-
1
-
-
84992645760
-
Alzheimer's disease: The cost to U.S. businesses in 2002
-
Koppel, R. (2002) Alzheimer's disease: the cost to U.S. businesses in 2002. Alzheimer's Disease and Related Disorders Association (http://www.alz.org/Media/newsreleases/current/062702cost.html).
-
(2002)
Alzheimer's Disease and Related Disorders Association
-
-
Koppel, R.1
-
2
-
-
0036303818
-
Genetically engineered mouse models of neurodegenerative diseases
-
Wong P.C., et al. Genetically engineered mouse models of neurodegenerative diseases. Nat. Neurosci. 5:2002;633-639.
-
(2002)
Nat. Neurosci.
, vol.5
, pp. 633-639
-
-
Wong, P.C.1
-
3
-
-
0019781601
-
A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease
-
Appel S.H. A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease. Ann. Neurol. 10:1981;499-505.
-
(1981)
Ann. Neurol.
, vol.10
, pp. 499-505
-
-
Appel, S.H.1
-
4
-
-
0034941330
-
Nerve growth factor signaling, neuroprotection, and neural repair
-
Sofroniew M.V., et al. Nerve growth factor signaling, neuroprotection, and neural repair. Annu. Rev. Neurosci. 24:2001;1217-1281.
-
(2001)
Annu. Rev. Neurosci.
, vol.24
, pp. 1217-1281
-
-
Sofroniew, M.V.1
-
5
-
-
46149128942
-
Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease
-
Goedert M., et al. Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease. Brain Res. 387:1986;85-92.
-
(1986)
Brain Res.
, vol.387
, pp. 85-92
-
-
Goedert, M.1
-
6
-
-
0025993361
-
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
-
Phillips H.S., et al. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron. 7:1991;695-702.
-
(1991)
Neuron
, vol.7
, pp. 695-702
-
-
Phillips, H.S.1
-
7
-
-
0028129444
-
NGF mRNA is not decreased in frontal cortex from Alzheimer's disease patients
-
Jette N., et al. NGF mRNA is not decreased in frontal cortex from Alzheimer's disease patients. Mol. Brain Res. 25:1994;242-250.
-
(1994)
Mol. Brain Res.
, vol.25
, pp. 242-250
-
-
Jette, N.1
-
8
-
-
0029022112
-
Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis
-
Scott S.A., et al. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J. Neurosci. 15:1995;6213-6221.
-
(1995)
J. Neurosci.
, vol.15
, pp. 6213-6221
-
-
Scott, S.A.1
-
9
-
-
0021827420
-
Alzheimer's disease in Down's syndrome: Clinicopathologic studies
-
Wisniewski K.E., et al. Alzheimer's disease in Down's syndrome: clinicopathologic studies. Neurology. 35:1985;957-961.
-
(1985)
Neurology
, vol.35
, pp. 957-961
-
-
Wisniewski, K.E.1
-
10
-
-
0021814284
-
Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age
-
Mann D.M., et al. Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age. J. Ment. Defic. Res. 29:1985;125-135.
-
(1985)
J. Ment. Defic. Res.
, vol.29
, pp. 125-135
-
-
Mann, D.M.1
-
11
-
-
0029114706
-
A mouse model for Down syndrome exhibits learning and behaviour deficits
-
Reeves R.H., et al. A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat. Genet. 11:1995;177-184.
-
(1995)
Nat. Genet.
, vol.11
, pp. 177-184
-
-
Reeves, R.H.1
-
12
-
-
10544243361
-
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome
-
Holtzman D.M., et al. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc. Natl. Acad. Sci. U. S. A. 93:1996;13333-13338.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 13333-13338
-
-
Holtzman, D.M.1
-
13
-
-
2942591228
-
Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion
-
Cooper J.D., et al. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc. Natl. Acad. Sci. U. S. A. 98:2001;10439-10444.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 10439-10444
-
-
Cooper, J.D.1
-
14
-
-
0034097607
-
Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome
-
Granholm A.C., et al. Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Exp. Neurol. 161:2000;647-663.
-
(2000)
Exp. Neurol.
, vol.161
, pp. 647-663
-
-
Granholm, A.C.1
-
15
-
-
0030799383
-
Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits
-
Chen K.S., et al. Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits. J. Neurosci. 17:1997;7288-7296.
