Biophysics of TRP channels

Comprehensive Biophysics

Volumn 6, Issue , 2012, Pages 68-107

  Parnas, M ^a   Peters, M ^a   Minke, B ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Allosteric gating mechanism; Chemical Sensing; Drosophila TRP and TRPL channels; Heteromultimerization; Lipid rafts; Mechanosensitivity; Phosphoinositides; Thermosensation; Translocation; TRP channels; TRP modules; Voltage dependence

Indexed keywords

EID: 84870862340     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374920-8.00617-2     Document Type: Chapter

References (401)

1. Cosens D.J., Manning A. Abnormal electroretinogram from a Drosophila mutant. Nature 1969, 224:285-287.
2. Minke B., Wu C., Pak W.L. Induction of photoreceptor voltage noise in the dark in Drosophila mutant. Nature 1975, 258:84-87.
3. Minke B. Light-induced reduction in excitation efficiency in the trp mutant of Drosophila. J. Gen. Physiol. 1982, 79:361-385.
4. Montell C., Rubin G.M. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 1989, 2:1313-1323.
5. 2+ channel in Drosophila photoreceptors. Neuron 1992, 8:643-651.
6. Peretz A., Suss-Toby E., Rom-Glas A., Arnon A., Payne R., Minke B. The light response of Drosophila photoreceptors is accompanied by an increase in cellular calcium: effects of specific mutations. Neuron 1994, 12:1257-1267.
7. 2+ influx into Drosophila photoreceptors. J. Gen. Physiol. 1994, 104:1057-1077.
8. Bloomquist B.T., Shortridge R.D., Schneuwly S., Perdew M., Montell C., Steller H., Rubin G., Pak W.L. Isolation of a putative phospholipase C gene of Drosophila, norpA, and its role in phototransduction. Cell 1988, 54:723-733.
9. Devary O., Heichal O., Blumenfeld A., Cassel D., Suss E., Barash S., Rubinstein C.T., Minke B., Selinger Z. Coupling of photoexcited rhodopsin to inositol phospholipid hydrolysis in fly photoreceptors. Proc. Natl. Acad. Sci. USA 1987, 84:6939-6943.
10. Selinger Z., Minke B. Inositol lipid cascade of vision studied in mutant flies. Cold Spring Harb. Symp. Quant. Biol. 1988, 53(Pt 1):333-341.
11. Phillips A.M., Bull A., Kelly L.E. Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene. Neuron 1992, 8:631-642.
12. 2+ mobilization. Trends. Neurosci. 1993, 16:371-376.
13. Wes P.D., Chevesich J., Jeromin A., Rosenberg C., Stetten G., Montell C. TRPC1, a human homolog of a Drosophila store-operated channel. Proc. Natl. Acad. Sci. USA 1995, 92:9652-9656.
14. Zhu X., Chu P.B., Peyton M., Birnbaumer L. Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. FEBS Lett. 1995, 373:193-198.
15. Clapham D.E., Runnels L.W., Strubing C. The TRP ion channel family. Nat. Rev. Neurosci. 2001, 2:387-396.
16. Minke B., Cook B. TRP channel proteins and signal transduction. Physiol. Rev. 2002, 82:429-472.
17. Montell C., Birnbaumer L., Flockerzi V. The TRP channels, a remarkably functional family. Cell 2002, 108:595-598.
18. Clapham D.E. TRP channels as cellular sensors. Nature 2003, 426:517-524.
19. Corey D.P. New TRP channels in hearing and mechanosensation. Neuron 2003, 39:585-588.
20. Delmas P. Polycystins: from mechanosensation to gene regulation. Cell 2004, 118:145-148.
21. Montell C., Birnbaumer L., Flockerzi V., Bindels R.J., Bruford E.A., Caterina M.J., Clapham D.E., Harteneck C., Heller S., Julius D., Kojima I., Mori Y., Penner R., Prawitt D., Scharenberg A.M., Schultz G., Shimizu N., Zhu M.X. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 2002, 9:229-231.
22. Nilius B., Voets T. TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch. 2005, 451:1-10.
23. Sidi S., Friedrich R.W., Nicolson T. NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science 2003, 301:96-99.
24. Walker R.G., Willingham A.T., ZGBRer C.S. A Drosophila mechanosensory transduction channel. Science 2000, 287:2229-2234.
25. Ramsey I.S., Delling M., Clapham D.E. An introduction to TRP channels. Annu. Rev. Physiol. 2006, 68:619-647.
26. Strubing C., Krapivinsky G., Krapivinsky L., Clapham D.E. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem. 2003, 278:39014-39019.
27. Strubing C., Krapivinsky G., Krapivinsky L., Clapham D.E. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 2001, 29:645-655.
28. Kedei N., Szabo T., Lile J.D., Treanor J.J., Olah Z., Iadarola M.J., Blumberg P.M. Analysis of the native quaternary structure of vanilloid receptor 1. J. Biol. Chem. 2001, 276:28613-28619.
29. Phelps C.B., Gaudet R. The role of the N terminus and transmembrane domain of TRPM8 in channel localization and tetramerization. J. Biol. Chem. 2007, 282:36474-36480.
30. Barrera N.P., Shaifta Y., McFadzean I., Ward J.P., Henderson R.M., Edwardson J.M. AFM imaging reveals the tetrameric structure of the TRPC1 channel. Biochem. Biophys. Res. Commun. 2007, 358:1086-1090.
31. Clapham D.E., Julius D., Montell C., Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol. Rev. 2005, 57:427-450.
32. Flockerzi V. An introduction on TRP channels. Handb. Exp. Pharmacol. 2007, 1-19.
33. Sedgwick S.G., Smerdon S.J. The ankyrin repeat: a diversity of interactions on a common structural framework. Trends Biochem. Sci. 1999, 24:311-316.
34. Jin X., Touhey J., Gaudet R. Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J. Biol. Chem. 2006, 281:25006-25010.
35. Schindl R., Romanin C. Assembly domains in TRP channels. Biochem. Soc. Trans. 2007, 35:84-85.
36. Story G.M., Peier A.M., Reeve A.J., Eid S.R., Mosbacher J., Hricik T.R., Earley T.J., Hergarden A.C., Andersson D.A., Hwang S.W., McIntyre P., Jegla T., Bevan S., Patapoutian A. ANKTM1, a TRPlike channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 2003, 112:819-829.
37. Corey D.P., Garcia-Anoveros J., Holt J.R., Kwan K.Y., Lin S.Y., Vollrath M.A., Amalfitano A., Cheung E.L., Derfler B.H., Duggan A., Geleoc G.S., Gray P.A., Hoffman M.P., Rehm H.L., Tamasauskas D., Zhang D.S. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 2004, 432:723-730.
38. Howard J., Bechstedt S. Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors. Curr. Biol. 2004, 14:R224-R226.
39. Venkatachalam K., Montell C. TRP channels. Annu. Rev. Biochem. 2007, 76:387-417.
40. Lepage P.K., Lussier M.P., Barajas-Martinez H., Bousquet S.M., Blanchard A.P., Francoeur N., Dumaine R., Boulay G. Identification of two domains involved in the assembly of transient receptor potential canonical channels. J. Biol. Chem. 2006, 281:30356-30364.
41. Crick F.H. Is alpha-keratin a coiled coil?. Nature 1952, 170:882-883.
42. Harbury P.B., Zhang T., Kim P.S., Alber T. A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants. Science 1993, 262:1401-1407.
43. Malashkevich V.N., Kammerer R.A., Efimov V.P., Schulthess T., Engel J. The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel?. Science 1996, 274:761-765.
44. 2+-binding proteins in the functional regulation of TRP channels. Pflugers Arch. 2005, 451:105-115.
45. Xu X.Z., Chien F., Butler A., Salkoff L., Montell C. TRPγ, a Drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron 2000, 26:647-657.
46. Xu X.Z.S., Li H.S., Guggino W.B., Montell C. Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell 1997, 89:1155-1164.
47. 301 mutant and TRPL cation channels expressed in a stably transfected Drosophila cell line. Cell Calcium 1997, 21:431-440.
48. Kunze D.L., Sinkins W.G., Vaca L., Schilling W.P. Properties of single Drosophila Trpl channels expressed in Sf9 insect cells. Am. J. Physiol. 1997, 272:C27-C34.
49. 2+ underlies the voltage dependence of Drosophila TRPL channel. J. Gen. Physiol. 2007, 129:17-28.
50. 2+. Pflugers Arch. 2000, 440:409-417.
51. Hardie R.C., Minke B. Spontaneous activation of light-sensitive channels in Drosophila photoreceptors. J. Gen. Physiol. 1994, 103:389-407.
