Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation

Journal of Alzheimer's Disease

Volumn 9, Issue 1, 2006, Pages 1-12

  Gong, Cheng Xin ^a,b   Liu, Fei ^a   Grundke Iqbal, Inge ^a   Iqbal, Khalid ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b Brain Metabolism Laboratory   (United States)

Author keywords

Alzheimer disease; Glucose uptake metabolism; Neurofibrillary degeneration; O GlcNAcylation; Phosphorylation; Tau; Tauopathies

Indexed keywords

N ACETYLGLUCOSAMINE; TAU PROTEIN;

ACYLATION; ALZHEIMER DISEASE; BRAIN DEGENERATION; DEMENTIA; DRUG TARGETING; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HUMAN; NEUROFIBRILLARY DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; REVIEW; SYMPTOMATOLOGY; TAUOPATHY;

EID: 33646002650     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2006-9101     Document Type: Review

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