Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration

Acta Neuropathologica

Volumn 104, Issue 4, 2002, Pages 369-376

  Pei, Jin Jing ^a   Braak, Heiko ^b   Gong, Cheng Xin ^c   Grundke Iqbal, Inge ^c   Iqbal, Khalid ^c   Winblad, Bengt ^a   Cowburn, Richard F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GOETHE UNIVERSITY   (Germany)

^c NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Alzheimer's disease; cdc2; Neurofibrillary tangle

Indexed keywords

AMYLOID; CELL CYCLE PROTEIN; PROTEIN KINASE; TAU PROTEIN;

ADULT; ALZHEIMER DISEASE; ARTICLE; BRAIN NERVE CELL; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; NEUROFIBRILLARY TANGLE; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TEMPORAL CORTEX; UPREGULATION;

EID: 0036938381     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-002-0565-1     Document Type: Article

References (33)

1. Baumann K, Mandelkow EM, Biernat J, Piwnica-Worms H, Mandelkow E (1993) Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdc2 and cdk5. FEBS Lett 336:417-424
2. Braak H, Braak E, Ohm T, Bohl J (1988) Silver impregnation of Alzheimer's neurofibrillary changes counterstained for basophilic material and lipofuscin pigment. Stain Technol 63: 197-200
3. Braak E, Braak H, Mandelkow EM (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol 87:554-567
4. Braak E, Braak H (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82:239-259
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
6. Campbell SK, Switzer RC, Martin TL (1987) Alzheimer's plaques and tangles: a controlled and enhanced silver-staining method. Soc Neurosci Abstr 13:H678
7. Ding XL, Husseman J, Tomashevski A, Nochlin D, Jin LW, Vincent I (2000) The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease. Am J Pathol 57:1983-1990
8. Gallyas F (1971) Silver staining of Alzheimer's neurofibrillary changes by means of physical development. Acta Morphol Acad Sci Hung 19:1-8
9. Gong C-X, Singh TJ, Grundke-Iqbal I, Iqbal K (1993) Phosphoprotein phosphatase activities in Alzheimer's disease brain. J Neurochem 61:921-927
10. Grundke-Iqbal I, Iqbal K, Quinlan M, Tung Y-C, Zaide MS, Wisniewski HM (1986) Microtubule-associated protein tau, a component of Alzheimer paired helical filaments. J Biol Chem 261:6084-6089
11. Grundke-Iqbal I, Iqbal K, Tung Y-C, Quinlan M, Wisniewski HM, Binder I (1986) Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeleton pathology. Proc Natl Acad Sci USA 83:4913-4917
12. Imahori K, Uchida T (1997) Physiology and pathology of tau protein kinase in relation to Alzheimer's disease. J Biochem 121:179-188
13. Iqbal K, Grundke-Iqbal I (1992) Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease. Mol Neurobiol 5:399-410
14. Iqbal K, Grundke-Iqbal I, Smith AJ, George L, Tung Y-C, Zaidi T (1989) Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proc Natl Acad Sci USA 86:5646-5650
15. Iqbal K, Grundke-Iqbal I, Zaidi T, Merz PA, Wen GY, Shaikh SS, Wisniewski HM, Alafuzoff I, Winblad B (1986) Defective brain microtubule assembly in Alzheimer disease. Lancet 2: 421-426
16. Köpke E, Tung Y-C, Shaikh S, Alonso A del C, Iqbal K, Grundke-Iqbal I (1993) Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem 268:24374-24384
17. Lee J, Kumagai A, Dunphy WG (2001) Positive regulation of Weel by Chk1 and 14-3-3 proteins. Mol Biol Cell 12:551-563
18. Liu W-K, Williams RT, Hall FL, Dickson DW, Yen S-H (1995) Detection of a cdc2-related kinase associated with Alzheimer paired helical filaments. Am J Pathol 146:228-238
19. Pei J-J, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (1999) Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer's disease neurofibrillary changes. J Neuropathol Exp Neurol 58: 1010-1019
20. Pei J-J, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (200) Distribution of active forms of C-jun kinase (JNK) and p38 kinase in brains staged with Alzheimer's disease neurofibrillary changes. J Alzheimer Dis 3:41-48
21. cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals. Brain Res 655:70-76
22. Pope W, Enam SA, Bawa N, Miller BE, Ghanbari HA, Klein WL (1993) Phosphorylated tau epitopes of Alzheimer's disease is coupled to axon development in the avian central nervous system. Exp Neurol 120:106-113
23. Pope WB, Lambert MP, Leypold B, Seupaul R, Sletten L, Krafft G, Klein WL (1994) Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y. Exp Neurol 126:185-194
24. Preuss U, Doring F, Illenberger S, Mandelkow E-M (1995) Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells. Mol Biol Cell 6:1397-1410
25. Rhind N, Russell P (2001) Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints. Mol Cell Biol 21:1499-1508
26. Scott C, Vulliet PR, Caputo CB (1993) Phosphorylation of tau by proline-directed protein kinase (p34cdc2 / p58 cyclin A) decreases tau-induced microtubule assembly and antibody SMI33 reactivity. Brain Res 611:237-242
27. Sherr CJ (1994) G1 phase progression: cycling on cue. Cell 79:551-555
28. Tanaka T, Zhong J, Iqbal K, Trenkner E, Grundke-Iqbal I (1998) The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases. FEBS Lett 426:248-254
29. Vincent I, Jicha G, Rosado M, Dicksom DW (1997) Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J Neurosci 17:3588-3598
30. Vulliet R, Halloran SM, Braun RB, Smith AJ, Lee G (1992) Proline-directed phosphorylation of human tau protein. J Biol Chem 267:22570-22574
31. Watanabe N, Broome M, Hunter T (1995) Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J 14:1878-1891
32. Wood JG, Lu Q, Reich C, Zinsmeister P (1993) Proline-directed kinase system in Alzheimer's disease pathology. Neurosci Lett 156:83-86
33. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993) p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704