The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling

Nature Immunology

Volumn 7, Issue 10, 2006, Pages 1074-1081

  Carty, Michael ^a   Goodbody, Rory ^a   Schröder, Martina ^a   Stack, Julianne ^a   Moynagh, Paul N ^b   Bowie, Andrew G ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CHEMOKINE; CYTOKINE; INTERLEUKIN 1 RECEPTOR; PROTEIN SARM; PROTEIN TRIF; REGULATOR PROTEIN; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; KNOCKOUT GENE; MAMMAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ARMADILLO DOMAIN PROTEINS; CELLS, CULTURED; CHEMOKINES; CYTOKINES; CYTOSKELETAL PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTERFERON REGULATORY FACTOR-7; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 33748871187     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1382     Document Type: Article

References (35)

1. Beutler, B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430, 257-263 (2004).
2. Moynagh, P.N. TLR signalling and activation of IRFs: Revisiting old friends from the NF-κB pathway. Trends Immunol. 26, 469-476 (2005).
3. O'Neill, L.A.J., Fitzgerald, K. & Bowie, A.G. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol. 24, 286-289 (2003).
4. Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signalling pathway. Science 301, 640-643 (2003).
5. McGettrick, A.F. & O'Neill, L.A. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol. Immunol. 41, 577-582 (2004).
6. Fitzgerald, K.A. et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83 (2001).
7. Horng, T., Barton, G.M. & Medzhitov, R. TIRAP: An adapter molecule in the Toll signaling pathway. Nat. Immunol. 2, 835-841 (2001).
8. Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. & Seya, T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction. Nat. Immunol. 4, 161-167 (2003).
9. Yamamoto, M. et al. Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signalling. J. Immunol. 169, 6668-6672 (2002).
10. Hoebe, K. et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424, 743-748 (2003).
11. Fitzgerald, K.A. et al. LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043-1055 (2003).
12. Mink, M., Fogelgren, B., Olszewski, K., Maroy, P. & Csiszar, K. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/β-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. Genomics 74, 234-244 (2001).
13. Couillault, C. et al. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Nat. Immunol. 5, 488-494 (2004).
14. Liberati, N.T. et al. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc. Natl. Acad. Sci. USA 101, 6593-6598 (2004).
15. Chuang, C.F. & Bargmann, C.I.A. Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signalling. Genes Dev. 19, 270-281 (2005).
16. Kaiser, W.J. & Offermann, M.K. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J. Immunol. 174, 4942-4952 (2005).
17. Wald, D. et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signalling. Nat. Immunol. 4, 920-927 (2003).
18. Brint, E.K. et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol. 5, 373-379 (2004).
19. Meylan, E. et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167-1172 (2005).
20. Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in doublestranded RNA-induced innate antiviral responses. Nat. Immunol. 5, 730-737 (2004).
21. Clemens, M.J. PKR-a protein kinase regulated by double-stranded RNA. Int. J. Biochem. Cell Biol. 29, 945-949 (1997).
22. Honda, K. et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434, 772-777 (2005).
23. Kawai, T. et al, Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 5, 1061-1068 (2004).
24. Honda, K. et al. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signalling. Proc. Natl. Acad. Sci. USA 101, 15416-15421 (2004).
25. Meylan, E. et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation. Nat. Immunol. 5, 503-507 (2004).
26. Fitzgerald, K.A. et al. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491-496 (2003).
27. Stack, J. et al. Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J. Exp. Med. 201, 1007-1018 (2005).
28. Kariko, K. et al. Exogenous siRNA mediates sequence-independent gene suppression by signaling through Toll-like receptor 3. Cells Tissues Organs 177, 132-138 (2004).
29. Hoebe, K. et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol. 4, 1162-1164 (2003).
30. Weighardt, H. et al. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. Eur. J. Immunol. 34, 558-564 (2004).
31. Li, K. et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc. Natl. Acad. Sci. USA 102, 2992-2997 (2005).
32. Liew, F.Y., Xu, D., Brint, E.K. & O'Neill, L.A. Negative regulation of toll-like receptormediated immune responses. Nat. Rev. Immunol. 5, 446-58 (2005).
33. Sato, S. et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171, 4304-4310 (2003).
34. Kim, C.A. & Bowie, J.U. SAM domains: Uniform structure, diversity of function. Trends Biochem. Sci. 28, 625-628 (2003).
35. Muzio, M., Ni, J., Feng, P. & Dixit, V.M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612-1615 (1997).