Nuclear receptors PXR and CAR: Implications for drug metabolism regulation, pharmacogenomics and beyond

Expert Opinion on Drug Metabolism and Toxicology

Volumn 9, Issue 3, 2013, Pages 253-266

  Chai, Xiaojuan ^a,b   Zeng, Su ^a   Xie, Wen ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

'orphan' nuclear receptors; Cytochrome P450s; Endobiotic metabolism; Xenobiotic metabolism

Indexed keywords

ANTINEOPLASTIC AGENT; BILIRUBIN; CARBAMAZEPINE; CHOLESTANETRIOL 26 MONOOXYGENASE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; ENICONAZOLE; FLUCONAZOLE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HETERODIMER; KETOCONAZOLE; ORPHAN NUCLEAR RECEPTOR; PACLITAXEL; PHENYTOIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); POLYCHLORINATED BIPHENYL; PREGNANE X RECEPTOR; RIFAXIMIN; SULFORAPHANE; SULFOTRANSFERASE; TRABECTEDIN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

BILE ACID METABOLISM; CHOLESTASIS; CHOLESTEROL METABOLISM; CONJUGATION; DETOXIFICATION; DNA BINDING; DNA POLYMORPHISM; DNA RESPONSIVE ELEMENT; DRUG METABOLISM; DRUG RECEPTOR BINDING; EXON; FATTY LIVER; GENE EXPRESSION; GENE TARGETING; GLUCOSE METABOLISM; HUMAN; INFLAMMATION; LIGAND BINDING; LIPID METABOLISM; MOLECULAR INTERACTION; NONHUMAN; PHARMACOGENOMICS; PROTEIN EXPRESSION; PSEUDOGENE; REVIEW; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; X RAY CRYSTALLOGRAPHY; XENOBIOTIC METABOLISM;

ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; GLUCOSE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HUMANS; LIPID METABOLISM; METABOLIC DETOXICATION, DRUG; PHARMACOGENETICS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SULFOTRANSFERASES; TRANSCRIPTION FACTORS; XENOBIOTICS;

EID: 84874025943     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2013.754010     Document Type: Review

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