-1632
-
-
Kayagaki, N.1
-
38
-
-
33646342149
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
-
Kato, H. et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441, 101-105 (2006).
-
(2006)
Nature
, vol.441
, pp. 101-105
-
-
Kato, H.1
-
39
-
-
33646592188
-
The specific and essential role of MAVS in antiviral innate immune responses
-
Sun, Q. et al. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24, 633-642 (2006).
-
(2006)
Immunity
, vol.24
, pp. 633-642
-
-
Sun, Q.1
-
40
-
-
0038714270
-
Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFκB and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR
-
Jiang, Z. et al. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFκB and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J. Biol. Chem. 278, 16713-16719 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 16713-16719
-
-
Jiang, Z.1
-
41
-
-
34249095729
-
Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling
-
Kawagoe, T. et al. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J. Exp. Med. 204, 1013-1024 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 1013-1024
-
-
Kawagoe, T.1
-
42
-
-
44049097129
-
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
-
Kawagoe, T. et al. Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat. Immunol. 9, 684-691 (2008).
-
(2008)
Nat. Immunol
, vol.9
, pp. 684-691
-
-
Kawagoe, T.1
-
43
-
-
17144413785
-
Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
-
Kaiser, W.J. & Offermann, M.K. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J. Immunol. 174, 4942-4952 (2005).
-
(2005)
J. Immunol
, vol.174
, pp. 4942-4952
-
-
Kaiser, W.J.1
Offermann, M.K.2
-
44
-
-
0034745420
-
-
Xiao, G., Harhaj, E.W. & Sun, S.C. NF-κB-inducing kinase regulates the processing of NF-κB2 p100. Mol. Cell 7, 401-409 (2001).
-
Xiao, G., Harhaj, E.W. & Sun, S.C. NF-κB-inducing kinase regulates the processing of NF-κB2 p100. Mol. Cell 7, 401-409 (2001).
-
-
-
-
45
-
-
11244341060
-
Tumorsuppressor negatively regulates JNK signaling pathway downstream of TNFR members
-
Reiley, W., Zhang, M. & Sun, S.-C. Tumorsuppressor negatively regulates JNK signaling pathway downstream of TNFR members. J. Biol. Chem. 279, 55161-55167 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 55161-55167
-
-
Reiley, W.1
Zhang, M.2
Sun, S.-C.3
-
46
-
-
0024394044
-
Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages
-
Racoosin, E.L. & Swanson, J.A. Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages. J. Exp. Med. 170, 1635-1648 (1989).
-
(1989)
J. Exp. Med
, vol.170
, pp. 1635-1648
-
-
Racoosin, E.L.1
Swanson, J.A.2
-
47
-
-
49649123561
-
Regulation of IκB kinase-related kinases and antiviral responses by tumor suppressor CYLD
-
Zhang, M. et al. Regulation of IκB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J. Biol. Chem. 283, 18621-18626 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 18621-18626
-
-
Zhang, M.1
-
48
-
-
33645103440
-
Regulation of T cell development by the deubiquitinating enzyme CYLD
-
Reiley, W.W. et al. Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat. Immunol. 7, 411-417 (2006).
-
(2006)
Nat. Immunol
, vol.7
, pp. 411-417
-
-
Reiley, W.W.1
-
49
-
-
0034682831
-
The NF-κ B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death
-
Rivera-Walsh, I., Cvijic, M.E., Xiao, G. & Sun, S.C. The NF-κ B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death. J. Biol. Chem. 275, 25222-25230 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 25222-25230
-
-
Rivera-Walsh, I.1
Cvijic, M.E.2
Xiao, G.3
Sun, S.C.4
|