52. Minke B., Parnas M. Insights on TRP channels from in vivo studies in Drosophila. Annu. Rev. Physiol. 2006, 68:649-684.
53. Reuss H., Mojet M.H., Chyb S., Hardie R.C. In vivo analysis of the Drosophila light-sensitive channels, TRP and TRPL. Neuron 1997, 19:1249-1259.
54. Goel M., Sinkins W.G., Schilling W.P. Selective association of TRPC channel subunits in rat brain synaptosomes. J. Biol. Chem. 2002, 277:48303-48310.
55. Hofmann T., Schaefer M., Schultz G., Gudermann T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc. Natl. Acad. Sci. USA 2002, 99:7461-7466.
56. Hellwig N., Albrecht N., Harteneck C., Schultz G., Schaefer M. Homoand heteromeric assembly of TRPV channel subunits. J. Cell Sci. 2005, 118:917-928.
57. Liapi A., Wood J.N. Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur. J. Neurosci. 2005, 22:825-834.
58. Kottgen M., Buchholz B., Garcia-Gonzalez M.A., Kotsis F., Fu X., Doerken M., Boehlke C., Steffl D., Tauber R., Wegierski T., Nitschke R., Suzuki M., Kramer-Zucker A., Germino G.G., Watnick T., Prenen J., Nilius B., Kuehn E.W., Walz G. TRPP2 and TRPV4 form a polymodal sensory channel complex. J. Cell Biol. 2008, 182:437-447.
59. Hanaoka K., Qian F., Boletta A., Bhunia A.K., Piontek K., Tsiokas L., SGBRhatme V.P., Guggino W.B., Germino G.G. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 2000, 408:990-994.
60. Kottgen M., Walz G. Subcellular localization and trafficking of polycystins. Pflugers Arch. 2005, 451:286-293.
61. Giamarchi A., Padilla F., Coste B., Raoux M., Crest M., Honore E., Delmas P. The versatile nature of the calcium-permeable cation channel TRPP2. EMBO Rep. 2006, 7:787-793.
62. Liedtke W. Molecular mechanisms of TRPV4-mediated neural signaling. Ann. N. Y. Acad. Sci. 2008, 1144:42-52.
63. Nilius B., Vriens J., Prenen J., Droogmans G., Voets T. TRPV4 calcium entry channel: a paradigm for gating diversity. Am. J. Physiol. Cell Physiol. 2004, 286:C195-C205.
64. Yamaguchi H., Matsushita M., Nairn A.C., Kuriyan J. Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol. Cell 2001, 7:1047-1057.
65. Jenke M., Sanchez A., Monje F., Stuhmer W., Weseloh R.M., Pardo L.A. C-terminal domains implicated in the functional surface expression of potassium channels. EMBO J. 2003, 22:395-403.
66. Montell C. The TRP superfamily of cation channels. Sci. STKE. 2005, 2005:re3.
67. Lupas A.N., Gruber M. The structure of alpha-helical coiled coils. Adv. Protein Chem. 2005, 70:37-78.
68. Woolfson D.N. The design of coiled-coil structures and assemblies. Adv. Protein Chem. 2005, 70:79-112.
69. Garcia-Sanz N., Fernandez-Carvajal A., Morenilla-Palao C., Planells-Cases R., Fajardo-Sanchez E., Fernandez-Ballester G., Ferrer-Montiel A. Identification of a tetramerization domain in the C terminus of the vanilloid receptor. J. Neurosci. 2004, 24:5307-5314.
70. Launay P., Cheng H., Srivatsan S., Penner R., Fleig A., Kinet J.P. TRPM4 regulates calcium oscillations after T cell activation. Science 2004, 306:1374-1377.
71. Tsuruda P.R., Julius D., Minor D.L. Coiled coils direct assembly of a cold-activated TRP channel. Neuron 2006, 51:201-212.
72. Moiseenkova-Bell V.Y., Stanciu L.A., Serysheva I.I., Tobe B.J., Wensel T.G. Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc. Natl. Acad. Sci. USA 2008, 105:7451-7455.
73. Mio K., Ogura T., Kiyonaka S., Hiroaki Y., Tanimura Y., Fujiyoshi Y., Mori Y., Sato C. The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J. Mol. Biol. 2007, 367:373-383.
74. Long S.B., Campbell E.B., MacKinnon R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science 2005, 309:903-908.
75. Sato C., Ueno Y., Asai K., Takahashi K., Sato M., Engel A., Fujiyoshi Y. The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities. Nature 2001, 409:1047-1051.
76. Gaudet R. TRP channels entering the structural era. J. Physiol. 2008, 586:3565-3575.
77. McCleverty C.J., Koesema E., Patapoutian A., Lesley S.A., Kreusch A. Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci. 2006, 15:2201-2206.
78. Arniges M., Fernandez-Fernandez J.M., Albrecht N., Schaefer M., Valverde M.A. Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J. Biol. Chem. 2006, 281:1580-1586.
79. 2+/calmodulin modulates TRPV1 activation by capsaicin. J. Gen. Physiol. 2004, 123:53-62.
80. + channel. Science 2005, 309:897-903.
81. Iwasaki H., Murata Y., Kim Y., Hossain M.I., Worby C.A., Dixon J.E., McCormack T., Sasaki T., Okamura Y. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. USA 2008, 105:7970-7975.
82. 2. J. Physiol. 2007, 583:875-889.
83. Murata Y., Iwasaki H., Sasaki M., Inaba K., Okamura Y. Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature 2005, 435:1239-1243.
84. Sasaki M., Takagi M., Okamura Y. A voltage sensor-domain protein is a voltage-gated proton channel. Science 2006, 312:589-592.
85. Jordt S.E., Julius D. Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell 2002, 108:421-430.
86. Marin-Burgin A., Reppenhagen S., Klusch A., Wendland J.R., Petersen M. Low-threshold heat response antagonized by capsazepine in chick sensory neurons, which are capsaicin-insensitive. Eur. J. Neurosci. 2000, 12:3560-3566.
87. Garcia-Martinez C., Morenilla-Palao C., Planells-Cases R., Merino J.M., Ferrer-Montiel A. Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties. J. Biol. Chem. 2000, 275:32552-32558.
88. Voets T., Prenen J., Vriens J., Watanabe H., Janssens A., Wissenbach U., Bodding M., Droogmans G., Nilius B. Molecular determinants of permeation through the cation channel TRPV4. J. Biol. Chem. 2002, 277:33704-33710.
89. 2+ selectivity filter in the Drosophila transient receptor potential channel. J. Neurosci. 2007, 27:604-615.
90. Welch J.M., Simon S.A., Reinhart P.H. The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. Proc. Natl. Acad. Sci. USA 2000, 97:13889-13894.
91. Nilius B., Prenen J., Janssens A., Owsianik G., Wang C., Zhu M.X., Voets T. The selectivity filter of the cation channel TRPM4. J. Biol. Chem. 2005, 280:22899-22906.
92. 2+ channel ECaC1. Br. J. Pharmacol. 2001, 134:453-462.
93. 2+- dependent Gating and Strong Inward Rectification of the Cation Channel TRPV6. J. Gen. Physiol. 2003, 121:245-260.
94. 2+ channels TRPV5 and TRPV6. EMBO J. 2003, 22:776-785.
95. Voets T., Prenen J., Fleig A., Vennekens R., Watanabe H., Hoenderop J.G., Bindels R.J., Droogmans G., Penner R., Nilius B. CaT1 and the calcium release-activated calcium channel manifest distinct pore properties. J. Biol. Chem. 2001, 276:47767-47770.
96. Numazaki M., Tominaga T., Takeuchi K., Murayama N., Toyooka H., Tominaga M. Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc. Natl. Acad. Sci. USA 2003, 100:8002-8006.
97. Zagotta W.N., Olivier N.B., Black K.D., Young E.C., Olson R., Gouaux E. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 2003, 425:200-205.
98. Huang J., Zhang X., McNaughton P.A. Modulation of temperaturesensitive TRP channels. Semin. Cell Dev. Biol. 2006, 17:638-645.
99. 2 binding site as a determinant of capsaicin receptor sensitivity. Science 2003, 300:1284-1288.
100. Brauchi S., Orta G., Salazar M., Rosenmann E., Latorre R. A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels. J. Neurosci. 2006, 26:4835-4840.
101. Hellwig N., Plant T.D., Janson W., Schafer M., Schultz G., Schaefer M. TRPV1 acts as proton channel to induce acidification in nociceptive neurons. J. Biol. Chem. 2004, 279:34553-34561.
102. Balla T. Phosphoinositide-derived messengers in endocrine signaling. J. Endocrinol. 2006, 188:135-153.
103. Ben-Chaim Y., Tour O., Dascal N., Parnas I., Parnas H. The M2 muscarinic G-protein-coupled receptor is voltage-sensitive. J. Biol. Chem. 2003, 278:22482-22491.
