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Volumn 38, Issue 2, 1996, Pages 200-208

Restoration of biological activity of Alzheimer abnormally phosphorylated τ by dephosphorylation with protein phosphatase-2A, -2B and -1

Author keywords

Alzheimer disease; Microtubule associated protein; Microtubules; Neurofibrillary degeneration; Paired helical filaments; Protein phosphatases

Indexed keywords

PHOSPHATE; PHOSPHOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE; TAU PROTEIN;

EID: 0029995590     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(95)00316-K     Document Type: Article
Times cited : (162)

References (44)
  • 1
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
    • Alonso, A. del C., Zaidi, T., Grundke-Iqbal, I. and Iqbal, K., Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease, Proc. Natl. Acad. Sci. USA. 91 (1994) 5562-5566.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5562-5566
    • Del Alonso, A.C.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 2
    • 0025788253 scopus 로고
    • Processes induced by tau expression in sf9 cells have an axon-like microtubule organization
    • Baas, P.W., Pienkowski, T.P. and Kosik, K.S., Processes induced by tau expression in sf9 cells have an axon-like microtubule organization, J. Cell Biol., 115 (1991) 1333-1344.
    • (1991) J. Cell Biol. , vol.115 , pp. 1333-1344
    • Baas, P.W.1    Pienkowski, T.P.2    Kosik, K.S.3
  • 3
    • 0017277818 scopus 로고
    • Assay of proteins in the presence of interfering materials
    • Bensadoun, A. and Weinstein, D., Assay of proteins in the presence of interfering materials, Anal. Biochem., 70 (1976) 241-250.
    • (1976) Anal. Biochem. , vol.70 , pp. 241-250
    • Bensadoun, A.1    Weinstein, D.2
  • 4
    • 0022365608 scopus 로고
    • The distribution of tau in the mammalian central nervous system
    • Binder, L.I., Frankfurter, A. and Rebhun, L.I., The distribution of tau in the mammalian central nervous system, J. Cell Biol., 101 (1985) 1371-1378.
    • (1985) J. Cell Biol. , vol.101 , pp. 1371-1378
    • Binder, L.I.1    Frankfurter, A.2    Rebhun, L.I.3
  • 6
    • 0022967090 scopus 로고
    • Microheterogenity of microtubule-associated τ protein is due to differences in phosphorylation
    • Butler, M. and Shelanski, M.L., Microheterogenity of microtubule-associated τ protein is due to differences in phosphorylation, J. Neurochem., 47 (1986) 1517-1522.
    • (1986) J. Neurochem. , vol.47 , pp. 1517-1522
    • Butler, M.1    Shelanski, M.L.2
  • 7
    • 0017649032 scopus 로고
    • Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly
    • Cleveland, D.W., Hwo, S.Y. and Kirschner, M.W., Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly, J. Mol. Biol., 116 (1977) 207-225.
    • (1977) J. Mol. Biol. , vol.116 , pp. 207-225
    • Cleveland, D.W.1    Hwo, S.Y.2    Kirschner, M.W.3
  • 9
    • 0027753055 scopus 로고
    • Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A
    • Drewes, G., Mandelkow, E.-M., Baumann, K., Goris, J., Merlevede, W. and Mandelkow, E., Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A, FEBS Lett., 336 (1993) 425-432.
    • (1993) FEBS Lett. , vol.336 , pp. 425-432
    • Drewes, G.1    Mandelkow, E.-M.2    Baumann, K.3    Goris, J.4    Merlevede, W.5    Mandelkow, E.6
  • 10
    • 0021334090 scopus 로고
    • Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes
    • Drubin, D., Caput, D. and Kirschner, M., Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes, J. Cell Biol., 98 (1984) 1090-1097.
    • (1984) J. Cell Biol. , vol.98 , pp. 1090-1097
    • Drubin, D.1    Caput, D.2    Kirschner, M.3
  • 11
    • 0022896901 scopus 로고
    • Tau protein function in living cells
    • Drubin, D. and Kirschner, M., Tau protein function in living cells, J. Cell Biol., 103 (1986) 2739-2746.
    • (1986) J. Cell Biol. , vol.103 , pp. 2739-2746
    • Drubin, D.1    Kirschner, M.2
  • 12
    • 0027414336 scopus 로고
    • Differences in microtubule binding and self-association abilities of bovine brain tau isoforms