-
(1997)
J. Neurosci.
, vol.17
, pp. 7288-7296
-
-
Chen, K.S.1
-
16
-
-
0030761205
-
A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo
-
Fagan A.M., et al. A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. J. Neurosci. 17:1997;7644-7654.
-
(1997)
J. Neurosci.
, vol.17
, pp. 7644-7654
-
-
Fagan, A.M.1
-
17
-
-
0028920679
-
Regulation of TrkA and ChAT expression in developing rat basal forebrain: Evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons
-
Li Y., et al. Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J. Neurosci. 15:1995;2888-2905.
-
(1995)
J. Neurosci.
, vol.15
, pp. 2888-2905
-
-
Li, Y.1
-
18
-
-
0034612256
-
Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice
-
Capsoni S., et al. Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 97:2000;6826-6831.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 6826-6831
-
-
Capsoni, S.1
-
19
-
-
0030767243
-
The cholinergic system in Alzheimer's disease
-
Kasa P., et al. The cholinergic system in Alzheimer's disease. Prog. Neurobiol. 52:1997;511-535.
-
(1997)
Prog. Neurobiol.
, vol.52
, pp. 511-535
-
-
Kasa, P.1
-
20
-
-
0033813571
-
Neurotrophic factors in Alzheimer's and Parkinson's disease brain
-
Siegel G.J., Chauhan N.B. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res. Rev. 33:2000;199-227.
-
(2000)
Brain Res. Rev.
, vol.33
, pp. 199-227
-
-
Siegel, G.J.1
Chauhan, N.B.2
-
21
-
-
0030601663
-
Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease
-
Salehi A., et al. Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience. 75:1996;373-387.
-
(1996)
Neuroscience
, vol.75
, pp. 373-387
-
-
Salehi, A.1
-
22
-
-
0034054499
-
P75 neurotrophin receptor in the nucleus basalis of Meynert in relation to age, sex, and Alzheimer's disease
-
Salehi A., et al. P75 neurotrophin receptor in the nucleus basalis of Meynert in relation to age, sex, and Alzheimer's disease. Exp. Neurol. 161:2000;245-258.
-
(2000)
Exp. Neurol.
, vol.161
, pp. 245-258
-
-
Salehi, A.1
-
23
-
-
0030939457
-
Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease
-
Mufson E.J., et al. Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease. NeuroReport. 8:1996;25-29.
-
(1996)
NeuroReport
, vol.8
, pp. 25-29
-
-
Mufson, E.J.1
-
24
-
-
0037016848
-
Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease
-
Mufson E.J., et al. Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease. J. Comp. Neurol. 443:2002;136-153.
-
(2002)
J. Comp. Neurol.
, vol.443
, pp. 136-153
-
-
Mufson, E.J.1
-
25
-
-
0035959515
-
Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease
-
Chu Y., et al. Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease. J. Comp. Neurol. 437:2001;296-307.
-
(2001)
J. Comp. Neurol.
, vol.437
, pp. 296-307
-
-
Chu, Y.1
-
26
-
-
0029039162
-
Nerve growth factor in Alzheimer's disease: Defective retrograde transport to nucleus basalis
-
Mufson E.J., et al. Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis. NeuroReport. 6:1995;1063-1066.
-
(1995)
NeuroReport
, vol.6
, pp. 1063-1066
-
-
Mufson, E.J.1
-
27
-
-
0024323287
-
NGF amplifies expression of NGF receptor messenger RNA in forebrain cholinergic neurons of rats
-
Cavicchioli L., et al. NGF amplifies expression of NGF receptor messenger RNA in forebrain cholinergic neurons of rats. Eur. J. Neurosci. 1:1989;258-262.
-
(1989)
Eur. J. Neurosci.
, vol.1
, pp. 258-262
-
-
Cavicchioli, L.1
-
28
-
-
0026613071
-
P140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF
-
Holtzman D.M., et al. p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron. 9:1992;465-478.
-
(1992)
Neuron
, vol.9
, pp. 465-478
-
-
Holtzman, D.M.1
-
29
-
-
0035950188
-
New frontiers in Alzheimer's disease genetics
-
Tanzi R.E., Bertram L. New frontiers in Alzheimer's disease genetics. Neuron. 32:2001;181-184.