104. Bezanilla F. The voltage sensor in voltage-dependent ion channels. Physiol. Rev. 2000, 80:555-592.
105. Cha A., Snyder G.E., Selvin P.R., Bezanilla F. Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy. Nature 1999, 402:809-813.
106. Yang N., Horn R. Evidence for voltage-dependent S4 movement in sodium channels. Neuron 1995, 15:213-218.
107. Keynes R.D., Elinder F. The screw-helical voltage gating of ion channels. Proc. Biol. Sci. 1999, 266:843-852.
108. Swartz K.J. Towards a structural view of gating in potassium channels. Nat. Rev. Neurosci. 2004, 5:905-916.
109. Bezanilla F., Armstrong C.M. Gating currents of the sodium channels: three ways to block them. Science 1974, 183:753-754.
110. Armstrong C.M., Bezanilla F. Currents related to movement of the gating particles of the sodium channels. Nature 1973, 242:459-461.
111. Kaupp U.B., Niidome T., Tanabe T., Terada S., Bonigk W., Stuhmer W., Cook N.J., Kangawa K., Matsuo H., Hirose T. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature 1989, 342:762-766.
112. Zagotta W.N., Siegelbaum S.A. Structure and function of cyclic nucleotide-gated channels. Annu. Rev. Neurosci. 1996, 19:235-263.
113. Kaupp U.B., Seifert R. Cyclic nucleotide-gated ion channels. Physiol. Rev. 2002, 82:769-824.
114. Cull-Candy, S. G.; Leszkiewicz, D. N. Role of distinct NMDA receptor subtypes at central synapses. Sci. STKE. 2004, 2004, re16.
115. Dingledine R., Borges K., Bowie D., Traynelis S.F. The glutamate receptor ion channels. Pharmacol. Rev. 1999, 51:7-61.
116. Ascher P., Nowak L. The role of divalent cations in the N-methyl-Daspartate responses of mouse central neurones in culture. J. Physiol. 1988, 399:247-266.
117. 2+ of N-methyl-D-aspartate-activated channels. Biophys. J. 1990, 57:1085-1090.
118. Nilius B., Talavera K., Owsianik G., Prenen J., Droogmans G., Voets T. Gating of TRP channels: a voltage connection?. J. Physiol. 2005, 567:35-44.
119. Voets T., Droogmans G., Wissenbach U., Janssens A., Flockerzi V., Nilius B. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 2004, 430:748-754.
120. Voets T., Owsianik G., Janssens A., Talavera K., Nilius B. TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat. Chem. Biol. 2007, 3:174-182.
121. Latorre R., Brauchi S., Orta G., Zaelzer C., Vargas G. ThermoTRP channels as modular proteins with allosteric gating. Cell Calcium 2007, 42:427-438.
122. 2+- activated cation channel TRPM4. J. Biol. Chem. 2003, 278:30813-30820.
123. 2+ influx by interaction with a site in the C terminus of TrpC1. Mol. Cell 2002, 9:739-750.
124. Xiao R., Tang J., Wang C., Colton C.K., Tian J., Zhu M.X. Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J. Biol. Chem. 2008, 283:6162-6174.
125. 2+ block and regulates inward current amplitude of a transient receptor potential channel. J. Neurosci. 2005, 25:1234-1239.
126. Shi J., Mori E., Mori Y., Mori M., Li J., Ito Y., Inoue R. Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J. Physiol. 2004, 561:415-432.
127. .ATP-regulated divalent cation channel required for cell viability. Nature 2001, 411:590-595.
128. Hui K., Guo Y., Feng Z.P. Biophysical properties of menthol-activated cold receptor TRPM8 channels. Biochem. Biophys. Res. Commun. 2005, 333:374-382.
129. i. Proc. Natl. Acad. Sci. USA 2003, 100:15166-15171.
130. Hardie R.C., Mojet M.H. Magnesium-dependent block of the lightactivated and trp- dependent conductance in Drosophila photoreceptors. J. Neurosci. 1995, 74:2590-2599.
131. Gu Y., Oberwinkler J., Postma M., Hardie R.C. Mechanisms of light adaptation in Drosophila photoreceptors. Curr. Biol. 2005, 15:1228-1234.
132. Parnas M., Katz B., Lev S., Tzarfaty V., Dadon D., Gordon-Shaag A., Metzner H., Yaka R., Minke B. Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. J. Neurosci. 2009, 29:2371-2383.
133. Scott K., Sun Y., Beckingham K., ZGBRer C.S. Calmodulin regulation of Drosophila light-activated channels and receptor function mediates termination of the light response. in vivo. Cell 1997, 91:375-383.
134. Chao S.H., Suzuki Y., Zysk J.R., Cheung W.Y. Activation of calmodulin by various metal cations as a function of ionic radius. Mol. Pharmacol. 1984, 26:75-82.
135. Hille B. Ionic Channels of Excitable Membranes 1992, Sinauer Associate, Inc., Sunderland, MA. 2nd ed.
136. 2+-binding site in the pore of cyclic nucleotidegated channels: S5/S6 segments control affinity of intrapore glutamates. EMBO J. 1999, 18:119-130.
137. Lucas P., GBRhanov K., Leinders-Zufall T., Zufall F. A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 2003, 40:551-561.
138. Spassova M.A., Hewavitharana T., Xu W., Soboloff J., Gill D.L. A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc. Natl. Acad. Sci. USA 2006, 103:16586-16591.
139. Hu H.Z., Xiao R., Wang C., Gao N., Colton C.K., Wood J.D., Zhu M.X. Potentiation of TRPV3 channel function by unsaturated fatty acids. J. Cell Physiol. 2006, 208:201-212.
140. Topala C.N., Groenestege W.T., Thebault S., van den B.D., Nilius B., Hoenderop J.G., Bindels R.J. Molecular determinants of permeation through the cation channel TRPM6. Cell Calcium 2007, 41:513-523.
141. Caterina M.J., Schumacher M.A., Tominaga M., Rosen T.A., Levine J.D., Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997, 389:816-824.
142. Caterina M.J., Rosen T.A., Tominaga M., Brake A.J., Julius D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 1999, 398:436-441.
143. Peier A.M., Reeve A.J., Andersson D.A., Moqrich A., Earley T.J., Hergarden A.C., Story G.M., Colley S., Hogenesch J.B., McIntyre P., Bevan S., Patapoutian A. A heat-sensitive TRP channel expressed in keratinocytes. Science 2002, 296:2046-2049.
144. Watanabe H., Vriens J., Suh S.H., Benham C.D., Droogmans G., Nilius B. Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J. Biol. Chem. 2002, 277:47044-47051.
145. Watanabe H., Davis J.B., Smart D., Jerman J.C., Smith G.D., Hayes P., Vriens J., Cairns W., Wissenbach U., Prenen J., Flockerzi V., Droogmans G., Benham C.D., Nilius B. Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J. Biol. Chem. 2002, 277:13569-13577.
146. Peier A.M., Moqrich A., Hergarden A.C., Reeve A.J., Andersson D.A., Story G.M., Earley T.J., Dragoni I., McIntyre P., Bevan S., Patapoutian A. A TRP channel that senses cold stimuli and menthol. Cell 2002, 108:705-715.
147. Togashi K., Hara Y., Tominaga T., Higashi T., Konishi Y., Mori Y., Tominaga M. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J. 2006, 25(9):1804-1815.
148. Talavera K., Yasumatsu K., Voets T., Droogmans G., Shigemura N., Ninomiya Y., Margolskee R.F., Nilius B. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature 2005, 438:1022-1025.
149. McKemy D.D., Neuhausser W.M., Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 2002, 416:52-58.
150. Brauchi S., Orio P., Latorre R. Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8. Proc. Natl. Acad. Sci. USA 2004, 101:15494-15499.
151. Julius D. From peppers to peppermints: natural products as probes of the pain pathway. Harvey Lect. 2005, 101:89-115.
152. Trevisani M., Siemens J., Materazzi S., Bautista D.M., Nassini R., Campi B., Imamachi N., Andre E., Patacchini R., Cottrell G.S., Gatti R., Basbaum A.I., Bunnett N.W., Julius D., Geppetti P. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc. Natl. Acad. Sci. USA 2007, 104:13519-13524.
153. Taylor-Clark T.E., Undem B.J., Macglashan D.W., Ghatta S., Carr M.J., McAlexander M.A. Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Mol. Pharmacol. 2008, 73:274-281.
154. Andersson D.A., Gentry C., Moss S., Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J. Neurosci. 2008, 28:2485-2494.
155. Taylor-Clark T.E., Ghatta S., Bettner W., Undem B.J. Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol. Pharmacol. 2009, 75:820-829.