    • García de Ancos, J., Correas, I. and Avila, J., Differences in microtubule binding and self-association abilities of bovine brain tau isoforms, J. Biol. Chem., 268 (1993) 7976-7982.
    • (1993) J. Biol. Chem. , vol.268 , pp. 7976-7982
    • García De Ancos, J.1    Correas, I.2    Avila, J.3
  • 13
    • 0024387161 scopus 로고
    • Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: Differential expression of tau protein mRNAs in human brain
    • Goedert, M., Spillantini, M.G., Potier, M.C., Ulrich, J. and Crowther, R.A., Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain, EMBO J., 8 (1989) 393-399.
    • (1989) EMBO J. , vol.8 , pp. 393-399
    • Goedert, M.1    Spillantini, M.G.2    Potier, M.C.3    Ulrich, J.4    Crowther, R.A.5
  • 14
    • 0029113874 scopus 로고
    • Phosphatase activity toward abnormally phosphorylated τ: Decrease in Alzheimer disease brain
    • Gong, C.-X., Shaikh, S., Wang, J.-Z., Zaidi, T., Grundke-Iqbal, I. and Iqbal, K., Phosphatase activity toward abnormally phosphorylated τ: decrease in Alzheimer disease brain. J. Neurochem., 65 (1995) 732-738.
    • (1995) J. Neurochem. , vol.65 , pp. 732-738
    • Gong, C.-X.1    Shaikh, S.2    Wang, J.-Z.3    Zaidi, T.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 15
    • 0027214404 scopus 로고
    • Phospho-protein phosphatase activities in Alzheimer disease
    • Gong, C.-X., Singh, T.J., Grundke-Iqbal, I. and Iqbal, K., Phospho-protein phosphatase activities in Alzheimer disease, J. Neurochem., 61 (1993) 921-927.
    • (1993) J. Neurochem. , vol.61 , pp. 921-927
    • Gong, C.-X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 16
    • 0028044722 scopus 로고
    • Alzheimer disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase 2B (calcineurin)
    • Gong, C.-X., Singh, T.J., Grundke-Iqbal, I. and Iqbal, K., Alzheimer disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase 2B (calcineurin). J. Neurochem., 62 (1994) 803-806.
    • (1994) J. Neurochem. , vol.62 , pp. 803-806
    • Gong, C.-X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 17
    • 0028350740 scopus 로고
    • Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease
    • Gong, C.-X., Grundke-Iqbal, I., Damuni, Z. and Iqbal, K., Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease, FEBS Lett., 341 (1994) 94-98.
    • (1994) FEBS Lett. , vol.341 , pp. 94-98
    • Gong, C.-X.1    Grundke-Iqbal, I.2    Damuni, Z.3    Iqbal, K.4
  • 18
    • 0028064431 scopus 로고
    • Dephosphorylation of Alzheimer disease abnormally phosphorylated tau by protein phosphatase-2A
    • Gong, C.-X., Grundke-Iqbal, I. and Iqbal, K., Dephosphorylation of Alzheimer disease abnormally phosphorylated tau by protein phosphatase-2A, Neurosci., 61 (1994) 765-772.
    • (1994) Neurosci. , vol.61 , pp. 765-772
    • Gong, C.-X.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 20
  • 21
    • 0028273420 scopus 로고
    • Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase β (Hptpβ) using synthetic phosphopeptides
    • Harder, M.W., Owen, P., Wong, L.K.H., Aebersold, R., Clark-Lewis, I. and Jirik, F.R., Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase β (Hptpβ) using synthetic phosphopeptides, Biochem. J., 298 (1994) 395-401.
    • (1994) Biochem. J. , vol.298 , pp. 395-401
    • Harder, M.W.1    Owen, P.2    Wong, L.K.H.3    Aebersold, R.4    Clark-Lewis, I.5    Jirik, F.R.6
  • 22
    • 0027155834 scopus 로고
    • Characterization of two distinct monoclonal antibodies to paired helical filaments: Further evidence for fetal-type phosphorylation of the τ in paired helical filaments
    • Hasegawa, M., Watanabe, A., Takio, K., Suzuki, M., Arai, T., Titani, K. and Ihara, Y., Characterization of two distinct monoclonal antibodies to paired helical filaments: further evidence for fetal-type phosphorylation of the τ in paired helical filaments, J. Neurochem., 60 (1993) 2068-2077.
    • (1993) J. Neurochem. , vol.60 , pp. 2068-2077
    • Hasegawa, M.1    Watanabe, A.2    Takio, K.3    Suzuki, M.4    Arai, T.5    Titani, K.6    Ihara, Y.7
  • 23
    • 0016631203 scopus 로고
    • Assay of inorganic and organic phosphorous in the 0.1-5 nanomole range
