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Volumn 3, Issue 1, 2006, Pages 71-73

Has the amyloid cascade hypothesis for Alzheimer's disease been proved?

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; CALCIUM; GAMMA SECRETASE; PRESENILIN 1; TAU PROTEIN;

EID: 33645829653     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720506775697098     Document Type: Conference Paper
Times cited : (215)

References (28)
  • 1
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 286: 184-185 (1992).
    • (1992) Science , vol.286 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 2
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharm Sci 12: 383-388 (1991).
    • (1991) Trends Pharm Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 3
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron 6(4): 487-98 (1991).
    • (1991) Neuron , vol.6 , Issue.4 , pp. 487-498
    • Selkoe, D.J.1
  • 4
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • 297
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 19: 297(5580): 353-6 (2002).
    • (2002) Science , vol.19 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 5
    • 0028945660 scopus 로고
    • Evidence that a beta 42 is the real culprit in Alzheimer's disease
    • Younkin SG. Evidence that A beta 42 is the real culprit in Alzheimer's disease. Ann Neurol 37(3): 287-8 (1995).
    • (1995) Ann Neurol , vol.37 , Issue.3 , pp. 287-288
    • Younkin, S.G.1
  • 6
    • 0027526419 scopus 로고
    • Release of excess amyloid beta protein from a mutant amyloid beta protein precursor
    • 259
    • Cai XD, Golde TE, Younkin SG. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science 22: 259(5094): 514-6 (1993).
    • (1993) Science , vol.22 , Issue.5094 , pp. 514-516
    • Cai, X.D.1    Golde, T.E.2    Younkin, S.G.3
  • 7
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
    • 264
    • Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L Jr, Eckman C, et al. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science. 27: 264(5163): 1336-40, (1994).
    • (1994) Science , vol.27 , Issue.5163 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Cai, X.D.3    Odaka, A.4    Otvos Jr., L.5    Eckman, C.6
  • 8
    • 0026745610 scopus 로고
    • Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
    • 360
    • Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, et al. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 17: 360(6405): 672-4 (1992).
    • (1992) Nature , vol.17 , Issue.6405 , pp. 672-674
    • Citron, M.1    Oltersdorf, T.2    Haass, C.3    McConlogue, L.4    Hung, A.Y.5    Seubert, P.6
  • 9
    • 0026894414 scopus 로고
    • Framing b-amyloid
    • Hardy JA. Framing b-amyloid. Nature Genet 1: 233-234, (1992).
    • (1992) Nature Genet , vol.1 , pp. 233-234
    • Hardy, J.A.1
  • 10
    • 0034837775 scopus 로고    scopus 로고
    • The amyloid precursor protein locus and very-late-onset Alzheimer disease
    • Olson JM, Goddard KA, Dudek DM. The amyloid precursor protein locus and very-late-onset Alzheimer disease. Am J Hum Genet 69(4): 895-9 (2001)
    • (2001) Am J Hum Genet , vol.69 , Issue.4 , pp. 895-899
    • Olson, J.M.1    Goddard, K.A.2    Dudek, D.M.3
  • 12
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid b-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, et al. Secreted amyloid b-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med 2: 864-870 (1996).
    • (1996) Nature Med , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3    Song, X.4    Citron, M.5    Suzuki, N.6
  • 13
    • 0036548070 scopus 로고    scopus 로고
    • γ-Secretase, Notch, Abeta and Alzheimer's disease: Where do the presenilins fit in?
    • Sisodia SS, St George-Hyslop PH. γ-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci 3(4): 281-90 (2002).
    • (2002) Nat Rev Neurosci , vol.3 , Issue.4 , pp. 281-290
    • Sisodia, S.S.1    St George-Hyslop, P.H.2
  • 14
    • 0036898485 scopus 로고    scopus 로고
    • Alzheimer disease gamma-secretase: A complex story of GxGD-type presenilin proteases
    • Haass C, Steiner H. Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases. Trends Cell Biol 12(12): 556-62 (2002).
    • (2002) Trends Cell Biol , vol.12 , Issue.12 , pp. 556-562
    • Haass, C.1    Steiner, H.2
  • 15
    • 1342288871 scopus 로고    scopus 로고
    • Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability
