Nuclear receptor coregulators: Cellular and molecular biology

Endocrine Reviews

Volumn 20, Issue 3, 1999, Pages 321-344

  McKenna, N J ^a   Lanz, R B ^a   O'Malley, B W ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANDROGEN; ANDROGEN RECEPTOR; CELL NUCLEUS RECEPTOR; COLECALCIFEROL; CORTICOSTEROID; DNA; ESTROGEN; ESTROGEN RECEPTOR; GESTAGEN; GLUCOCORTICOID RECEPTOR; HISTONE DEACETYLASE; MINERALOCORTICOID RECEPTOR; RECEPTOR PROTEIN; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; SEX HORMONE; STEROID RECEPTOR COACTIVATOR 1; THYROID HORMONE; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE; VITAMIN D RECEPTOR;

CHROMATIN; DEACETYLATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPRESSOR GENE; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0033305547     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.20.3.321     Document Type: Review

References (216)

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3. Regulation of gene expression by nuclear hormone receptors
4. Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins
5. Mutational analysis of the chicken progesterone receptor
6. Evidence that the conserved region in the steroid-binding domain of the glucocorticoid receptor is required for both optimal binding of hsp90 and protection from proteolytic cleavage
7. Two signals mediate hormone-dependent nuclear localisation of the glucocorticoid receptor
8. The role of general initiation factors in transcription by RNA polymerase II
9. Common themes in assembly and function of eukaryotic transcription complexes
10. Human TAF(II)30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor
11. Cloning and characterization of hTAF(II)18, hTAF(II)20 and hTAF(II)28: Three subunits of the human transcription factor TFIID
12. Model for binding of transcription factor TFIIB to the TBP-DNA complex
13. Multiple functional domains of human transcription factor IIB: Distinct interactions with two general transcription factors and RNA polymerase II
14. An RNA polymerase II holoenzyme responsive to activators
15. Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain
16. Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation
17. Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein
18. Identification of a transactivation function in the progesterone receptor that interacts with the TAF(II)110 subunit of the TFIID complex
19. Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF
20. Stimulation of RARα activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7
21. Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription
22. Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)
23. Steroid hormone receptors compete for factors that mediate their enhancer function
24. The human estrogen receptor has two independent non-acidic transcriptional activation functions
25. Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors
26. Estrogen receptor-associated proteins: Possible mediators of hormone-induced transcription
27. A fraction enriched in a novel glucocorticoid receptor-interacting protein stimulates receptor-dependent transcription in vitro
28. Interaction of proteins with transcriptionally active estrogen receptors
29. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor
30. Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2
31. The receptor-associated coactivator 3 activates transcription through CREB-binding protein recruitment and autoregulation
32. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
33. SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4
34. Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor γ
35. Steroid receptor induction of gene transcription - A two-step model
36. Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits
37. Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations
38. Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations
39. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors
40. Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator
41. Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators
42. Mapping the domains of the interaction of the vitamin D receptor and steroid receptor coactivator-1
43. Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator
44. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
45. The aryl hydrocarbon receptor complex
46. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
47. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
48. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
49. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
50. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
51. Yeast hormone response element assays detect and characterize GRIP1 coactivator-dependent activation of transcription by thyroid and retinoid nuclear receptors
52. Nuclear receptor co-activator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
53. RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
54. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
55. TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule exhibits distinct properties from steroid receptor coactivator-1
56. A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity
57. Distinct steady state nuclear receptor coregulator complexes exist in vivo
58. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene
59. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
60. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): Multiple motifs with different binding specificities
61. Structure and specificity of nuclear receptor-coactivator interactions
62. Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators
63. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
64. The nuclear receptor ligand-binding domain: Structure and function
65. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
66. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
67. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily
68. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
69. Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors
70. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT
71. TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors
72. hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the prooncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II
73. Interaction of thyroid-hormone receptor with a conserved transcriptional mediator
74. Identification of the GAL4 suppressor Sug1 as a subunit of the yeast 26S proteasome
75. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex
76. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor
77. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
78. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
79. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
80. Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator
81. Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID
82. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes
83. A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators
84. Human TAF(II)28 promotes transcriptional stimulation by activation function 2 of the retinoid X receptors
85. Human TAF(II)135 potentiates transcriptional activation by the AF-2 s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells
86. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor
87. Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes
88. Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription
89. Tuberous sclerosis
90. Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease
91. Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members
92. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex
93. Cloning and characterization of a specific coactivator, ARA-70, for the androgen receptor in human prostate cells
94. Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells
95. A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein
96. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
97. High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells
98. Nuclear protein CBP is a coactivator for the transcription factor CREB
99. Recruitment of p300/CBP in p53-dependent signal pathways
100. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator
