Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors

Journal of Alzheimer's Disease

Volumn 21, Issue 1, 2010, Pages 167-179

  Wang, Hai Hong ^a,b   Li, Hong Lian ^a   Liu, Rong ^a   Zhang, Yao ^a   Liao, Kai ^a   Wang, Qun ^a   Wang, Jian Zhi ^a   Liu, Shi Jie ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; apoptosis; GSK 3; tau; catenin

Indexed keywords

BETA CATENIN; CASPASE 3; CASPASE 9; CYCLIN DEPENDENT KINASE 5; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3; LITHIUM; PROTEIN P53; ROSCOVITINE; STAUROSPORINE; TAU PROTEIN; CAMPTOTHECIN; EMTANSINE; ENHANCED GREEN FLUORESCENT PROTEIN; ENZYME INHIBITOR; GREEN FLUORESCENT PROTEIN; LIPOCORTIN 5; MAPT PROTEIN, HUMAN; MAYTANSINE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANALOGS AND DERIVATIVES; ANIMAL; CELL FRACTIONATION; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HIPPOCAMPUS; HUMAN; METABOLISM; MUTATION; NEUROBLASTOMA; PATHOLOGY; PHYSIOLOGY; PROCEDURES; TIME; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; ANNEXIN A5; APOPTOSIS; BETA CATENIN; CAMPTOTHECIN; CASPASE 3; CELL LINE, TUMOR; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; HUMANS; MAYTANSINE; MICE; MICE, TRANSGENIC; MUTATION; NEUROBLASTOMA; RNA, SMALL INTERFERING; STAUROSPORINE; SUBCELLULAR FRACTIONS; TAU PROTEINS; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77955011172     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-091279     Document Type: Article

References (40)

