Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity

Molecular Cell

Volumn 7, Issue 5, 2001, Pages 1047-1057

  Yamaguchi, Hiroto ^a,b   Matsushita, Masayuki ^c   Nairn, Angus C ^b   Kuriyan, John ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL; PHOSPHOTRANSFERASE; PROTEIN KINASE; SERINE; THREONINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EUKARYOTE; NONHUMAN; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY;

EID: 0035947077     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00256-8     Document Type: Article

References (44)

1. Receptor-activated Ca2+ inflow in animal cells: A variety of pathways tailored to meet different intracellular Ca2+ signalling requirements
2. 3D domain swapping: A mechanism for oligomer assembly
3. + adenylyl imidodiphosphate and inhibitor peptide PKI(5-24)
4. The CCP4 suite: Programs for protein crystallography
5. Novel compounds, "1,3-selenazine derivatives" as specific inhibitors of eukaryotic elongation factor-2 kinase
6. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha
7. Mapping of the novel protein kinase catalytic domain of Dictyostelium myosin II heavy chain kinase A
8. Two "unrelated" families of ATP-dependent enzymes share extensive structural similarities about their cofactor binding sites
9. Analysis of the domain structure of elongation factor-2 kinase by mutagenesis
10. Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis
11. A novel type of protein kinase phosphorylates actin in the actin-fragmin complex
12. Phosphatidylinositol phosphate kinase: A link between protein kinase and glutathione synthase folds
13. Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: The role of Ca2+ and trp
14. From worm to man: Three subfamilies of TRP channels
15. Dali: A network tool for protein structure comparison
16. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases
17. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
18. The eleventh Datta lecture. The structural basis for substrate recognition and control by protein kinases
19. Improved methods for binding protein models in electron density maps and the location of errors in these models
20. ADP-binding site of Escherichia coli succinyl-CoA synthetase revealed by x-ray crystallography
21. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
22. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
23. Maximum-likelihood heavy-atom parameter refinement in the MIR and MAD methods
24. The structure of SAICAR synthase: An enzyme in the de novo pathway of purine nucleotide biosynthesis
25. Modulation of ion channels by protein phosphorylation. How the brain works
26. The three-dimensional structure of peptide-MHC complexes
27. Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction
28. Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p
29. Molecular characterization of the Drosophila trp locus: A putative integral membrane protein required for phototransduction
30. Efficient anisotropic refinement of macromolecular structures using FFT
31. AMoRe: An automated package for molecular replacement
32. Processing of X-ray diffraction data collected in oscillation mode
33. Release of proteins and peptides from fusion proteins using a recombinant plant virus proteinase
34. Signal transduction in Drosophila photoreceptors
35. Structure of type IIβ phosphatidylinositol phosphate kinase: A protein kinase fold flattened for interfacial phosphorylation
36. Cloning and expression of cDNA encoding protein synthesis elongation factor-2 kinase
37. Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5′-triphosphate
38. TRP-PLIK, a bifunctional protein with kinase and ion channel activities
39. Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase
40. Alpha-kinases: A new class of protein kinases with a novel catalytic domain
41. Zinc mining for protein domains
42. Crystal structure of the Src family tyrosine kinase Hck
43. The crystal structure of the Physarum polycephalum actin-fragmin kinase: An atypical protein kinase with a specialized substrate-binding domain