-
(2001)
Neuron
, vol.32
, pp. 181-184
-
-
Tanzi, R.E.1
Bertram, L.2
-
30
-
-
0028218871
-
Neuropathological changes in Alzheimer disease
-
Terry R.D. Neuropathological changes in Alzheimer disease. Prog. Brain Res. 1994;383-390.
-
(1994)
Prog. Brain Res.
, pp. 383-390
-
-
Terry, R.D.1
-
31
-
-
0033671137
-
Cytokines and neurotrophins interact in normal and diseased states
-
Otten U., et al. Cytokines and neurotrophins interact in normal and diseased states. Ann. New York Acad. Sci. 917:2000;322-330.
-
(2000)
Ann. New York Acad. Sci.
, vol.917
, pp. 322-330
-
-
Otten, U.1
-
32
-
-
0035690976
-
Interleukin-1, neuroinflammation, and Alzheimer's disease
-
Mrak R.E., Griffin W.S. Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol. Aging. 22:2001;903-908.
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 903-908
-
-
Mrak, R.E.1
Griffin, W.S.2
-
33
-
-
0028220243
-
Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease
-
Cataldo A.M., et al. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain Res. 640:1994;68-80.
-
(1994)
Brain Res.
, vol.640
, pp. 68-80
-
-
Cataldo, A.M.1
-
34
-
-
0034718205
-
The role of complement in Alzheimer's disease pathology
-
Emmerling M.R., et al. The role of complement in Alzheimer's disease pathology. Biochim. Biophys. Acta. 1502:2000;158-171.
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 158-171
-
-
Emmerling, M.R.1
-
35
-
-
0026468915
-
Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease
-
Su J.H., et al. Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience. 51:1992;801-813.
-
(1992)
Neuroscience
, vol.51
, pp. 801-813
-
-
Su, J.H.1
-
36
-
-
0028973319
-
Differential expression of TGF-β 1, 2 and 3 isotypes in Alzheimer's disease: A comparative immunohistochemical study with cerebral infarction, aged human and mouse control brains
-
Peress N.S., Perillo E. Differential expression of TGF-β 1, 2 and 3 isotypes in Alzheimer's disease: a comparative immunohistochemical study with cerebral infarction, aged human and mouse control brains. J. Neuropathol. Exp. Neurol. 54:1995;802-811.
-
(1995)
J. Neuropathol. Exp. Neurol.
, vol.54
, pp. 802-811
-
-
Peress, N.S.1
Perillo, E.2
-
37
-
-
0344542092
-
Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease
-
Takami K., et al. Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease. Brain Res. 802:1998;89-97.
-
(1998)
Brain Res.
, vol.802
, pp. 89-97
-
-
Takami, K.1
-
38
-
-
0032526652
-
Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Aβ1-42 pathogenesis
-
Yang A.J., et al. Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Aβ1-42 pathogenesis. J. Neurosci. Res. 52:1998;691-698.
-
(1998)
J. Neurosci. Res.
, vol.52
, pp. 691-698
-
-
Yang, A.J.1
-
39
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
-
Arriagada P.V., et al. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology. 42:1992;631-639.
-
(1992)
Neurology
, vol.42
, pp. 631-639
-
-
Arriagada, P.V.1
-
40
-
-
0034940160
-
Neurodegenerative tauopathies
-
Lee V.M., et al. Neurodegenerative tauopathies. Annu. Rev. Neurosci. 24:2001;1121-1159.
-
(2001)
Annu. Rev. Neurosci.
, vol.24
, pp. 1121-1159
-
-
Lee, V.M.1
-
41
-
-
0029999787
-
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
-
Alonso A.C., et al. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat. Med. 2:1996;783-787.
-
(1996)
Nat. Med.
, vol.2
, pp. 783-787
-
-
Alonso, A.C.1
-
42
-
-
0033850407
-
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
-
Buée L., et al. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res. Rev. 33:2000;95-130.
-
(2000)
Brain Res. Rev.
