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Volumn 20, Issue 1, 2010, Pages 145-157

Overexpression of tau proteins antagonizes amyloid-β - Potentiated apoptosis through mitochondria - Caspase-3 pathway in n2a cells

Author keywords

Alzheimer's disease; amyloid ; apoptosis; hyperphosphorylation; mitochondria; tau

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CASPASE 3; CYTOCHROME C; HYDROGEN PEROXIDE; PROTEIN BAX; PROTEIN BCL 2; TAU PROTEIN;

EID: 77954467417     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-1351     Document Type: Article
Times cited : (36)

References (48)
  • 2
    • 35948969760 scopus 로고    scopus 로고
    • Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease
    • Anandatheerthavarada HK, Devi L (2007) Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease. Neuroscientist 13, 626-638.
    • (2007) Neuroscientist , vol.13 , pp. 626-638
    • Anandatheerthavarada, H.K.1    Devi, L.2
  • 6
    • 34249788738 scopus 로고    scopus 로고
    • Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders
    • Sas K, Robotka H, Toldi J, Vecsei L (2007) Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders. J Neurol Sci 257, 221-239.
    • (2007) J Neurol Sci , vol.257 , pp. 221-239
    • Sas, K.1    Robotka, H.2    Toldi, J.3    Vecsei, L.4
  • 7
    • 0029686696 scopus 로고    scopus 로고
    • Evolution of the neuropathology of Alzheimer's disease
    • Braak H, Braak E (1996) Evolution of the neuropathology of Alzheimer's disease. Acta Neurol Scand Suppl 165, 3-12. (Pubitemid 26143161)
    • (1996) Acta Neurologica Scandinavica, Supplement , vol.93 , Issue.165 , pp. 3-12
    • Braak, H.1    Braak, E.2
  • 8
    • 0028362458 scopus 로고
    • A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
    • Braak E, Braak H, Mandelkow EM (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol 87, 554-567.
    • (1994) Acta Neuropathol , vol.87 , pp. 554-567
    • Braak, E.1    Braak, H.2    Mandelkow, E.M.3
  • 9
    • 0031880094 scopus 로고    scopus 로고
    • A suicide note from Alzheimer disease neurons?
    • Perry G, Nunomura A, Smith MA (1998) A suicide note from Alzheimer disease neurons? Nat Med 4, 897-898.
    • (1998) Nat Med , vol.4 , pp. 897-898
    • Perry, G.1    Nunomura, A.2    Smith, M.A.3
  • 11
    • 0030036176 scopus 로고    scopus 로고
    • Research communication copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical
    • Tsang SY, Tam SC, Bremner I, Burkitt MJ (1996) Research communication copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical. Biochem J 317 (Pt 1), 13-16.
    • (1996) Biochem J , vol.317 , Issue.PART 1 , pp. 13-16
    • Tsang, S.Y.1    Tam, S.C.2    Bremner, I.3    Burkitt, M.J.4
  • 12
    • 0031558654 scopus 로고    scopus 로고
    • Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain
    • Su JH, Deng G, Cotman CW (1997) Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res 774, 193-199.
    • (1997) Brain Res , vol.774 , pp. 193-199
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 13
    • 2642680857 scopus 로고    scopus 로고
    • Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
    • Stadelmann C, Bruck W, Bancher C, Jellinger K, Lassmann H (1998) Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J Neuropathol Exp Neurol 57, 456-464.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 456-464
    • Stadelmann, C.1    Bruck, W.2    Bancher, C.3    Jellinger, K.4    Lassmann, H.5
  • 16
    • 0035139425 scopus 로고    scopus 로고
    • Do neurons have a choice in death?
    • Perry G, Zhu X, Smith MA (2001) Do neurons have a choice in death? Am J Pathol 158, 1-2.
    • (2001) Am J Pathol , vol.158 , pp. 1-2
    • Perry, G.1    Zhu, X.2    Smith, M.A.3
  • 21
    • 0032550129 scopus 로고    scopus 로고
    • Neuronal apoptosis is associated with a decrease in tau mRNA expression
    • Esclaire F, Terro F, Yardin C, Hugon J (1998) Neuronal apoptosis is associated with a decrease in tau mRNA expression. Neuroreport 9, 1173-1177.
    • (1998) Neuroreport , vol.9 , pp. 1173-1177
    • Esclaire, F.1    Terro, F.2    Yardin, C.3    Hugon, J.4
  • 22
    • 0031127495 scopus 로고    scopus 로고
    • Cultured neurons expressing phosphorylated tau are more resistant to apoptosis induced by NMDA or serum deprivation
    • Lesort M, Blanchard C, Yardin C, Esclaire F, Hugon J (1997) Cultured neurons expressing phosphorylated tau are more resistant to apoptosis induced by NMDA or serum deprivation. Brain Res Mol Brain Res 45, 127-132.
