Elucidating the 'Jekyll and Hyde' nature of PXR: The case for discovering antagonists or allosteric antagonists

Pharmaceutical Research

Volumn 26, Issue 8, 2009, Pages 1807-1815

  Biswas, Arunima ^a   Mani, Sridhar ^a   Redinbo, Matthew R ^b   Krasowski, Matthew D ^c   Li, Hao ^a   Ekins, Sean ^d,e,f,g  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d Collaborations in Chemistry ^*  (United States)

^e Collaborative Drug Discovery Inc ^*  (United States)

^f UNIVERSITY OF MARYLAND   (United States)

^g RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Agonists; Antagonists; Machine learning; Pharmacophore; Pregnane X receptor

Indexed keywords

A 792611; COUMESTROL; ENILCONAZOLE; ETHINYLESTRADIOL; FLUCONAZOLE; HORMONE RECEPTOR BLOCKING AGENT; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; IRINOTECAN; ITRACONAZOLE; KETOCONAZOLE; LEFLUNOMIDE; PACLITAXEL; POLYCHLORINATED BIPHENYL DERIVATIVE; PREGNANE X RECEPTOR; PREGNANE X RECEPTOR ANTAGONIST; SPB 00574; SPB 02372; SPB 03255; SPB 06257; SPB 3256; SPB 6061; SULFORAPHANE; TRABECTEDIN; UNCLASSIFIED DRUG;

BLOOD BRAIN BARRIER; CHEMICAL MODEL; DRUG BIOAVAILABILITY; DRUG PROTEIN BINDING; GASTROINTESTINAL TOXICITY; GENETIC MODEL; HUMAN; HYPERICUM PERFORATUM; MOLECULAR MODEL; NONHUMAN; OSTEOMALACIA; PRIORITY JOURNAL; REVIEW;

ALLOSTERIC REGULATION; ANIMALS; RECEPTORS, STEROID;

EID: 67650082856     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9901-7     Document Type: Review

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