101. Role of CBP/p300 in nuclear receptor signalling
102. CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1
103. CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription
104. Nuclear receptors have distinct affinities for coactivators: Characterization by fluorescence resonance energy transfer
105. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
106. Molecular cloning and functional analysis of the adenovirus E1A-associated 300 kD protein (p300) reveals a protein with properties of a transcriptional adaptor
107. Human p300 protein is a coactivator for the transcription factor MyoD
108. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300
109. p300 Is a component of an estrogen receptor coactivator complex
110. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
111. p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
112. Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression
113. Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer
114. Dimerization among nuclear hormone receptors
115. Interaction of human thyroid hormone receptor β with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone
116. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist
117. A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor
118. Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor
119. The τ4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing
120. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
121. Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR
122. Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain
123. A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains
124. Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT)
125. Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1
126. The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAF(II)32 and TAF(II)70
127. A transcriptional co-repressor that interacts with nuclear hormone receptors
128. Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors
129. SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers
130. Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors
131. A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage
132. 3 receptors and transcriptional corepressors
133. Nuclear, receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone
134. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein
135. SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia
136. Role of the histone deacetylase complex in acute promyelocytic leukaemia
137. Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia
138. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
139. Cell-specific inhibition of retinoic acid receptor-α silencing by the AF2/τc activation domain can be overcome by the corepressor SMRT, but not by N-CoR
140. Stoichiometric and steric principles governing repression by nuclear hormone receptors
141. Proteasomal regulation of nuclear receptor corepressor-mediated repression
142. A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors
143. Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex
144. The extreme C terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressor
145. The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor
146. A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors
147. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
148. A nuclear receptor corepressor modulates transcriptional activity of antagonist-occupied steroid hormone receptor
149. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
150. The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor
151. Structure of the nucleosome core particle at 7 A resolution
152. Crystal structure of the nucleosome core particle at 2.8 A resolution
153. Transcription factor loading on the MMTV promoter: A bimodal mechanism for promoter activation
154. Dissection of progesterone receptor-mediated chromatin remodeling and transcriptional activation in vivo
155. Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: Hormone-regulated chromatin disruption is not sufficient for transcriptional activation
156. Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter
157. Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo
158. Transcriptional repression of Xenopus TRβ gene is mediated by a thyroid hormone response element located near the start site
159. A role for nucleosome assembly in both silencing and activation of the Xenopus TRβA gene by the thyroid hormone receptor
160. Targeting chromatin disruption: Transcription regulators that acetylate histones
161. The nucleosome core all wrapped up
162. Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
163. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity
164. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
165. The yeast Ada complex mediates the ligand-dependent activation function AF-2 of retinoid X and estrogen receptors
166. Steroid receptor coactivator-1 is a histone acetyltransferase
167. The histone acetylase PCAF is a nuclear receptor coactivator
168. Histone-like TAFs within the PCAF histone acetylase complex
169. A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation
170. The transcriptional coactivators p300 and CBP are histone acetyltransferases
171. The CBP co-activator is a histone acetyltransferase
172. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
173. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
174. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
175. Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila
176. Cell cycle control of the yeast HO gene: Cis- and trans-acting regulators
177. Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection
178. The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation
179. Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex
180. Facilitated binding of TATA-binding protein to nucleosomal DNA
181. Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors
182. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor
183. Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2
184. Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complex
185. Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex
186. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
187. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
188. A possible involvement of TIF1α and TIF1β in the epigenetic control of transcription by nuclear receptors
189. TIF1α: A possible link between KRAB zinc finger proteins and nuclear receptors
190. Transcriptional repression by RING finger protein TIF1β that interacts with the KRAB repressor domain of KOX1
191. The RING finger: A novel protein sequence motif related to the zinc finger
192. Coactivator TIF1β interacts with transcription factor C/EBPβ and glucocorticoid receptor to induce α1-acid glycoprotein gene expression
193. The putative cofactor TIF1α is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors
194. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes
195. E(z): A polycomb group gene or a trithorax group gene?
196. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae
197. Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator
198. Sinful repression
199. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
200. A mammalian histone deacetylase related to the yeast transcriptional regulator RPD3p
201. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3
202. A site-specific endonuclease essential for mating-type switching in Saccharomyces cerevisiae
203. Control of the yeast cell cycle by the CDC28 protein kinase
204. The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator
205. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
206. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
207. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
208. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression
209. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
210. A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase
211. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
212. Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription
213. A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins
214. Activation of androgen receptor function by a novel nuclear protein kinase