    • 24
    • Stutzmann GE, Caccamo A, LaFerla FM, Parker I. Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J Neurosci 14: 24(2): 508-13 (2004).
    • (2004) J Neurosci , vol.14 , Issue.2 , pp. 508-513
    • Stutzmann, G.E.1    Caccamo, A.2    LaFerla, F.M.3    Parker, I.4
  • 16
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • 430
    • Mattson MP. Pathways towards and away from Alzheimer's disease. Nature. 5: 430: 631-9 (2004).
    • (2004) Nature , vol.5 , pp. 631-639
    • Mattson, M.P.1
  • 17
    • 0034426011 scopus 로고    scopus 로고
    • Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
    • Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genet 25: 402-405 (2000).
    • (2000) Nature Genet , vol.25 , pp. 402-405
    • Lewis, J.1    McGowan, E.2    Rockwood, J.3    Melrose, H.4    Nacharaju, P.5    Van Slegtenhorst, M.6
  • 18
    • 17944382037 scopus 로고    scopus 로고
    • Enhanced Neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
    • Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, et al. Enhanced Neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293: 1487-1491 (2001).
    • (2001) Science , vol.293 , pp. 1487-1491
    • Lewis, J.1    Dickson, D.W.2    Lin, W.L.3    Chisholm, L.4    Corral, A.5    Jones, G.6
  • 19
    • 4043167747 scopus 로고    scopus 로고
    • Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • 43
    • Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 5: 43(3): 321-32 (2004)
    • (2004) Neuron , vol.5 , Issue.3 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    LaFerla, F.M.5
  • 20
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9(4): 448-52 (2003).
    • (2003) Nat Med , vol.9 , Issue.4 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 21
    • 0035676453 scopus 로고    scopus 로고
    • Chromosome 13 dementia syndromes as models of neurodegeneration
    • Ghiso J, Revesz T, Holton J, Rostagno A, Lashley T, Houlden H, et al. Chromosome 13 dementia syndromes as models of neurodegeneration. Amyloid 8(4): 277-84 (2001).
    • (2001) Amyloid , vol.8 , Issue.4 , pp. 277-284
    • Ghiso, J.1    Revesz, T.2    Holton, J.3    Rostagno, A.4    Lashley, T.5    Houlden, H.6
  • 22
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • 261
    • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 13: 261(5123): 921-3 (1993).
    • (1993) Science , vol.13 , Issue.5123 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 24
    • 0034704197 scopus 로고    scopus 로고
    • Susceptibility locus for Alzheimer's disease on chromosome 10
    • Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, et al. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290: 2304-05 (2000).
    • (2000) Science , vol.290 , pp. 2304-2305
    • Myers, A.1    Holmans, P.2    Marshall, H.3    Kwon, J.4    Meyer, D.5    Ramic, D.6
  • 25
    • 0034703979 scopus 로고    scopus 로고
    • Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
    • 290
    • Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, et al. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 22: 290(5500): 2303-4 (2000).
    • (2000) Science , vol.22 , Issue.5500 , pp. 2303-2304
    • Ertekin-Taner, N.1    Graff-Radford, N.2    Younkin, L.H.3    Eckman, C.4    Baker, M.5    Adamson, J.6
  • 26
    • 0033538502 scopus 로고    scopus 로고
    • Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease
    • Wavrant-De Vrieze F, Crook R, Holmans P, Kehoe P, Owen MJ, Williams J, et al. Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease. Neurosci Lett 269: 67-70 (1999).
    • (1999) Neurosci Lett , vol.269 , pp. 67-70
    • Wavrant-De Vrieze, F.1    Crook, R.2    Holmans, P.3    Kehoe, P.4    Owen, M.J.5    Williams, J.6
  • 27
    • 0024274055 scopus 로고
    • The proteins and genes of Alzheimer's disease
    • Glenner GG. The proteins and genes of Alzheimer's disease. Biomed Pharmacother 42(9): 579-84 (1988).
    • (1988) Biomed Pharmacother , vol.42 , Issue.9 , pp. 579-584
    • Glenner, G.G.1
  • 28
    • 0024383814 scopus 로고
    • The pathology of the amyloid A4 precursor of Alzheimer's disease
    • Masters CL, Beyreuther KT. The pathology of the amyloid A4 precursor of Alzheimer's disease. Ann Med 21(2): 89-90 (1989).
    • (1989) Ann Med , vol.21 , Issue.2 , pp. 89-90
    • Masters, C.L.1    Beyreuther, K.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.