Microtubule reduction in Alzheimer's disease and aging is independent of τ filament formation

American Journal of Pathology

Volumn 162, Issue 5, 2003, Pages 1623-1627

  Cash, Adam D ^a   Aliev, Gjumrakch ^a   Siedlak, Sandra L ^a   Nunomura, Akihiko ^b   Fujioka, Hisashi ^a   Zhu, Xiongwei ^a   Raina, Arun K ^a   Vinters, Harry V ^c   Tabaton, Massimo ^d   Johnson, Anne B ^e   Paula Barbosa, Manuel ^f   Avíla, Jesus ^g   Jones, Paul K ^a   Castellani, Rudy J ^a,h   Smith, Mark A ^a   Perry, George ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF GENOA   (Italy)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f Albert Einstein College of Medicine ^*  (Portugal)

^g UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^h MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN BIOPSY; CELL ULTRASTRUCTURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MICROTUBULE ASSEMBLY; MORPHOMETRICS; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

EID: 0242600546     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64296-4     Document Type: Article

References (26)

1. Alzheimer A: Über eine eigneartige Ehrankung der Himrinde. Allg Z Psychiatr Psychish-Gerichtliche Med 1907, 64:146-148. Translated in Neurological Classics in Modern Translation. Edited by DA Rottenberg, FH Hochberg. New York, Hafner Press, 1977, pp 41-43
2. Alzheimer A: Über eine eigneartige Ehrankung der Himrinde. Allg Z Psychiatr Psychish-Gerichtliche Med 1907, 64:146-148. Translated in Neurological Classics in Modern Translation. Edited by DA Rottenberg, FH Hochberg. New York, Hafner Press, 1977, pp 41-43
3. Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI: Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 1986, 83:4913-4917
4. Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten JC, Nagashima K, Ihara Y: Molecular analysis of mutant and wild-type-tau deposited in the brain affected by the FTDP-17 R406W mutation. Am J Pathol 2001, 158:373-379
5. Suzuki K, Terry RD: Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementia. Acta Neuropathologica 1967, 8:276-284
6. Praprotnik D, Smith MA, Richey PL, Vinters HV, Perry G: Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease. Acta Neuropathol 1996, 91:226-235
7. Hirai K, Aliev G, Nunomura A, Figioka H, Russdl RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PLR, Jones PK, Peterson RB, Perry G, Smith MA: Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 2001, 21:3017-3023
8. Terry RD: The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis. J Neuropathol Exp Neurol 1996, 55:1023-1025
9. Scheff SW, DeKosky ST, Price DA: Quantitative assessment of cortical synaptic density in Alzheimer's disease. Neurobiol Aging 1990, 11:29-37
10. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R: Physical basis of cognitive alterations in Alzheimer disease: synapse loss is a major correlate of cognitive impairment. Ann Neurol 1991, 30:572-580
11. Praprotnik D, Smith MA, Richey PL, Vinters HV, Perry G: Plasma membrane fragility in dystrophic neurites in senile plaques of Alzheimer's disease: an index of oxidative stress. Acta Neuropathol 1996, 91:1-5
12. McKhann GD, Drachman DA, Folstein MF, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer's disease. Neurology 1984, 34:939-944
13. Porter KR: Cytoplasmic microtubules and their functions. In Principles of Biomolecular Organization. Edited by GEW Wolstenholme, M O'Connor. London, CIBA Foundation Symposium, J and A Churchill, 1966, pp 308-345
14. Lawrence ME, Possingham JV: Observations of microtubule-like structures within spinach plastids. Biol Cell 1984, 52:77-82
15. Carpenter MB, Sutin J: Human Neuroanatomy, ed 8. Baltimore, Williams and Wilkins, 1983
16. DeKosky ST, Scheff SW: Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990, 27:457-464
17. Perry G, Lipphardt S, Mulvihill P, Kancherla M, Mijares M, Gambetti P, Sharma S, Maggiora L, Cornette J, Lobl T, Greenberg B: Amyloid precursor protein in senile plaques of Alzheimer disease. Lancet 1998, ii:746
18. Sternberger LA, Sternberger NH: Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci USA 1983, 80:6126-6130
19. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA: Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 2001, 60:759-767
20. Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA: RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci 1999, 19:1959-1964
21. Nunomura A, Perry G, Papolla MA, Friedland RP, Hirai K, Chiba S, Smith MA: Neuronal oxidative stress precedes amyloid-β deposition in Down Syndrome. J Neuropathol Exp Neurol 2000, 59:1011-1017
22. Paula-Barbosa M, Tavares MA, Cadete-Leite A: A quantitative study of frontal cortex dendritic microtubules in patients with Alzheimer disease. Brain Res 1987, 417:139-142
23. Yan SB, Hwang S, Rustan TD, Frey WH: Human brain tubulin purification: decrease in soluble tubulin with age. Neurochem Res 1985, 10:1-18
24. DeKosky ST, Scheff SW, Styren SD: Structural correlates of cognition in dementia: quantification and assessment of synapse change Neurodegeneration 1996, 5:417-421
25. Terry RD, Katzman R: Life span and synapses: will there be a primary senile dementia? Neurobiol Aging 2001, 22:347-348
26. Stieber A, Mourelatos Z, Gonatas NK: In Alzheimer's disease the Golgi apparatus of a population of neurons without neurofibrillary tangles is fragmented and atrophic. Am J Pathol 1996, 148: 415-426