Regulatory cross-talk between drug metabolism and lipid homeostasis: Constitutive androstane receptor and pregnane X receptor increase Insig-1 expression

Molecular Pharmacology

Volumn 73, Issue 4, 2008, Pages 1282-1289

  Roth, Adrian ^a   Looser, Renate ^a   Kaufmann, Michel ^a   Blättler, Sharon M ^a   Rencurel, Franck ^a   Huang, Wendong ^b   Moore, David D ^c   Meyer, Urs A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSIG 1 PROTEIN; LIPID; PREGNANE X RECEPTOR; PROTEIN; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; COMPUTER MODEL; CONTROLLED STUDY; DRUG METABOLISM; DRUG TARGETING; ENZYME ACTIVITY; GENE REPRESSION; GENETIC ANALYSIS; HOMEOSTASIS; LIPID LIVER LEVEL; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SYNTHESIS;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; GENE EXPRESSION REGULATION; HEPATOCYTES; HOMEOSTASIS; HUMANS; INJECTIONS, INTRAPERITONEAL; LIPID METABOLISM; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PHARMACEUTICAL PREPARATIONS; PHENOBARBITAL; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR CROSS-TALK; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RESPONSE ELEMENTS; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 41149102969     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.041012     Document Type: Article

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