156. Macpherson L.J., Dubin A.E., Evans M.J., Marr F., Schultz P.G., Cravatt B.F., Patapoutian A. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 2007, 445:541-545.
157. 3 receptor: a model ligand-gated ion channel (review). Mol. Membr. Biol. 2002, 19:11-26.
158. Yoshida T., Inoue R., Morii T., Takahashi N., Yamamoto S., Hara Y., Tominaga M., Shimizu S., Sato Y., Mori Y. Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat. Chem. Biol. 2006, 2:596-607.
159. Jung J., Lee S.Y., Hwang S.W., Cho H., Shin J., Kang Y.S., Kim S., Oh U. Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. J. Biol. Chem. 2002, 277:44448-44454.
160. Lundbaek J.A., Birn P., Tape S.E., Toombes G.E., Sogaard R., Koeppe R.E., Gruner S.M., Hansen A.J., Andersen O.S. Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity. Mol. Pharmacol. 2005, 68:680-689.
161. Phillips R., Ursell T., Wiggins P., Sens P. Emerging roles for lipids in shaping membrane-protein function. Nature 2009, 459:379-385.
162. Walpole C.S., Bevan S., Bovermann G., Boelsterli J.J., Breckenridge R., Davies J.W., Hughes G.A., James I., Oberer L., Winter J. The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin. J. Med. Chem. 1994, 37:1942-1954.
163. Shen Y., Heimel J.A., Kamermans M., Peachey N.S., Gregg R.G., Nawy S. A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. J. Neurosci. 2009, 29:6088-6093.
164. Ultee A., Gorris L.G., Smid E.J. Bactericidal activity of carvacrol towards the food-borne pathogen Bacillus cereus. J. Appl. Microbiol. 1998, 85:211-218.
165. Kim K.Y., Bang S., Han S., Nguyen Y.H., Kang T.M., Kang K.W., Hwang S.W. TRP-independent inhibition of the phospholipase C pathway by natural sensory ligands. Biochem. Biophys. Res. Commun. 2008, 370:295-300.
166. Macpherson L.J., Hwang S.W., Miyamoto T., Dubin A.E., Patapoutian A., Story G.M. More than cool: promiscuous relationships of menthol and other sensory compounds. Mol. Cell Neurosci. 2006, 32:335-343.
167. Parnas M., Peters M., Dadon D., Lev S., Vertkin I., Slutsky I., Minke B. Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium 2009, 45:300-309.
168. Thorneloe K.S., Sulpizio A.C., Lin Z., Figueroa D.J., Clouse A.K., McCafferty G.P., Chendrimada T.P., Lashinger E.S., Gordon E., Evans L., Misajet B.A., Demarini D.J., Nation J.H., Casillas L.N., Marquis R.W., Votta B.J., Sheardown S.A., Xu X., Brooks D.P., Laping N.J., Westfall T.D. N-((1S)-1-{[4-((2S)-2-{[(2,4- dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1 - piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2- carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J. Pharmacol. Exp. Ther. 2008, 326:432-442.
169. Smith P.L., Maloney K.N., Pothen R.G., Clardy J., Clapham D.E. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J. Biol. Chem. 2006, 281:29897-29904.
170. 2+ release. J. Biochem. Tokyo. 1997, 122:498-505.
171. Chorna-Ornan I., Joel-Almagor T., Cohen-Ben A.H., Frechter S., Gillo B., Selinger Z., Gill D.L., Mink B. A common mechanism underlies vertebrate calcium signaling and Drosophila phototransduction. J. Neurosci. 2001.
172. 3 receptors. J. Physiol. 2001, 536:3-19.
173. 2+ channels. Science 2000, 287:1647-1651.
174. Hu H.Z., Gu Q., Wang C., Colton C.K., Tang J., Kinoshita-Kawada M., Lee L.Y., Wood J.D., Zhu M.X. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem. 2004, 279:35741-35748.
175. Tao L., Harris A.L. 2-aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32. Mol. Pharmacol. 2007, 71:570-579.
176. Liu B., Hui K., Qin F. Thermodynamics of heat activation of single capsaicin ion channels VR1. Biophys. J. 2003, 85:2988-3006.
177. Ryu S., Liu B., Qin F. Low pH potentiates both capsaicin binding and channel gating of VR1 receptors. J. Gen. Physiol. 2003, 122:45-61.
178. Hui K., Liu B., Qin F. Capsaicin activation of the pain receptor, VR1: multiple open states from both partial and full binding. Biophys. J. 2003, 84:2957-2968.
179. Colquhoun D., Hawkes A.G. The principles of the stochastic interpretation of ion-channel mechanisms. Single-Channel Recording 1995, Plenum Press, New York, pp 397-482. 2nd ed. B. Sakmann, E. Neher (Eds.).
180. Kanzaki M., Zhang Y.Q., Mashima H., Li L., Shibata H., Kojima I. Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat. Cell Biol. 1999, 1:165-170.
181. Meyer N.E., Joel-Almagor T., Frechter S., Minke B., Huber A. Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. J. Cell Sci. 2006, 119:2592-2603.
182. Niemeyer B.A., Suzuki E., Scott K., Jalink K., ZGBRer C.S. The Drosophila light-activated conductance is composed of the two channels TRP and TRPL. Cell 1996, 85:651-659.
183. Bähner M., Frechter S., Da Silva N., Minke B., Paulsen R., Huber A. Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current. Neuron 2002, 34:83-93.
184. Bezzerides V.J., Ramsey I.S., Kotecha S., Greka A., Clapham D.E. Rapid vesicular translocation and insertion of TRP channels. Nat. Cell Biol. 2004, 6:709-720.
185. Odell A.F., Scott J.L., Van Helden D.F. Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4. J. Biol. Chem. 2005, 280:37974-37987.
186. 2 hydrolysis. Nat. Cell Biol. 2002, 4:329-336.
187. Brauchi S., Krapivinsky G., Krapivinsky L., Clapham D.E. TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc. Natl. Acad. Sci. USA 2008, 105:8304-8308.
188. Krapivinsky G., Mochida S., Krapivinsky L., Cibulsky S.M., Clapham D.E. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron 2006, 52:485-496.
189. Montell C. An exciting release on TRPM7. Neuron 2006, 52:395-397.
190. Oancea E., Wolfe J.T., Clapham D.E. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ. Res. 2006, 98:245-253.
191. McLaughlin S., Murray D. Plasma membrane phosphoinositide organization by protein electrostatics. Nature 2005, 438:605-611.
192. + channels. J. Gen. Physiol. 2007, 130:241-256.
193. Gamper N., Shapiro M.S. Target-specific PIP(2) signalling: how might it work?. J. Physiol. 2007, 582:967-975.
194. Rohacs T. Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium 2009, 45:554-565.
195. Blero D., Payrastre B., Schurmans S., Erneux C. Phosphoinositide phosphatases in a network of signalling reactions. Pflugers Arch. 2007, 455:31-44.
196. Liu B., Zhang C., Qin F. Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. J. Neurosci. 2005, 25:4835-4843.
197. 2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat. Neurosci. 2005, 8:626-634.
198. 2-mediated inhibition. Nature 2001, 411:957-962.
199. 2) is the endogenous lipid regulating TRPV1. J. Biol. Chem. 2008, 283:26208-26216.
200. Chyb S., Raghu P., Hardie R.C. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature 1999, 397:255-259.
201. Jors S., Kazanski V., Foik A., Krautwurst D., Harteneck C. Receptorinduced activation of Drosophila TRP gamma by polyunsaturated fatty acids. J. Biol. Chem. 2006, 281:29693-29702.
202. Parnas M., Peters M., Minke B. Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action. Channels (Austin) 2009, 3:164-166.
203. Pak W.L. Molecular genetic studies of photoreceptor function using Drosophila mutants. Molecular Biology of the Retina: Basic and Clinical Relevant Studies 1991, 1-32. Wiley-Liss, New York. J. Piatigorsky, T. Shinohara, P.S. Zelenka (Eds.).
204. Pak W.L. Drosophila in vision research. The Friedenwald Lecture. Invest. Ophthalmol. Vis. Sci. 1995, 36:2340-2357.
205. Schneuwly S., Burg M.G., Lending C., Perdew M.H., Pak W.L. Properties of photoreceptor-specific phospholipase C encoded by the norpA gene of Drosophila melanogaster. J. Biol. Chem. 1991, 266:24314-24319.
206. Hotta Y., Benzer S. Abnormal electroretinograms in visual mutants of Drosophila. Nature 1969, 222:354-356.
207. Pak W.L., Grossfield J., White N.V. Nonphototactic mutants in a study of vision of Drosophila. Nature 1969, 222:351-354.
