A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels

Journal of Neuroscience

Volumn 26, Issue 18, 2006, Pages 4835-4840

  Brauchi, Sebastian ^a,b   Orta, Gerardo ^a   Salazar, Marcelo ^a   Rosenmann, Eduardo ^a   Latorre, Ramon ^a  

^a CENTRO DE ESTUDIOS CIENTÍFICOS CECS   (Chile)

^b UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

Author keywords

C terminal domain; Chimeras; PIP2; Temperature activation; TRPM8; TRPV1

Indexed keywords

PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; VANILLOID RECEPTOR 1; CALCIUM; CAPSAICIN; HYBRID PROTEIN; MENTHOL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM8 PROTEIN, HUMAN; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CHIMERA; CONTROLLED STUDY; ELECTRIC POTENTIAL; HEAT SENSITIVITY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SENSOR; TEMPERATURE SENSE; THERMAL ANALYSIS; THERMORECEPTOR; ANALYSIS OF VARIANCE; BIOSYNTHESIS; CELL LINE; CELL MEMBRANE POTENTIAL; CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; DOSE RESPONSE; DRUG EFFECT; ELECTROSTIMULATION; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MOLECULAR CLONING; PATCH CLAMP; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RADIATION EXPOSURE; RADIATION RESPONSE; SEQUENCE ALIGNMENT; TEMPERATURE;

ANALYSIS OF VARIANCE; CALCIUM; CAPSAICIN; CELL LINE, TRANSFORMED; CLONING, MOLECULAR; DIAGNOSTIC IMAGING; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIALS; MENTHOL; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; TEMPERATURE; TEMPERATURE SENSE; THERMORECEPTORS; TRANSFECTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPM CATION CHANNELS; TRPV CATION CHANNELS;

EID: 33646899582     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5080-05.2006     Document Type: Article

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