    • Hess, H.H. and Derr, J.E., Assay of inorganic and organic phosphorous in the 0.1-5 nanomole range, Anal. Biochem., 63 (1975) 607-613.
    • (1975) Anal. Biochem. , vol.63 , pp. 607-613
    • Hess, H.H.1    Derr, J.E.2
  • 24
    • 0024507707 scopus 로고
    • Tau consists of a set of proteins with repeated C-terminal microtubule binding domains and variable N-terminal domains
    • Himmler, A., Drechsel, D., Kirschner, M.W. and Martin, D.W. Jr., Tau consists of a set of proteins with repeated C-terminal microtubule binding domains and variable N-terminal domains, Mol. Cell. Biol., 9 (1989) 1381-1388.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 1381-1388
    • Himmler, A.1    Drechsel, D.2    Kirschner, M.W.3    Martin D.W., Jr.4
  • 26
    • 0024312664 scopus 로고
    • Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease
    • Iqbal, K., Grundke-Iqbal, I., Smith, A.J., George, L., Tung, Y.-C. and Zaidi, T., Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease, Proc. Natl. Acad. Sci. USA, 86 (1989) 5646-5650.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5646-5650
    • Iqbal, K.1    Grundke-Iqbal, I.2    Smith, A.J.3    George, L.4    Tung, Y.-C.5    Zaidi, T.6
  • 27
    • 0028361538 scopus 로고
    • Alzheimer paired helical filaments: Restoration of the biological activity by dephosphorylation
    • Iqbal, K., Zaidi, T., Bancher, C. and Grundke-Iqbal, I., Alzheimer paired helical filaments: Restoration of the biological activity by dephosphorylation, FEBS Lett., 349 (1994) 104-108.
    • (1994) FEBS Lett. , vol.349 , pp. 104-108
    • Iqbal, K.1    Zaidi, T.2    Bancher, C.3    Grundke-Iqbal, I.4
  • 28
    • 0343418993 scopus 로고
    • Alzheimer neurofibrillary degeneration: Importance, mechanism and therapeutic approaches
    • K. Iqbal, J.A. Mortimer, B. Winblad and H.M. Wisniewski (Eds.), John Wiley and Sons, Chichester
    • Iqbal, K., Alonso A. del C., Gong, C-X., Haque, N., Khatoon, S., Pei, J.J., Singh, S., Tanaka, T., Wang, J.-Z. and Grundke-Iqbal, I., Alzheimer neurofibrillary degeneration: importance, mechanism and therapeutic approaches. In K. Iqbal, J.A. Mortimer, B. Winblad and H.M. Wisniewski (Eds.), Alzheimer's Disease and Related Disorders, John Wiley and Sons, Chichester, 1995, pp. 513-522.
    • (1995) Alzheimer's Disease and Related Disorders , pp. 513-522
    • Iqbal, K.1    Alonso, A.D.C.2    Gong, C.-X.3    Haque, N.4    Khatoon, S.5    Pei, J.J.6    Singh, S.7    Tanaka, T.8    Wang, J.-Z.9    Grundke-Iqbal, I.10
  • 29
    • 0024438227 scopus 로고
    • Expression of multiple tau isoforms and MT bundle formation in fibroblasts transfected with a single tau cDNA
    • Kanai, Y., Takemura, R., Oshima, T., Mori, H., Ihara, Y., Yanagisawa, M., Maaki, T. and Hirokawa, N., Expression of multiple tau isoforms and MT bundle formation in fibroblasts transfected with a single tau cDNA, J. Cell Biol., 109 (1989) 1173-1184.
    • (1989) J. Cell Biol. , vol.109 , pp. 1173-1184
    • Kanai, Y.1    Takemura, R.2    Oshima, T.3    Mori, H.4    Ihara, Y.5    Yanagisawa, M.6    Maaki, T.7    Hirokawa, N.8
  • 30
    • 0026694783 scopus 로고
    • Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: A radioimmuno-slot-blot assay for nanograms of the protein
    • Khatoon, S., Grundke-Iqbal, I. and Iqbal, K., Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein, J. Neurochem., 59 (1992) 750-753.
    • (1992) J. Neurochem. , vol.59 , pp. 750-753
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 31
    • 0025883663 scopus 로고
    • Overproduction of tau in the neuronal cell induces long cellular processes
    • Knops, J., Kosik, K., Lee, G., Pardee, J., Cohengould, L. and McConlogue, L., Overproduction of tau in the neuronal cell induces long cellular processes, J. Cell Biol., 114 (1991) 725-733.
    • (1991) J. Cell Biol. , vol.114 , pp. 725-733
    • Knops, J.1    Kosik, K.2    Lee, G.3    Pardee, J.4    Cohengould, L.5    McConlogue, L.6
  • 32
    • 0027361281 scopus 로고
    • Microbutule associated protein tau: Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