208. Minke B., Selinger Z. The inositol-lipid pathway is necessary for light excitation in fly photoreceptors. Sensory Transduction 1992, Vol. 47:202-217. The Rockofeller University Press, New York.
209. Deland M.C., Pak W.L. Reversibly temperature sensitive phototransduction mutant of Drosophila melanogaster. Nat. New Biol. 1973, 244:184-186.
210. Pearn M.T., Randall L.L., Shortridge R.D., Burg M.G., Pak W.L. Molecular, biochemical, and electrophysiological characterization of Drosohpila norpA mutannts. J. Biol. Chem. 1996, 271:4937-4945.
211. Katz B., Minke B. Drosophila photoreceptors and signaling mechanisms. Front Cell Neurosci. 2009, 3:2.
212. Yuan J.P., Zeng W., Huang G.N., Worley P.F., Muallem S. STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat. Cell Biol. 2007, 9:636-645.
213. Putney J.W. Inositol lipids and TRPC channel activation. Biochem. Soc. Symp. 2007, 37-45.
214. Payne R., Corson D.W., Fein A. Pressure injection of calcium both excites and adapts Limulus ventral photoreceptors. J. Gen. Physiol. 1986, 88:107-126.
215. 2+ facilitates and inactivates but does not directly excite light-sensitive channels in Drosophila photoreceptors. J. Neurosci. 1995, 15:889-902.
216. 3 is not sufficient. Cell Calcium 1998, 24:153-163.
217. 3 receptor gene. Mol. Cell Neurosci. 2000, 15:429-445.
218. Hardie R.C. Regulation of trp channels via lipid second messengers. Annu. Rev. Physiol. 2003, 65:735-759.
219. Hardie R.C., Peretz A., Suss Toby E., Rom Glas A., Bishop S.A., Selinger Z., Minke B. Protein kinase C is required for light adaptation in Drosophila photoreceptors. Nature 1993, 363:634-637.
220. Raghu P., Usher K., Jonas S., Chyb S., Polyanovsky A., Hardie R.C. Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant. rdgA, Neuron 2000, 26:169-179.
221. P24, by the diacylglycerol kinase mutant, rdgA, and by metabolic inhibition. J. Biol. Chem. 2003, 278:18851-18858.
222. Delgado R., Bacigalupo J. Unitary recordings of TRP and TRPL channels from isolated Drosophila retinal photoreceptor rhabdomeres: Activation by light and lipids. J. Neurophysiol. 2009, 101:2372-2379.
223. Masai I., Suzuki E., Yoon C.S., Kohyama A., Hotta Y. Immunolocalization of Drosophila eye-specific diacylgylcerol kinase, rdgA, which is essential for the maintenance of the photoreceptor. J. Neurobiol. 1997, 32:695-706.
224. Leung H.T., Tseng-Crank J., Kim E., Mahapatra C., Shino S., Zhou Y., An L., Doerge R.W., Pak W.L. DAG lipase activity is necessary for TRP channel regulation in Drosophila photoreceptors. Neuron 2008, 58:884-896.
225. Raghu P., Hardie R.C. Regulation of Drosophila TRPC channels by lipid messengers. Cell Calcium 2009, 45:566-573.
226. Estacion M., Sinkins W.G., Schilling W.P. Regulation of Drosophila transient receptor potential-like (TrpL) channels by phospholipase Cdependent mechanisms. J. Physiol. 2001, 530:1-19.
227. 2 levels in Drosophila photoreceptors. Neuron 2001, 30:149-159.
228. Janmey P.A., Kinnunen P.K. Biophysical properties of lipids and dynamic membranes. Trends Cell Biol. 2006, 16:538-546.
229. Gudermann T., Hofmann T., Schnitzler M., Dietrich A. Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins. Novartis. Found. Symp. 2004, 258:103-118.
230. Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 1999, 397:259-263.
231. Venkatachalam K., Zheng F., Gill D.L. Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J. Biol. Chem. 2003, 278:29031-29040.
232. Hardie R.C., Raghu P. Visual transduction in Drosophila. Nature 2001, 413:186-193.
233. Abramowitz J., Birnbaumer L. Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J. 2009, 23:297-328.
234. 2+entry channels: still elusive!. Sci. STKE. 2004, 2004:e36.
235. 2+- permeable nonselective cation channels. Cell Calcium 2003, 33:441-450.
236. Trebak M., Bird G.S., McKay R.R., Putney J.W. Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition. J. Biol. Chem. 2002, 277:21617-21623.
237. Maroto R., Raso A., Wood T.G., Kurosky A., Martinac B., Hamill O.P. TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat. Cell Biol. 2005, 7:179-185.
238. Pedersen S.F., Nilius B. Transient receptor potential channels in mechanosensing and cell volume regulation. Methods Enzymol. 2007, 428:183-207.
239. Methfessel C., Witzemann V., Takahashi T., Mishina M., Numa S., Sakmann B. Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflugers Arch. 1986, 407:577-588.
240. Colbert H.A., Smith T.L., Bargmann C.I. OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J. Neurosci. 1997, 17:8259-8269.
241. Gong Z., Son W., Chung Y.D., Kim J., Shin D.W., McClung C.A., Lee Y., Lee H.W., Chang D.J., Kaang B.K., Cho H., Oh U., Hirsh J., Kernan M.J., Kim C. Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. J. Neurosci. 2004, 24:9059-9066.
242. Kim J., Chung Y.D., Park D.Y., Choi S., Shin D.W., Soh H., Lee H.W., Son W., Yim J., Park C.S., Kernan M.J., Kim C.A TRPV family ion channel required for hearing in Drosophila. Nature 2003, 424:81-84.
243. Davis M.J., Hill M.A. Signaling mechanisms underlying the vascular myogenic response. Physiol. Rev. 1999, 79:387-423.
244. -/- mice. Mol. Cell Biol. 2005, 25:6980-6989.
245. Earley S., Waldron B.J., Brayden J.E. Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Circ. Res. 2004, 95:922-929.
246. + channels. J. Biol. Chem. 2002, 277:2369-2372.
247. Numata T., Shimizu T., Okada Y. Direct mechano-stress sensitivity of TRPM7 channel. Cell Physiol. Biochem. 2007, 19:1-8.
248. Numata T., Shimizu T., Okada Y. TRPM7 is a stretch- and swellingactivated cation channel involved in volume regulation in human epithelial cells. Am. J. Physiol. Cell Physiol. 2007, 292:C460-C467.
249. Grimm C., Kraft R., Sauerbruch S., Schultz G., Harteneck C. Molecular and functional characterization of the melastatin-related cation channel TRPM3. J. Biol. Chem. 2003, 278:21493-21501.
250. Birder L.A. TRPs in bladder diseases. Biochim. Biophys. Acta 2007, 1772:879-884.
251. Liedtke W., Choe Y., Marti-Renom M.A., Bell A.M., Denis C.S., Sali A., Hudspeth A.J., Friedman J.M., Heller S. Vanilloid receptorrelated osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 2000, 103:525-535.
252. -/- mice. Proc. Natl. Acad. Sci. USA 2003, 100:13698-13703.
253. Praetorius H.A., Spring K.R. A physiological view of the primary cilium. Annu. Rev. Physiol. 2005, 67:515-529.
254. Praetorius H.A., Spring K.R. Bending the MDCK cell primary cilium increases intracellular calcium. J. Membr. Biol. 2001, 184:71-79.
255. 2+- permeable channel in the yeast vacuolar membrane. Proc. Natl. Acad. Sci. USA 2001, 98:7801-7805.
256. Zhou X.L., Loukin S.H., Coria R., Kung C., Saimi Y. Heterologously expressed fungal transient receptor potential channels retain mechanosensitivity in vitro and osmotic response in vivo. Eur. Biophys. J. 2005, 34:413-422.
257. Zhou X.L., Batiza A.F., Loukin S.H., Palmer C.P., Kung C., Saimi Y. The transient receptor potential channel on the yeast vacuole is mechanosensitive. Proc. Natl. Acad. Sci. USA 2003, 100:7105-7110.
258. Liedtke W., Tobin D.M., Bargmann C.I., Friedman J.M. Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 2003, 100(Suppl 2):14531-14536.
259. Mizuno A., Matsumoto N., Imai M., Suzuki M. Impaired osmotic sensation in mice lacking TRPV4. Am. J. Physiol. Cell Physiol. 2003, 285:C96-C101.
260. Alessandri-Haber N., Dina O.A., Joseph E.K., Reichling D., Levine J.D. A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. J. Neurosci. 2006, 26:3864-3874.
261. Becker D., Blase C., Bereiter-Hahn J., Jendrach M. TRPV4 exhibits a functional role in cell-volume regulation. J. Cell Sci. 2005, 118:2435-2440.