1. Khatoon S, Grundke-Iqbal I, Iqbal K (1994) Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBSLett 351, 80-84.
2. Braak E, Braak H, Mandelkow EM (1994) A sequence of cy-toskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. ActaNeuropathol 87, 554-567.
3. Coleman PD, Yao PJ (2003) Synaptic slaughter in Alzheimer's disease. Neurobiol Aging 24, 1023-1027.
4. Raina AK, Hochman A, Ickes H, Zhu X, Ogawa O, Cash AD, Shimohama S, Perry G, Smith MA (2003) Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? Prog Neuropsychopharmacol Biol Psychiatry 27, 251254.
5. Raina AK, Zhu X, Shimohama S, Perry G, Smith MA (2003) Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept. Cell Biochem Biophys 39, 249-255.
6. Perry G, Nunomura A, Smith MA (1998) A suicide note from Alzheimer disease neurons? Nat Med 4, 897-898.
7. Perry G, Nunomura A, Lucassen P, Lassmann H, Smith MA (1998) Apoptosis and Alzheimer's disease. Science 282, 12681269.
8. Morsch R, Simon W, Coleman PD (1999) Neurons may live for decades with neurofibrillary tangles. J Neuropathol Exp Neurol 58, 188-197.
9. Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. Microtubule-associated protein tau (1986) A component ofAlzheimer paired helical filaments. J Biol Chem 261, 6084-6089.
10. Fath T, Eidenmuller J, Brandt R (2002) Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease. J Neurosci 22, 9733-9741.
11. Chung CW, Song YH, Kim IK, Yoon WJ, Ryu BR, Jo DG, Woo HN, Kwon YK, Kim HH, Gwag BJ, Mook-Jung IH, Jung YK (2001) Proapoptotic effects of tau cleavage product generated by caspase-3. Neurobiol Dis 8, 162-172.
12. Yoshiyama Y, Zhang B, Bruce J, Trojanowski JQ, Lee VM (2003) Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astro-cytes. JNeurosci 23, 10662-10671.
13. Andorfer C, Acker CM, Kress Y, Hof PR, Duff K, Davies P (2005) Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci 25, 5446-5454.
14. Alonso Adel C, Li B, Grundke-Iqbal I, Iqbal K (2006) Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proc Natl Acad Sci USA 103, 8864-8869.
15. Li HL, Wang HH, Liu SJ, Deng YQ, Zhang YJ, Tian Q, Wang XC, Chen XQ, Yang Y, Zhang JY, Wang Q, Xu H, Liao FF, Wang JZ (2007) Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc Natl Acad Sci U S A 104, 3591-3596.
16. Andorfer C, Kress Y, Espinoza M, de Silva R, Tucker KL, Barde YA, Duff K, Davies P (2003). Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86, 582-590.
17. Cooper JK, Schilling G, Peters MF, Herring WJ, Sharp AH, Kaminsky Z, Masone J, Khan FA, Delanoy M, Borchelt DR, Dawson VL, Dawson TM, Ross CA (1998) Truncated N-terminal fragments ofhuntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum Mol Genet 7, 783-790.
18. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T, Traganos F (1997) Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 27, 1-20.
19. Nakagawa S, Kim JE, Lee R, Chen J, Fujioka T, Malberg J, Tsuji S, Duman RS (2002) Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. J Neurosci 22, 9868-9876. (Pubitemid 35332871)
20. von Ahsen O, Renken C, Perkins G, Kluck RM, Bossy-Wetzel, Newmeyer DD (2000) Preservation of mitochondrial structure and function after Bid-or Bax-mediated cytochrome c release. J Cell Biol 150, 1027-1036.
21. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC (2001) Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3, 245-252.
22. Giuliano KA, Chen YT, and Taylor DL (2004) High-content screening with siRNA optimizes a cell biological approach to drug discovery: defining the role of p53 activation in the cellular response to anticancer drugs. J Biomol Screening 9, 557-568.
23. Chaudhari M, Jayaraj R, Bhaskar AS, Lakshmana Rao PV (2009) Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells. Toxicology 262, 153-161.
24. Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, D'Agnano I, Florenzano F, Felicioni L, Buttitta C, Marchetti A, Sacchi A, Pontecorvi A, Soddu S, Moretti F (2009) MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway. EMBO J 28, 1926-1939.
25. Vaseva AV, Marchenko ND, Moll UM (2009) The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. Cell Cycle 8, 1711-1719.
26. Lee JH, Kim KT (2007) Regulation of cyclin-dependent kinase 5 and p53 by ERK1/2 pathway in the DNA damage-induced neuronal death. J Cell Physiol 210, 784-797.
27. Yuan J, Zhang J, Wong BW, Si X, Wong J, Yang D, Luo H (2005) Inhibition of glycogen synthase kinase 3beta suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of beta-catenin. Cell Death Differ 12, 1097-1106.
28. Marx J (2001) Science. New leads on the 'how' of Alzheimer's. Science 293, 2192-2194.
29. Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, Cribbs DH (2001) Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am J Pathol 158, 189-198.
30. Yang F, Sun X, Beech W, Teter B, Wu S, Sigel J, Vinters HV, Frautschy SA, Cole GM (1998) Antibody to caspasecleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am J Pathol 152, 379-389.
31. Guo Q, Fu W, Xie J, Luo H, Sells SF, Geddes JW, Bondada V, Rangnekar VM, Mattson MP (1998) Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nat Med 4, 957-962.
32. Braak H, Braak E (1996) Evolution of the neuropathology of Alzheimer's disease. Acta Neurol Scand Suppl 165, 3-12. (Pubitemid 26143161)
33. Braak E, Braak H, Mandelkow EM (1994) A sequence of cy-toskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. ActaNeuropathol 87, 554-567.
34. Perry G, Zhu X, Smith MA (2001) Do neurons have a choice in death? Am J Pathol 158, 1-2.
35. Wang JZ, Liu F (2008) Microtubule-associated protein tau in development, degeneration and protection of neurons. Prog Neurobiol 85, 148-175.
36. Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA (2005) Tau phosphoryla-tion in Alzheimer's disease: pathogen or protector? Trends MolMed 11, 164-169.
37. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754.
38. Wang H, MacNaughton WK (2005) Overexpressed beta-catenin blocks nitric oxide-induced apoptosis in colonic cancer cells. Cancer Res 65, 8604-8607.
39. Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA (1998) Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698-702.
40. Chen YZ (2004) APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin. Apopto-sis 9, 415-422.