    • (1997) Brain Res Mol Brain Res , vol.45 , pp. 127-132
    • Lesort, M.1    Blanchard, C.2    Yardin, C.3    Esclaire, F.4    Hugon, J.5
  • 24
    • 7444229915 scopus 로고    scopus 로고
    • Rosuvastatin reduces caspase-3 activity and up-regulates alpha-secretase in human neuroblastoma SH-SY5Y cells exposed to A beta
    • Famer D, Crisby M (2004) Rosuvastatin reduces caspase-3 activity and up-regulates alpha-secretase in human neuroblastoma SH-SY5Y cells exposed to A beta. Neurosci Lett 371, 209-214.
    • (2004) Neurosci Lett , vol.371 , pp. 209-214
    • Famer, D.1    Crisby, M.2
  • 25
    • 3042719566 scopus 로고    scopus 로고
    • Bcl-2 protects against Abeta(25-35)- induced oxidative PC12 cell death by potentiation of antioxidant capacity
    • Jang JH, Surh YJ (2004) Bcl-2 protects against Abeta(25-35)- induced oxidative PC12 cell death by potentiation of antioxidant capacity. Biochem Biophys Res Commun 320, 880-886.
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 880-886
    • Jang, J.H.1    Surh, Y.J.2
  • 26
    • 14944340150 scopus 로고    scopus 로고
    • Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways
    • Watson K, Fan GH (2005) Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways. Mol Pharmacol 67, 757-765.
    • (2005) Mol Pharmacol , vol.67 , pp. 757-765
    • Watson, K.1    Fan, G.H.2
  • 27
    • 13944275183 scopus 로고    scopus 로고
    • Beta-amyloidinduced neuronal apoptosis involves c-Jun N-terminal kinasedependent downregulation of Bcl-w
    • Yao M, Nguyen TV, Pike CJ (2005) Beta-amyloidinduced neuronal apoptosis involves c-Jun N-terminal kinasedependent downregulation of Bcl-w. J Neurosci 25, 1149-1158.
    • (2005) J Neurosci , vol.25 , pp. 1149-1158
    • Yao, M.1    Nguyen, T.V.2    Pike, C.J.3
  • 28
    • 14044273642 scopus 로고    scopus 로고
    • Biomarkers for apoptosis in Alzheimer's disease
    • Ankarcrona M, Winblad B (2005) Biomarkers for apoptosis in Alzheimer's disease. Int J Geriatr Psychiatry 20, 101-105.
    • (2005) Int J Geriatr Psychiatry , vol.20 , pp. 101-105
    • Ankarcrona, M.1    Winblad, B.2
  • 29
    • 33748457094 scopus 로고    scopus 로고
    • Amyloid beta peptide, 4-hydroxynonenal and apoptosis
    • Lovell MA, Markesbery WR (2006) Amyloid beta peptide, 4-hydroxynonenal and apoptosis. Curr Alzheimer Res 3, 359-364.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 359-364
    • Lovell, M.A.1    Markesbery, W.R.2
  • 30
    • 0034043907 scopus 로고    scopus 로고
    • Presenilins and cellular damage: A link through amyloid?
    • Lucassen PJ (2000) Presenilins and cellular damage: a link through amyloid? J Alzheimers Dis 2, 61-67.
    • (2000) J Alzheimers Dis , vol.2 , pp. 61-67
    • Lucassen, P.J.1
  • 31
    • 0033009194 scopus 로고    scopus 로고
    • Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: Central roles of superoxide production and caspase activation
    • Guo Q, Sebastian L, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP (1999) Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J Neurochem 72, 1019-1029.
    • (1999) J Neurochem , vol.72 , pp. 1019-1029
    • Guo, Q.1    Sebastian, L.2    Sopher, B.L.3    Miller, M.W.4    Ware, C.B.5    Martin, G.M.6    Mattson, M.P.7
  • 32
    • 0029912056 scopus 로고    scopus 로고
    • Mechanisms of neuronal death in Alzheimer's disease
    • Cotman CW, Su JH (1996) Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol 6, 493-506.
    • (1996) Brain Pathol , vol.6 , pp. 493-506
    • Cotman, C.W.1    Su, J.H.2
  • 33
    • 18744416806 scopus 로고    scopus 로고
    • Effect of amyloid peptides on serum withdrawal-induced cell differentiation and cell viability
    • Wang YP, Wang ZF, Zhang YC, Tian Q, Wang JZ (2004) Effect of amyloid peptides on serum withdrawal-induced cell differentiation and cell viability. Cell Res 14, 467-472.
    • (2004) Cell Res , vol.14 , pp. 467-472
    • Wang, Y.P.1    Wang, Z.F.2    Zhang, Y.C.3    Tian, Q.4    Wang, J.Z.5
  • 34
    • 0034717317 scopus 로고    scopus 로고
    • Kinetic characterization of the nitric oxide toxicity for PC12 cells: Effect of half-life time of NO release
    • Yamamoto T, Yuyama K, Nakamura K, Kato T, Yamamoto H (2000) Kinetic characterization of the nitric oxide toxicity for PC12 cells: effect of half-life time of NO release. Eur J Pharmacol 397, 25-33.
    • (2000) Eur J Pharmacol , vol.397 , pp. 25-33
    • Yamamoto, T.1    Yuyama, K.2    Nakamura, K.3    Kato, T.4    Yamamoto, H.5
  • 35
    • 0035860286 scopus 로고    scopus 로고