262. Pan Z., Yang H., Mergler S., Liu H., Tachado S.D., Zhang F., Kao W.W., Koziel H., Pleyer U., Reinach P.S. Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells. Cell Calcium 2008, 44:374-385.
263. 2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J. Biol. Chem. 2004, 279:54062-54068.
264. Liu X., Bandyopadhyay B.C., Nakamoto T., Singh B., Liedtke W., Melvin J.E., Ambudkar I. A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J. Biol. Chem. 2006, 281:15485-15495.
265. q-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J. 2008, 27:3092-3103.
266. Lockwich T.P., Liu X., Singh B.B., Jadlowiec J., Weiland S., Ambudkar I.S. Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J. Biol. Chem. 2000, 275:11934-11942.
267. Morenilla-Palao C., Pertusa M., Meseguer V., Cabedo H., Viana F. Lipid raft segregation modulates TRPM8 channel activity. J. Biol. Chem. 2009, 284:9215-9224.
268. Liu M., Huang W., Wu D., Priestley J.V. TRPV1, but not P2X, requires cholesterol for its function and membrane expression in rat nociceptors. Eur. J. Neurosci. 2006, 24:1-6.
269. Sanxaridis P.D., Cronin M.A., Rawat S.S., Waro G., Acharya U., Tsunoda S. Light-induced recruitment of INAD-signaling complexes to detergent-resistant lipid rafts in Drosophila photoreceptors. Mol. Cell Neurosci. 2007, 36:36-46.
270. Sheetz M.P., Singer S.J. Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions. Proc. Natl. Acad. Sci. USA 1974, 71:4457-4461.
271. Bruno M.J., Koeppe R.E., Andersen O.S. Docosahexaenoic acid alters bilayer elastic properties. Proc. Natl. Acad. Sci. USA 2007, 104:9638-9643.
272. Maingret F., Lauritzen I., Patel A.J., Heurteaux C., Reyes R., Lesage F., Lazdunski M., Honore E. TREK-1 is a heat-activated background K(+) channel. EMBO J. 2000, 19:2483-2491.
273. Sobko A.A., Kotova E.A., Antonenko Y.N., Zakharov S.D., Cramer W.A. Effect of lipids with different spontaneous curvature on the channel activity of colicin E1: evidence in favor of a toroidal pore. FEBS Lett. 2004, 576:205-210.
274. Schmidt D., Jiang Q.X., MacKinnon R. Phospholipids and the origin of cationic gating charges in voltage sensors. Nature 2006, 444:775-779.
275. Andersen O.S., Koeppe R.E. Bilayer thickness and membrane protein function: an energetic perspective. Annu. Rev. Biophys. Biomol. Struct. 2007, 36:107-130.
276. Aloia R.C., Raison J.K. Membrane function in mammalian hibernation. Biochim. Biophys. Acta 1989, 988:123-146.
277. Dhaka A., Viswanath V., Patapoutian A. TRP ion channels and temperature sensation. Annu. Rev. Neurosci. 2006, 135-161.
278. Bai C.X., Giamarchi A., Rodat-Despoix L., Padilla F., Downs T., Tsiokas L., Delmas P. Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep. 2008, 9:472-479.
279. van A.M., Hoenderop J.G., Bindels R.J. The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease. Naunyn Schmiedebergs Arch. Pharmacol. 2005, 371:295-306.
280. Singh B.B., Zheng C., Liu X., Lockwich T., Liao D., Zhu M.X., Birnbaumer L., Ambudkar I.S. Trp1-dependent enhancement of salivary gland fluid secretion: role of store-operated calcium entry. FASEB J. 2001, 15:1652-1654.
281. Hartmann J., Dragicevic E., Adelsberger H., Henning H.A., Sumser M., Abramowitz J., Blum R., Dietrich A., Freichel M., Flockerzi V., Birnbaumer L., Konnerth A. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 2008, 59:392-398.
282. Greka A., Navarro B., Oancea E., Duggan A., Clapham D.E. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat. Neurosci. 2003, 6:837-845.
283. Leuner K., Kazanski V., Muller M., Essin K., Henke B., Gollasch M., Harteneck C., Muller W.E. Hyperforin - a key constituent of St. John's wort specifically activates TRPC6 channels. FASEB J. 2007, 21:4101-4111.
284. Wissenbach U., Niemeyer B.A., Fixemer T., Schneidewind A., Trost C., Cavalie A., Reus K., Meese E., Bonkhoff H., Flockerzi V. Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. J. Biol. Chem. 2001, 276:19461-19468.
285. 2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat. Med. 2008, 14:738-747.
286. Aarts M., Iihara K., Wei W.L., Xiong Z.G., Arundine M., Cerwinski W., MacDonald J.F., Tymianski M. A key role for TRPM7 channels in anoxic neuronal death. Cell 2003, 115:863-877.
287. Narayanan K.L., Irmady K., Subramaniam S., Unsicker K., von Bohlen und H.O. Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death. Neurosci. Lett. 2008, 446:117-122.
288. Becker E.B., Oliver P.L., Glitsch M.D., Banks G.T., Achilli F., Hardy A., Nolan P.M., Fisher E.M., Davies K.E. A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc. Natl. Acad. Sci. USA 2009, 106:6706-6711.
289. Xu S.Z., SGBRumar P., Zeng F., Li J., Jairaman A., English A., Naylor J., Ciurtin C., Majeed Y., Milligan C.J., Bahnasi Y.M., Al-Shawaf E., Porter K.E., Jiang L.H., Emery P., Sivaprasadarao A., Beech D.J. TRPC channel activation by extracellular thioredoxin. Nature 2008, 451:69-72.
290. Liu X., Bandyopadhyay B.C., Singh B.B., Groschner K., Ambudkar I.S. Molecular analysis of a store-operated and 2-acetyl-sn-glycerolsensitive non-selective cation channel. Heteromeric assembly of TRPC1-TRPC3. J. Biol. Chem. 2005, 280:21600-21606.
291. Chu X., Tong Q., Cheung J.Y., Wozney J., Conrad K., Mazack V., Zhang W., Stahl R., Barber D.L., Miller B.A. Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx. J. Biol. Chem. 2004, 279:10514-10522.
292. Poteser M., Graziani A., Rosker C., Eder P., Derler I., Kahr H., Zhu M.X., Romanin C., Groschner K. TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells. J. Biol. Chem. 2006, 281:13588-13595.
293. Zhang W., Chu X., Tong Q., Cheung J.Y., Conrad K., Masker K., Miller B.A. A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J. Biol. Chem. 2003, 278:16222-16229.
294. Murakami M., Xu F., Miyoshi I., Sato E., Ono K., Iijima T. Identification and characterization of the murine TRPM4 channel. Biochem. Biophys. Res. Commun. 2003, 307:522-528.
295. Chubanov V., Waldegger S., Schnitzler M., Vitzthum H., Sassen M.C., Seyberth H.W., Konrad M., Gudermann T. Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. Proc. Natl. Acad. Sci. USA 2004, 101:2894-2899.
296. Schaefer M. Homo- and heteromeric assembly of TRP channel subunits. Pflugers Arch. 2005, 451:35-42.
297. Cheng W., Yang F., Takanishi C.L., Zheng J. Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J. Gen. Physiol. 2007, 129:191-207.
298. Nagata K., Duggan A., Kumar G., Garcia-Anoveros J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J. Neurosci. 2005, 25:4052-4061.
299. 2+- permeable cation channel activated by calcium store depletion. Neuron 1996, 16:1189-1196.
300. Sinkins W.G., Estacion M., Schilling W.P. Functional expression of TrpC1: a human homologue of the Drosophila Trp channel. Biochem. J. 1998, 331:331-339.
301. 3 receptors and store-operated Htrp3 channels. Nature 1998, 396:478-482.
302. Schaefer M., Plant T.D., Obukhov A.G., Hofmann T., Gudermann T., Schultz G. Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J. Biol. Chem. 2000, 275:17517-17526.
303. Walker R.L., Koh S.D., Sergeant G.P., Sanders K.M., Horowitz B. TRPC4 currents have properties similar to the pacemaker current in interstitial cells of Cajal. Am. J. Physiol. Cell Physiol. 2002, 283:C1637-C1645.
304. Dietrich A., Schnitzler M., Emmel J., Kalwa H., Hofmann T., Gudermann T. N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity. J. Biol. Chem. 2003, 278:47842-47852.
305. 2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J. Biol. Chem. 1999, 274:27359-27370.
306. Vazquez G., Bird G.S., Mori Y., Putney J.W. Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism. J. Biol. Chem. 2006, 281:25250-25258.
307. Oancea E., Vriens J., Brauchi S., Jun J., Splawski I., Clapham D.E. TRPM1 forms ion channels associated with melanin content in melanocytes. Sci. Signal 2009, 2:ra21.