, vol.33
, pp. 95-130
-
-
Buée, L.1
-
44
-
-
0031012497
-
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
-
Alonso A.D., et al. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc. Natl. Acad. Sci. U. S. A. 94:1997;298-303.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 298-303
-
-
Alonso, A.D.1
-
45
-
-
0035851157
-
Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein
-
Alonso A.D., et al. Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein. J. Biol. Chem. 276:2001;37967-37973.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37967-37973
-
-
Alonso, A.D.1
-
47
-
-
0034329543
-
Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants
-
Flaherty D.B., et al. Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants. J. Neurosci. Res. 62:2000;463-472.
-
(2000)
J. Neurosci. Res.
, vol.62
, pp. 463-472
-
-
Flaherty, D.B.1
-
48
-
-
0029737421
-
Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II
-
Yamaguchi H., et al. Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II. Acta Neuropathol. (Berl.). 92:1996;232-241.
-
(1996)
Acta Neuropathol. (Berl.)
, vol.92
, pp. 232-241
-
-
Yamaguchi, H.1
-
49
-
-
0034859101
-
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling
-
Grimes C.A., Jope R.S. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog. Neurobiol. 65:2001;391-426.
-
(2001)
Prog. Neurobiol.
, vol.65
, pp. 391-426
-
-
Grimes, C.A.1
Jope, R.S.2
-
50
-
-
0030635495
-
Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain
-
Pei J.J., et al. Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain. J. Neuropathol. Exp. Neurol. 56:1997;70-78.
-
(1997)
J. Neuropathol. Exp. Neurol.
, vol.56
, pp. 70-78
-
-
Pei, J.J.1
-
51
-
-
0028675873
-
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
-
Lovestone S., et al. Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr. Biol. 4:1994;1077-1086.
-
(1994)
Curr. Biol.
, vol.4
, pp. 1077-1086
-
-
Lovestone, S.1
-
52
-
-
0035863188
-
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
-
Lucas J.J., et al. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J. 20:2001;27-39.
-
(2001)
EMBO J.
, vol.20
, pp. 27-39
-
-
Lucas, J.J.1
-
53
-
-
0034602179
-
Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal
-
Crowder R.J., Freeman R.S. Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal. J. Biol. Chem. 275:2000;34266-34271.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34266-34271
-
-
Crowder, R.J.1
Freeman, R.S.2
-
54
-
-
0036169172
-
Cdk5 behind the wheel: A role in trafficking and transport?
-
Smith D.S., Tsai L.H. Cdk5 behind the wheel: a role in trafficking and transport? Trends Cell Biol. 12:2002;28-36.
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 28-36
-
-
Smith, D.S.1
Tsai, L.H.2
-
55
-
-
0034595872
-
Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau
-
Sobue K., et al. Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau. J. Biol. Chem. 275:2000;16673-16680.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16673-16680
-
-
Sobue, K.1
-
56
-
-
0035448915
-
P35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment
-
Ko J., et al. p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J. Neurosci. 21:2001;6758-6771.
-
(2001)
J. Neurosci.
, vol.21
, pp. 6758-6771
-
-
Ko, J.1
-
57
-
-
0033540060
-
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
-
Patrick G.N., et al. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature. 402:1999;615-622.
-
(1999)
Nature
, vol.402
, pp. 615-622
-
-
Patrick, G.N.1
-
58
-
-
0037029740
-
Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice
-
Bian F., et al. Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice. J. Comp. Neurol. 446:2002;257-266.
-
(2002)
J. Comp. Neurol.
, vol.446
, pp. 257-266
-
-
Bian, F.1
-
59
-
-
0032799381
-
Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles
-
Trinczek B., et al. Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles. J. Cell Sci. 112:1999;2355-2367.
-
(1999)
J. Cell Sci.
, vol.112
, pp. 2355-2367
-
-
Trinczek, B.1
-
60
-
-
0037128935
-
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
-
Stamer K., et al. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J. Cell Biol. 156:2002;1051-1063.
-
(2002)
J. Cell Biol.
, vol.156
, pp. 1051-1063
-
-
Stamer, K.1
-
61
-
-
0026694783
-
Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: A radioimmuno-slot-blot assay for nanograms of the protein
-
Khatoon S., et al. Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. J. Neurochem. 59:1992;750-753.