    • Phorbol myristate acetate inhibits okadaic acid-induced apoptosis and downregulation of X-linked inhibitor of apoptosis in U937 cells
    • Kwon TK (2001) Phorbol myristate acetate inhibits okadaic acid-induced apoptosis and downregulation of X-linked inhibitor of apoptosis in U937 cells. Biochem Biophys Res Commun 287, 135-141.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 135-141
    • Kwon, T.K.1
  • 36
    • 0042847291 scopus 로고    scopus 로고
    • Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: Oxidative stress, caspases, and the JNK pathway
    • Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, Eckert A (2003) Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway. J Biol Chem 278, 28294-28302.
    • (2003) J Biol Chem , vol.278 , pp. 28294-28302
    • Marques, C.A.1    Keil, U.2    Bonert, A.3    Steiner, B.4    Haass, C.5    Muller, W.E.6    Eckert, A.7
  • 37
    • 18844462415 scopus 로고    scopus 로고
    • Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease
    • Wang J, Xiong S, Xie C, Markesbery WR, Lovell MA (2005) Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. J Neurochem 93, 953-962.
    • (2005) J Neurochem , vol.93 , pp. 953-962
    • Wang, J.1    Xiong, S.2    Xie, C.3    Markesbery, W.R.4    Lovell, M.A.5
  • 39
    • 15744398884 scopus 로고    scopus 로고
    • Oxidative modifications and aggregation of Cu,Znsuperoxide dismutase associated with Alzheimer and Parkinson diseases
    • Choi J, Rees HD, Weintraub ST, Levey AI, Chin LS, Li L (2005) Oxidative modifications and aggregation of Cu,Znsuperoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem 280, 11648-11655.
    • (2005) J Biol Chem , vol.280 , pp. 11648-11655
    • Choi, J.1    Rees, H.D.2    Weintraub, S.T.3    Levey, A.I.4    Chin, L.S.5    Li, L.6
  • 40
    • 0037089068 scopus 로고    scopus 로고
    • BH3-only proteins - Evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death
    • Bouillet P, Strasser A (2002) BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J Cell Sci 115, 1567-1574.
    • (2002) J Cell Sci , vol.115 , pp. 1567-1574
    • Bouillet, P.1    Strasser, A.2
  • 41
    • 34249819032 scopus 로고    scopus 로고
    • BH3-only proteins trigger cytochrome c release but how?
    • Hacker G, Weber A (2007) BH3-only proteins trigger cytochrome c release, but how? Arch Biochem Biophys 462, 150-155.
    • (2007) Arch Biochem Biophys , vol.462 , pp. 150-155
    • Hacker, G.1    Weber, A.2
  • 44
    • 0028095224 scopus 로고
    • Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
    • Khatoon S, Grundke-Iqbal I, Iqbal K (1994) Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBS Lett 351, 80-84.
    • (1994) FEBS Lett , vol.351 , pp. 80-84
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 45
    • 0343384322 scopus 로고    scopus 로고
    • Differential association of tau with subsets of microtubules containing posttranslationally-modified tubulin variants in neuroblastoma cells
    • Saragoni L, Hernandez P, Maccioni RB (2000) Differential association of tau with subsets of microtubules containing posttranslationally-modified tubulin variants in neuroblastoma cells. Neurochem Res 25, 59-70.
    • (2000) Neurochem Res , vol.25 , pp. 59-70
    • Saragoni, L.1    Hernandez, P.2    MacCioni, R.B.3
  • 46
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubuleassociated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
    • Alonso AD, Grundke-Iqbal I, Barra HS, IqbalK(1997) Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubuleassociated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA 94, 298-303.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 298-303
    • Alonso, A.D.1    Grundke-Iqbal, I.2    Barra, H.S.3    Iqbal, K.4
  • 47
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
    • Alonso AC, Zaidi T, Grundke-Iqbal I, Iqbal K (1994) Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci USA 91, 5562-5566.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5562-5566
    • Alonso, A.C.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 48
    • 0037128935 scopus 로고    scopus 로고
    • Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    • Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM (2002) Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 156, 1051-1063.
    • (2002) J Cell Biol , vol.156 , pp. 1051-1063
    • Stamer, K.1    Vogel, R.2    Thies, E.3    Mandelkow, E.4    Mandelkow, E.M.5


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