308. 2+ influx system mediated by LTRPC2. Science 2001, 293:1327-1330.
309. Kraft R., Grimm C., Grosse K., Hoffmann A., Sauerbruch S., Kettenmann H., Schultz G., Harteneck C. Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am. J. Physiol. Cell Physiol. 2004, 286:C129-C137.
310. Oberwinkler J., Lis A., Giehl K.M., Flockerzi V., Philipp S.E. Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J. Biol. Chem. 2005, 280:22540-22548.
311. Grimm C., Kraft R., Schultz G., Harteneck C. Activation of the melastatinrelated cation channel TRPM3 by D-erythro-sphingosine. Mol. Pharmacol. 2005, 67:798-805.
312. 2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 2002, 109:397-407.
313. 2+-activated monovalent selective cation channel. Curr. Biol. 2003, 13:1153-1158.
314. 2+]i. Proc. Natl. Acad. Sci. USA 2003, 100:15166-15171.
315. 2+ absorption. J. Biol. Chem. 2004, 279:19-25.
316. Li M., Jiang J., Yue L. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J. Gen. Physiol. 2006, 127:525-537.
317. Monteilh-Zoller M.K., Hermosura M.C., Nadler M.J., Scharenberg A.M., Penner R., Fleig A. TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions. J. Gen. Physiol. 2003, 121:49-60.
318. Oseguera A.J., Islas L.D., Garcia-Villegas R., Rosenbaum T. On the mechanism of TBA block of the TRPV1 channel. Biophys. J. 2007, 92:3901-3914.
319. Xu H., Ramsey I.S., Kotecha S.A., Moran M.M., Chong J.A., Lawson D., Ge P., Lilly J., Silos-Santiago I., Xie Y., DiStefano P.S., Curtis R., Clapham D.E. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 2002, 418:181-186.
320. Strotmann R., Harteneck C., Nunnenmacher K., Schultz G., Plant T.D. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nature Cell Biol. 2000, 2:695-702.
321. 2+ channel ECaC. J. Physiol. 2000, 527(Pt 2):239-248.
322. Yue L., Peng J.B., Hediger M.A., Clapham D.E. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 2001, 410:705-709.
323. Hardie R.C., Postma M. Phototransduction in microvillar photoreceptors of Drosophila and other invertebrates. The Senses: A Comprehensive Reference 2008, 77-130. Academic Press, New York. I.B. Allan, K. Akimichi, M.S. Gordon, W. Gerald, D.A. Thomas, H.M. Richard, D. Peter, O. Donata, F. Stuart, K.B. Gary, M.C. Bushnell, H.K. Jon, G. Esther (Eds.).
324. 2+ channel family: comparison of mammalian ECaC1 and 2. J. Physiol. 2001, 537:747-761.
325. Kolisek M., Beck A., Fleig A., Penner R. Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol. Cell 2005, 18:61-69.
326. Talavera K., Gees M., Karashima Y., Meseguer V.M., Vanoirbeek J.A., Damann N., Everaerts W., Benoit M., Janssens A., Vennekens R., Viana F., Nemery B., Nilius B., Voets T. Nicotine activates the chemosensory cation channel TRPA1. Nat. Neurosci. 2009.
327. Jordt S.E., Bautista D.M., Chuang H.H., McKemy D.D., Zygmunt P.M., Hogestatt E.D., Meng I.D., Julius D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004, 427:260-265.
328. Bandell M., Story G.M., Hwang S.W., Viswanath V., Eid S.R., Petrus M.J., Earley T.J., Patapoutian A. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 2004, 41:849-857.
329. Brone B., Peeters P.J., Marrannes R., Mercken M., Nuydens R., Meert T., Gijsen H.J. Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol. Appl. Pharmacol. 2008, 231:150-156.
330. Hu H., Bandell M., Petrus M.J., Zhu M.X., Patapoutian A. Zinc activates damage-sensing TRPA1 ion channels. Nat. Chem. Biol. 2009, 5:183-190.
331. Eid S.R., Crown E.D., Moore E.L., Liang H.A., Choong K.C., Dima S., Henze D.A., Kane S.A., Urban M.O. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol. Pain 2008, 4:48.
332. Petrus M., Peier A.M., Bandell M., Hwang S.W., Huynh T., Olney N., Jegla T., Patapoutian A. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol. Pain 2007, 3:40.
333. Wang G.X., Poo M.M. Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones. Nature 2005, 434:898-904.
334. Kiyonaka S., Kato K., Nishida M., Mio K., Numaga T., Sawaguchi Y., Yoshida T., Wakamori M., Mori E., Numata T., Ishii M., Takemoto H., Ojida A., Watanabe K., Uemura A., Kurose H., Morii T., Kobayashi T., Sato Y., Sato C., Hamachi I., Mori Y. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc. Natl. Acad. Sci. USA 2009, 106:5400-5405.
335. 2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem. Biophys. Res. Commun. 2007, 361:230-236.
336. Jung S., Muhle A., Schaefer M., Strotmann R., Schultz G., Plant T.D. Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J. Biol. Chem. 2003, 278:3562-3571.
337. Flemming P.K., Dedman A.M., Xu S.Z., Li J., Zeng F., Naylor J., Benham C.D., Bateson A.N., Muraki K., Beech D.J. Sensing of lysophospholipids by TRPC5 calcium channel. J. Biol. Chem. 2006, 281:4977-4982.
338. Bahnasi Y.M., Wright H.M., Milligan C.J., Dedman A.M., Zeng F., Hopkins P.M., Bateson A.N., Beech D.J. Modulation of TRPC5 cation channels by halothane, chloroform and propofol. Br. J. Pharmacol. 2008, 153:1505-1512.
339. Estacion M., Li S., Sinkins W.G., Gosling M., Bahra P., Poll C., Westwick J., Schilling W.P. Activation of human TRPC6 channels by receptor stimulation. J. Biol. Chem. 2004, 279:22047-22056.
340. Perraud A.L., Fleig A., Dunn C.A., Bagley L.A., Launay P., Schmitz C., Stokes A.J., Zhu Q., Bessman M.J., Penner R., Kinet J.P., Scharenberg A.M. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 2001, 411:595-599.
341. Hill K., McNulty S., Randall A.D. Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch. Pharmacol. 2004, 370:227-237.
342. Hill K., Benham C.D., McNulty S., Randall A.D. Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. Neuropharmacology 2004, 47:450-460.
343. Kraft R., Grimm C., Frenzel H., Harteneck C. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br. J. Pharmacol. 2006, 148:264-273.
344. Wagner T.F., Loch S., Lambert S., Straub I., Mannebach S., Mathar I., Dufer M., Lis A., Flockerzi V., Philipp S.E., Oberwinkler J. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat. Cell Biol. 2008, 10:1421-1430.
345. Nilius B., Prenen J., Janssens A., Voets T., Droogmans G. Decavanadate modulates gating of TRPM4 cation channels. J. Physiol. 2004, 560:753-765.
346. 2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity. Mol. Pharmacol. 2006, 69:1413-1420.
347. 2+-activated nonselective cation channel in mouse sino-atrial node cells. Cardiovasc. Res. 2007, 73:531-538.
348. Grand T., Demion M., Norez C., Mettey Y., Launay P., Becq F., Bois P., Guinamard R. 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br. J. Pharmacol. 2008, 153:1697-1705.
349. 2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains. J. Biol. Chem. 2005, 280:20691-20699.
350. Bodding M., Wissenbach U., Flockerzi V. Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 2007, 42:618-628.
351. Behrendt H.J., Germann T., Gillen C., Hatt H., Jostock R. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br. J. Pharmacol. 2004, 141:737-745.
352. Lashinger E.S., Steiginga M.S., Hieble J.P., Leon L.A., Gardner S.D., Nagilla R., Davenport E.A., Hoffman B.E., Laping N.J., Su X. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am. J. Physiol. Renal Physiol. 2008, 295:F803-F810.
353. Weil A., Moore S.E., Waite N.J., Randall A., Gunthorpe M.J. Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol. Pharmacol. 2005, 68:518-527.
354. Zygmunt P.M., Petersson J., Andersson D.A., Chuang H., Sorgard M., Di M.V, Julius D., Hogestatt E.D. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 1999, 400:452-457.
355. Huang S.M., Bisogno T., Trevisani M., Al-Hayani A., De P.L., Fezza F., Tognetto M., Petros T.J., Krey J.F., Chu C.J., Miller J.D., Davies S.N., Geppetti P., Walker J.M., Di M.V An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc. Natl. Acad. Sci. USA 2002, 99:8400-8405.