    • Köpke, E., Tung, Y.-C., Shaikh, S., Alonso A. del C., Iqbal, K. and Grundke-Iqbal, I., Microbutule associated protein tau: abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J. Biol. Chem., 268 (1993) 24374-24384.
    • (1993) J. Biol. Chem. , vol.268 , pp. 24374-24384
    • Köpke, E.1    Tung, Y.-C.2    Shaikh, S.3    Alonso, A.D.C.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 33
    • 0023905288 scopus 로고
    • The primary structure and heterogeneity of tau protein from mouse brain
    • Lee, G., Cowan, N. and Kirschner, M., The primary structure and heterogeneity of tau protein from mouse brain, Science, 239 (1988) 285-288.
    • (1988) Science , vol.239 , pp. 285-288
    • Lee, G.1    Cowan, N.2    Kirschner, M.3
  • 34
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal tau
    • Lee, V.M.-Y., Balin, B.J., Otvos, Jr., L. and Trojanowski, J.Q., A68: A major subunit of paired helical filaments and derivatized forms of normal tau, Science, 251 (1991) 675-678.
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.-Y.1    Balin, B.J.2    Otvos L., Jr.3    Trojanowski, J.Q.4
  • 35
    • 0021338217 scopus 로고
    • Phosphorylation affects the ability of tau protein to promote microtubule assembly
    • Lindwall, G. and Cole, R.D., Phosphorylation affects the ability of tau protein to promote microtubule assembly. J. Biol. Chem., 259 (1984) 5301-5305.
    • (1984) J. Biol. Chem. , vol.259 , pp. 5301-5305
    • Lindwall, G.1    Cole, R.D.2
  • 37
    • 0027978340 scopus 로고
    • cdc2 in the hippocampus of patients with Alzheimer disease and normal aged individuals
    • cdc2 in the hippocampus of patients with Alzheimer disease and normal aged individuals, Brain Res., 655 (1994) 70-76.
    • (1994) Brain Res. , vol.655 , pp. 70-76
    • Pei, J.-J.1    Sersen, E.2    Iqbal, K.3    Grundke-Iqbal, I.4
  • 38
    • 0023833792 scopus 로고
    • Electron microscope studies of free and proteinase-bound duck ovostatins (ovomacroglobins): Model of ovostatin structure and its transformation upon proteolysis
    • Ruben, G.C., Harris, Jr., E.D. and Nagase, H., Electron microscope studies of free and proteinase-bound duck ovostatins (ovomacroglobins): model of ovostatin structure and its transformation upon proteolysis, J. Biol. Chem., 263 (1988) 2861-2869.
    • (1988) J. Biol. Chem. , vol.263 , pp. 2861-2869
    • Ruben, G.C.1    Harris, J.2    Nagase, H.3
  • 39
    • 0020993936 scopus 로고
    • Use of calmodulin affinity chromatography for purification of specific calmodulin-dependent enzymes
    • Sharma, R.K., Taylor, W.A. and Wang, J.H., Use of calmodulin affinity chromatography for purification of specific calmodulin-dependent enzymes, Methods Enzymol., 102 (1983) 210-219.
    • (1983) Methods Enzymol. , vol.102 , pp. 210-219
    • Sharma, R.K.1    Taylor, W.A.2    Wang, J.H.3
  • 41
    • 0018380690 scopus 로고
    • Decoration and stabilization of intact, smooth-walled microtubule-associated protein
    • Sloboda, R.D. and Rosenbaum, J.L., Decoration and stabilization of intact, smooth-walled microtubule-associated protein, Biochemistry, 18 (1979) 48-55.
    • (1979) Biochemistry , vol.18 , pp. 48-55
    • Sloboda, R.D.1    Rosenbaum, J.L.2
  • 42
    • 0028902487 scopus 로고
    • Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B
    • Wang, J.-Z., Gong, C.-X., Zaidi, T., Grundke-Iqbal, I. and Iqbal, K., Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B, J. Biol. Chem., 270 (1995) 4854-4860.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4854-4860
    • Wang, J.-Z.1    Gong, C.-X.2    Zaidi, T.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 44
    • 0021691350 scopus 로고
    • Ultrastructure of paired helical filaments of Alzheimer's neurofibrillary tangle
    • Wisniewski, H.M., Merz, P.A. and Iqbal, K., Ultrastructure of paired helical filaments of Alzheimer's neurofibrillary tangle, J. Neuropathol. Exp. Neurol., 43 (1984) 643-656.
    • (1984) J. Neuropathol. Exp. Neurol. , vol.43 , pp. 643-656
    • Wisniewski, H.M.1    Merz, P.A.2    Iqbal, K.3


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