-
(1992)
J. Neurochem.
, vol.59
, pp. 750-753
-
-
Khatoon, S.1
-
62
-
-
0027361281
-
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
-
Köpke E., et al. Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J. Biol. Chem. 268:1993;24374-24384.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 24374-24384
-
-
Köpke, E.1
-
63
-
-
0036469290
-
Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility
-
Morfini G., et al. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. EMBO J. 21:2002;281-293.
-
(2002)
EMBO J.
, vol.21
, pp. 281-293
-
-
Morfini, G.1
-
64
-
-
0034682414
-
Neurotoxicity induces cleavage of p35 to p25 by calpain
-
Lee M.S., et al. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature. 405:2000;360-364.
-
(2000)
Nature
, vol.405
, pp. 360-364
-
-
Lee, M.S.1
-
65
-
-
0024369451
-
Nerve growth factor-induced decrease in the calpain activity of PC12 cells
-
Oshima M., et al. Nerve growth factor-induced decrease in the calpain activity of PC12 cells. J. Biol. Chem. 264:1989;20811-20816.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 20811-20816
-
-
Oshima, M.1
-
66
-
-
0034507918
-
A 'protease activation cascade' in the pathogenesis of Alzheimer's disease
-
Nixon R.A. A 'protease activation cascade' in the pathogenesis of Alzheimer's disease. Ann. New York Acad. Sci. 924:2000;117-131.
-
(2000)
Ann. New York Acad. Sci.
, vol.924
, pp. 117-131
-
-
Nixon, R.A.1
-
67
-
-
0035818998
-
Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP
-
Kamal A., et al. Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP. Nature. 414:2001;643-648.
-
(2001)
Nature
, vol.414
, pp. 643-648
-
-
Kamal, A.1
-
68
-
-
0035829720
-
Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila
-
Gunawardena S., Goldstein L.S. Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron. 32:2001;389-401.
-
(2001)
Neuron
, vol.32
, pp. 389-401
-
-
Gunawardena, S.1
Goldstein, L.S.2
-
69
-
-
84992567578
-
Presenilin-1 regulates intracellular trafficking and cell surface delivery of β APP
-
in press
-
Cai, D. et al. Presenilin-1 regulates intracellular trafficking and cell surface delivery of β APP. J. Biol. Chem. (in press).
-
J. Biol. Chem.
-
-
Cai, D.1
-
70
-
-
0001521232
-
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains
-
Perry G., et al. Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. Proc. Natl. Acad. Sci. U. S. A. 84:1987;3033-3036.
-
(1987)
Proc. Natl. Acad. Sci. U. S. A.
, vol.84
, pp. 3033-3036
-
-
Perry, G.1
-
71
-
-
0027193036
-
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments
-
Morishima-Kawashima M., et al. Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments. Neuron. 10:1993;1151-1160.
-
(1993)
Neuron
, vol.10
, pp. 1151-1160
-
-
Morishima-Kawashima, M.1
-
72
-
-
0035139109
-
Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
-
Sherman M.Y., Goldberg A.L. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron. 29:2001;15-32.
-
(2001)
Neuron
, vol.29
, pp. 15-32
-
-
Sherman, M.Y.1
Goldberg, A.L.2
-
73
-
-
0034131044
-
Impaired proteasome function in Alzheimer's disease
-
Keller J.N., et al. Impaired proteasome function in Alzheimer's disease. J. Neurochem. 75:2000;436-439.
-
(2000)
J. Neurochem.
, vol.75
, pp. 436-439
-
-
Keller, J.N.1
-
74
-
-
0034142022
-
A distinct ER/IC γ -secretase competes with the proteasome for cleavage of APP
-
Skovronsky D.M., et al. A distinct ER/IC γ -secretase competes with the proteasome for cleavage of APP. Biochemistry. 39:2000;810-817.
-
(2000)
Biochemistry
, vol.39
, pp. 810-817
-
-
Skovronsky, D.M.1
-
75
-
-
0344466781
-
Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera
-
García-Mata R., et al. Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. J. Cell Biol. 146:1999;1239-1254.
-
(1999)
J. Cell Biol.
, vol.146
, pp. 1239-1254
-
-
García-Mata, R.1
-
76
-
-
0032576605
-
Aggresomes: A cellular response to misfolded proteins
-
Johnston J.A., et al. Aggresomes: a cellular response to misfolded proteins. J. Cell Biol. 143:1998;1883-1898.