356. McNamara F.N., Randall A., Gunthorpe M.J. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br. J. Pharmacol. 2005, 144:781-790.
357. Doherty E.M., Fotsch C., Bannon A.W., Bo Y., Chen N., Dominguez C., Falsey J., Gavva N.R., Katon J., Nixey T., Ognyanov V.I., Pettus L., Rzasa R.M., Stec M., Surapaneni S., Tamir R., Zhu J., Treanor J.J., Norman M.H. Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. J. Med. Chem. 2007, 50:3515-3527.
358. Wahl P., Foged C., Tullin S., Thomsen C. Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Mol. Pharmacol. 2001, 59:9-15.
359. Neeper M.P., Liu Y., Hutchinson T.L., Wang Y., Flores C.M., Qin N. Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence. J. Biol. Chem. 2007, 282:15894-15902.
360. Qin N., Neeper M.P., Liu Y., Hutchinson T.L., Lubin M.L., Flores C.M. TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J. Neurosci. 2008, 28:6231-6238.
361. Bang S., Kim K.Y., Yoo S., Lee S.H., Hwang S.W. Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci. Lett. 2007, 425:120-125.
362. Juvin V., Penna A., Chemin J., Lin Y.L., Rassendren F.A. Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2- aminoethoxydiphenyl borate. Mol. Pharmacol. 2007, 72:1258-1268.
363. Moussaieff A., Rimmerman N., Bregman T., Straiker A., Felder C.C., Shoham S., Kashman Y., Huang S.M., Lee H., Shohami E., Mackie K., Caterina M.J., Walker J.M., Fride E., Mechoulam R. Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J. 2008, 22:3024-3034.
364. Moqrich A., Hwang S.W., Earley T.J., Petrus M.J., Murray A.N., Spencer K.S., Andahazy M., Story G.M., Patapoutian A. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 2005, 307:1468-1472.
365. Vogt-Eisele A.K., Weber K., Sherkheli M.A., Vielhaber G., Panten J., Gisselmann G., Hatt H. Monoterpenoid agonists of TRPV3. Br. J. Pharmacol. 2007, 151:530-540.
366. Watanabe H., Vriens J., Prenen J., Droogmans G., Voets T., Nilius B. Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 2003, 424:434-438.
367. Vincent F., Acevedo A., Nguyen M.T., Dourado M., DeFalco J., Gustafson A., Spiro P., Emerling D.E., Kelly M.G., Duncton M.A. Identification and characterization of novel TRPV4 modulators. Biochem. Biophys. Res. Commun. 2009, 389:490-494.
368. Dai X.Q., Ramji A., Liu Y., Li Q., Karpinski E., Chen X.Z. Inhibition of TRPP3 channel by amiloride and analogs. Mol. Pharmacol. 2007, 72:1576-1585.
369. Delmas P., Wanaverbecq N., Abogadie F.C., Mistry M., Brown D.A. Signaling microdomains define the specificity of receptor-mediated InsP(3) pathways in neurons. Neuron 2002, 34:209-220.
370. Zagranichnaya T.K., Wu X., Villereal M.L. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J. Biol. Chem. 2005, 280:29559-29569.
371. Xu S.Z., Zeng F., Boulay G., Grimm C., Harteneck C., Beech D.J. Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br. J. Pharmacol. 2005, 145:405-414.
372. Lemonnier L., Trebak M., Lievremont J.P., Bird G.S., Putney J.W. Protection of TRPC7 cation channels from calcium inhibition by closely associated SERCA pumps. FASEB J. 2006, 20:503-505.
373. Togashi K., Inada H., Tominaga M. Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br. J. Pharmacol. 2008, 153:1324-1330.
374. Hu H., Grandl J., Bandell M., Petrus M., Patapoutian A. Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc. Natl. Acad. Sci. USA 2009, 106:1626-1631.
375. 2+ entry. Role in signaling increased endothelial permeability. J. Biol. Chem. 2003, 278:33492-33500.
376. Smyth J.T., Lemonnier L., Vazquez G., Bird G.S., Putney J.W. Dissociation of regulated trafficking of TRPC3 channels to the plasma membrane from their activation by phospholipase C. J. Biol. Chem. 2006, 281:11712-11720.
377. 2+ influx. Mol. Cell 2004, 15:635-646.
378. Kim J.Y., Zeng W., Kiselyov K., Yuan J.P., Dehoff M.H., Mikoshiba K., Worley P.F., Muallem S. Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J. Biol. Chem. 2006, 281:32540-32549.
379. q protein-coupled receptor activation. J. Biol. Chem. 2004, 279:7241-7246.
380. Cheng H., Beck A., Launay P., Gross S.A., Stokes A.J., Kinet J.P., Fleig A., Penner R. TRPM4 controls insulin secretion in pancreatic beta-cells. Cell Calcium 2007, 41:51-61.
381. Thebault S., Alexander R.T., Tiel Groenestege W.M., Hoenderop J.G., Bindels R.J. EGF increases TRPM6 activity and surface expression. J. Am. Soc. Nephrol. 2009, 20:78-85.
382. Van Buren J.J., Bhat S., Rotello R., Pauza M.E., Premkumar L.S. Sensitization and translocation of TRPV1 by insulin and IGF-I. Mol. Pain 2005, 1:17.
383. Lambers T.T., Oancea E., de G.T., Topala C.N., Hoenderop J.G., Bindels R.J. Extracellular pH dynamically controls cell surface delivery of functional TRPV5 channels. Mol. Cell Biol. 2007, 27:1486-1494.
384. 2+- induced differentiation of human keratinocytes. J. Biol. Chem. 2007, 282:22582-22591.
385. Rugiero F., Wood J.N. The mechanosensitive cell line ND-C does not express functional thermoTRP channels. Neuropharmacology 2009, 56:1138-1146.
386. Dietrich A., Kalwa H., Storch U., Schnitzler M., Salanova B., Pinkenburg O., Dubrovska G., Essin K., Gollasch M., Birnbaumer L., Gudermann T. Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch. 2007, 455:465-477.
387. Gomis A., Soriano S., Belmonte C., Viana F. Hypoosmotic- and pressureinduced membrane stretch activate TRPC5 channels. J. Physiol. 2008, 586:5633-5649.
388. Morita H., Honda A., Inoue R., Ito Y., Abe K., Nelson M.T., Brayden J.E. Membrane stretch-induced activation of a TRPM4-like nonselective cation channel in cerebral artery myocytes. J. Pharmacol. Sci. 2007, 103:417-426.
389. Bessac B.F., Fleig A. TRPM7 channel is sensitive to osmotic gradients in human kidney cells. J. Physiol. 2007, 582:1073-1086.
390. Sharif N.R., Witty M.F., Seguela P., Bourque C.W. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat. Neurosci. 2006, 9:93-98.
391. 2+-permeable growth factor-regulated channel. J. Cell Biol. 2003, 161:957-967.
392. Hartmannsgruber V., Heyken W.T., Kacik M., Kaistha A., Grgic I., Harteneck C., Liedtke W., Hoyer J., Kohler R. Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS One 2007, 2:e827.
393. Nauli S.M., Alenghat F.J., Luo Y., Williams E., Vassilev P., Li X., Elia A.E., Lu W., Brown E.M., Quinn S.J., Ingber D.E., Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 2003, 33:129-137.
394. Pedersen S.F., Owsianik G., Nilius B. TRP channels: an overview. Cell Calcium 2005, 38:233-252.
395. Voets T., Talavera K., Owsianik G., Nilius B. Sensing with TRP channels. Nat. Chem. Biol. 2005, 1:85-92.
396. van Rossum D.B., Oberdick D., Rbaibi Y., Bhardwaj G., Barrow R.K., Nikolaidis N., Snyder S.H., Kiselyov K., Patterson R.L. TRP_2, a lipid/trafficking domain that mediates diacylglycerol-induced vesicle fusion. J. Biol. Chem. 2008, 283:34384-34392.
397. Demeuse P., Penner R., Fleig A. TRPM7 channel is regulated by magnesium nucleotides via its kinase domain. J. Gen. Physiol. 2006, 127:421-434.
398. 2+ homeostasis. Science 2008, 322:756-760.
399. Takezawa R., Schmitz C., Demeuse P., Scharenberg A.M., Penner R., Fleig A. Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. Proc. Natl. Acad. Sci. USA 2004, 101:6009-6014.
400. Maruyama Y., Ogura T., Mio K., Kiyonaka S., Kato K., Mori Y., Sato C. Three-dimensional reconstruction using transmission electron microscopy reveals a swollen, bell-shaped structure of transient receptor potential melastatin type 2 cation channel. J. Biol. Chem. 2007, 282:36961-36970.
401. Lishko P.V., Procko E., Jin X., Phelps C.B., Gaudet R. The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 2007, 54:905-918.