A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology

Journal of Neural Transmission

Volumn 113, Issue 10, 2006, Pages 1487-1497

  Zhang, Y ^a   Li, H L ^a   Wang, D L ^a   Liu, S J ^a   Wang, J Z ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Abnormal hyperphosphorylation; Alzheimer's disease; cAMP dependent protein kinase; Glycogen synthase kinase 3; Tau

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME ACTIVATOR; FORSKOLIN; GLYCOGEN SYNTHASE KINASE 3; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; TAU HYPERPHOSPHORYLATION;

ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FORSKOLIN; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; PHOSPHORYLATION; TAU PROTEINS; TIME FACTORS;

EID: 33748945559     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-005-0421-2     Document Type: Article

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