-
(1998)
J. Cell Biol.
, vol.143
, pp. 1883-1898
-
-
Johnston, J.A.1
-
77
-
-
0034578389
-
Aggresomes, inclusion bodies and protein aggregation
-
Kopito R.R. Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol. 10:2000;524-530.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 524-530
-
-
Kopito, R.R.1
-
78
-
-
0033788787
-
Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations
-
Goedert M., et al. Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations. J. Neurochem. 75:2000;2155-2162.
-
(2000)
J. Neurochem.
, vol.75
, pp. 2155-2162
-
-
Goedert, M.1
-
79
-
-
0035409575
-
α-synuclein and neurodegenerative diseases
-
Goedert M. α-synuclein and neurodegenerative diseases. Nat. Rev. Neurosci. 2:2001;492-501.
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 492-501
-
-
Goedert, M.1
-
80
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos M.H., et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
-
81
-
-
18344417178
-
Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
-
Lippa C.F., et al. Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am. J. Pathol. 153:1998;1365-1370.
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 1365-1370
-
-
Lippa, C.F.1
-
82
-
-
0031763264
-
The synuclein family
-
Lavedan C. The synuclein family. Genome Res. 8:1998;871-880.
-
(1998)
Genome Res.
, vol.8
, pp. 871-880
-
-
Lavedan, C.1
-
83
-
-
0033933048
-
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
-
Shimura H., et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25:2000;302-305.
-
(2000)
Nat. Genet.
, vol.25
, pp. 302-305
-
-
Shimura, H.1
-
84
-
-
18444398035
-
Complex relationship between Parkin mutations and Parkinson disease
-
West A., et al. Complex relationship between Parkin mutations and Parkinson disease. Am. J. Med. Genet. 114:2002;584-591.
-
(2002)
Am. J. Med. Genet.
, vol.114
, pp. 584-591
-
-
West, A.1
-
85
-
-
0032190090
-
The ubiquitin pathway in Parkinson's disease
-
Leroy E., et al. The ubiquitin pathway in Parkinson's disease. Nature. 395:1998;451-452.
-
(1998)
Nature
, vol.395
, pp. 451-452
-
-
Leroy, E.1
-
86
-
-
0036247208
-
Parkinson's disease: One biochemical pathway to fit all genes?
-
Krüger R., et al. Parkinson's disease: one biochemical pathway to fit all genes? Trends Mol. Med. 8:2002;236-240.
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 236-240
-
-
Krüger, R.1
-
87
-
-
0035910634
-
Proteasomal function is impaired in substantia nigra in Parkinson's disease
-
McNaught K.S., Jenner P. Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci. Lett. 297:2001;191-194.
-
(2001)
Neurosci. Lett.
, vol.297
, pp. 191-194
-
-
McNaught, K.S.1
Jenner, P.2
-
88
-
-
0037059040
-
Chaperoning brain degeneration
-
10.1073/pnas.152330499
-
Bonini, N.M. (2002) Chaperoning brain degeneration. Proc. Natl. Acad. Sci. U. S. A. 10.1073/pnas.152330499 (http://www.pnas.org/).
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
-
-
Bonini, N.M.1
-
89
-
-
0035871295
-
Beyond the Qs in the polyglutamine diseases
-
Orr H.T. Beyond the Qs in the polyglutamine diseases. Genes Dev. 15:2001;925-932.
-
(2001)
Genes Dev.
, vol.15
, pp. 925-932
-
-
Orr, H.T.1
-
90
-
-
0037184063
-
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity
-
Niwa J.I., et al. Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J. Biol. Chem. 277:2002;36793-36798.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 36793-36798
-
-
Niwa, J.I.1
-
91
-
-
0029004898
-
Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis
-
Collard J.F., et al. Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature. 375:1995;61-64.
-
(1995)
Nature
, vol.375
, pp. 61-64
-
-
Collard, J.F.1
-
92
-
-
0033366384
-
Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons
-
Williamson T.L., Cleveland D.W. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat. Neurosci. 2:1999;50-56.
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 50-56
-
-
Williamson, T.L.1
Cleveland, D.W.2
|