Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

Journal of Neuroscience

Volumn 24, Issue 26, 2004, Pages 6021-6027

  Caricasole, Andrea ^a   Copani, Agata ^b,f   Caraci, Filippo ^b   Aronica, Eleonora ^c   Rozemuller, Annemieke J ^c   Caruso, Alessandra ^d   Storto, Marianna ^e   Gaviraghi, Giovanni ^a   Terstappen, Georg C ^a   Nicoletti, Ferdinando ^d,e  

^a Siena Biotech SpA   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e IRCCS NEUROMED   (Italy)

^f CNR   (Italy)

Author keywords

amyloid; Alzheimer's disease; Apoptosis; Dickkopf 1; Tau phosphorylation; Wnt pathway

Indexed keywords

AMYLOID BETA PROTEIN; ANTISENSE OLIGONUCLEOTIDE; DICKKOPF 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOPROTEIN; PROTEIN P53; REGULATOR PROTEIN; TAU PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CONTROLLED STUDY; DYSTROPHY; EMBRYO; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; KNOCKOUT GENE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NEURITE; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN HYPERPHOSPHORYLATION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELLS, CULTURED; DIZOCILPINE MALEATE; GENE EXPRESSION REGULATION; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOENZYME TECHNIQUES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROFIBRILLARY TANGLES; NEURONS; OLIGODEOXYRIBONUCLEOTIDES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOXALINES; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TAU PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; WNT PROTEINS;

EID: 3042834662     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1381-04.2004     Document Type: Article

References (36)

1. Arends M, Duyckaerts C, Rozemuller JM, Eikelenboom P, Hauw J-J (2000) Microglia, amyloid and dementia in Alzheimer disease. A correlative study. Neurobiol Aging 21:39-47.
2. Bettini E, Magnani E, Terstappen GC (2002) Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells. Neurosci Lett 317:50-52.
3. Braak H, Braak E (1995) Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16:271-278.
4. Caricasole A, Ferraro T, Rimland JM, Terstappen GC (2002) Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine. Gene 288:147-157.
5. Caricasole A, Copani A, Caruso A, Caraci F, Iacovelli L, Sortino MA, Terstappen GC, Nicoletti F (2003) The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease? Trends Pharmacol Sci 24:233-238.
6. Chen R-W, Saunders PA, Wei H, Li Z, Seth P, Chuang DM (1999) Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53. J Neurosci 19:9654-9662.
7. Copani A, Condorelli F, Caruso A, Vancheri C, Sala A, Giuffrida Stella AM, Canonico PL, Nicoletti F, Sortino MA (1999) Mitotic signaling by beta-amyloid causes neuronal death. FASEB J 13:2225-2234.
8. Copani A, Sortino MA, Caricasole A, Chiechio S, Chisari M, Battaglia G, Giuffrida-Stella AM, Vancheri C, Nicoletti F (2002) Erratic expression of DNA polymerases by beta-amyloid causes neuronal death. FASEB J 16:2006-2008.
9. Cotman CW, Anderson AJ (1995) A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol 10:19-45.
10. Cotter D, Kerwin R, al-Sarraji S, Brion JP, Chadwich A, Lovestone S, Anderton B, Everall I (1998) Abnormalities of Wnt signalling in schizophrenia-evidence for neurodevelopmental abnormality. NeuroReport 9:1379-1383.
11. Dale TC (1998) Signal transduction by the Wnt family of ligands. Biochem J 329:209-223.
12. De Ferrari GV, Inestrosa NC (2000) Wnt signaling function in Alzheimer's disease. Brain Res Brain Res Rev 33:1-12.
13. De Ferrari GV, Chacon MA, Barria MI, Garrido IL, Godoy JA, Olivares G, Reyes AE, Alvarez A, Bronfman M, Inestrosa NC (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol Psychiatry 8:195-208.
14. Fukumoto S, Hsieh CM, Maemura K, Layne MD, Yet SF, Lee KH, Matsui T, Rosenzweig A, Taylor WG, Rubin IS, Perrella MA, Lee ME (2001) Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem 2 76:17479-17483.
15. Garrido JL, Godoy JA, Alvarez A, Bronfman M, Inestrosa NC (2002) Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway. FASEB J 16:1982-1984.
16. Godemann R, Biernat J, Mandelkow E, Mandelkow EM (1999) Phosphorylation of tau protein by recombinant GSK-3beta: pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain. FEBS Lett 454:157-164.
17. Grimes CA, Jope RS (2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 65:391-426.
18. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
19. Hinck L, Nelson WJ, Papkoff J (1994) Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin. J Cell Biol 124:729-741.
20. Inestrosa N, De Ferrari GV, Garrido JL, Alvarez A, Olivares GH, Barria MI, Bronfman M, Chacon MA (2002) Wnt signaling involvement in beta-amyloid-dependent neurodegeneration. Neurochem Int 41:341-344.
21. Lakin ND, Jackson SP (1999) Regulation of p53 in response to DNA damage. Oncogene 18:7644-7655.
22. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW (1993) Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 90:7951-7955.
23. Otth C, Concha II, Arendt T, Stieler J, Schliebs R, Gonzalez-Billault C, Maccioni RB (2002) AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576. J Alzheimer's Dis 4:417-430.
24. Rocchi A, Pellegrini S, Siciliano G, Murri L (2003) Causative and susceptibility genes for Alzheimer's disease: a review. Brain Res Bull 61:1-24.
25. Roelen BA, Lin YH, Knezevic V, Freund E, Mummery CL (1994) Expression of TGF-betas and their receptors during implantation and organogenesis of the mouse embryo. Dev Biol 166:716-728.
26. Saunders AM, Trowers MK, Shimkets RA, Blakemore S, Crowther DJ, Mansfield TA, Wallace DM, Strittmatter WJ, Roses AD (2000) The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. Biochim Biophys Acta 1502:85-94.
27. Shen Y, White E (2001) p53-dependent apoptosis pathways. Adv Cancer Res 82: 55-84.
28. Shou J, Ali-Osman F, Multani AS, Pathak S, Fedi P, Srivenugopal KS (2002) Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene 21:878-889.
29. Smale G, Nichols NR, Brady DR, Finch CE, Horton Jr WE (1995) Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 133:225-230.
30. Takashima A, Honda T, Yasutake K, Michel G, Murayama O, Murayama M, Ishiguro K, Yamaguchi H (1998) Activation of tau protein kinase I/gly cogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neurosci Res 4:317-323.
31. Wang J, Shou J, Chen X (2000) Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Oncogene 19:1843-1848.
32. Wassink TH, Piven J, Vieland VJ, Huang J, Swiderski RE, Pietila J, Braun T, Beck G, Folstein SE, Haines JL, Sheffield VC (2001) Evidence supporting WNT2 as an autism susceptibility gene. Am J Med Genet 105:406-413.
33. Willert K, Nusse R (1998) Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 8:95-102.
34. Yu X, Malenka RC (2003) Beta-catenin is critical for dendritic morphogenesis. Nat Neurosci 6:1179-1187.
35. Zhang Y, McLaughlin R, Goodyer C, LeBlanc A (2002) Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol 156:519-529.
36. Zorn AM (2001) Wnt signalling: antagonistic Dickkopfs. Curr Biol 11: R592-R595.