A voltage sensor-domain protein is a voltage-gated proton channel

Science

Volumn 312, Issue 5773, 2006, Pages 589-592

  Sasaki, Mari ^a,b,c   Takagi, Masahiro ^a,c   Okamura, Yasushi ^a,b,c,d  

^a OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNELS; PROTON CHANNELS; VOLTAGE SENSORS;

ELECTRIC POTENTIAL; ION EXCHANGE; MOLECULAR DYNAMICS; PH; PROTONS; ZINC;

PROTEINS;

ION CHANNEL; ZINC ION;

CYTOLOGY; ION; PH; PROTEIN; SENSOR;

AMINO ACID SEQUENCE; ARTICLE; CELL PH; CHANNEL GATING; DEPOLARIZATION; ION CONDUCTANCE; MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL LINE; CIONA INTESTINALIS; ELECTRIC CONDUCTIVITY; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; PROTONS; TRANSFECTION;

EID: 33646229810     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1122352     Document Type: Article

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23. We thank T. Mohri for help with pH imaging; K. Saito, Y. Murata, and T. Kurokawa for sharing preliminary electrophysiological data; K. Ikenaka and S. Hitoshi for help in the analysis of the gene expression profile; T. McCormack and J. Cui for their critical reading of the manuscript; and members of the Okamura lab for helpful discussion. This work was completed in a partial fulfillment of a Ph.D. degree to M.S. at the Graduate University for Advanced Studies. This work was supported by Grants-in-Aid for Scientific Research and for Creative Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology; the Naito Foundation; and the Mochida Memorial Foundation for Medical and Pharmaceutical Research in Japan. The full-length cDNA sequence of Ci-VSOP is deposited in the DNA Data Bank of Japan (DDBJ) with accession number AB218779. The authors declare no competing financial interests.